LOCUS       NM_001164580            4842 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus modulator of smoothened (Mosmo), mRNA.
ACCESSION   NM_001164580 XM_001479114 XM_133786
VERSION     NM_001164580.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4842)
  AUTHORS   Kong JH, Young CB, Pusapati GV, Espinoza FH, Patel CB, Beckert F,
            Ho S, Patel BB, Gabriel GC, Aravind L, Bazan JF, Gunn TM, Lo CW and
            Rohatgi R.
  TITLE     Gene-teratogen interactions influence the penetrance of birth
            defects by altering Hedgehog signaling strength
  JOURNAL   Development 148 (19) (2021)
   PUBMED   34486668
  REMARK    GeneRIF: Gene-teratogen interactions influence the penetrance of
            birth defects by altering Hedgehog signaling strength.
REFERENCE   2  (bases 1 to 4842)
  AUTHORS   Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M,
            Briscoe J, Aravind L and Rohatgi R.
  TITLE     CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity
            to the Morphogen Sonic Hedgehog
  JOURNAL   Dev Cell 44 (1), 113-129 (2018)
   PUBMED   29290584
  REMARK    GeneRIF: This gene encodes a four-pass transmembrane protein that
            dampens signaling through the Hedgehog pathway by reducing the
            levels of the Smoothened oncoprotein at the cell surface and the
            primary cilium.
            Erratum:[Dev Cell. 2018 Jan 22;44(2):271. PMID: 29401421]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099930.11, BC030336.1 and AC122214.4.
            
            [WARNING] On May 2, 2023 this sequence was replaced by
            NM_001164580.2.
            
            On or before Sep 9, 2009 this sequence version replaced
            XM_001479114.1, XM_133786.9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.206101.1,
                                           SRR1660815.152539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC099930.11        160525-160650
            127-1242            BC030336.1         11-1126
            1243-4842           AC122214.4         40291-43890
FEATURES             Location/Qualifiers
     source          1..4842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..4842
                     /gene="Mosmo"
                     /gene_synonym="Atthog"
                     /note="modulator of smoothened"
                     /db_xref="GeneID:233812"
                     /db_xref="MGI:MGI:2446240"
     exon            1..251
                     /gene="Mosmo"
                     /gene_synonym="Atthog"
                     /inference="alignment:Splign:2.1.0"
     exon            252..464
                     /gene="Mosmo"
                     /gene_synonym="Atthog"
                     /inference="alignment:Splign:2.1.0"
     exon            465..4842
                     /gene="Mosmo"
                     /gene_synonym="Atthog"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcgcgga gggcgcgagc gcgcggcgcg ggccgagggc cgagggcggc ggcgcgggga
       61 ccccggggcc cggcggccca tggggcgcga ggagtgaggc cgcggcctgc cctgcggtgg
      121 ggggtggggg gagcggggcg gggcgatgga taaactgacc atcatctcag gatgtctctt
      181 tctggccgcc gatatcttcg ccatcgccag catcgccaac ccggactgga tcaacaccgg
      241 ggagtcggcg ggagcactca ctgtgggcct ggtgcggcag tgtcagacaa tccatggacg
      301 agaccggacc tgcatccctc ctcggcttcc cccagaatgg gtcaccaccc tgttttttat
      361 catcatggga atcatttcct tgactgtcac atgtggtttg ctggtggctt cccactggcg
      421 aagagaagct acaaaatatg ctcgatggat agcattcact ggaatgatcc ttttctgtat
      481 ggctgcccta atatttccaa taggatttta catcaatgaa gtcggaggtc aaccttataa
      541 gttacccaac aacacagtag ttgggtcatc atatgtactt tttgtcttat cgattttctt
      601 cacaatagta ggacttctgt ttgctggcaa agtctgttta ccaggctgac gaatgtctaa
      661 acggcttaac tctttttatt tttttatttt attttttatt tttagaggtt gggaggacaa
      721 agagaaggca tctgggcagt cctctcatag gaagatgctt agatgaacct gatgctgaaa
      781 aggaaaaatt gctttgattt gttctcacta tgcactttgg atttaaaaaa aagaatgaga
      841 gccttttcca taaccaaata caatattgac taaatctcct gagcatattc aggcagtcag
      901 tctgcactgt gatagcaacc tagtgaagga gagtgcttta tgctgaaagc atgtggcccc
      961 ttgtgactct gttgatctgt ttttaatgtc taatgattca tttgagaggg gggaaagtct
     1021 agtatttatg aatcatgatg gaccagaagg gtgcaggagg ttcgtgtggg gctggcctca
     1081 cctcctaaga tattagtatt ctcaatttcc ttgtcatgtt atgagccttt ggcaccacaa
     1141 tggattgccg ttgcattact gcaccaagaa gccaatagat caaaacttgt ttgctaaaat
     1201 gtatgtaaaa attctaaaac tccctaatct ctgtgtacaa aagaaaaaag aaaacactaa
     1261 gaaacaagtt tggggtgggt gggggaaatc ttccttatat ttatataaat atatatataa
     1321 tatatatatt ttgctgatgc agtatacagt gtgtatatgt gtgtgtgtgt atgtgtgtgt
     1381 acatttgtat atgcacacat gcaaacagtt cctggacgag aactctgaat gcttgctagc
     1441 aaaacactgt ggtgtgcaac ctagaactca atagaaaaaa gccatttatc tgaaggctgc
     1501 atagtggaga gagtcttcag tttacctcat tctttgtagc agcctttgat tttgacaggt
     1561 ttctgtaata ggtacaaata actccatacc tttctaggtg caattttaag ttaagctaaa
     1621 gattctttct aagtttaatt tatttgtata tgacagtaaa ggtaaggtca tgccaaacct
     1681 tatagtttgg ggaatctgac actgttggaa tgaataacaa ttgtcatcta ttgtacattc
     1741 attttttcca ctggttcagt ctgctacgtt aacaatgcag tgtatacgtt caggcataca
     1801 acttcacata aacattaagg tcactagcaa atatctggct gttttggcta tttacaacac
     1861 tagttctgct cttccataaa aatcgcattt tatctgtatt agtagatctt caccaaactc
     1921 ttaagcaata caatattccc tctaatgctt tacacacgtg tgtgctgaaa agctaccatt
     1981 ctttcatttg ctttgaagac tgcattaaac cttaaggggt tttttgtttg tttggttggt
     2041 tggggtttgt tttgttttgt tttgtttttt gtagaaacag caatgcagct gattctgaac
     2101 tcacaagtac ttttaaaacc cagtcctttc ctccccacat tcccatgcct gtgtcaacac
     2161 ctcgattctt cctggggaac acttgtttga atcttgtcac aagggtgttt catggcagtg
     2221 gagctgagtt tgtcctctct agagtgaatg gcaattcaag tatccctatt agtgggcaga
     2281 gtacaagtct tacatagcct gtacttcaaa caaatgggaa tgactcctaa gcaactcgat
     2341 tctccctcac aggatggtat tcggagatgg gttacctgct cagatctgac ctagagtgga
     2401 agacttgggt cagtcctcac caatgtgtct gttattcagc tgtctcagta ttaaattgtg
     2461 aatgaaaacc cagtgtttgg gctcatacag gaaccttgga gaagtggacc cctctgtgtg
     2521 agaagcctgc agtcagtcgg aggaaggacg ctttccacca cctgttccgt ccaggcagtt
     2581 ctaaaaccac cactagacat gttctgtgga cattcgggat tgggctttga tcagtcatca
     2641 gtcaaatggg tcactctgaa ggaaaggttt ggtggttggc attataccac tgatacaaag
     2701 tattagcaaa gtatagttca aattaagtga catgaccaag agcttttctc ttaaaaaaga
     2761 tggattttat tgtaaatagt ttctcaaaat atttttaact ggatcatgag catggggaga
     2821 gaaagtttct cagctgctat gaatttcccc actgtttact tctctcattt acagtggtat
     2881 tgcataagat tacaaaatgt taggttttat ttgtatctat tacccaaacc attaaattgt
     2941 ctttaatttc atcattgtct tggaaggcca gtgcatgaag agctgatggg ggaagcccct
     3001 ctagccactc agcgctctag cccaggatta agaccatccc atcgagtagt gtgtcaagtc
     3061 cagtctttgt aaactctctc agaccaaacg ttgttgaagt ggactaatcc gtgtaatcgg
     3121 tcctgtaagt ggacggacaa acagctgcca gcagctgctt ttaaaaggtc actatgagta
     3181 ctacatagca cagtattaat ttatagcagg aatcatatct tgtaaaatgt atataaaaca
     3241 cttttatggt gcaatcattt gtcaaatttt gtctgttacg ttgttcttag agtgtacatt
     3301 cttctcatgc ctaagaatat cactgtaaaa tctgctgaaa actattttta ggttttattt
     3361 gcacaagact gaactagttt gagtgtttag gaagctccta tcgaacaagc ctaaacatct
     3421 gtatagataa aaatcttcaa ttcattaaaa gcaaccatta gtacaattct ttccaaaggt
     3481 aatccatgtt ctgtgttgtt agtgtgggtg tgatgtttct gacttctcca tctctcacaa
     3541 gcctggtttc tgttccatct gttttgtttt agaaagatgc cttttttttt ttttcttttg
     3601 taatgttcta gatgaccaaa acacattctt gggttttgcc tacagctttg atttctccgt
     3661 gtggtgttgt gcgagttcac tgtttaatct cttcagtgaa ataaatagtc ctggtgacag
     3721 gcaatctatt ggtttagagg aaaggtcctt aagaagtgtt ggaaactaac tttggatctg
     3781 ttcttagctg ttgttttgca tcatggactt catgagaaga acatgttgca tttattttgt
     3841 ctttattaaa agactactag tcaccggtta ctctggttat agtaactgtt atatcaaccc
     3901 actttgatct tctttttaaa attaaattta cattcacaag tcaaaacaat aagctgtctt
     3961 ttagaaaatt tttgaaggat aaaaataaat gaaggaaaaa ggtggtctgt gtaggtagaa
     4021 ttgtctacac agaattttag ttgtattgcc ttgagagatt ttagtttgtg gtcaaggtct
     4081 gtatattatc caaaacttta ttaagaattg ttttctaatt ggttataaca ttttttcaat
     4141 taatagtttc aaaacaaatt gttaatacaa ctgtataaag tgaacataat tttcttcact
     4201 tgtatttttg ttattgagca agtttatcaa aataaattgt ctactaaaga aactaaaaag
     4261 gcttctatta cttttaatac attttgattt taaatgttta tttctagaga tgtagctgtc
     4321 ttgttaaaga agtaacttgg tagagtgtgt tcagtcccca gcactgagta aaccaggtat
     4381 aatgggactt gcctgtaact cgatcattca ggaggtagaa gccaaggctt aaggtaatct
     4441 tcagctacat cgcatcgttg caaggctagc ctgtctggaa acagcacagt actgtagcat
     4501 tttcccttac agagacctgg cctcctggtt gtgttagtgt tgtatgtgag ggagctcccc
     4561 tcctccctgg acagtctttg ctcactttag tcaggaatga gactgtgccc catagtctca
     4621 gatgtttggg tcttggtccc cagttggtgg ctgtttgggg aggtttaaga agaggtgtct
     4681 ccttgaggaa aaaacatgtc tctggggctg ggctttgaga tgtcagagct gcatgccatt
     4741 cccagtcctc tgctccaggc ttgcagtcca caatgggaga cctcagcttc tgctctgatt
     4801 gacgcctctg gaaccgtaag ccaaataaac ctcttcttct gt
//
