LOCUS       NM_010816               3050 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus microrchidia 1 (Morc1), mRNA.
ACCESSION   NM_010816 XM_358868
VERSION     NM_010816.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3050)
  AUTHORS   Uneme,Y., Maeda,R., Nakayama,G., Narita,H., Takeda,N.,
            Hiramatsu,R., Nishihara,H., Nakato,R., Kanai,Y., Araki,K.,
            Siomi,M.C. and Yamanaka,S.
  TITLE     Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted
            transposons in gonocytes
  JOURNAL   Proc Natl Acad Sci U S A 121 (13), e2317095121 (2024)
   PUBMED   38502704
  REMARK    GeneRIF: Morc1 reestablishes H3K9me3 heterochromatin on
            piRNA-targeted transposons in gonocytes.
REFERENCE   2  (bases 1 to 3050)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   3  (bases 1 to 3050)
  AUTHORS   Shi,B., Xue,J., Zhou,J., Kasowitz,S.D., Zhang,Y., Liang,G.,
            Guan,Y., Shi,Q., Liu,M., Sha,J., Huang,X. and Wang,P.J.
  TITLE     MORC2B is essential for meiotic progression and fertility
  JOURNAL   PLoS Genet 14 (1), e1007175 (2018)
   PUBMED   29329290
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3050)
  AUTHORS   Schmidt,M., Brandwein,C., Luoni,A., Sandrini,P., Calzoni,T.,
            Deuschle,M., Cirulli,F., Riva,M.A. and Gass,P.
  TITLE     Morc1 knockout evokes a depression-like phenotype in mice
  JOURNAL   Behav Brain Res 296, 7-14 (2016)
   PUBMED   26275923
  REMARK    GeneRIF: Morc1-/- mice display increased depressive-like behavior;
            a promising novel mouse model for depression.
REFERENCE   5  (bases 1 to 3050)
  AUTHORS   Pastor,W.A., Stroud,H., Nee,K., Liu,W., Pezic,D., Manakov,S.,
            Lee,S.A., Moissiard,G., Zamudio,N., Bourc'his,D., Aravin,A.A.,
            Clark,A.T. and Jacobsen,S.E.
  TITLE     MORC1 represses transposable elements in the mouse male germline
  JOURNAL   Nat Commun 5, 5795 (2014)
   PUBMED   25503965
  REMARK    GeneRIF: MORC1 represses transposable elements in the mouse male
            germline.
            Erratum:[Nat Commun. 2015 Jul 10;6:7604. doi: 10.1038/ncomms8604..
            PMID: 26159654]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3050)
  AUTHORS   Costoya,J.A., Hobbs,R.M., Barna,M., Cattoretti,G., Manova,K.,
            Sukhwani,M., Orwig,K.E., Wolgemuth,D.J. and Pandolfi,P.P.
  TITLE     Essential role of Plzf in maintenance of spermatogonial stem cells
  JOURNAL   Nat Genet 36 (6), 653-659 (2004)
   PUBMED   15156143
REFERENCE   7  (bases 1 to 3050)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3050)
  AUTHORS   Inoue,N., Wei,F., Seldin,M.F., Zinn,A.R. and Watson,M.L.
  TITLE     Assignment of microrchidia (Morc) to mouse chromosome 16 by
            interspecific backcross linkage analysis and human chromosome 3q13
            using somatic cell hybrids and in situ hybridization
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 123-125 (2000)
   PUBMED   11060461
REFERENCE   9  (bases 1 to 3050)
  AUTHORS   Inoue,N., Hess,K.D., Moreadith,R.W., Richardson,L.L., Handel,M.A.,
            Watson,M.L. and Zinn,A.R.
  TITLE     New gene family defined by MORC, a nuclear protein required for
            mouse spermatogenesis
  JOURNAL   Hum Mol Genet 8 (7), 1201-1207 (1999)
   PUBMED   10369865
REFERENCE   10 (bases 1 to 3050)
  AUTHORS   Watson,M.L., Zinn,A.R., Inoue,N., Hess,K.D., Cobb,J., Handel,M.A.,
            Halaban,R., Duchene,C.C., Albright,G.M. and Moreadith,R.W.
  TITLE     Identification of morc (microrchidia), a mutation that results in
            arrest of spermatogenesis at an early meiotic stage in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14361-14366 (1998)
   PUBMED   9826705
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF084945.1.
            
            On Sep 3, 2004 this sequence version replaced XM_358868.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF084945.1, BC030893.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.75 cM"
     gene            1..3050
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /note="microrchidia 1"
                     /db_xref="GeneID:17450"
                     /db_xref="MGI:MGI:1316740"
     exon            1..166
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2957
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /note="protein microrchidia"
                     /codon_start=1
                     /product="MORC family CW-type zinc finger protein 1"
                     /protein_id="NP_034946.1"
                     /db_xref="CCDS:CCDS37351.1"
                     /db_xref="GeneID:17450"
                     /db_xref="MGI:MGI:1316740"
                     /translation="MDKYALLQRAKLHLDFIHANSTTHSFLFGALAELLDNARDAGAV
                     RLDVFSVDNETLQGGFMLCFLDDGCGMSPDEASDVIYFGTSKKRLSTLKFIGQYGNGL
                     KSGSMRIGKDCILFTKKEETMTCLFFSQTFCEKEGLTEVVVPIPSWLTRTRESITDDP
                     QKFFTELSIIFKYSPFKTEAELMQQFDMIYGRCGTLLIIYNLKLLLSGEPELDVTTDK
                     EDILMAEAPEEIPERRSFRAYTAVLYFEPRMKIFIQAKRVQTKHLCYSLYKPRKYQYT
                     TSSFKGKFKTEVQKAEEAVKRAELLFKEVQAKVNQPDRIALSSTQDALQKALQDVDTK
                     HKSLRQKQRALRKARTLSLFFGVNTEDQHQAGMFIYSNNRLIKMYEKVGPQLKMKSLL
                     GAGIIGIVNIPLETMEPSHNKQEFLNVQEYNHLLKVMGQYLIQYCKDIGISNRNLTLF
                     WDEFKYQHSKDTDSSLESLQWRRRQAMGIPFILQCDLCLKWRVLPSSSNYQEKGLPDL
                     WICASNPNNLENSCNQIERLPSIPLGTVNRRPPSKDERERQLQESVQRYQDKLVEAQP
                     QKSQLIVTSKIPEFKSSCLSSALKEKSKLGRIQPSGADLTQGSPSSVKLSFMQRSQKR
                     STEDTHSDVEFICMTKIPKKSVKKTVKYLQPGHAPALLENLKLEDTAQVSSREIKKQQ
                     SESLVQAGKASTDVASSRDPTVTMVWDQSSTKVSLKQEEEEEVPLIKPDKQELCDDTP
                     VVKGNSSALHWKSLPGVQMEDLSPRSGHKINSVSGDCQLPASPMPSQSMSVEETARKL
                     LSNLREILLYFVPEFQLSSEFECTSVEELITNPELERCPENINEKLKTCFNQIQNIYM
                     AQYEKRLKRKMQSIVYEANRRGLLNQVFLGQCELKRKRTEEKLSDLRAKLALLLQKLQ
                     LGGPAGDPQQIDAYLEDLLKEDRLPTALHEKSPESA"
     exon            167..220
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            221..255
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            256..324
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            325..415
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            416..524
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            525..684
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            685..790
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            791..916
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            917..996
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1067
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1132
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1276
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1431
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1560
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1666
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1805
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1874
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2120
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2222
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2295
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2362
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2512
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2600
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2654
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2849
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..3050
                     /gene="Morc1"
                     /gene_synonym="Morc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaagtgagc caggccgtac gcgtggacgt aggcgtgggc gtgggccaac agtttccggt
       61 cagacatcca cgtcttctgt tgtccgcagg tggtgcctga agacatggac aaatatgcct
      121 tgctgcagag ggctaaactg catctggatt tcatccacgc gaattccaca acacacagtt
      181 tcctctttgg agcactggct gagttgctgg acaacgcaag agatgccggg gctgtaagac
      241 tcgatgtgtt ttcagtggat aatgaaacac tgcagggagg attcatgttg tgtttcctgg
      301 atgatggatg tggcatgagc cctgatgaag cttcagacgt aatttacttt ggaacatcca
      361 agaaacgctt gtcgaccttg aagttcatcg ggcaatatgg taacgggctt aagagcggct
      421 ccatgagaat cggcaaagac tgtattcttt tcacaaagaa ggaagagacc atgacctgtc
      481 tgttcttctc tcagactttc tgtgaaaaag aaggtctcac tgaggttgta gttccaatac
      541 cttcatggct aacgagaacc agagagagta tcacagatga cccgcagaag ttcttcacag
      601 aattgtccat cattttcaag tactccccat ttaagaccga agctgaattg atgcagcagt
      661 ttgatatgat ctacgggaga tgtggaactt tgctgattat ttataacttg aagctgctgc
      721 ttagcggaga accagagttg gatgttacaa ccgacaaaga agatatactg atggccgagg
      781 ctccggagga aattccagag agacggtcat tcagagccta cacagctgtt ctgtattttg
      841 aaccccggat gaaaatattt attcaggcca aaagagttca aacaaagcat ctgtgttatt
      901 ccctctacaa acccagaaaa taccaatata ctacatcttc tttcaaaggg aagtttaaaa
      961 ctgaagttca aaaggcagaa gaagcagtaa agagggctga actcctgttt aaagaggtgc
     1021 aagccaaagt aaaccagccg gacagaattg ctttgtcttc tacccaggat gcattacaga
     1081 aagctctgca agacgtggac acaaagcata aaagtcttcg ccagaaacag agggccctaa
     1141 ggaaagcaag aactctctct ctgttctttg gagtgaacac agaagaccaa caccaagctg
     1201 gaatgttcat ttacagtaat aaccgattga tcaaaatgta cgagaaggtt ggtccccagc
     1261 tgaaaatgaa gtcattactt ggtgcaggta taattggaat tgtgaacata cctttggaga
     1321 ccatggaacc atcccataat aaacaagaat tcctcaatgt ccaagaatac aatcatctac
     1381 taaaagtcat gggacagtac ttgatccagt actgtaagga cattgggatc agtaatagaa
     1441 acctaacact gttttgggac gaatttaaat atcagcatag caaagacaca gacagctctt
     1501 tggaatctct ccaatggcga agaagacaag ccatgggtat cccattcatc ctacaatgcg
     1561 atctttgtct caaatggaga gtcctgcctt cctcttccaa ttaccaggaa aaaggattac
     1621 ctgacctatg gatttgtgcc agtaatccca acaacctgga aaacagctgt aaccagatag
     1681 agcgcctgcc ttctatccca ctgggcaccg tgaacagaag accaccatca aaagatgaga
     1741 gagagaggca acttcaagag tcagtccaga gatatcagga caagctggtg gaagcgcagc
     1801 cgcagaagtc tcaacttata gtaacaagca agatccccga gttcaagtcc tcctgccttt
     1861 cctcagcact caaggaaaaa tccaaacttg ggagaatcca gccttcaggg gcagacctga
     1921 ctcagggcag tccctcatct gttaagcttt cgttcatgca aagaagccaa aagaggagca
     1981 cagaggatac tcactcggac gtggagttca tctgcatgac gaagattccg aagaagtctg
     2041 tgaagaagac cgtgaagtac ctgcagcctg gtcacgctcc agctctattg gaaaacctca
     2101 aactcgagga cacagcccag gtttcttcac gggaaataaa aaagcagcag agtgagagcc
     2161 tcgtgcaggc aggcaaggca tccactgacg tggctagcag cagagatcca actgtgacca
     2221 tggtttggga tcaaagcagc accaaggtct cactgaaaca agaagaagag gaggaagttc
     2281 ccctcataaa gccagacaaa caagagctgt gtgatgatac tccagtagtg aaaggaaatt
     2341 cttcagcgct tcactggaaa agcttgcccg gggtgcaaat ggaagattta agtccacgtt
     2401 ctggacacaa aatcaactct gtgagtggtg actgtcagct gccggcttca ccaatgcctt
     2461 ctcaaagcat gtctgtggaa gaaacagcaa gaaaactgct gtctaactta agggaaattc
     2521 ttctatactt tgttcccgag tttcagctat catcagaatt tgagtgcaca tctgtggaag
     2581 aactcataac aaatcctgag ctggagcgat gcccagagaa tataaacgaa aagctaaaaa
     2641 cgtgtttcaa ccagatccag aatatctaca tggctcagta tgagaaaaga ctcaagagga
     2701 aaatgcagtc cattgtctat gaggcaaaca gaaggggctt actcaaccaa gtgtttctgg
     2761 gacagtgtga actgaaaagg aagaggactg aggagaaact cagtgacctt cgtgcaaagc
     2821 tggccttgct gctgcagaaa cttcagctgg gtggtccagc aggagacccg cagcagattg
     2881 atgcttactt agaagatttg cttaaagaag atcggctccc gaccgcttta catgaaaagt
     2941 ctccagagtc agcgtaagca aaagatacag aaccctgaga gggtatctca gaagtcagaa
     3001 aagatgtttt ttcttaaaac cactaataaa gaaaactgga aaatcctttt
//
