LOCUS       NM_020042               2601 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus molybdenum cofactor synthesis 1 (Mocs1), transcript
            variant 1, mRNA.
ACCESSION   NM_020042 XM_001003122
VERSION     NM_020042.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Mayr,S.J., Roper,J. and Schwarz,G.
  TITLE     Alternative splicing of the bicistronic gene molybdenum cofactor
            synthesis 1 (MOCS1) uncovers a novel mitochondrial protein
            maturation mechanism
  JOURNAL   J Biol Chem 295 (10), 3029-3039 (2020)
   PUBMED   31996372
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   Kugler,S., Hahnewald,R., Garrido,M. and Reiss,J.
  TITLE     Long-term rescue of a lethal inherited disease by adeno-associated
            virus-mediated gene transfer in a mouse model of
            molybdenum-cofactor deficiency
  JOURNAL   Am J Hum Genet 80 (2), 291-297 (2007)
   PUBMED   17236133
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   Reiss,J., Bonin,M., Schwegler,H., Sass,J.O., Garattini,E.,
            Wagner,S., Lee,H.J., Engel,W., Riess,O. and Schwarz,G.
  TITLE     The pathogenesis of molybdenum cofactor deficiency, its delay by
            maternal clearance, and its expression pattern in microarray
            analysis
  JOURNAL   Mol Genet Metab 85 (1), 12-20 (2005)
   PUBMED   15862276
  REMARK    GeneRIF: Inactivity results in elevated sulfite and diminished
            sulfate levels throughout the organism, and various brain
            dysmorphisms.
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Lee,H.J., Adham,I.M., Schwarz,G., Kneussel,M., Sass,J.O., Engel,W.
            and Reiss,J.
  TITLE     Molybdenum cofactor-deficient mice resemble the phenotype of human
            patients
  JOURNAL   Hum Mol Genet 11 (26), 3309-3317 (2002)
   PUBMED   12471057
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   Gray,T.A. and Nicholls,R.D.
  TITLE     Diverse splicing mechanisms fuse the evolutionarily conserved
            bicistronic MOCS1A and MOCS1B open reading frames
  JOURNAL   RNA 6 (7), 928-936 (2000)
   PUBMED   10917590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165258.2.
            
            On Nov 8, 2022 this sequence version replaced NM_020042.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157231.1, SRR13422603.594819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC165258.2         133236-133408       c
            174-300             AC165258.2         128504-128630       c
            301-468             AC165258.2         126538-126705       c
            469-633             AC165258.2         122214-122378       c
            634-695             AC165258.2         112639-112700       c
            696-807             AC165258.2         112254-112365       c
            808-920             AC165258.2         111939-112051       c
            921-1031            AC165258.2         111428-111538       c
            1032-1152           AC165258.2         109469-109589       c
            1153-1200           AC165258.2         108958-109005       c
            1201-2601           AC165258.2         106370-107770       c
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 25.45 cM"
     gene            1..2601
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /note="molybdenum cofactor synthesis 1"
                     /db_xref="GeneID:56738"
                     /db_xref="MGI:MGI:1928904"
     exon            1..173
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1961
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /EC_number="4.1.99.22"
                     /EC_number="4.6.1.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     molybdenum cofactor synthesis-step 1 proteins A and B;
                     molybdenum cofactor biosynthesis protein 1"
                     /codon_start=1
                     /product="molybdenum cofactor biosynthesis protein 1
                     isoform 1"
                     /protein_id="NP_064426.2"
                     /db_xref="CCDS:CCDS50143.1"
                     /db_xref="GeneID:56738"
                     /db_xref="MGI:MGI:1928904"
                     /translation="MAARPAFGIVRQLLRSNARGCSSGAPVTQPRPGEPSRPTREGLS
                     LRLQFLQEHAAPFSAFLTDSFGRQHSYLRISLTEKCNLRCQYCMPEEGVPLTPKADLL
                     TTEEILTLARLFVKEGVDKIRLTGGEPLIRPDVVDIVARLHGLEGLRTIGLTTNGINL
                     ARLLPRLQQAGLNAVNISLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYKPVKVNC
                     VVMRGLNEDELLDFVALTEGLPLDVRFIEYMPFDGNKWNFKKMVSYKEMLDTIRQRWP
                     GLEKLPEEDSSTAKAFKIPGFQGQISFITSMSEHFCGTCNRLRITADGNLKVCLFGNS
                     EVSLRDHLRAGASEEELLRIIGAAVGRKKRQHAGMFNIAQMKNRPMILIGVLLMLQDS
                     PPARWSNFSWDPLRVRNPSARQCLSDQMASLWKRHCIPKALPLSQQCLGSGSPQRHYS
                     SYPDPDTHSKCLSTGSQAPDAPSGPGPTSNQLTHVDSAGRASMVDVGGKPETERVAVA
                     SAMVLLGPVAFKLVQQNQLKKGDALVVAQLAGVQAAKLTSQLIPLCHHVALSHVQVHL
                     ELDSTRHAVLIQASCRARGPTGVEMEALTSAAMAALTVYDMCKAVSRDIVVTEVKLIS
                     KTGGQRGDFHRA"
     exon            174..300
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            301..468
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            469..633
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            634..695
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..807
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            808..920
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1031
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1152
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1200
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..2601
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2577..2582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2601
                     /gene="Mocs1"
                     /gene_synonym="3110045D15Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagtgctct ggaggcccac ttcaggccgg gtacttcctt tgctgacttc atggcggcgc
       61 ggcctgcgtt cggaatagtg cggcagctcc tgaggtccaa tgctcggggt tgcagctcgg
      121 gggctccggt gacgcagcct cgccccgggg agccctcgag acctaccagg gaggggctgt
      181 ccctgaggct ccagttcctc caggagcatg cggctccctt ctctgccttc ctcacggaca
      241 gctttggccg acaacatagt tacctgcgga tctctctcac agagaagtgc aacctccgat
      301 gccagtattg catgcccgag gagggtgtgc ccctgacccc caaagctgac ctactgacca
      361 cagaggagat cctgaccctt gcccgcctct ttgtgaagga aggtgtggac aagatccgtc
      421 tcactggtgg ggagcctctc atccgaccgg atgtggtgga catcgtggcc agacttcatg
      481 ggctggaagg gctgagaacc atcggcctca ccaccaacgg catcaaccta gcccggctgc
      541 tgccccgact tcagcaagca gggctcaatg ctgttaacat cagcctggac actctggttc
      601 ccgccaagtt tgagttcatc gtccgcagaa aaggcttcca caaggttatg gagggtatcc
      661 acaaagccat cgagctgggt tacaagcctg tgaaggtgaa ctgtgtggtg atgcgaggcc
      721 tgaatgaaga cgagctgctg gacttcgtgg ccctgacaga gggccttccc ttggacgtgc
      781 gcttcattga gtacatgcca tttgacggca acaagtggaa cttcaagaag atggttagct
      841 acaaggagat gctggacacc atccgacagc ggtggccagg gctggagaag ctgccggagg
      901 aggactcgag cactgccaag gcctttaaga tccctggctt ccagggtcag atcagcttca
      961 tcacatccat gtcagagcat ttctgtggga cctgcaaccg gttgcgcatc acagctgatg
     1021 ggaacctcaa ggtctgcctc tttgggaact ctgaggtgtc actgcgggac cacctgcggg
     1081 cgggggcctc tgaggaggag ctgctgagaa tcattggggc cgcagtgggt aggaagaagc
     1141 ggcagcacgc aggcatgttc aatattgccc agatgaagaa ccggcccatg atcctcatcg
     1201 gggtactttt gatgcttcag gattccccac cagctcgttg gagcaatttc tcctgggatc
     1261 ccctccgtgt tcggaatcca agtgccagac agtgtctctc tgaccagatg gcatctttgt
     1321 ggaagagaca ctgcatcccc aaggcccttc ctctgtctca acagtgccta gggtctggct
     1381 cccctcagag acactacagc tcctatccag accctgacac tcactcaaag tgccttagca
     1441 cagggtccca ggcacctgat gccccctcag gtccagggcc gacctcaaat cagctaactc
     1501 atgtggattc agcagggcgg gcatctatgg tagatgtggg tgggaagccg gagacagagc
     1561 gggtggctgt ggcctctgcc atggttcttc ttggacccgt ggccttcaag cttgtccagc
     1621 agaaccaact gaagaagggc gatgctctcg tggtggccca gctggctgga gtccaggcag
     1681 ccaagctaac cagtcagttg atccccctct gccaccatgt ggccctgagc cacgtgcagg
     1741 tacacctgga gttagacagc acacgccacg ctgtgttgat ccaggcatcc tgccgggccc
     1801 ggggtcccac cggggtagag atggaggcgc tgacctcggc tgccatggct gccctgacgg
     1861 tgtatgacat gtgcaaggca gtcagcaggg acattgtggt gacagaggtg aagctcatta
     1921 gtaagactgg agggcagcgg ggagacttcc atcgggctta gagtgccaca ctctccagtc
     1981 atgtctccca aggggatgca attcaggctg aggaaaagat gccatatccc tctaaatcta
     2041 gtgattagac ctaggatcac cctgtctctt taccactaac ctgtgaggtg tcgtcaccag
     2101 aggacacctg aggccttgac accttccagg actctggcaa tgggagtttt gatactggat
     2161 acccaagaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     2221 tcatattgct caggttgttt cagacagaca gctttatgca gcccttctca tttagggtcc
     2281 tctcttctct tccccgggga gagaataagg gctcactaag cagaggaacc cacttagagg
     2341 aaggaaaagc acaaactccc taaggaatgt atcacagacc gtcacccccc accccccacc
     2401 cccatctccg gccttctctt ccgacaggat gcacacttgt ggaccacaac cctaaggtct
     2461 tgtgccagca tctacccaca cctggttctg ttcactgtgg tctgcccaca cctgtctact
     2521 ctggcatgtg tcaggaaaag gagcgtcaaa ggtgaccttt accctcacag cgtaccaata
     2581 aaccacggtg ccagctttgg a
//
