LOCUS       NM_001039365            1516 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus myelin-associated oligodendrocytic basic protein
            (Mobp), transcript variant 3, mRNA.
ACCESSION   NM_001039365
VERSION     NM_001039365.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1516)
  AUTHORS   Yu,Z., Yang,Z., Ren,G., Wang,Y., Luo,X., Zhu,F., Yu,S., Jia,L.,
            Chen,M., Worley,P.F. and Xiao,B.
  TITLE     GATOR2 complex-mediated amino acid signaling regulates brain
            myelination
  JOURNAL   Proc Natl Acad Sci U S A 119 (3) (2022)
   PUBMED   35022234
REFERENCE   2  (bases 1 to 1516)
  AUTHORS   Kennedy,A.J., Rahn,E.J., Paulukaitis,B.S., Savell,K.E.,
            Kordasiewicz,H.B., Wang,J., Lewis,J.W., Posey,J., Strange,S.K.,
            Guzman-Karlsson,M.C., Phillips,S.E., Decker,K., Motley,S.T.,
            Swayze,E.E., Ecker,D.J., Michael,T.P., Day,J.J. and Sweatt,J.D.
  TITLE     Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory
            Function
  JOURNAL   Cell Rep 16 (10), 2666-2685 (2016)
   PUBMED   27568567
REFERENCE   3  (bases 1 to 1516)
  AUTHORS   Maloney,S.E., Khangura,E. and Dougherty,J.D.
  TITLE     The RNA-binding protein Celf6 is highly expressed in diencephalic
            nuclei and neuromodulatory cell populations of the mouse brain
  JOURNAL   Brain Struct Funct 221 (4), 1809-1831 (2016)
   PUBMED   25682262
REFERENCE   4  (bases 1 to 1516)
  AUTHORS   Schafer,I., Muller,C., Luhmann,H.J. and White,R.
  TITLE     MOBP levels are regulated by Fyn kinase and affect the
            morphological differentiation of oligodendrocytes
  JOURNAL   J Cell Sci 129 (5), 930-942 (2016)
   PUBMED   26801084
  REMARK    GeneRIF: MOBP synthesis is stimulated by Fyn activity.
REFERENCE   5  (bases 1 to 1516)
  AUTHORS   Mardaryev,A.N., Liu,B., Rapisarda,V., Poterlowicz,K.,
            Malashchuk,I., Rudolf,J., Sharov,A.A., Jahoda,C.A., Fessing,M.Y.,
            Benitah,S.A., Xu,G.L. and Botchkarev,V.A.
  TITLE     Cbx4 maintains the epithelial lineage identity and cell
            proliferation in the developing stratified epithelium
  JOURNAL   J Cell Biol 212 (1), 77-89 (2016)
   PUBMED   26711500
REFERENCE   6  (bases 1 to 1516)
  AUTHORS   Montague,P., Barrie,J.A., Thomson,C.E., Kirkham,D., McCallion,A.S.,
            Davies,R.W., Kennedy,P.G. and Griffths,I.R.
  TITLE     Cytoskeletal and nuclear localization of myelin oligodendrocytic
            basic protein isoforms
  JOURNAL   Eur J Neurosci 10 (4), 1321-1328 (1998)
   PUBMED   9749786
REFERENCE   7  (bases 1 to 1516)
  AUTHORS   Holz,A., Frank,M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Schwab,M.E.
  TITLE     Chromosomal localization of the myelin-associated oligodendrocytic
            basic protein and expression in the genetically linked neurological
            mouse mutants ducky and tippy
  JOURNAL   J Neurochem 69 (5), 1801-1809 (1997)
   PUBMED   9349522
REFERENCE   8  (bases 1 to 1516)
  AUTHORS   Montague,P., Dickinson,P.J., McCallion,A.S., Stewart,G.J.,
            Savioz,A., Davies,R.W., Kennedy,P.G. and Griffiths,I.R.
  TITLE     Developmental expression of the murine Mobp gene
  JOURNAL   J Neurosci Res 49 (2), 133-143 (1997)
   PUBMED   9272636
REFERENCE   9  (bases 1 to 1516)
  AUTHORS   McCallion,A.S., Guenet,J.L., Montague,P., Griffiths,I.R., Savioz,A.
            and Davies,R.W.
  TITLE     The mouse gene (Mobp) encoding myelin-associated oligodendrocytic
            basic protein maps to distal chromosome 9
  JOURNAL   Mamm Genome 7 (11), 847-849 (1996)
   PUBMED   8875894
REFERENCE   10 (bases 1 to 1516)
  AUTHORS   Holz,A., Schaeren-Wiemers,N., Schaefer,C., Pott,U., Colello,R.J.
            and Schwab,M.E.
  TITLE     Molecular and developmental characterization of novel cDNAs of the
            myelin-associated/oligodendrocytic basic protein
  JOURNAL   J Neurosci 16 (2), 467-477 (1996)
   PUBMED   8551331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140055.1 and AI839250.1.
            
            On Feb 27, 2018 this sequence version replaced NM_001039365.2.
            
            Transcript Variant: This variant (3) uses an alternate 3' terminal
            exon compared to variant 1. The resulting protein (isoform b) is
            longer and has a distinct C-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048492.1, AK140055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1499              AK140055.1         2-1500
            1500-1516           AI839250.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.41 cM"
     gene            1..1516
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /note="myelin-associated oligodendrocytic basic protein"
                     /db_xref="GeneID:17433"
                     /db_xref="MGI:MGI:108511"
     exon            1..56
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /inference="alignment:Splign:2.1.0"
     exon            57..135
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /inference="alignment:Splign:2.1.0"
     exon            136..345
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..652
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /note="isoform b is encoded by transcript variant 3;
                     myelin-associated oligodendrocyte basic protein"
                     /codon_start=1
                     /product="myelin-associated oligodendrocyte basic protein
                     isoform b"
                     /protein_id="NP_001034454.1"
                     /db_xref="CCDS:CCDS23626.1"
                     /db_xref="GeneID:17433"
                     /db_xref="MGI:MGI:108511"
                     /translation="MSQKMAKEGPRLSKNQKFSEHFSIHCCPPFTFLNSKREIVDRKY
                     SICKSGCFYQKKEEDWICCACQKTSRRATSPQRPKHQPAASPVVVRAPPAKPKSPLMP
                     AKPRSPPRPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKQPARSSPLRGPGTSRG
                     GSPTRAPRFW"
     exon            346..1501
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /inference="alignment:Splign:2.1.0"
     regulatory      764..769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /note="hexamer: ATTAAA"
     polyA_site      785
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /note="major polyA site"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
                     /note="hexamer: ATTAAA"
     polyA_site      1501
                     /gene="Mobp"
                     /gene_synonym="MOBP155; MOBP170; MOBP69; MOBP73; MOBP81"
ORIGIN      
        1 agctccacca gggcccgcta tccacaggaa cctttcacaa cagccattac tcgcagggca
       61 acaaagaatc aaatgagagc aagacaagcg gagaccagag ttctggttgc cagaccggca
      121 cggatgaaaa cccagtgaga tgagtcagaa aatggccaag gagggcccca ggctctccaa
      181 gaaccagaag ttctccgagc acttcagcat ccactgctgc ccacccttca ccttcctcaa
      241 ctccaagcgt gagatcgtgg accgcaagta cagcatctgc aagagcggtt gcttttacca
      301 gaagaaggag gaggactgga tctgctgtgc ctgccagaag actagccgcc gtgccacgtc
      361 ccctcagagg cccaagcacc agccagctgc gtccccagtg gtggtcagag cgccgccagc
      421 caagccaaag tcccctctga tgccagccaa gccaaggtcc ccaccgaggc cagccaagcc
      481 aaggtcccct tcaaggactg agcgccagcc gcgtccccgc ccagaggtcc gaccaccacc
      541 agccaagcag aagccccctc agaagtctaa gcagccagca cgcagcagcc ccctcagagg
      601 gccaggcacc agccgcgggg ggtctcccac cagagctcct aggttctggt aacaccatct
      661 cttgcctttt gtcccctcta gcctaaggtc agtagctgct ctctgcaagt actaacatgg
      721 gggatctgtc cacagtacca agcctgtgta atccactccc tgcattaaac cccctctgtt
      781 tgaaagacct ggcgtggctt ctgtttttcc agatgttacc ggtcctcact ttagatggct
      841 gtgtctgtgc caatccatag gactggaagt cactaattta ccagcatagt attggccaca
      901 gtggcaggct gagtgtatga gcctccttaa ccaccttgtg cctcagagag acatagtggt
      961 aactgatgag ttgtatctgt gcatgtgtga tgggaggacc cgatgctcga tttgctgacc
     1021 ctcctgacgc atctcatcag atatctgttt gctcatacag ccactcagca aactctactg
     1081 ctttatagat aataaggttc atatgctgta ctggggagag gaaaataatt tgtgatttct
     1141 gagtaccaaa aagagacaag ctggccctga tgtactgtaa tcactccagt actgccatgc
     1201 tcagggtgtt tatgcccatg ggagccccaa ctgggaactt tccagctctg ccgtgggaac
     1261 ctgaggcttc acagagaaaa ttaggttgga gtgagcaaac tggagaagga tggccagaga
     1321 ggaacttacc catctgctct acctcgggta gaccagtttc ctttcttctt tttgagacag
     1381 agactcacac tgtagttcag gctagcccag atcttactcc gtatctaagg ttgacttcaa
     1441 acttataaaa atcttactgc tttaaattcc caaatgcttg gattaaaggt gtgaactgca
     1501 aaaaaaaaaa aaaaaa
//
