LOCUS       NM_177448               1787 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus monoacylglycerol O-acyltransferase 2 (Mogat2), mRNA.
ACCESSION   NM_177448
VERSION     NM_177448.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1787)
  AUTHORS   Lang,Y., Zhong,C., Guo,L., Liu,Z., Zuo,D., Chen,X., Ding,L.,
            Huang,B., Li,B., Yuan,Y., Niu,Y., Qiu,J. and Qian,C.
  TITLE     Monoacylglycerol acyltransferase-2 inhibits colorectal
            carcinogenesis in APCmin+/- mice
  JOURNAL   iScience 27 (7), 110205 (2024)
   PUBMED   39055928
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1787)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1787)
  AUTHORS   Mochida,T., Take,K., Maki,T., Nakakariya,M., Adachi,R., Sato,K.,
            Kitazaki,T. and Takekawa,S.
  TITLE     Inhibition of MGAT2 modulates fat-induced gut peptide release and
            fat intake in normal mice and ameliorates obesity and diabetes in
            ob/ob mice fed on a high-fat diet
  JOURNAL   FEBS Open Bio 10 (3), 316-326 (2020)
   PUBMED   31837122
  REMARK    GeneRIF: Inhibition of MGAT2 modulates fat-induced gut peptide
            release and fat intake in normal mice and ameliorates obesity and
            diabetes in ob/ob mice fed on a high-fat diet.
REFERENCE   4  (bases 1 to 1787)
  AUTHORS   Brandt,C., McFie,P.J. and Stone,S.J.
  TITLE     Diacylglycerol acyltransferase-2 and monoacylglycerol
            acyltransferase-2 are ubiquitinated proteins that are degraded by
            the 26S proteasome
  JOURNAL   Biochem J 473 (20), 3621-3637 (2016)
   PUBMED   27531967
REFERENCE   5  (bases 1 to 1787)
  AUTHORS   McFie,P.J., Izzard,S., Vu,H., Jin,Y., Beauchamp,E., Berthiaume,L.G.
            and Stone,S.J.
  TITLE     Membrane topology of human monoacylglycerol acyltransferase-2 and
            identification of regions important for its localization to the
            endoplasmic reticulum
  JOURNAL   Biochim Biophys Acta 1861 (9 Pt A), 1192-1204 (2016)
   PUBMED   27373844
REFERENCE   6  (bases 1 to 1787)
  AUTHORS   Hou,J., Charters,A.M., Lee,S.C., Zhao,Y., Wu,M.K., Jones,S.J.,
            Marra,M.A. and Hoodless,P.A.
  TITLE     A systematic screen for genes expressed in definitive endoderm by
            Serial Analysis of Gene Expression (SAGE)
  JOURNAL   BMC Dev Biol 7, 92 (2007)
   PUBMED   17683524
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1787)
  AUTHORS   Cao,J., Hawkins,E., Brozinick,J., Liu,X., Zhang,H., Burn,P. and
            Shi,Y.
  TITLE     A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2
            in dietary fat absorption implicated by tissue distribution,
            subcellular localization, and up-regulation by high fat diet
  JOURNAL   J Biol Chem 279 (18), 18878-18886 (2004)
   PUBMED   14966132
REFERENCE   8  (bases 1 to 1787)
  AUTHORS   Cao,J., Burn,P. and Shi,Y.
  TITLE     Properties of the mouse intestinal acyl-CoA:monoacylglycerol
            acyltransferase, MGAT2
  JOURNAL   J Biol Chem 278 (28), 25657-25663 (2003)
   PUBMED   12730219
  REMARK    GeneRIF: MGAT2 possessed an intrinsic acyl-CoA:diacylglycerol
            acyltransferase (DGAT) activity which could provide an alternative
            pathway for triacylglycerol synthesis in the absence of DGAT
REFERENCE   9  (bases 1 to 1787)
  AUTHORS   Yen,C.L. and Farese,R.V. Jr.
  TITLE     MGAT2, a monoacylglycerol acyltransferase expressed in the small
            intestine
  JOURNAL   J Biol Chem 278 (20), 18532-18537 (2003)
   PUBMED   12621063
  REMARK    GeneRIF: MGAT catalyzes the synthesis of diacylglycerol, a
            precursor of triacylglycerol. MGAT mediates the absorption of
            dietary fat by catalyzing the resynthesis of triacylglycerol in
            enterocytes, a step required for delivering absorbed fat to other
            tissues.
REFERENCE   10 (bases 1 to 1787)
  AUTHORS   Cao,J., Lockwood,J., Burn,P. and Shi,Y.
  TITLE     Cloning and functional characterization of a mouse intestinal
            acyl-CoA:monoacylglycerol acyltransferase, MGAT2
  JOURNAL   J Biol Chem 278 (16), 13860-13866 (2003)
   PUBMED   12576479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133854.1 and BC052831.1.
            
            On Jun 18, 2008 this sequence version replaced NM_177448.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052831.1, AK133854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1290              AK133854.1         9-1298
            1291-1787           BC052831.1         1295-1791
FEATURES             Location/Qualifiers
     source          1..1787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.03 cM"
     gene            1..1787
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /note="monoacylglycerol O-acyltransferase 2"
                     /db_xref="GeneID:233549"
                     /db_xref="MGI:MGI:2663253"
     exon            1..137
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1051
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /EC_number="2.3.1.20"
                     /EC_number="2.3.1.22"
                     /note="acyl CoA:monoacylglycerol acyltransferase 2;
                     diacylglycerol acyltransferase 2-like protein 5"
                     /codon_start=1
                     /product="2-acylglycerol O-acyltransferase 2"
                     /protein_id="NP_803231.1"
                     /db_xref="CCDS:CCDS21478.1"
                     /db_xref="GeneID:233549"
                     /db_xref="MGI:MGI:2663253"
                     /translation="MVEFAPLLVPWERRLQTFAVLQWVFSFLALAQLCIVIFVGLLFT
                     RFWLFSVLYATWWYLDWDKPRQGGRPIQFFRRLAIWKYMKDYFPVSLVKTAELDPSRN
                     YIAGFHPHGVLAAGAFLNLCTESTGFTSLFPGIRSYLMMLTVWFRAPFFRDYIMSGGL
                     VSSEKVSADHILSRKGGGNLLAIIVGGAQEALDARPGAYRLLLKNRKGFIRLALMHGA
                     ALVPIFSFGENNLFNQVENTPGTWLRWIQNRLQKIMGISLPLFHGRGVFQYSFGLMPF
                     RQPITTIVGKPIEVQMTPQPSREEVDRLHQRYIKELCKLFEEHKLKFNVPEDQHLEFC
                     "
     exon            138..316
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..521
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..696
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..896
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1772
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /note="hexamer: AATGAA"
     polyA_site      1772
                     /gene="Mogat2"
                     /gene_synonym="DGAT2L5; Mgat1l; MGAT2"
                     /note="major polyA site"
ORIGIN      
        1 aacctagagc aaagcccgtg tgtagagcct cctgagccag ctcagcatgg tggagttcgc
       61 ccccctgttg gtaccatggg agcgcaggtt acagaccttc gcggtccttc agtgggtctt
      121 ctccttcctg gccttggccc agctctgcat cgtcatcttc gtaggcctcc tattcacaag
      181 gttctggctc ttctctgtcc tgtatgccac ctggtggtac ctggactggg acaagccgcg
      241 gcagggaggc cggcccatcc agttcttcag acgcttggcc atatggaagt acatgaagga
      301 ttatttccct gtctctttgg tcaagacagc tgagctggac ccttcccgga actacatcgc
      361 gggcttccac ccccatggag tcctagcagc tggagccttt cttaacctgt gcactgaaag
      421 cacgggcttt acctcgcttt tcccgggcat ccgctcctat ctgatgatgc tgactgtgtg
      481 gttccgggcc cccttcttcc gagattacat catgtctggg gggctggtct catcagaaaa
      541 ggtgagtgcc gatcacattc tgtccaggaa gggcggcggg aacttgcttg ccatcatcgt
      601 tgggggcgcg caggaggcac tggacgccag gcctggagcc tacaggctgc tgctgaagaa
      661 tcgcaagggc ttcatcaggc tcgccctgat gcatggggca gctcttgtgc caatcttctc
      721 ctttggagaa aacaacctgt tcaaccaggt tgagaacacc cctggtacct ggctgcgctg
      781 gatccagaac cggctacaga agatcatggg catctccctc cctctcttcc acggcagagg
      841 tgtcttccag tacagctttg gcctcatgcc cttccgccag cccatcacca ccatagtggg
      901 gaagcccatc gaggtgcaga tgacaccaca gccctcaagg gaggaggtgg accggcttca
      961 tcagcgctat atcaaggagc tctgcaagct ctttgaggag cacaaactca agttcaacgt
     1021 ccctgaggac cagcatctgg agttctgcta agtgtctcca gccggaagac agctgcatct
     1081 gagcgcctgc aggagtgtgg gattaggggg acttccacag ccaccagaca ctcctacaaa
     1141 cctagccaca actgccaaga tggaagaggg ggcagctcct aatcctggga tttgaacctg
     1201 tagccaaagc tctgaggtct ccctgtcctt ggcctgtctg cacatctgta gaatggggga
     1261 aaagcagtca gagagaaatt cctgaggtct cttcccacag ttgtaatgtc attcaaacat
     1321 gaccaaagga caaacaggga gaaagagaac aaaactgttc ttcatctacc cttgagggac
     1381 agtgcaagag aagccagcac cccaggcctc cctgtgcatg gtccctgatg ctgcttcttc
     1441 cctctgaggc agagacgggg agccaagtct gccctggcac ctactctatg tttcttcaga
     1501 ttctgggtcc tctgagctat gataccaaag gagcccagaa ggcagataag gagggcaggg
     1561 gtcactgact atgaccgagg gtaggtctcc ttcccatatc ctgagcctca gtttccccag
     1621 ccttaatgac ctgggagcgc cacactgctc accacagagg ctccaccaga gagcctctta
     1681 ctcatgcttt ctagtgaact ccagcctctg tcttggcact gaagggcagc actgtacatg
     1741 ttacctcaat aaatgaaagg agtctgtctt aaaaaaaaaa aaaaaaa
//
