LOCUS       NM_173015               5047 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MON1 homolog B, secretory traffciking associated
            (Mon1b), transcript variant 1, mRNA.
ACCESSION   NM_173015
VERSION     NM_173015.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5047)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5047)
  AUTHORS   Kinchen,J.M. and Ravichandran,K.S.
  TITLE     Identification of two evolutionarily conserved genes regulating
            processing of engulfed apoptotic cells
  JOURNAL   Nature 464 (7289), 778-782 (2010)
   PUBMED   20305638
  REMARK    GeneRIF: data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical
            and evolutionarily conserved components regulating the processing
            of ingested apoptotic cell corpses
REFERENCE   3  (bases 1 to 5047)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   4  (bases 1 to 5047)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY742778.1, AK030288.1, BC062639.1 and AC125463.4.
            
            On Nov 6, 2013 this sequence version replaced NM_173015.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062639.1, AK173047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY742778.1         1-36
            37-3353             AK030288.1         3-3319
            3354-5034           BC062639.1         3030-4710
            5035-5047           AC125463.4         116035-116047
FEATURES             Location/Qualifiers
     source          1..5047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 59.65 cM"
     gene            1..5047
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /note="MON1 homolog B, secretory traffciking associated"
                     /db_xref="GeneID:270096"
                     /db_xref="MGI:MGI:1923231"
     exon            1..471
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1985
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /codon_start=1
                     /product="vacuolar fusion protein MON1 homolog B"
                     /protein_id="NP_766603.1"
                     /db_xref="CCDS:CCDS22685.1"
                     /db_xref="GeneID:270096"
                     /db_xref="MGI:MGI:1923231"
                     /translation="MEAGGDNAVPAPGGVEDLVDTQFPREEAGDSERVHASTLDPGDG
                     DPEDTGSKDQPSSLLSPLPQTEAASSTCEHWETAAASDSSPPGEPESNSEGQGEDPDD
                     GGDPSDEDWRSQRKHVFVLSEAGKPIYSRYGSVEALSATMGVMTALVSFVQSAGDAIR
                     AIYAEDHKLVFLQQGPLLLVAVSRTPQSAAQLRGELLAVHAQIVSTLTRASVARIFAH
                     KQNYDLRRLLAGSERTLDRLLDSVEQDPGALLLGAVRCVPLARPLRDALGTLLRRCTA
                     PGLALSVLAVGGRLITVAQERNVLAECRLDPADLQLLLDWVGAPAFAAGEAWAPVCLP
                     RFNPDGFFYAYVARLDSMPVCLLLLGTNREAFHAMAACRRLVEDGMHNLGALRTLGEA
                     ANFSNGPAASAPAYSVQAVGAPGLRHFLYKPLDIPEQHRQLPQFTSPELEAPYSREEE
                     RQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKFELYTCLSPLVTKAGAI
                     LVVTKLLRWVRKEEDRLFIRYPPKYSTPPSTSADQAPNNGLFTGL"
     exon            472..816
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1636
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1784
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..5047
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3335..3340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3355
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /note="major polyA site"
     regulatory      5009..5014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5034
                     /gene="Mon1b"
                     /gene_synonym="5031407H10; 5033413H12Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgtgg caagtcccca ccacaccagg aagtgtggtg cggcagcggc tcctcaaagt
       61 gttgctgtcc acccagttga gataagaggt tgaaacaggt gttgatgtac cgtgttggca
      121 gaagcccagc ggagcgtcac ccatccgaaa gtgccggagg gtgcaagtat ttggtcatgg
      181 ttttgaatgt cgcgtcctgt cgaaaaccgt aggggaaacc gcactaggaa tgtatccggg
      241 gggtctggct ccctgaaggc ttgtaagaag ttttctgttg ctgcccatca ccctcgattc
      301 cccttctctc cagggatgtg cagatggagg ccggaggaga taatgctgtc ccagcccccg
      361 ggggcgtgga ggacttggtg gacacgcagt tccccagaga ggaggctgga gacagtgaaa
      421 gggttcacgc aagcacgctg gatcccggag atggggaccc ggaggacaca ggatccaagg
      481 accagccatc cagcctccta tcacctctgc ctcagactga ggctgcatca agcacctgtg
      541 agcactggga aactgcagca gcctcagaca gcagcccccc cggagaacct gagagtaact
      601 ctgagggtca gggagaagac cccgacgatg ggggggaccc cagtgacgag gactggcgca
      661 gccagcggaa gcacgtgttc gtgctgagtg aggcaggcaa gcccatctac tcacggtacg
      721 gtagcgtgga ggcactgtcg gccaccatgg gggtgatgac agccctggtg tcctttgtgc
      781 agagtgcagg agacgccatc cgtgccatct atgctgagga tcacaagctg gtgttcctgc
      841 agcagggtcc actcctgctc gtggctgtgt cccggactcc acagtctgca gcacagctac
      901 gaggtgaact gcttgctgta cacgcccaaa ttgtgagcac actaacgcgt gcaagcgtgg
      961 cccgcatctt cgcacataag cagaactatg acctccgtcg cctgttggcc ggctcagagc
     1021 gcacactgga ccggctcttg gacagtgtgg agcaagaccc gggcgccctg ctcctgggcg
     1081 ctgtgcgctg tgtgcctctg gcccgtccac tgcgggatgc cctgggcaca ctactgcggc
     1141 gctgtacagc cccaggcctg gccttgtcag tgctggctgt tggcggtcga ctgataaccg
     1201 tggcccagga gaggaatgtg ctggcggagt gccggctgga ccctgctgat ctacagttgc
     1261 tgcttgactg ggtgggtgca ccagccttcg cggcaggtga agcatgggca cctgtgtgcc
     1321 tgcctcgctt taacccagat ggtttcttct atgcctatgt ggcccgcctg gattccatgc
     1381 ccgtctgcct gctgctgctt ggtaccaacc gtgaagcctt ccatgccatg gccgcctgcc
     1441 ggcgcttagt tgaagatggg atgcacaacc ttggtgccct gcgtactctt ggggaggctg
     1501 ccaacttctc taatggccca gcagccagtg ccccagccta cagtgtgcag gctgtgggag
     1561 cccctggcct ccggcatttt ctctataagc cactggatat ccctgaacaa caccgccagc
     1621 tgccacagtt taccagtccc gagctagagg ccccatacag cagagaggaa gagcgacagc
     1681 gactgtcaga cttgtatcac cgcctgcatg ctcgcctcca cagcacctcc cggcccctgc
     1741 gcctcattta ccacgtggct gagaaagaga cgctgctggc ttgggtgact tccaagtttg
     1801 agctctatac ttgcctcagc cccctggtaa ccaaggctgg tgccatctta gtagtgacga
     1861 agctcttgcg ctgggtaagg aaggaagagg accggctttt catccgttac ccacccaaat
     1921 actccacacc cccatccacc tcggcggacc aggcccccaa caatggcttg ttcacaggac
     1981 tctgaacaac tgctggagtg accacatttg gctttaaata ctgtgtctac tctggaaatg
     2041 tgggtagagg tctgtgcaga gctggtcccc gtctccctgg gcaggtgggc aagatgtcag
     2101 ggtttgccca caaatgggag aagagtgaca gcagccagag gcacaggttg ctctctgagc
     2161 cccctcatgc acctccatgt ttaggaaagt gggacacttc ctctgtcctt tgcctcacct
     2221 ccctaactag cctgaatgcc actgtaccct ccgtcaccag ctgtctccac caagcctctt
     2281 ctaagcagcc caggttgcta ccatgtccat cttccaagca gacctgagac tgggctgagg
     2341 ctctcctcag ggtaggggtg ggtaacccac aagggctcta gaatttggaa tgcagggcta
     2401 gcctgtgctt gaaaccagcc tgggtgtttg aacacacaca cacacacaca cacacacaca
     2461 cactgtacag aaagggccta aagctgaaac cttcaagaca ttcctctgtt cttcatgctc
     2521 cctccgtccc catcattttt ccctatccct actttaaagc aaacaacccc ccaaaagact
     2581 caagccccac catgttgggc tgtttcttac acgaataaga aggtggcctc cagcatccac
     2641 ctgacttcat ccttgggccg ggatgcagct ttgtgaagat gctcttagct gcccaagtgt
     2701 tcactttctt ctgaaccttt tagtggagac ctgtaaacaa acggacaggg gttggaaatg
     2761 tgttgtgctg atgcctagca tgaacatatt ctggacattg aacgcttaca gtaacaacct
     2821 aaagaagagc ccttaaagag cttgtgctca caacccacct caacttctca ctacctggct
     2881 tccagccctc ttatagagac tcggccctgt ggttgcgcgc atgcgtgcaa acgcaagcta
     2941 gcagttgcat ttgcagatgt tctgcgcttg ctccaagcag acacctgtgc cgccccgccc
     3001 cctgttttcc tacaatgtct atagtggcac gtgctgcctt tccctgctgt ttctcttccg
     3061 aggctcatgc gcagataccc cacgttggga aatggctgcg gagctggagc ctttgatggc
     3121 ggagtggctg ggagctgaga aagctgaaga cacccgaggt agtgaaggcc aacagggtag
     3181 atgggaaaga ggcttcggct cattacgata attgagaatt ttttttagaa aaaaagtttt
     3241 tagcctattg aaacttataa cttccacaaa gtggaaaaaa aaataacatg cgtgtactca
     3301 tcacctaggt aaacttgcca actttattga tcatattaaa tatcttaagc aagtagttca
     3361 agacccatta ctcagcaagt cagggggagg ggaggggagg ataatgatgt cctcccaaaa
     3421 ggtctctgtc gctgcacagc tgagggaagg atcttctcgg tcacttcaca gccagcctac
     3481 atcactactt ttgggtttct cggggctctt gagcacggct ttccccggtt ttgtccgatt
     3541 tggtttgact tttagtaatg acagtttctc ttcctcattg gggtcaagga agtggagtcc
     3601 agcctagaaa ctactggaaa ttgcagttcc ttggaaagaa aatatctctc atggtaaatt
     3661 cactagaaga gcattcttgt tttaattata gaaaatttct aaccattcta aagtagagaa
     3721 aatagtgtga ccaaggaccc tgaccctgct tcaacgggtg ttcaatcttt gtccttgtat
     3781 ctgtctccac ctccccttcc tgcacaccca gcccgtcact acatggccaa acaggggagg
     3841 tggcatcttg ccagacctgt tcactcagat tccaaaacaa tgaatgtgac cttcaagagc
     3901 aagacccaca gtttccctgg gcacctgaaa cacctgcctg gtgcttggca ctcagtgacc
     3961 tttccttttc cttttccttt tccttttcct tttttttttt cttctttttt gtgggtgaat
     4021 attgaaatca ttttaacaga atttgtctta aattggagtc acatgtcggg tgtcagtttt
     4081 caaagaatag aaatcagaca agttgcattt tatgacccac gcggtacagt gccgcagaga
     4141 tgtaaacatt tagcttcaac ctttcaaatt cctcagttta agtaatcagg gacttcattg
     4201 gcccgggagg aaggcagaag acgaatcagg tcacatttct tcgccactga ctggccatag
     4261 gggggatgct ctgcagcccc agtggccttc tggtaggggc ttgcggtttt cagcagatgc
     4321 tgttccacat ctgcaatctc catgctaggt catcacagga gacagactgc acgagcgtgg
     4381 accaggggtg gccagtggtg tgttactaac aggcagagag agaagaattg aatccaaaac
     4441 ctgaccaaat ctaggtatat ccatgcagat tgtagatttt ttttaaaaat aagaggtgga
     4501 gaaatttaaa tttcagttga taaaattgtt tatcaaaatt gttcataaga ggtgggccct
     4561 aggagttttg tttttattat tgaatatcaa gattgaaacg agaaaggcgg ggatgtacct
     4621 ggcaagggca gctctagaat ggcctgaggt aagcacactg ataattatga agaggggcct
     4681 tggatttgtg ggaggggagc aaagtggagg ccttcgtgat gtattatttt atttatctct
     4741 tagaaaattg gtagtgatac gtaatttaca atgtaagagg tcaaggggaa actgagcagc
     4801 agcccgaggg accaatgcta acacccagat tttaagttat gccagtacct ggagcccccg
     4861 tataatggga aatgtgcact ggagtattca ggactagtgg gtcatactat gtacaactta
     4921 gagatgacaa acactcaaca catggagatg ccgatagagt accacagcct atttctatga
     4981 cttttgtgta catctgaaac aatttcaaaa taaaatgtta tatgggggaa cttaccctct
     5041 cagcctc
//
