LOCUS       NM_028369               2112 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus MON1 homolog A, secretory traffciking associated
            (Mon1a), mRNA.
ACCESSION   NM_028369
VERSION     NM_028369.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2112)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2112)
  AUTHORS   Delaby,C., Oustric,V., Schmitt,C., Muzeau,F., Robreau,A.M.,
            Letteron,P., Couchi,E., Yu,A., Lyoumi,S., Deybach,J.C., Puy,H.,
            Karim,Z., Beaumont,C., Grandchamp,B., Demant,P. and Gouya,L.
  TITLE     Epistasis in iron metabolism: complex interactions between Cp,
            Mon1a, and Slc40a1 loci and tissue iron in mice
  JOURNAL   Mamm Genome 24 (11-12), 427-438 (2013)
   PUBMED   24121729
  REMARK    GeneRIF: Genetic interactions between Cp, Mon1a, and the Slc40a1
            locus are involved in iron metabolism.
REFERENCE   3  (bases 1 to 2112)
  AUTHORS   Bagley,D.C., Paradkar,P.N., Kaplan,J. and Ward,D.M.
  TITLE     Mon1a protein acts in trafficking through the secretory apparatus
  JOURNAL   J Biol Chem 287 (30), 25577-25588 (2012)
   PUBMED   22665492
  REMARK    GeneRIF: a role for Mon1a in anterograde trafficking through the
            secretory apparatus.
REFERENCE   4  (bases 1 to 2112)
  AUTHORS   Kinchen,J.M. and Ravichandran,K.S.
  TITLE     Identification of two evolutionarily conserved genes regulating
            processing of engulfed apoptotic cells
  JOURNAL   Nature 464 (7289), 778-782 (2010)
   PUBMED   20305638
  REMARK    GeneRIF: data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical
            and evolutionarily conserved components regulating the processing
            of ingested apoptotic cell corpses
REFERENCE   5  (bases 1 to 2112)
  AUTHORS   Wang,F., Paradkar,P.N., Custodio,A.O., McVey Ward,D., Fleming,M.D.,
            Campagna,D., Roberts,K.A., Boyartchuk,V., Dietrich,W.F., Kaplan,J.
            and Andrews,N.C.
  TITLE     Genetic variation in Mon1a affects protein trafficking and modifies
            macrophage iron loading in mice
  JOURNAL   Nat Genet 39 (8), 1025-1032 (2007)
   PUBMED   17632513
  REMARK    GeneRIF: Study presents evidence that Mon1a is involved in
            trafficking of ferroportin, the major mammalian iron exporter, to
            the surface of iron-recycling macrophages.
REFERENCE   6  (bases 1 to 2112)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY064239.1, AK013387.1 and AW045198.1.
            
            On Sep 19, 2009 this sequence version replaced NM_028369.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.244349.1, BC048852.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               BY064239.1         1-162
            163-2081            AK013387.1         110-2028
            2082-2112           AW045198.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..2112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..2112
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /note="MON1 homolog A, secretory traffciking associated"
                     /db_xref="GeneID:72825"
                     /db_xref="MGI:MGI:1920075"
     exon            1..274
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            275..414
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1958
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /codon_start=1
                     /product="vacuolar fusion protein MON1 homolog A"
                     /protein_id="NP_082645.1"
                     /db_xref="CCDS:CCDS23508.1"
                     /db_xref="GeneID:72825"
                     /db_xref="MGI:MGI:1920075"
                     /translation="MAADMQRKRSSECPEGTLAPSNGQSVERAESPTPGLTQGTEPGA
                     GQEGAMFVHTRSYEDLTELEDREASGDSPKECVGSPPPLATDMRQISQDFSELSTQLT
                     GVARDLQEEMLPGSSEDWPEPQGAAGRGAATEPSQEGSTEGEEEDATEAWRLHQKHVF
                     VLSEAGKPVYSRYGSEEALSSTMGVMVALVSFLEADKNAIRSIHADGYKVVFVRRSPL
                     VLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERIT
                     DNLLQLMARDPSFLMGAARCLPLAAAVRDTVSASLQQARARSLVFSILLAHNQLVALV
                     RRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFSAAGFFHAHISYLEPDTDL
                     CLLLISTDREDFFAVSDCRRRFQERLRKRGTHLALREALRTPYYSVAQVGIPDLRHFL
                     YKSKSSGLFTSPEIEAPYSSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLL
                     AWVTGAFELYMCYSPLGTKASAVSAIHKLMRWIRKEEDRLFILTPLTY"
     exon            415..903
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1669
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1817
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2095
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2088
                     /gene="Mon1a"
                     /gene_synonym="2810468K17Rik"
                     /note="major polyA site"
ORIGIN      
        1 acacaggggc gggctggggc tggccaagag gctggaaccg ggcctccgcc accagaggcc
       61 ggtgaaagct gtcttcctgc gccggtggcc ggttaagggt cggcaggaga gatcggttcc
      121 tccgctgtgg ccatgtctgt atcctccagg ggcggtagcc ccgcgaagtt gcactctgag
      181 gccaggcact gctggacact tatatctccc caggggtctg gcagagggca gtgactggta
      241 ccctcggtag gtcctgtgtt tccccaagaa acaggacagc ccaaaagatg gctgctgaca
      301 tgcagaggaa gagaagcagc gaatgccccg agggcacatt ggctccttcc aatggccaaa
      361 gtgtggaaag agctgagagc cccacgccag gactaaccca gggaacggag ccaggtgctg
      421 ggcaggaggg tgcgatgttc gtccatacac gttcctatga agacctgaca gagttagaag
      481 acagagaagc ttctggggac agccccaaag agtgcgttgg gagtccccca ccactggcta
      541 cggacatgcg ccagattagc caggacttca gcgagctaag cacccagctg accggtgtgg
      601 cccgggacct gcaggaggaa atgctgccag gaagctctga agactggccg gagccccagg
      661 gcgcagctgg ccgaggagca gccacagagc cctcccaaga aggctcaact gaaggggaag
      721 aggaagacgc tacggaggca tggcgtctcc accagaagca tgtgtttgta ctgagtgagg
      781 cagggaagcc tgtgtattct cgctatgggt ctgaggaagc cctttccagc actatgggtg
      841 tcatggttgc cctggtgtcc ttcctggagg cagacaagaa tgccatccgc tccatccatg
      901 cagatggcta caaggtagta ttcgtgcgcc ggagccctct ggtgctggtg gcggtggccc
      961 gcacgcggca gtcggcccag gagctggcgc aggagctact gtacatctac taccagatcc
     1021 tgagccttct taccggcgcg cagctgagcc acatcttcca gcagaagcag aactacgacc
     1081 tgcggcgcct gctctcgggc tcggagcgaa tcaccgataa cctgctgcag ctaatggctc
     1141 gagaccccag tttcctgatg ggcgcggcgc ggtgcctgcc tttggcagcg gccgtgcggg
     1201 acacggtgag tgccagcctg cagcaggcgc gtgctcgcag cctggtcttt tccatcctgc
     1261 tggcccataa ccagctggtg gcgctcgtgc gccgcaagga ccaattcctt catcccatcg
     1321 acctgcacct gcttttcaac ctcattagct cctcctcctc cttccgtgag ggcgaggctt
     1381 ggaccccagt gtgcctgcca aagttcagtg cggccggctt cttccacgca cacatctctt
     1441 acctagaacc tgacaccgac ctctgcctgc tgctgatctc cactgaccgt gaggacttct
     1501 ttgcagtctc tgactgccga cggcgcttcc aggaacgcct ccgaaagcgg ggaacccatt
     1561 tggccctgcg ggaggcgctg cgcacacctt actacagcgt tgcccaagtg ggcatccctg
     1621 accttcgcca cttcctctat aaatcaaaga gctcaggact cttcaccagt cctgagattg
     1681 aggccccgta ctccagtgag gaggagcagg agcgactgtt gggcctctac cagtacctgc
     1741 atagccgtgc ccacaatgcc tctcgcccac tcaagaccat ctactacaca ggccccaatg
     1801 agaacctcct agcctgggtg acaggtgcct ttgaactcta catgtgctac agcccactgg
     1861 ggaccaaggc atcagctgtc agcgccatcc ataagctgat gcgctggatc cgtaaagagg
     1921 aagaccgtct cttcatcctc acgcccctca cctattgatg gaggtgggaa ggcactctgg
     1981 gcatgggaag ccatgggagc ctccaggtga ggctggcttc ccctgcccag ccagcaggca
     2041 gggactgtgg gctggtgcgt gcaagtgcat taaagtggtt gagaaaaaca ctgttaaaaa
     2101 aaaaaaaaaa aa
//
