LOCUS       NM_024431               1896 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus mortality factor 4 like 1 (Morf4l1), transcript
            variant 2, mRNA.
ACCESSION   NM_024431
VERSION     NM_024431.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Tian,C., Min,X., Zhao,Y., Wang,Y., Wu,X., Liu,S., Dou,W., Zhou,T.,
            Liu,Y., Luo,R., Li,Z., Lui,K.O., Li,Y., Zhou,B. and Ding,Q.
  TITLE     MRG15 aggravates non-alcoholic steatohepatitis progression by
            regulating the mitochondrial proteolytic degradation of TUFM
  JOURNAL   J Hepatol 77 (6), 1491-1503 (2022)
   PUBMED   35985547
  REMARK    GeneRIF: MRG15 aggravates non-alcoholic steatohepatitis progression
            by regulating the mitochondrial proteolytic degradation of TUFM.
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Wei,Y., Tian,C., Zhao,Y., Liu,X., Liu,F., Li,S., Chen,Y., Qiu,Y.,
            Feng,Z., Chen,L., Zhou,T., Ren,X., Feng,C., Liu,Y., Yu,W., Ying,H.
            and Ding,Q.
  TITLE     MRG15 orchestrates rhythmic epigenomic remodelling and controls
            hepatic lipid metabolism
  JOURNAL   Nat Metab 2 (5), 447-460 (2020)
   PUBMED   32694659
  REMARK    GeneRIF: MRG15 orchestrates rhythmic epigenomic remodelling and
            controls hepatic lipid metabolism.
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Brandsma,I., Sato,K., van Rossum-Fikkert,S.E., van Vliet,N.,
            Sleddens,E., Reuter,M., Odijk,H., van den Tempel,N.,
            Dekkers,D.H.W., Bezstarosti,K., Demmers,J.A.A., Maas,A.,
            Lebbink,J., Wyman,C., Essers,J., van Gent,D.C., Baarends,W.M.,
            Knipscheer,P., Kanaar,R. and Zelensky,A.N.
  TITLE     HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required
            for Mouse Spermatogenesis
  JOURNAL   Cell Rep 27 (13), 3790-3798 (2019)
   PUBMED   31242413
REFERENCE   5  (bases 1 to 1896)
  AUTHORS   Iwamori,N., Tominaga,K., Sato,T., Riehle,K., Iwamori,T., Ohkawa,Y.,
            Coarfa,C., Ono,E. and Matzuk,M.M.
  TITLE     MRG15 is required for pre-mRNA splicing and spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 113 (37), E5408-E5415 (2016)
   PUBMED   27573846
  REMARK    GeneRIF: In round spermatids, MRG15 colocalizes with splicing
            factors PTBP1 and PTBP2 at H3K36me3 sites between the exons and
            single intron of transition nuclear protein 2 (Tnp2). Thus, our
            results reveal that MRG15 is essential for pre-mRNA splicing during
            spermatogenesis and that epigenetic regulation of pre-mRNA splicing
            by histone modification could be useful to understand not only
            spermatogenesis but also, epigenetic disorder
REFERENCE   6  (bases 1 to 1896)
  AUTHORS   Tominaga,K. and Pereira-Smith,O.M.
  TITLE     The genomic organization, promoter position and expression profile
            of the mouse MRG15 gene
  JOURNAL   Gene 294 (1-2), 215-224 (2002)
   PUBMED   12234683
REFERENCE   7  (bases 1 to 1896)
  AUTHORS   Matsuoka,Y., Matsuoka,Y., Shibata,S., Ban,T., Toratani,N.,
            Shigekawa,M., Ishida,H. and Yoneda,Y.
  TITLE     A chromodomain-containing nuclear protein, MRG15 is expressed as a
            novel type of dendritic mRNA in neurons
  JOURNAL   Neurosci Res 42 (4), 299-308 (2002)
   PUBMED   11985882
REFERENCE   8  (bases 1 to 1896)
  AUTHORS   Bertram,M.J. and Pereira-Smith,O.M.
  TITLE     Conservation of the MORF4 related gene family: identification of a
            new chromo domain subfamily and novel protein motif
  JOURNAL   Gene 266 (1-2), 111-121 (2001)
   PUBMED   11290425
REFERENCE   9  (bases 1 to 1896)
  AUTHORS   Lopez-Fernandez,L.A., Parraga,M. and del Mazo,J.
  TITLE     Tex261, a novel gene presumably related but distinct from
            steroidogenic acute regulatory (StAR) gene, is regulated during the
            development of germ cells
  JOURNAL   Biochem Biophys Res Commun 242 (3), 565-569 (1998)
   PUBMED   9464256
REFERENCE   10 (bases 1 to 1896)
  AUTHORS   Lopez-Fernandez,L.A. and del Mazo,J.
  TITLE     Characterization of genes expressed early in mouse spermatogenesis,
            isolated from a subtractive cDNA library
  JOURNAL   Mamm Genome 7 (9), 698-700 (1996)
   PUBMED   8703127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140392.3, AK167079.1 and BC085103.1.
            
            On Sep 18, 2009 this sequence version replaced NM_024431.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092293.1, AK168674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC140392.3         132706-132946       c
            242-1862            AK167079.1         1-1621
            1863-1896           BC085103.1         1830-1863
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.42 cM"
     gene            1..1896
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /note="mortality factor 4 like 1"
                     /db_xref="GeneID:21761"
                     /db_xref="MGI:MGI:1096551"
     exon            1..285
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1217
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /note="isoform b is encoded by transcript variant 2;
                     mortality factor 4-like protein 1; MORF-related gene 15
                     protein; testis-expressed gene 189 protein; transcription
                     factor-like protein MRG15; testis expressed gene 189"
                     /codon_start=1
                     /product="mortality factor 4-like protein 1 isoform b"
                     /protein_id="NP_077751.1"
                     /db_xref="CCDS:CCDS52885.1"
                     /db_xref="GeneID:21761"
                     /db_xref="MGI:MGI:1096551"
                     /translation="MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFI
                     HYSGWNKNWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQ
                     QKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKI
                     PEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVV
                     AGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAY
                     TPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV"
     exon            286..332
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            333..400
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            401..487
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            488..568
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            569..594
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            595..683
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            684..785
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            786..874
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1047
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1132
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1866
                     /gene="Morf4l1"
                     /gene_synonym="mKIAA4002; MORFRG15; MRG15; TEG-189;
                     Tex189"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accaatcccg gcatgcctct gggcggcacg ggcgcaggct tgtgtgcgta gcggttagcc
       61 gttggctgag gcggcggctg cgcgggtcgc ggtgctgtga ggtcaggcgg cgctggcaaa
      121 tcgcgcccag gatgtagagc tggctgtggc cgacggcgcg tctgacgctg agttgggtgg
      181 ggtagagagt agggggcggt agtcgggggt ggtgggagaa ggaggaggcg gcgaatcact
      241 tataaatggc gcccaagcag gaccctaagc cgaaattcca ggagggcgag cgagtgctgt
      301 gctttcatgg gcctcttctc tatgaagcaa agtgtgtaaa ggttgccata aaggacaaac
      361 aagtgaaata cttcatccat tacagtggct ggaataaaaa ttgggatgaa tgggtgccag
      421 aaagcagagt actcaaatac gtggacacca atttgcagaa acagcgagaa cttcaaaagg
      481 ccaatcagga acaatatgca gagggcaaga tgagaggggc tgctccgggg aagaagacat
      541 ccggcctgca acagaaaaat gtcgaagtga aaacaaaaaa gaacaagcag aaaacacctg
      601 gaaatggaga tggtggcagt accagtgaga cacctcagcc tcctaggaag aagagagccc
      661 gggtagatcc taccgttgaa aatgaagaaa ccttcatgaa cagagttgaa gttaaagtga
      721 agatccctga agagctgaaa ccctggcttg tggatgactg ggacttgatc accagacaga
      781 agcagctttt ttatcttcct gccaagaaga atgtggattc cattttggag gattatgcaa
      841 attataagaa gtctcgagga aatacagata ataaagagta tgctgttaat gaggtggtgg
      901 caggcataaa ggagtacttc aatgtcatgt tgggcactca gctcctctac aagtttgaga
      961 gaccacagta cgctgaaatc ctcgccgacc acccggatgc gcccatgtcc caggtgtacg
     1021 gagcgccaca tttgctgaga ttatttgtgc gaattggagc gatgttggcc tacacgcctc
     1081 tagatgagaa aagccttgct ttattactga actatctaca tgattttctc aagtacctgg
     1141 cgaagaattc tgcaaccttg ttcagtgcca gtgattatga agtggcccct cctgagtacc
     1201 accggaaagc cgtgtgaggg cgtgctcgcc ctctctccct cgtgcttgga tctctgtaaa
     1261 cagtttggtt cttagtcctt ctcttgtaca aatgatgtac tttgaagacc gttagtgtat
     1321 aacagagttg tttgtttcct ctttgatttt aaacagagaa aataaaagga gtaactgctc
     1381 cttttttctt ccttttttca tttcaaagtt tctaccagtg tatcagtgac ggacaacaga
     1441 gagacatgct gtagagtgtt tgcctagttg acaaagctgc ttttgaatgc tggtggttct
     1501 gttcctttga cactacgcac ttttataata tgtgttaatg ctctatgaca aatgctctga
     1561 ttcctagtgc caaaggttca cttcagtgta tataactgaa cactcatcca tctgtgctct
     1621 tttttttttt tttaatggtg cttaaagagc ccatcctttg caagtcatcc atgtcattcc
     1681 ttaggcatct tatctttgct caactgttaa agaatggtgg cttgttttca tgggttttgt
     1741 atttgtgtct aatgcacgtt ttaacatgat agacgcaatg catcgtgtag ctgcagtttt
     1801 atggaaaagt caatcttgta ggagttgttt ttcagatctt caataaattt tttctttaaa
     1861 tttcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
