LOCUS       NM_011973               5509 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus MOK protein kinase (Mok), transcript variant 1, mRNA.
ACCESSION   NM_011973
VERSION     NM_011973.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5509)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5509)
  AUTHORS   Li,N., Wen,L., Shen,Y., Li,T., Wang,T., Qiao,M., Song,L. and
            Huang,X.
  TITLE     Differential expression of SLC30A10 and RAGE in mouse pups by early
            life lead exposure
  JOURNAL   J Trace Elem Med Biol 79, 127233 (2023)
   PUBMED   37315391
  REMARK    GeneRIF: Differential expression of SLC30A10 and RAGE in mouse pups
            by early life lead exposure.
REFERENCE   3  (bases 1 to 5509)
  AUTHORS   Perez-Cabello,J.A., Silvera-Carrasco,L., Franco,J.M.,
            Capilla-Gonzalez,V., Armaos,A., Gomez-Lima,M., Garcia-Garcia,R.,
            Yap,X.W., Leal-Lasarte,M., Lall,D., Baloh,R.H., Martinez,S.,
            Miyata,Y., Tartaglia,G.G., Sawarkar,R., Garcia-Dominguez,M.,
            Pozo,D. and Roodveldt,C.
  TITLE     MAPK/MAK/MRK overlapping kinase (MOK) controls microglial
            inflammatory/type-I IFN responses via Brd4 and is involved in ALS
  JOURNAL   Proc Natl Acad Sci U S A 120 (28), e2302143120 (2023)
   PUBMED   37399380
  REMARK    GeneRIF: MAPK/MAK/MRK overlapping kinase (MOK) controls microglial
            inflammatory/type-I IFN responses via Brd4 and is involved in ALS.
REFERENCE   4  (bases 1 to 5509)
  AUTHORS   Leal-Lasarte,M.M., Franco,J.M., Labrador-Garrido,A., Pozo,D. and
            Roodveldt,C.
  TITLE     Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping
            kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia
  JOURNAL   FASEB J 31 (7), 2797-2816 (2017)
   PUBMED   28336525
  REMARK    GeneRIF: This provides new insight into the immune phenotype,
            mechanisms, and signaling pathways that operate in microglial
            neurotoxic activation in amyotrophic lateral sclerosis.
REFERENCE   5  (bases 1 to 5509)
  AUTHORS   Broekhuis,J.R., Verhey,K.J. and Jansen,G.
  TITLE     Regulation of cilium length and intraflagellar transport by the
            RCK-kinases ICK and MOK in renal epithelial cells
  JOURNAL   PLoS One 9 (9), e108470 (2014)
   PUBMED   25243405
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5509)
  AUTHORS   Uesaka,T. and Kageyama,N.
  TITLE     Cdx2 homeodomain protein regulates the expression of MOK, a member
            of the mitogen-activated protein kinase superfamily, in the
            intestinal epithelial cells
  JOURNAL   FEBS Lett 573 (1-3), 147-154 (2004)
   PUBMED   15327990
  REMARK    GeneRIF: identification of MOK, a member of the mitogen-activated
            protein kinase superfamily, as one of the genes induced by a
            caudal-related homeobox transcription factor, Cdx2
REFERENCE   7  (bases 1 to 5509)
  AUTHORS   Flyvbjerg,A., Denner,L., Schrijvers,B.F., Tilton,R.G.,
            Mogensen,T.H., Paludan,S.R. and Rasch,R.
  TITLE     Long-term renal effects of a neutralizing RAGE antibody in obese
            type 2 diabetic mice
  JOURNAL   Diabetes 53 (1), 166-172 (2004)
   PUBMED   14693711
REFERENCE   8  (bases 1 to 5509)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5509)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 5509)
  AUTHORS   Miyata,Y., Akashi,M. and Nishida,E.
  TITLE     Molecular cloning and characterization of a novel member of the MAP
            kinase superfamily
  JOURNAL   Genes Cells 4 (5), 299-309 (1999)
   PUBMED   10421840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101875.7 and AL596265.12.
            
            On Mar 6, 2023 this sequence version replaced NM_011973.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB022695.1, SRR5189685.212465.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC101875.7         60054-60235         c
            183-297             AC101875.7         53434-53548         c
            298-387             AC101875.7         47349-47438         c
            388-458             AC101875.7         45750-45820         c
            459-537             AC101875.7         34439-34517         c
            538-586             AC101875.7         34276-34324         c
            587-765             AC101875.7         32823-33001         c
            766-867             AC101875.7         31087-31188         c
            868-1041            AC101875.7         29913-30086         c
            1042-1156           AC101875.7         29217-29331         c
            1157-1357           AC101875.7         27513-27713         c
            1358-4847           AC101875.7         23940-27429         c
            4848-5509           AL596265.12        1-662
FEATURES             Location/Qualifiers
     source          1..5509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 60.81 cM"
     gene            1..5509
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /note="MOK protein kinase"
                     /db_xref="GeneID:26448"
                     /db_xref="MGI:MGI:1336881"
     exon            1..182
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1438
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAPK/MAK/MRK overlapping kinase; T/STK 30;
                     serine/threonine kinase 30; renal tumor antigen"
                     /codon_start=1
                     /product="MAPK/MAK/MRK overlapping kinase isoform 1"
                     /protein_id="NP_036103.1"
                     /db_xref="CCDS:CCDS49176.1"
                     /db_xref="GeneID:26448"
                     /db_xref="MGI:MGI:1336881"
                     /translation="MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQ
                     VNSLREIQALRRLNPHPNILALHEVVFDRKSGSLALICELMDMNIYELIRGRRHPLSE
                     KKIMLYMYQLCKSLDHMHRNGIFHRDVKPENILVKQDVLKLGDFGSCRSVYSKQPYTE
                     YISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVI
                     GTPCQKTLTKFKQSRAMSFDFPFKKGSGIPLLTANLSPQCLSLLHAMVAYDPDERIAA
                     HQALQHPYFQVQRAAETQTLAKHRRAFCPKFSMVPESSSHNWSFSQEGRKQKQSLRHE
                     EGHARRQGPTSLMELPKLRLSGMTKLSSCSSPALRSVLGTGANGKVPVLRPLKCAAVN
                     KKTDTQKDIKPHLKHYHLPTINRKGGEY"
     exon            183..297
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            298..387
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            388..458
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            459..537
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            538..586
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            587..765
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            766..867
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1041
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1156
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1357
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..5509
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /note="hexamer: AATATA"
     polyA_site      1681
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /note="major polyA site"
     regulatory      5489..5494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
                     /note="hexamer: ATTAAA"
     polyA_site      5509
                     /gene="Mok"
                     /gene_synonym="Rage; RAGE1; Stk30"
ORIGIN      
        1 aaggcgacag gaatacaata tggcggccgg atcctaacgc tccccagcca gggaccaccg
       61 cgaaggtcct cgagccggaa gccacctctg gaagggagaa ggccggtacc acagtctcct
      121 cttttctttt cggtccgggg ccgtccaggg gctgacggcg tcatccgcgt tcaggatgaa
      181 gaactacaaa gcaattggca agataggaga ggggacgttt tctgaagtta tgaagatgca
      241 gagtctgaga gatgggaatt actatgcgtg caaacaaatg aagcagcact ttgaaagtat
      301 tgagcaagtg aacagtctgc gagagatcca agcactgagg cgcctgaacc cacaccccaa
      361 catccttgca ctgcacgaag tagtttttga cagaaaatct ggttctcttg cactaatatg
      421 tgaacttatg gacatgaata tttatgagct aatacgaggg agaagacacc cattatcaga
      481 gaaaaagatt atgctctaca tgtatcagct gtgcaaatcg ctggaccaca tgcacagaaa
      541 cgggatcttt cacagagacg tgaagccgga gaatatccta gtaaagcagg atgtcctgaa
      601 actaggggac ttcgggtcat gccggagtgt ctattccaag cagccctaca cagagtacat
      661 ctctacccgg tggtaccggg ccccagagtg tctcctcacc gacgggttct acacatacaa
      721 gatggacctg tggagcgctg gctgcgtgtt ctacgagatt gccagcctgc agcccctctt
      781 tcctggtgtg aatgaactgg accagatctc aaaaatccat gatgtcatcg gcacaccttg
      841 tcagaagacc ctcactaagt tcaaacagtc gagagctatg agttttgatt ttccttttaa
      901 aaagggatca ggaatacctc tactgacagc caatttgtcc ccgcaatgcc tctccctcct
      961 gcacgcaatg gtggcttatg accctgacga acgaattgcg gctcaccaag cccttcagca
     1021 cccctatttc caggtgcaga gggcagctga gacacagacc ctggccaaac acagaagagc
     1081 tttctgtccc aagttctcca tggtgccaga atcatccagt cacaactggt cattctcaca
     1141 ggaaggcaga aagcagaaac agtccctgcg gcacgaggag ggccatgcca gacgacaggg
     1201 gccgaccagc ttgatggagc ttcccaaact gaggctgtcg ggaatgacca aactgtcatc
     1261 atgttccagc cctgcactgc ggtcagtgct gggcactgga gcaaatggaa aagtccctgt
     1321 gctgagaccc ctgaagtgtg ctgctgtgaa caagaagaca gacacgcaga aggacatcaa
     1381 acctcacctg aaacactatc acctgcccac gatcaacagg aaagggggcg aatactgaac
     1441 ggcccgccac ccagtcgtcc tcttggagag caagggctgg caccatggca ggcgtaggcc
     1501 tctgcggctg agagtggatg ggccagaggc tgccccatgc tggtgctcct cgcactgcgt
     1561 ggtggccagg acatgctgcc ttgcagcctg tctctctcca caagctggag ccttgcgtgt
     1621 ttgcagctcc agagcggctg cactgaatgt ttccgtttaa tatatttgta aaaccacctt
     1681 atgcaagggt ttgtttcatt ttcttaatgt aaggatctga ggtgactttc tatgaaagaa
     1741 cagatatgat ggggcatggc agctagctcg tgcctgtaat tctagcactc aggaggcaga
     1801 ggaggaggag gcctgggcta tacagtgagt atccctgcct caaaaagaga aataaaagat
     1861 agaccaaaat ctgtgatgag ggacgtaggc ttagttgaga ggcggttgtg catgttgtac
     1921 ctcagtgttt cctgacagga ctggcaggta ttgtaggtgt tgtgactgtg gtacctccta
     1981 ggaatgctgt tggagacaga atcccactga ataaggcact gtcacagtgt ctcatccaaa
     2041 cattcttcac ttagatatgt tgagccacac ctttgtgttt gctttcctga gctgcagatg
     2101 ggcaggctga tctccgagtg ccagcttcaa gtggccacat tgtcttggct gccaatgcct
     2161 aggctccttt agggatgtcc accaagttga ctggattgcc agtgttgctt ggagcaagta
     2221 ggaaagttgg ggcaccttgt gccctggaaa aagacactgg gctagggaga tagtgtgcag
     2281 gtaagatgct tgctgcatct gaggacctga atcaggttcc atagagtccg tgtaacatcc
     2341 ctataacccc atcactgggg aagggaacag tacagaatgg gaaagacagg agggtctctg
     2401 ggggctttct ggcccctaaa gcgtgctgaa ccaaaaccca gcaagctcca gattcagtga
     2461 gattatcccg tgggaatcaa tgactcagaa aacagttaat ggcacactag gtgtcctcct
     2521 gggactcctg cacatgcgca tgggtgcact ctagcacaca gtgtgtgttc tcctcctgcc
     2581 tgttttacta cagggaaggg atggaaacac tataaaaaca gcactgagtg gactcagggc
     2641 aaaagcagcc atcagacagc tggacttgag cacaagatcc ccctaagctc cttagggctt
     2701 gtttttgctt ttgccatgtg gaatccgggg ccccatgcac tctgggtaag cagtcttagc
     2761 agtagcctag cctctgctca gtcctgggga acaaaggaat tgagtatgct ttttttcttt
     2821 tctatctttt caaatttata ccatttaaaa agcaaaactt cacagggaag tattgagtct
     2881 caatctgatc ccttccttaa ggactctact gacccaagct tcaggccacc aggcaggtgg
     2941 gggggttggg gcagtgacac cacaggacaa tgtgggacag cagagggcag tatgggcgtg
     3001 gaacattgtg ggtatgggtg tccagcacag gcaggcttga gactggagat ggggcttaga
     3061 atgggcagag ccagggcctg gagggtctct tctacattta tgtgacagtc ttgtgtaccc
     3121 tggcatggag gagagtgtct gcagagaagg gctgtcctgc ctttgctgtt ggttttagga
     3181 gtctcagtcc agtagtatta accaggctca caggcaggcc agcacagaaa gggcccaacg
     3241 atgagagcta gcagagcagg cctgacagaa cggcccaaag gaggacctgc gtggctggca
     3301 agctggactg agcctgggga cagggttagg gtacctgccc ctggaaaggc tgctgcaagg
     3361 atctgagagg aaagcaagcc tctcggcttt ctcggcctcc tgtgcgtctg gcacacctgc
     3421 ccagcacagc agcttctgtg aatcgtcacc atagcattct gaatggaaag gccaacaagc
     3481 ctcaccattc tctgacgtgt atctaacatg actgtagaca ctagggtgca gcattccctc
     3541 tacctcagac ttcagagtgg catctgtcat ctcttacagt accaggtaag tgagctgttg
     3601 ttacttccta tggctccagg acctgctgta tgctgggtgt ccctggtgtt agggcagcta
     3661 tagaaccata tggaagacat cttagacctc ggggctaggg actaatctta gaaacagagc
     3721 cagaagattg ttacaggcac agagtcatct aaggtaaact gggacacatc tggtcaaaca
     3781 cagacctgtg acacagactg gtggaggttg gccccgagtt gtcagcaaga gccgtggggt
     3841 acaactgagc atctcgtcaa atggggctca agtttcccac aaatacttgc tgccctggtg
     3901 tccacctggt gtcctcctgt cacttcctat agatgggggc atcgaggagg gagccactct
     3961 gggaggtcac caggctctgt gctgcaggct tgggtttcga gggcagttcc taatcacttt
     4021 cttgtgggtg ttttggactc atagggctga gtttctctgt gtgatagatc agtgttccaa
     4081 gatgacagga acaccaaact gtaaaatgtg ccaacacttt cttctaatat gatctgagca
     4141 tgtgattcat aaattgtact tacatagtga gcaggctcaa tgccaccgac cctcatgacc
     4201 taccttgatc accagaacct gcatggtagg aaaggaggaa agagctccct cgagtgttct
     4261 aactccctac gcagtgtgcc tcttgaatga ggcacggtgg tgtatgcctg aaatccacgc
     4321 actgagactt ggatggccga gggagcatga ctgctttcat tttgaagtaa tctaagctac
     4381 actgtgagtt ccaggctagc caaggcctgt caaaacagaa cacaacagaa caaacaggaa
     4441 agaagaaagt gagtcttggc gtcctatgct gcaccttccc aagatggagg cagggctagg
     4501 ggccttgcag gcagcagcag aaggaagcgg cttccccagc ctgggagcca ggaacctacg
     4561 gtgaatgaag acaaacttgg gctttgcttt gtgaactgtg cagtagcatc atcctgtggc
     4621 aaattcatcc ggcctagcta gagcccacac tccttccttc cacggcccca gtttaatggg
     4681 ctcatttgga gaaatgtttt gataccttgt ggcttactct cacccacata aagcctacat
     4741 ggaacccgct gtgtatgatt ctttaaaagc tgtggaagcc cccccccccc ccagcttgga
     4801 aacccgggca ttgtctctat caccggcagc agctccaggt gagcgaggaa ttcaaccaga
     4861 gcaggcagac acatgccagc agatgccaac cctccggaag ccccatgtga ctgatgtccg
     4921 agctaactct gttctgtgct gcggcagagg ctgtggaaac gcacagtatg tggtttcagc
     4981 tttcaaggac agcaggggga ctctaagcca tgagaaaagg tcatgtgcct acaccaaagt
     5041 ccccatgccg ggcagcccca tagtgtgtgg acttggccca gagccaagac ttctccgaca
     5101 agacgcgttt ttaacagact gacaggagga tcaaggactg tgatacacaa aaaaatgaag
     5161 tacttcaata ccaaccaaga aatgaggcca aaacaaaaag atctatacaa tttaagttta
     5221 aaaaaggata aacaaatagt atattcaaga taattttaat attaatgttt ttgtgaatta
     5281 gaaatatcac tcttaaatga tgaaaattac tagtgggagt gactatttac ccccatttca
     5341 gaattacatt atttacacat ataatacaga cttgattgca tcggaaacaa cagtactaaa
     5401 ataaatgtta acagataaaa agggcatctc ctctcgtatc gtgaggccgg gagcccgtta
     5461 ccccatagtc aaagtcattt ctattagcat taaactattt aagtgcaaa
//
