LOCUS       NM_001045529            4237 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus microrchidia 3 (Morc3), mRNA.
ACCESSION   NM_001045529 XM_001004605 XM_489605 XM_622709 XM_898033 XM_898048
            XM_978468 XM_978538 XM_978584 XM_978615
VERSION     NM_001045529.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4237)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4237)
  AUTHORS   Desai,V.P., Chouaref,J., Wu,H., Pastor,W.A., Kan,R.L., Oey,H.M.,
            Li,Z., Ho,J., Vonk,K.K.D., San Leon Granado,D., Christopher,M.A.,
            Clark,A.T., Jacobsen,S.E. and Daxinger,L.
  TITLE     The role of MORC3 in silencing transposable elements in mouse
            embryonic stem cells
  JOURNAL   Epigenetics Chromatin 14 (1), 49 (2021)
   PUBMED   34706774
  REMARK    GeneRIF: The role of MORC3 in silencing transposable elements in
            mouse embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4237)
  AUTHORS   Kojima-Kita,K., Kuramochi-Miyagawa,S., Nakayama,M., Miyata,H.,
            Jacobsen,S.E., Ikawa,M., Koseki,H. and Nakano,T.
  TITLE     MORC3, a novel MIWI2 association partner, as an epigenetic
            regulator of piRNA dependent transposon silencing in male germ
            cells
  JOURNAL   Sci Rep 11 (1), 20472 (2021)
   PUBMED   34650118
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4237)
  AUTHORS   Andrews,F.H., Tong,Q., Sullivan,K.D., Cornett,E.M., Zhang,Y.,
            Ali,M., Ahn,J., Pandey,A., Guo,A.H., Strahl,B.D., Costello,J.C.,
            Espinosa,J.M., Rothbart,S.B. and Kutateladze,T.G.
  TITLE     Multivalent Chromatin Engagement and Inter-domain Crosstalk
            Regulate MORC3 ATPase
  JOURNAL   Cell Rep 16 (12), 3195-3207 (2016)
   PUBMED   27653685
REFERENCE   5  (bases 1 to 4237)
  AUTHORS   Li,S., Yen,L., Pastor,W.A., Johnston,J.B., Du,J., Shew,C.J.,
            Liu,W., Ho,J., Stender,B., Clark,A.T., Burlingame,A.L.,
            Daxinger,L., Patel,D.J. and Jacobsen,S.E.
  TITLE     Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked
            chromatin
  JOURNAL   Proc Natl Acad Sci U S A 113 (35), E5108-E5116 (2016)
   PUBMED   27528681
  REMARK    GeneRIF: Data show that the MORC3 N-terminal ATPase domain forms a
            dimer when bound to AMPPNP.
REFERENCE   6  (bases 1 to 4237)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4237)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 4237)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 4237)
  AUTHORS   Nelms,K.A. and Goodnow,C.C.
  TITLE     Genome-wide ENU mutagenesis to reveal immune regulators
  JOURNAL   Immunity 15 (3), 409-418 (2001)
   PUBMED   11567631
  REMARK    Review article
REFERENCE   10 (bases 1 to 4237)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK172896.1 and BC098072.1.
            
            On Aug 1, 2009 this sequence version replaced NM_001045529.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098072.1, BC145705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4013              AK172896.1         1-4013
            4014-4237           BC098072.1         3855-4078
FEATURES             Location/Qualifiers
     source          1..4237
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 54.88 cM"
     gene            1..4237
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /note="microrchidia 3"
                     /db_xref="GeneID:338467"
                     /db_xref="MGI:MGI:2136841"
     exon            1..228
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..3018
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /note="zinc finger, CW-type with coiled-coil domain 3;
                     nuclear matrix protein 2; zinc finger CW-type coiled-coil
                     domain protein 3"
                     /codon_start=1
                     /product="MORC family CW-type zinc finger protein 3"
                     /protein_id="NP_001038994.2"
                     /db_xref="CCDS:CCDS79490.1"
                     /db_xref="GeneID:338467"
                     /db_xref="MGI:MGI:2136841"
                     /translation="MAAQPPTGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPD
                     VNAKQIWIDKTVISDHICLTFTDNGNGMTADKLHKMLSFGFSDKVTMNGHVPVGLYGN
                     GFKSGSMRLGKDAMVFTKNGETMSVGFLSQTYLEVIKAEHVVVPIVTFNKHRQMINLT
                     ESKASLAAILEHSLFSTEQKLLAELNAIMGKKGTRIIIWNLRSYKNATEFDFEKDKYD
                     IRIPEDLDETAGRKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIIIRGQKVKTQ
                     LVSKSLAYIERDVYRPKFLTRTVRITFGFNCRNKDHYGIMMYHKNRLIKAYEKVGCQL
                     KANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTILALGEKLNDYWNEMKVKKNAE
                     YPVNLPVEDIQKRPDQTWVQCDACLKWRKLPDGIDQLPEKWYCSNNPDPQFRNCEVPE
                     EPEDEDLVHPTYEKTYKKTSKERFRIRQPEILPRILPQINPELLYQTSVSSQSFSPVK
                     ESVPRPHLSEVTSPFAARIINLNLASPASEPENSSMKRKLGVHSSILNAKTRRLSNPP
                     VENSSYKNDDDEDVIILEENSTPKPAVDLEVKSDIEVKSEQSHTEQSGIHVDLVSSPK
                     PCVQASSTSTSTSRSDPGITVSTQTDAPGLTVKKEESMEEDMGVRNGTATLSCVGTEA
                     KVQETSAESVDATSHQLQELRSELLVVTQERDDYKRQCQMFTDQIQVLQQRLLEMNDK
                     CVKKEKCHQSTETDAVFLLDSVNGQAESLDHLGSQYQQALQEIERLKRQCSALQQVKS
                     ECSQASCTESKSEVDEMAVQLDDVFRQLDKCTIERDQYKNEVQLLEIEKSHIHSQCEE
                     LQTEVEQLKSTGQQAAADGSTASNAEEPVSYVDGESLKLRSLRVNVGQLLAMIVPDLD
                     LQQVNYDVDVVDEILGQVVEQMSEISST"
     exon            229..301
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            302..434
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            435..649
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            650..797
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            798..945
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1074
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1194
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1292
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1397
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1520
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1595
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1653
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1817
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2706
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2864
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..4179
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4148..4153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /note="hexamer: AATAAA"
     polyA_site      4179
                     /gene="Morc3"
                     /gene_synonym="1110051N18Rik; D16Jhu32e; NXP2; Zcwcc3"
                     /note="major polyA site"
ORIGIN      
        1 caggcccgct cgggcaagcc tctgctgaga atcctaattc gcctttgccc gaggcggaaa
       61 tgagtgggtg tggcctggtg ttgtcggttc cgccccggaa gtgggcgggg cgttgaagcc
      121 cgcggcggac tcgtagcctc ccagtcgggc tgcggccgag gccggtcctg gctttgtagc
      181 tcactcaaga tggcggcgca gccacccacc gggatccgcc tcagcgcgct ttgcccgaag
      241 tttttacata caaattctac tagtcatacc tggccgttca gtgcagttgc tgagttaata
      301 gataatgctt atgatcctga tgtgaatgct aaacagatct ggatcgataa aacagtgatt
      361 agtgaccata tatgcttgac attcactgat aatggcaacg ggatgacagc agataagtta
      421 cataaaatgc taagctttgg cttcagtgac aaagtcacca tgaatggtca tgtcccagtt
      481 ggattgtacg ggaatggctt caagtcaggt tctatgcgac tgggcaaaga tgcaatggtt
      541 tttaccaaaa atggagaaac catgagtgtg ggcttcttgt ctcagaccta cctggaagtc
      601 ataaaggcgg agcacgttgt tgtcccgatc gtgacgttca acaaacaccg tcagatgatt
      661 aatttaacag aatcaaaagc aagcctagca gcaattctgg aacattctct gttttctacg
      721 gaacagaaat tactggcaga actcaatgct atcatgggta agaaggggac aagaatcatc
      781 atttggaatc tcagaagtta caaaaatgca acagaatttg attttgaaaa ggataaatac
      841 gacatcagaa ttcctgagga tttagatgag actgcaggga ggaaagggta caagaaacaa
      901 gaaagaatgg accaaattgc ccctgagagt gactattcct taagggctta ctgcagcatt
      961 ttatacctta aaccaagaat gcagatcatc atacgtggac agaaagtgaa gacacaacta
     1021 gtttcaaaga gtcttgccta cattgaacgt gatgtttacc gacctaaatt tttaactaga
     1081 acagtgagaa ttacttttgg attcaactgc agaaataaag atcactatgg gataatgatg
     1141 tatcacaaaa acagactcat caaggcttat gaaaaagtag gatgtcagtt aaaggcaaac
     1201 aacatgggtg ttggagtggt tggaattata gaatgtaatt tccttaagcc aactcataat
     1261 aagcaagatt ttgactacac taatgagtac aggcttacga tactagcact aggagaaaag
     1321 ctgaatgatt attggaatga aatgaaagtg aaaaaaaatg cagaatatcc tgtaaacttg
     1381 ccagtcgaag acatacagaa gcgtcctgat cagacatggg ttcaatgtga cgcttgtcta
     1441 aagtggcgaa agttaccaga tgggatagat cagcttccag aaaaatggta ttgctccaat
     1501 aaccctgacc cacagttcag aaactgtgaa gttccggaag aacctgaaga tgaggattta
     1561 gtgcatccta cttatgagaa aacctataaa aagacgagca aggagagatt caggatcaga
     1621 caaccggaaa tcctccctcg aatcctccct cagattaacc ctgagctatt gtatcagaca
     1681 agtgtttcaa gtcagagctt ctcccctgtg aaggagagcg ttccaagacc acatctttct
     1741 gaagtcacga gtccctttgc agcaaggatt ataaatctca accttgcttc accagcgtct
     1801 gaacctgaga acagtagcat gaagcggaaa cttggtgttc actcatcaat tctgaatgca
     1861 aagactcgga gattaagtaa tcctccagtt gaaaattcat cttacaaaaa tgatgatgat
     1921 gaagatgtca tcattttaga agaaaatagt acccccaagc ctgcagtaga tcttgaagtt
     1981 aaatcagata ttgaagtcaa gtcagaacag agccacactg agcagagcgg cattcatgtt
     2041 gaccttgtaa gcagtcctaa gccttgtgtc caggccagtt ccacaagcac ttccacctcc
     2101 aggagtgacc caggcattac ggtctccact cagaccgatg caccaggcct gaccgtgaaa
     2161 aaggaagaaa gtatggaaga ggacatgggt gtgaggaacg gcacagccac cctgtcctgt
     2221 gtcggtactg aggcaaaagt gcaggagacc tcggctgagt cggtagatgc cactagccat
     2281 cagttacaag aactgagaag tgagctgctt gtagtcacac aagaaagaga tgattacaag
     2341 agacagtgcc agatgtttac tgatcagata caggtgttac agcaaagact attggagatg
     2401 aacgacaagt gcgtgaagaa ggagaagtgc caccagtcta ctgaaactga cgcagtgttt
     2461 ctacttgaca gtgttaacgg tcaggctgag agcctggacc acttggggtc tcagtaccag
     2521 caagcactgc aggagataga aaggctgaag agacagtgca gcgcgctgca gcaggtgaag
     2581 agtgagtgca gccaggcttc ctgcactgag agcaaaagcg aggtggacga gatggccgtg
     2641 cagcttgatg atgtgttcag gcagctggac aagtgcacca ttgagaggga ccagtacaag
     2701 aacgaggttc agttgttgga aatagagaag tcacacattc attctcagtg tgaagagctg
     2761 cagactgaag tggagcagct gaagtccaca ggccaacagg cagcggccga tgggtccact
     2821 gcaagcaatg ccgaggagcc tgtcagttat gtggacgggg aaagcctcaa acttcgttct
     2881 cttcgagtca acgtaggaca gctgctggct atgatcgtgc ctgatctgga tcttcagcag
     2941 gtcaattatg acgtggacgt agtcgatgag attctaggac aagtggtgga gcagatgagc
     3001 gagatcagca gtacttaagt gcagacgtct ggtgatggtt tcagctctca cgtaacgcgt
     3061 gccaggtcac agactgaaga gcggcatctt tctgtattct atgcattcga gtgtcccagg
     3121 cactgtggac acacaactct tgacataacc tgtgaactgc tggggttgag cagcgtaata
     3181 gcgaacttag cctctgttct aaatgtcaat atttgtatta agtccacaaa tattttttta
     3241 ttgccctaga gactggtgtt tttcaccaag agcttttcag gttgttacaa tacagtttgt
     3301 gcaatttttc tggctcccta aatgtatttt tctcaaaatc gagggctgtg ccatagtgta
     3361 tgtaaatgga taagttgcta ctgttgtttc cttaaatgag cataagacag gatttgaaat
     3421 aatgtcatgg cactcctagc ggggtctgct tgtaagggaa ttgagcatta ctgctgtttt
     3481 ctatgaaatc ctgtctctga catgattctg ttcatagaga ggaaagccaa agctagctga
     3541 gtttgcctgg ctttttcttg tggtaagatt gctaattgtc aagtaaaaag tgttttccag
     3601 gacaaagaaa agatctttaa agtgttaaaa aatatccagt gacaaccatg tttactttga
     3661 agcccatttt tggctgttga ttcagcatga agtgggtgca ataattattt gagatttctt
     3721 tttgtgaaat ttcctgtata gcctttgtag ggttactgca ggttaatgta agctgagaag
     3781 gtagtctttc tcaaacagta ctgcatatct tttactgtat tatgaatgta agtgtttttt
     3841 agcctggagt taatcataaa tgggcctggg atcatagcac catatgctgt aaaatatgct
     3901 tttactggtc ccaagttttg tgcaatctga aaagaggtgg ctttttatta tatatgtaac
     3961 tgtatataat taagaatcat attttccaca actaaaaatg tgttattttt tccaaagttt
     4021 tattgttgct atttatttta acttttgttt ctgaaaattc agtacatact cattgtgtgt
     4081 gtggttaact acacatctgt tgtatacgaa gttgaatctt tatgtatagt accttctggg
     4141 aattgcaaat aaatgaagtt cttgttttta tttactcgaa aaaaaaaaaa aaaaaaaaaa
     4201 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
