LOCUS       NM_001193309            4108 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus microrchidia 4 (Morc4), transcript variant A, mRNA.
ACCESSION   NM_001193309
VERSION     NM_001193309.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4108)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672243.12.
            
            Transcript Variant: This variant (A) encodes the longer isoform
            (A).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098483.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               AL672243.12        128899-129281       c
            384-456             AL672243.12        128697-128769       c
            457-589             AL672243.12        122122-122254       c
            590-807             AL672243.12        116426-116643       c
            808-955             AL672243.12        115375-115522       c
            956-1088            AL672243.12        112486-112618       c
            1089-1217           AL672243.12        112037-112165       c
            1218-1337           AL672243.12        109640-109759       c
            1338-1438           AL672243.12        107276-107376       c
            1439-1528           AL672243.12        98325-98414         c
            1529-1657           AL672243.12        95481-95609         c
            1658-1726           AL672243.12        94112-94180         c
            1727-1778           AL672243.12        93563-93614         c
            1779-1951           AL672243.12        92037-92209         c
            1952-2630           AL672243.12        81593-82271         c
            2631-2914           AL672243.12        80757-81040         c
            2915-4108           AL672243.12        79262-80455         c
FEATURES             Location/Qualifiers
     source          1..4108
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.35 cM"
     gene            1..4108
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /note="microrchidia 4"
                     /db_xref="GeneID:75746"
                     /db_xref="MGI:MGI:1922996"
     exon            1..383
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..3068
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /note="isoform A is encoded by transcript variant A; zinc
                     finger, CW-type with coiled-coil domain 2; MORC family
                     CW-type zinc finger protein 4; zinc finger CW-type
                     coiled-coil domain protein 2"
                     /codon_start=1
                     /product="MORC family CW-type zinc finger protein 4
                     isoform A"
                     /protein_id="NP_001180238.1"
                     /db_xref="CCDS:CCDS57777.1"
                     /db_xref="GeneID:75746"
                     /db_xref="MGI:MGI:1922996"
                     /translation="MLLYRGAPAGPGTPGGGLARAGSVPQAFRIRLSTMSPRYLQSNS
                     SSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKKKPCLTFTDDGCGMTPHKLHRML
                     SFGFTDKVIKKSQRPIGVFGNGFKSGSMRLGKDALVFTKNGNTLAVGLLSQTYLECIQ
                     AQAVIVPIVPFSQQNKKMIVTEDSLPSLEAILNYSIFNCEKDLLSQFDAIPGKKGTRV
                     LIWNIRRNKDGKSELDFDTDQYDILVSDFDAEEKEIGGVTSELPETEYSLRAFCSILY
                     MKPRMKIFLRQKKVTTQMIAKSLANVEYDIYKPTSTNKQVRITFGFSCKYHNQFGVMM
                     YHNNRLIKAFEKAGCQLKPTCGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINAL
                     ARKLNAYWKEKISQENFEPLPTSRRIPDQTWVQCDECLKWRRLPGMVDPSTLPARWFC
                     YYNPHPKFKRCSVPEEQERIDEDLHRSKAKQQVEAAEKKQKPMESDKYQVFSNPPKTP
                     PLQDMAELNDKTIGYEQINSPSLLPSVREESRSPPRLKSLDSSAFQISRKYKLILGEE
                     PVEKRRKIQTEMPLSPIDYSMSGFYRRVEAATAYPEGENSPDKCSSERSTPPHLIPEY
                     PESNKHTEENREAPALCPGSQDQDQGFLLPEELEDQMPKLVAEESNRSSENIDKDMNK
                     GPFVAVVGVAKGVADSGAPIQLVPFNREEFVGKRKRAESWKRANPYSSAAPAATAGKG
                     KDCQDSRSRNMPKIKTPKESEELKRTTEKLERVLAERNLFQQKVEELEQEKNHWHSEY
                     KKAQHELVTYSTQETEGIYWSKKHMGYRQAEFQILKAELERTKEEKQELKEKLKETES
                     HLEVLQKAQVSFRNPEGDDLERALARLTRLRVHVSYLLTSVLPHLELREIGYDSEQVD
                     GILYTVLEANHILD"
     exon            384..456
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..589
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..807
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..955
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1088
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1217
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1337
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1438
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1528
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1657
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1726
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1778
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1951
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2630
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2914
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..4108
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3818..3823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /note="hexamer: AATAAA"
     polyA_site      3839
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /note="major polyA site"
     regulatory      4013..4018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
                     /note="hexamer: AGTAAA"
     polyA_site      4039
                     /gene="Morc4"
                     /gene_synonym="1600017G11Rik; 5630401M14Rik; Zcwcc2"
ORIGIN      
        1 atatttctgt acggcccagg ggcagccctg gcagtcggtg ggtcaggaga ggtgctgaca
       61 aggcggggcg ggcagacgct gggttcctcc ggcttcaccc ctcccgctgg ggacaggtgg
      121 ctgcagcgcg ccccgcctct gccagctgcg agtgggaacg agagagggcc agtccgggac
      181 ggccaccgcc agctgcgagt cgggggacag cgcgatctag tgcggggaca gccggcccag
      241 gggtccggca gcagcaaacc ggtatcctgg cggccaaaaa aatgctcctg taccgagggg
      301 cccctgcggg ccccggaacg ccgggaggcg gactggcccg ggcgggcagc gtcccgcagg
      361 ccttcaggat ccgcctgagc acgatgagcc cccgctacct ccagagcaac tccagcagcc
      421 acacgcgacc cttcagtgcc atcgcggagc tgctagataa tgctgtagat ccagatgtat
      481 ctgccaggac agtctttata gatgttgagg aagtcaagaa gaaaccgtgt ttgaccttta
      541 ctgatgacgg atgtggcatg acacctcaca agctccaccg aatgctcagc tttggcttta
      601 cagataaagt aataaagaaa agccagcgtc ccatcggggt ctttggtaat ggtttcaagt
      661 cgggttccat gcgactagga aaggatgctc ttgtcttcac caagaatggg aatactctcg
      721 ccgttggact tctgtcacag acctacctgg agtgtatcca ggcgcaggcg gttattgtac
      781 caattgttcc attcagccag caaaacaaaa aaatgattgt tactgaggat tctttgccca
      841 gcctagaagc catcttgaac tattcgattt tcaactgtga aaaagacctg ctgtctcagt
      901 tcgatgccat tccaggcaaa aaaggcaccc gagttctcat ttggaatatc cggagaaaca
      961 aagatggaaa gtctgagctg gacttcgata cagatcaata tgatatcctg gtatcagact
     1021 tcgatgctga agaaaaagag attggtggtg ttacctctga gctgccagaa acagagtatt
     1081 ccttacgggc attttgtagt attctatata tgaagccccg gatgaagatt tttctgcgac
     1141 aaaagaaggt gactacgcag atgattgcta agagcctggc caatgtagaa tatgatatat
     1201 ataagcctac ctccacgaat aagcaggtga gaatcacgtt tggattctct tgcaaatacc
     1261 ataaccagtt tggagttatg atgtatcata acaaccgcct tattaaggcc tttgagaaag
     1321 caggctgcca gttaaagcca acctgtggag aaggtgtggg agtaattgga gtcattgagt
     1381 gcaatttcct aaaacctgcc tacaacaaac aagactttga gtataccaaa gaataccggt
     1441 tgacaataaa tgcccttgca aggaagctca atgcttattg gaaggaaaaa atatctcaag
     1501 agaattttga gcccttacct acttccagga ggattcctga ccagacatgg gtacaatgtg
     1561 atgaatgtct taagtggagg aggcttcccg ggatggtgga tccatccaca ttacctgcaa
     1621 gatggttttg ttattataat ccccatccga aattcaagag atgctctgtt ccagaagaac
     1681 aagaacgtat tgatgaagac ttacaccgga gcaaggctaa gcaacaagtc gaggctgctg
     1741 agaagaagca gaagccgatg gaaagtgaca agtaccaggt cttcagtaat ccaccaaaga
     1801 ctcctcctct acaagatatg gctgaactaa atgacaagac aattggatat gagcaaatca
     1861 atagccccag cctgcttccg tctgttagag aagaaagcag atcaccccct cggcttaagt
     1921 ctctggattc cagtgctttt cagatttcca gaaagtacaa attgattcta ggcgaggagc
     1981 ctgtagagaa acgaaggaag atccaaactg agatgccgct atctcctata gattactcca
     2041 tgtccggttt ttacaggagg gtagaagcag ctaccgccta cccagaagga gaaaacagcc
     2101 ctgataaatg cagttctgag agaagtacac caccacatct cataccagaa tacccagaat
     2161 caaacaagca tacagaggag aacagggaag ccccagcact ttgtccaggg tcccaggacc
     2221 aagatcaggg gttcctgctt cctgaagaat tagaagatca gatgccaaaa ttggtagcag
     2281 aagagtctaa cagaagtagt gagaacatag acaaagacat gaataaaggg ccgtttgtag
     2341 ctgttgtcgg tgttgcaaag ggagttgcag attcaggcgc tcccatccag ttagtcccct
     2401 ttaacaggga ggaatttgta ggcaaaagaa agagagcaga atcctggaag agagcaaatc
     2461 cttactcttc tgcggctcct gcagccactg ctggaaaagg aaaggattgc caggacagta
     2521 gaagtcggaa catgccaaag ataaagaccc caaaagagtc ggaagaattg aagagaacca
     2581 cggaaaaatt ggaacgtgtt ttggctgaaa ggaatttgtt ccagcaaaag gtagaggagc
     2641 tggaacagga gaaaaaccac tggcattctg aatataagaa agctcaacat gaattggtga
     2701 cctatagtac ccaggagaca gaaggcatat actggagcaa gaagcacatg ggttatcgcc
     2761 aagctgaatt ccagattctg aaagccgagc tagaaagaac caaagaggag aagcaagaac
     2821 taaaagagaa actgaaagag acagagtcac acctggaagt attgcagaag gcccaggtct
     2881 ccttccggaa cccagaggga gatgacctag aaagggcttt ggccaggctc actcggctac
     2941 gtgtccacgt cagctatctc cttacttctg tcctccctca cttggagctt cgtgagatcg
     3001 ggtatgactc agaacaagtg gatgggatcc tgtacacagt gctggaagca aatcacatac
     3061 tggactgagc accaggctat atatcctctc gtagctttct tttctccctt gtgcctgtgt
     3121 actgaatgtc ctcccttgtc ttgtttctcc tttctcccct tctcccttcc tccccttctc
     3181 cccagacccc agcctctttc tttctcttca cctttatgcc ttatatggag aatctttgaa
     3241 tgagtcctgg ctcttaatcg gtgtgcttca catttatggt gggtgtgaag aaagaggccc
     3301 attcaacagc tttttttttt ttttaagagt tcaggaacag aaaagcaata gtcaccaagt
     3361 taggtgacct gaaagcttta attttgatga tctagtagat acttggcccg tttcatattc
     3421 ctgataatgg tttgtattaa tttaggtgaa accagtcagc aaatgttggg tccaatgtgc
     3481 ttggtgggat aagtaatgat ttcagccctg ccaaggttct agcaatctag ttggaagcac
     3541 aaggcacacc aagttaacta actatacaga gaagggtatg gtgtgtatga gtggtatcca
     3601 catgacatgg aagatagagt agagtggttt aaaggaaggc agtacaccat aagtgggacc
     3661 taaatgaagc tttcaagagt gaacatgacg gcactcttaa tgatggttgg tgcttaggtg
     3721 gtaggattat ggttgatgat tttttccttc ctatcttctt gccctcttta cactgcaatt
     3781 tttctctaac attcttgttg ccctccttac attgccaaat aaattgtttt gaaagctaac
     3841 aagtaggctt gaatttgggt gtcaaatgag acatttatga aagtatgatg taattttaca
     3901 tttataatta atgttgagtt taatattacc tctggagaga cagcataaac aaatgtgccc
     3961 ctccccccaa tccagaatgt gaaaaatgtg tttggtaaca acaatagact agagtaaagg
     4021 aaagctgcca gccaccgcac aagtgttcca tggtgttttt attgtcataa aagatatgtg
     4081 aaaataaata tataaggatc taaatctt
//
