LOCUS       NM_026735               3171 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus MOB kinase activator 1B (Mob1b), mRNA.
ACCESSION   NM_026735 XM_284098
VERSION     NM_026735.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3171)
  AUTHORS   Grego-Bessa,J., Gomez-Apinaniz,P., Prados,B., Gomez,M.J.,
            MacGrogan,D. and de la Pompa,J.L.
  TITLE     Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in
            Ventricular Development
  JOURNAL   Circ Res 133 (11), 927-943 (2023)
   PUBMED   37846569
REFERENCE   2  (bases 1 to 3171)
  AUTHORS   Soyama,H., Nishio,M., Otani,J., Sakuma,T., Takao,S., Hara,S.,
            Masuda,T., Mimori,K., Toyokuni,S., Lydon,J.P., Nakao,K.,
            Nishina,H., Fukumoto,T., Maehama,T. and Suzuki,A.
  TITLE     Hippo-TAZ signaling is the master regulator of the onset of
            triple-negative basal-like breast cancers
  JOURNAL   Proc Natl Acad Sci U S A 119 (29), e2123134119 (2022)
   PUBMED   35858357
REFERENCE   3  (bases 1 to 3171)
  AUTHORS   Ando,T., Arang,N., Wang,Z., Costea,D.E., Feng,X., Goto,Y.,
            Izumi,H., Gilardi,M., Ando,K. and Gutkind,J.S.
  TITLE     EGFR Regulates the Hippo pathway by promoting the tyrosine
            phosphorylation of MOB1
  JOURNAL   Commun Biol 4 (1), 1237 (2021)
   PUBMED   34725466
  REMARK    GeneRIF: EGFR Regulates the Hippo pathway by promoting the tyrosine
            phosphorylation of MOB1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3171)
  AUTHORS   Nishio,M., To,Y., Maehama,T., Aono,Y., Otani,J., Hikasa,H.,
            Kitagawa,A., Mimori,K., Sasaki,T., Nishina,H., Toyokuni,S.,
            Lydon,J.P., Nakao,K., Wah Mak,T., Kiyono,T., Katabuchi,H.,
            Tashiro,H. and Suzuki,A.
  TITLE     Endogenous YAP1 activation drives immediate onset of cervical
            carcinoma in situ in mice
  JOURNAL   Cancer Sci 111 (10), 3576-3587 (2020)
   PUBMED   32716083
REFERENCE   5  (bases 1 to 3171)
  AUTHORS   Omori,H., Nishio,M., Masuda,M., Miyachi,Y., Ueda,F., Nakano,T.,
            Sato,K., Mimori,K., Taguchi,K., Hikasa,H., Nishina,H., Tashiro,H.,
            Kiyono,T., Mak,T.W., Nakao,K., Nakagawa,T., Maehama,T. and
            Suzuki,A.
  TITLE     YAP1 is a potent driver of the onset and progression of oral
            squamous cell carcinoma
  JOURNAL   Sci Adv 6 (12), eaay3324 (2020)
   PUBMED   32206709
  REMARK    Erratum:[Sci Adv. 2023 Dec 15;9(50):eadn0844. doi:
            10.1126/sciadv.adn0844.. PMID: 38100596]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3171)
  AUTHORS   Tian,Y., Liu,Y., Wang,T., Zhou,N., Kong,J., Chen,L., Snitow,M.,
            Morley,M., Li,D., Petrenko,N., Zhou,S., Lu,M., Gao,E., Koch,W.J.,
            Stewart,K.M. and Morrisey,E.E.
  TITLE     A microRNA-Hippo pathway that promotes cardiomyocyte proliferation
            and cardiac regeneration in mice
  JOURNAL   Sci Transl Med 7 (279), 279ra38 (2015)
   PUBMED   25787764
REFERENCE   7  (bases 1 to 3171)
  AUTHORS   Nishio,M., Hamada,K., Kawahara,K., Sasaki,M., Noguchi,F., Chiba,S.,
            Mizuno,K., Suzuki,S.O., Dong,Y., Tokuda,M., Morikawa,T., Hikasa,H.,
            Eggenschwiler,J., Yabuta,N., Nojima,H., Nakagawa,K., Hata,Y.,
            Nishina,H., Mimori,K., Mori,M., Sasaki,T., Mak,T.W., Nakano,T.,
            Itami,S. and Suzuki,A.
  TITLE     Cancer susceptibility and embryonic lethality in Mob1a/1b
            double-mutant mice
  JOURNAL   J Clin Invest 122 (12), 4505-4518 (2012)
   PUBMED   23143302
  REMARK    GeneRIF: MOB1A and MOB1B have overlapping functions in skin
            homeostasis, and exert their roles as tumor suppressors by
            regulating downstream elements of the Hippo pathway.
REFERENCE   8  (bases 1 to 3171)
  AUTHORS   Zhou,D., Medoff,B.D., Chen,L., Li,L., Zhang,X.F., Praskova,M.,
            Liu,M., Landry,A., Blumberg,R.S., Boussiotis,V.A., Xavier,R. and
            Avruch,J.
  TITLE     The Nore1B/Mst1 complex restrains antigen receptor-induced
            proliferation of naive T cells
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20321-20326 (2008)
   PUBMED   19073936
  REMARK    GeneRIF: Mst1/2-catalyzed MOBKL1A/B phosphorylation slows
            proliferation and is therefore a likely contributor to the
            anti-proliferative action of Mst1 in naive T cells
REFERENCE   9  (bases 1 to 3171)
  AUTHORS   Praskova,M., Xia,F. and Avruch,J.
  TITLE     MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell
            proliferation
  JOURNAL   Curr Biol 18 (5), 311-321 (2008)
   PUBMED   18328708
  REMARK    GeneRIF: MOBKL1A/MOBKL1B phosphorylation, by MST1 and MST2, is
            sufficient to inhibit proliferation through actions at several
            points in the cell cycle.
REFERENCE   10 (bases 1 to 3171)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162120.1, AK077320.1 and AK042552.1.
            
            On Dec 2, 2006 this sequence version replaced NM_026735.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162120.1, SRR1660811.6317.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK162120.1         1-26
            27-963              AK077320.1         3-939
            964-2465            AK162120.1         964-2465
            2466-2564           AK077320.1         2441-2539
            2565-3171           AK042552.1         230-836
FEATURES             Location/Qualifiers
     source          1..3171
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.92 cM"
     gene            1..3171
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /note="MOB kinase activator 1B"
                     /db_xref="GeneID:68473"
                     /db_xref="MGI:MGI:1915723"
     exon            1..251
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..888
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /note="mps one binder kinase activator-like 1A; mob1
                     homolog 1A; MOB1, Mps One Binder kinase activator-like 1A"
                     /codon_start=1
                     /product="MOB kinase activator 1B"
                     /protein_id="NP_081011.1"
                     /db_xref="CCDS:CCDS39139.1"
                     /db_xref="GeneID:68473"
                     /db_xref="MGI:MGI:1915723"
                     /translation="MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMA
                     VMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTN
                     IKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYA
                     HIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR"
     exon            252..418
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            419..512
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            513..646
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            647..810
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            811..3171
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2365..2370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /note="major polyA site"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
                     /note="hexamer: AACAAG"
     polyA_site      2711
                     /gene="Mob1b"
                     /gene_synonym="1110003E08Rik; B230364F10; Mobkl1a"
ORIGIN      
        1 gaggaggacg cggcgggcgg tgcttcctcg gccgctctgc ttccagtccg gtgagcctgc
       61 cgagtcctgg ccttccactt ccgcccctca gccggccgcg gcaagtagcg aagccggaga
      121 agtcgcggcc gctccgccgc cggcgcgcgt ccttccccct ccgccacctt ttctctgatt
      181 caagcccgcc gccccaggct tcgctcagcc gagcccgcag cccacgccgc ggccgacatg
      241 agcttcttgt ttggtagtcg ctcttctaaa acttttaaac caaagaagaa cataccagag
      301 gggtctcacc agtatgaact cttaaagcat gcggaagcca cactgggcag cggcaaccta
      361 cggatggctg tcatgcttcc cgagggagag gatctgaatg agtgggttgc agttaacact
      421 gtggattttt tcaatcaaat caatatgctt tatggaacca tcacagactt ctgtacagag
      481 gagagctgtc cggtgatgtc agctggacca aaatatgaat atcactgggc agatggaaca
      541 aacataaaaa agcctattaa gtgttctgca ccaaagtata ttgattactt gatgacttgg
      601 gttcaggacc agctggatga tgagacatta tttccatcaa aaattggtgt tccattcccg
      661 aagaatttca tgtcagtggc aaaaacaata ctcaaacgac tctttagagt ttatgctcat
      721 atttatcacc aacattttga ccctgtgatc cagcttcagg aggaagcaca tctcaataca
      781 tctttcaagc actttatttt tttcgttcag gagttcaacc ttattgacag acgagagttg
      841 gcaccactgc aagagctgat tgaaaaactc acctcaaagg acagataaaa ggatgcaagc
      901 tgtgcaaact cttcttcaga tggagctgtg tacagtgtcc ttggctttgt tatagttcat
      961 ctttatctac attgtttctg ttttaggttt tggggcttgc ttgggttccc ttttctcttc
     1021 tgaatatata aaatcatatt ctcttgctag aggaagccga gaccgttctc tacatttgaa
     1081 aagggcaaat tttgtcatag tggtatacag tatttttttt tttctatttt atttttatca
     1141 atctggtttt ggttacttga ggaattttta tgatattgat gctggaaaca aatgcgacaa
     1201 atgcgaactg actgaagtgc tgatggactg ggtactttgc tgtgtaaact gtggtccact
     1261 ttgaagtcct taaaaaagac ttatatatat gtttttaagt gccttgatag gctcacttct
     1321 gaggtgcaaa gcacagatat aggactgaac aaagcttgaa acaatattag aatttctatc
     1381 tagggcactt acttgtgcat gttatgaagt tatctgttat aaaagccata gtttactcaa
     1441 attgttgatc tccagctttt actatgttga aaaaaaccca taatttgtaa agttgtgcat
     1501 gtagaacaca aatataaaac aacaaattat ttcttaatta tttttgacat aatttgtaaa
     1561 ggtgtgcatg tagaacataa atgtaaaact acaaaattct taattatttt tgatattgac
     1621 taatataatc tgttcaacag ccgtttaaag ttctacaagc aggtcttttt ccatctctta
     1681 atatctgtga tattgaaatt taaggatgtt gaaatgtaat agatactgca tttcagcttc
     1741 tttctacatg taagtgcact gtaagtgtaa aacttcaggt tatatataga attgccatct
     1801 tcagaaagga tgttgaactg tgaggtttcc tagcaattgc caaatgagcc gtaagtgcag
     1861 aatccctttg tacttcaaag aggaaaggaa aaatgagacc tgtcatggca ggcattagtt
     1921 tgggaaatta gagaggatta gtgtgggagt cagattttag aaagtcctgt tttaaaaccc
     1981 tgggatagat tggtgcccat acttacagtt tgggagactt ccttttagag atcagcttcc
     2041 atgagaagtt aaacataagt aattagtttt aggtacaaac attaaatatg gaattaacta
     2101 tttggggaaa ttgatcactt tttagcattt ccattcagtg aatggagctg gtatttgcct
     2161 gtcattttaa atgatacact accttgatta ttggtgcagt ttgaagcatc ctgactcctt
     2221 atttttccac tgtgagaaat cttttttctt tgtagtgata tcaagtaatg aaaatgttag
     2281 ctcagtagtt aataactttt aaatattagt tgagatgaca tcctgttatc ttcatcaatt
     2341 acaggttcag gaatttggtt tttgaataaa tactgaggtt ctctcacctt cagttttgtt
     2401 cttgagaaat actcttttca ggctctgagt tttaatttta tcagtttgga taaatcccct
     2461 tccctcaatt ttctctctct ttctagttag agacacatac tttcaaactt gtaaactaga
     2521 aatgcttgct gtgaagttgt atacaacacc tagtgaaaaa gaatctaaaa tgaaatgaac
     2581 aagtggacag tgatacagtt ggatgccctt acaatcatga tcactaggaa ctgccttttt
     2641 ctccatttga tttctataat ggcaattact accaagtacc aataataaaa gaaacaagag
     2701 agcttggaaa aggtaggcaa tcctggcatt tattagtaat gcttatttat cagccgacag
     2761 ctagctgatt tctttaaaat actttttttt ttttttttag tatctagata gagactatca
     2821 atcattatgg gttggttcag aattccgatg tttgattcct gtctatacag gaaatgaagc
     2881 acataatcac taactaaaat agtcttccgt agtatatgac tttctgtcac ccctgtaacg
     2941 ggtttttata gcagcagcat gtagagagaa gtaagaggtt gcttctggtc tttaagcctt
     3001 acacatatta actgtcagaa tggaaaccag tcctagaaac tagtgcttga cagcagactt
     3061 accactccgt gtggagagca gtttctgttc actttgccag aatctcaggt gctatgtttt
     3121 caagtcagca ctcgagcttt gggaaatgag gagacgtgtg tgtgtgtgtg t
//
