LOCUS       NM_020619               2774 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mannosyl-oligosaccharide glucosidase (Mogs), mRNA.
ACCESSION   NM_020619
VERSION     NM_020619.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2774)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2774)
  AUTHORS   Jiang,D., Burger,C.A., Casasent,A.K., Albrecht,N.E., Li,F. and
            Samuel,M.A.
  TITLE     Spatiotemporal gene expression patterns reveal molecular
            relatedness between retinal laminae
  JOURNAL   J Comp Neurol 528 (5), 729-755 (2020)
   PUBMED   31609468
REFERENCE   3  (bases 1 to 2774)
  AUTHORS   Liu,Y., Leslie,P.L., Jin,A., Itahana,K., Graves,L.M. and Zhang,Y.
  TITLE     p32 regulates ER stress and lipid homeostasis by down-regulating
            GCS1 expression
  JOURNAL   FASEB J 32 (7), 3892-3902 (2018)
   PUBMED   29465311
  REMARK    GeneRIF: Increased GCS1 expression alleviates fatty acid-induced ER
            stress and is critical for suppressing ER stress-associated
            lipogenic gene activation.
REFERENCE   4  (bases 1 to 2774)
  AUTHORS   Khan,F.A., Varma,G.M. and Vijay,I.K.
  TITLE     Genomic organization and promoter activity of glucosidase I gene
  JOURNAL   Glycobiology 9 (8), 797-806 (1999)
   PUBMED   10406845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051949.1 and BY625811.1.
            
            On May 29, 2018 this sequence version replaced NM_020619.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051949.1, AK157286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2770              BC051949.1         1-2770
            2771-2774           BY625811.1         385-388
FEATURES             Location/Qualifiers
     source          1..2774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..2774
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /note="mannosyl-oligosaccharide glucosidase"
                     /db_xref="GeneID:57377"
                     /db_xref="MGI:MGI:1929872"
     exon            1..421
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2580
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /EC_number="3.2.1.106"
                     /note="glycoprotein-processing glucosidase I; glucosidase
                     1; ER glu I; endoplasmic reticulum alpha-glucosidase I"
                     /codon_start=1
                     /product="mannosyl-oligosaccharide glucosidase"
                     /protein_id="NP_065644.2"
                     /db_xref="CCDS:CCDS20273.1"
                     /db_xref="GeneID:57377"
                     /db_xref="MGI:MGI:1929872"
                     /translation="MARGERRRRAAAAEGARPLERARAAGRRDGRAGGARGSASGAAL
                     AVVVLALAFGLSGRWVLAWLRVRRALTLHPAPSALPPDSSSPAVAPELFWGTYRPHVY
                     FGMKTRSPKPLLTGLMWAQQGATPGTPPKLRHTCEQGDGVGPYGWEFHDGRTFGRQHI
                     HDGALRLTTEFVKRPGGQHGGDWSWRVTVEPQASGTPSFPLVSLFFYVVTDGQEVLLP
                     EIGAKGQLKSISGHTSELGDFRLTLLPPTSPGDTVPKHGSYNVFWSSNPGLPQLTDMV
                     KSRLNSWFQHRPPGASPDRYLGLPGSLKWEERGPSGQGQFLIQQVTLKAPFSVEFVFE
                     SGSAATGGNQASGRLVGSQLTQALESHAAAFKERFEKTFQLKEKGLSPEEQALGQVAL
                     SGLLGGIGYFYGQGLVLPDTSMEGSEQKMDPALFPPVPLFSGVPSRSFFPRGFLWDEG
                     FHQLVVQRWDPHLTREALGHWLGLLNADGWIGREQILGDEARARVPPEFLVQRAAHAN
                     PPTLLLPVVHMLEGHDPDDLAFLRKAFPRLHAWFSWLHQSQAGPVPLSYRWRGRDLAL
                     PTLLNPKTLPSGLDDYPRASHPSTAERHLDLRCWVALGARVLSQLAEQLGETEAAAEL
                     GPLAASLEEPGSLDELHWAPELGVFADFGNHTKAVQLKSRPPQGLVRVVGRPPPRLQY
                     VDALGYVSLFPLLLQLLDPSSPRLGPLLDVLADSRHLWSPFGLRSLSASSLFYKQRNT
                     EHDPPYWRGAVWLNINYLALGALHHYGHVEGPHKVQAAKLYHELRANVVRNVRQQYQA
                     TGFLWEQYSDQDGRGMGCRPFQGWTSLVLLIMAEEY"
     exon            422..651
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..848
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..2774
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2749..2754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /note="hexamer: AATAAA"
     polyA_site      2770
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /note="major polyA site"
ORIGIN      
        1 gctcggggag gcgcgcggcg aaggctcggt ccgctgaccg cacggtggca gccggggagc
       61 gtgcaggctg cccgcatggc ccggggcgag aggcgacggc gcgctgcggc cgcagagggg
      121 gcgcggccgc tggagagggc gcgggcggcg ggccggcggg atggcagggc tggtggggcg
      181 cggggctcgg cgagcggcgc ggccctggcc gtggtggtgt tggcgctggc cttcggcctg
      241 tcggggcgct gggtgctggc gtggctccgt gtgcgccgcg cgctcacact gcaccccgcg
      301 ccgtctgcgc tgccgccgga ctcctccagt cctgccgtgg ccccggaact cttctggggc
      361 acctaccgcc cacacgtcta tttcggcatg aagactcgca gccccaaacc actgctcaca
      421 ggactgatgt gggcacagca aggcgccacc ccggggaccc ctcctaagct caggcacacg
      481 tgtgaacagg gagacggcgt gggtccctat ggctgggagt tccacgatgg ccgcaccttc
      541 ggtcggcagc atatccacga tggggcctta aggctcacca ctgagttcgt caagaggcct
      601 gggggtcagc acggagggga ttggagctgg agagtgaccg tagagcctca ggcctcaggt
      661 acaccttcct tccctttggt gtccctgttc ttctacgtgg tgacagatgg gcaagaggtc
      721 ctactaccag agatcggagc caaaggacag ttgaagtcca tcagtgggca caccagtgaa
      781 cttggtgact tccgcctcac acttctgccg ccaaccagtc caggagacac tgtccctaag
      841 catggcagct acaatgtctt ctggtcctcc aacccggggc tgccacagct cacagatatg
      901 gtaaagagcc gcctaaacag ctggtttcag caccggcccc caggagcctc tcctgaccgc
      961 tacctcggct tgcctggatc tctgaagtgg gaggagagag gccctagtgg gcaagggcaa
     1021 ttcttgatcc agcaggtgac actgaaagcc cctttctctg tggagtttgt gtttgaatct
     1081 ggcagtgcgg caacaggagg aaaccaagcc tctgggcggc tggtaggcag ccaactgacc
     1141 caggccctgg agagccatgc tgcagccttc aaggaacggt ttgagaagac cttccagcta
     1201 aaggagaagg gcttgagtcc cgaggaacag gctttgggtc aggttgccct cagtggcctt
     1261 cttggtggga ttggttactt ctatggacag ggtttagtgt tgccagacac tagcatggaa
     1321 gggtctgaac agaaaatgga ccctgccctg tttccacctg tccctctttt ctctggggtg
     1381 ccttctaggt cattcttccc acgaggcttc ctctgggatg aaggctttca ccagctagtg
     1441 gtccagcgat gggatcccca cctcacccgg gaggccctag gacactggct ggggctgctc
     1501 aatgctgacg gctggattgg gcgagagcag attctggggg atgaggccag agcccgagtg
     1561 cccccagaat tcctagtgca acgggcagcc catgccaacc ccccaaccct gctcctgcca
     1621 gtcgtacaca tgctagaagg ccatgaccct gatgatttgg cctttctccg caaggctttc
     1681 ccccgcctgc atgcctggtt ctcttggctc catcaaagtc aggcagggcc agtgccacta
     1741 tcctaccgct ggcggggcag ggacctagct ttgcctaccc tacttaaccc caagacgctg
     1801 ccctcaggcc tggatgacta ccctagggcc tcgcatcctt ccacagcaga gcggcacctg
     1861 gacctgcgct gctgggtggc actgggtgcc cgggtgctgt cccagcttgc agaacagctt
     1921 ggggagactg aagctgctgc agagctgggc ccattggctg cctctctaga agaacctgga
     1981 agtcttgatg agctgcactg ggctcctgag ctgggggtct ttgctgactt tgggaaccac
     2041 acaaaagcag tacagctcaa gtcgaggccc ccacaggggc tggttagggt ggtaggcagg
     2101 cctccacctc gattacagta tgtggatgcc ctgggctatg tctctctttt tcctttgcta
     2161 ctacagctgc tggaccccag ctcaccccgc ttaggacccc tgctagacgt tctagctgat
     2221 agtcgccatc tctggagccc ttttgggttg cgctctcttt cagcctctag cctcttttat
     2281 aaacagcgta acactgagca cgatccaccc tactggcgag gtgccgtgtg gctgaatatt
     2341 aactacctag ctttgggggc actacatcac tatgggcatg tggagggtcc tcacaaggtt
     2401 caggctgcca aactctacca tgaactgcgg gccaatgtag tgagaaacgt ccgccagcaa
     2461 taccaggcta ccggatttct gtgggagcag tacagtgacc aggatgggcg gggcatgggc
     2521 tgccgcccct tccaaggatg gaccagtctt gtcttactga tcatggctga agagtactaa
     2581 tgggacagaa ggaaagctag gccatttgtg tcacttggaa tatgcagaca agggcttggg
     2641 tttctggtct cattgtttca gatctttgta agctcatctc aggtgtctcc ttattgtcat
     2701 cccatatagc tctggggtga atgtgaactc aaagagtcta tttttctaaa taaactggaa
     2761 aagaacctaa ctga
//
