LOCUS       NP_065644                834 aa            linear   ROD 02-MAY-2024
DEFINITION  mannosyl-oligosaccharide glucosidase [Mus musculus].
ACCESSION   NP_065644
VERSION     NP_065644.2
DBSOURCE    REFSEQ: accession NM_020619.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 834)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 834)
  AUTHORS   Jiang,D., Burger,C.A., Casasent,A.K., Albrecht,N.E., Li,F. and
            Samuel,M.A.
  TITLE     Spatiotemporal gene expression patterns reveal molecular
            relatedness between retinal laminae
  JOURNAL   J Comp Neurol 528 (5), 729-755 (2020)
   PUBMED   31609468
REFERENCE   3  (residues 1 to 834)
  AUTHORS   Liu,Y., Leslie,P.L., Jin,A., Itahana,K., Graves,L.M. and Zhang,Y.
  TITLE     p32 regulates ER stress and lipid homeostasis by down-regulating
            GCS1 expression
  JOURNAL   FASEB J 32 (7), 3892-3902 (2018)
   PUBMED   29465311
  REMARK    GeneRIF: Increased GCS1 expression alleviates fatty acid-induced ER
            stress and is critical for suppressing ER stress-associated
            lipogenic gene activation.
REFERENCE   4  (residues 1 to 834)
  AUTHORS   Khan,F.A., Varma,G.M. and Vijay,I.K.
  TITLE     Genomic organization and promoter activity of glucosidase I gene
  JOURNAL   Glycobiology 9 (8), 797-806 (1999)
   PUBMED   10406845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051949.1 and BY625811.1.
            
            On Jun 19, 2003 this sequence version replaced NP_065644.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051949.1, AK157286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     Protein         1..834
                     /product="mannosyl-oligosaccharide glucosidase"
                     /EC_number="3.2.1.106"
                     /note="glycoprotein-processing glucosidase I; glucosidase
                     1; ER glu I; endoplasmic reticulum alpha-glucosidase I"
                     /calculated_mol_wt=91701
     Region          1..37
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UM7.1)"
     Region          3..9
                     /region_name="Endoplasmic reticulum targeting"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UM7.1)"
     Site            44..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UM7.1)"
     Region          74..136
                     /region_name="Required for endoplasmic reticulum
                     targeting. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UM7.1)"
     Region          92..>243
                     /region_name="Glyco_hydro_63N"
                     /note="Glycosyl hydrolase family 63 N-terminal domain;
                     pfam16923"
                     /db_xref="CDD:465316"
     Region          349..832
                     /region_name="Glyco_hydro_63"
                     /note="Glycosyl hydrolase family 63 C-terminal domain;
                     pfam03200"
                     /db_xref="CDD:397353"
     Site            654
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q13724; propagated from
                     UniProtKB/Swiss-Prot (Q80UM7.1)"
     CDS             1..834
                     /gene="Mogs"
                     /gene_synonym="1810017N02Rik; Gcs1"
                     /coded_by="NM_020619.3:76..2580"
                     /db_xref="CCDS:CCDS20273.1"
                     /db_xref="GeneID:57377"
                     /db_xref="MGI:MGI:1929872"
ORIGIN      
        1 margerrrra aaaegarple raraagrrdg raggargsas gaalavvvla lafglsgrwv
       61 lawlrvrral tlhpapsalp pdssspavap elfwgtyrph vyfgmktrsp kplltglmwa
      121 qqgatpgtpp klrhtceqgd gvgpygwefh dgrtfgrqhi hdgalrltte fvkrpggqhg
      181 gdwswrvtve pqasgtpsfp lvslffyvvt dgqevllpei gakgqlksis ghtselgdfr
      241 ltllpptspg dtvpkhgsyn vfwssnpglp qltdmvksrl nswfqhrppg aspdrylglp
      301 gslkweergp sgqgqfliqq vtlkapfsve fvfesgsaat ggnqasgrlv gsqltqales
      361 haaafkerfe ktfqlkekgl speeqalgqv alsgllggig yfygqglvlp dtsmegseqk
      421 mdpalfppvp lfsgvpsrsf fprgflwdeg fhqlvvqrwd phltrealgh wlgllnadgw
      481 igreqilgde ararvppefl vqraahanpp tlllpvvhml eghdpddlaf lrkafprlha
      541 wfswlhqsqa gpvplsyrwr grdlalptll npktlpsgld dyprashpst aerhldlrcw
      601 valgarvlsq laeqlgetea aaelgplaas leepgsldel hwapelgvfa dfgnhtkavq
      661 lksrppqglv rvvgrppprl qyvdalgyvs lfplllqlld pssprlgpll dvladsrhlw
      721 spfglrslsa sslfykqrnt ehdppywrga vwlninylal galhhyghve gphkvqaakl
      781 yhelranvvr nvrqqyqatg flweqysdqd grgmgcrpfq gwtslvllim aeey
//
