LOCUS       NM_145571               4382 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus MOB kinase activator 1A (Mob1a), transcript variant 1,
            mRNA.
ACCESSION   NM_145571 NM_178179
VERSION     NM_145571.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4382)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4382)
  AUTHORS   Grego-Bessa,J., Gomez-Apinaniz,P., Prados,B., Gomez,M.J.,
            MacGrogan,D. and de la Pompa,J.L.
  TITLE     Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in
            Ventricular Development
  JOURNAL   Circ Res 133 (11), 927-943 (2023)
   PUBMED   37846569
REFERENCE   3  (bases 1 to 4382)
  AUTHORS   Soyama,H., Nishio,M., Otani,J., Sakuma,T., Takao,S., Hara,S.,
            Masuda,T., Mimori,K., Toyokuni,S., Lydon,J.P., Nakao,K.,
            Nishina,H., Fukumoto,T., Maehama,T. and Suzuki,A.
  TITLE     Hippo-TAZ signaling is the master regulator of the onset of
            triple-negative basal-like breast cancers
  JOURNAL   Proc Natl Acad Sci U S A 119 (29), e2123134119 (2022)
   PUBMED   35858357
REFERENCE   4  (bases 1 to 4382)
  AUTHORS   Ando,T., Arang,N., Wang,Z., Costea,D.E., Feng,X., Goto,Y.,
            Izumi,H., Gilardi,M., Ando,K. and Gutkind,J.S.
  TITLE     EGFR Regulates the Hippo pathway by promoting the tyrosine
            phosphorylation of MOB1
  JOURNAL   Commun Biol 4 (1), 1237 (2021)
   PUBMED   34725466
  REMARK    GeneRIF: EGFR Regulates the Hippo pathway by promoting the tyrosine
            phosphorylation of MOB1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4382)
  AUTHORS   Nishio,M., To,Y., Maehama,T., Aono,Y., Otani,J., Hikasa,H.,
            Kitagawa,A., Mimori,K., Sasaki,T., Nishina,H., Toyokuni,S.,
            Lydon,J.P., Nakao,K., Wah Mak,T., Kiyono,T., Katabuchi,H.,
            Tashiro,H. and Suzuki,A.
  TITLE     Endogenous YAP1 activation drives immediate onset of cervical
            carcinoma in situ in mice
  JOURNAL   Cancer Sci 111 (10), 3576-3587 (2020)
   PUBMED   32716083
REFERENCE   6  (bases 1 to 4382)
  AUTHORS   Otsubo,K., Goto,H., Nishio,M., Kawamura,K., Yanagi,S., Nishie,W.,
            Sasaki,T., Maehama,T., Nishina,H., Mimori,K., Nakano,T.,
            Shimizu,H., Mak,T.W., Nakao,K., Nakanishi,Y. and Suzuki,A.
  TITLE     MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell
            differentiation, adhesion and tumour formation
  JOURNAL   Oncogene 36 (29), 4201-4211 (2017)
   PUBMED   28346423
REFERENCE   7  (bases 1 to 4382)
  AUTHORS   Miyamura,N., Hata,S., Itoh,T., Tanaka,M., Nishio,M., Itoh,M.,
            Ogawa,Y., Terai,S., Sakaida,I., Suzuki,A., Miyajima,A. and
            Nishina,H.
  TITLE     YAP determines the cell fate of injured mouse hepatocytes in vivo
  JOURNAL   Nat Commun 8, 16017 (2017)
   PUBMED   28681838
  REMARK    Erratum:[Nat Commun. 2017 Aug 07;8:16146. doi:
            10.1038/ncomms16146.. PMID: 28782751]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4382)
  AUTHORS   Nishio,M., Sugimachi,K., Goto,H., Wang,J., Morikawa,T., Miyachi,Y.,
            Takano,Y., Hikasa,H., Itoh,T., Suzuki,S.O., Kurihara,H.,
            Aishima,S., Leask,A., Sasaki,T., Nakano,T., Nishina,H.,
            Nishikawa,Y., Sekido,Y., Nakao,K., Shin-Ya,K., Mimori,K. and
            Suzuki,A.
  TITLE     Dysregulated YAP1/TAZ and TGF-beta signaling mediate
            hepatocarcinogenesis in Mob1a/1b-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (1), E71-E80 (2016)
   PUBMED   26699479
REFERENCE   9  (bases 1 to 4382)
  AUTHORS   Nishio,M., Hamada,K., Kawahara,K., Sasaki,M., Noguchi,F., Chiba,S.,
            Mizuno,K., Suzuki,S.O., Dong,Y., Tokuda,M., Morikawa,T., Hikasa,H.,
            Eggenschwiler,J., Yabuta,N., Nojima,H., Nakagawa,K., Hata,Y.,
            Nishina,H., Mimori,K., Mori,M., Sasaki,T., Mak,T.W., Nakano,T.,
            Itami,S. and Suzuki,A.
  TITLE     Cancer susceptibility and embryonic lethality in Mob1a/1b
            double-mutant mice
  JOURNAL   J Clin Invest 122 (12), 4505-4518 (2012)
   PUBMED   23143302
  REMARK    GeneRIF: MOB1A and MOB1B have overlapping functions in skin
            homeostasis, and exert their roles as tumor suppressors by
            regulating downstream elements of the Hippo pathway.
REFERENCE   10 (bases 1 to 4382)
  AUTHORS   Praskova,M., Xia,F. and Avruch,J.
  TITLE     MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell
            proliferation
  JOURNAL   Curr Biol 18 (5), 311-321 (2008)
   PUBMED   18328708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159713.6.
            
            On Mar 17, 2023 this sequence version replaced NM_145571.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009149.1, AK167515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC159713.6         141579-141800
            223-389             AC159713.6         145400-145566
            390-483             AC159713.6         147987-148080
            484-617             AC159713.6         149609-149742
            618-781             AC159713.6         153814-153977
            782-4382            AC159713.6         155709-159309
FEATURES             Location/Qualifiers
     source          1..4382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..4382
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /note="MOB kinase activator 1A"
                     /db_xref="GeneID:232157"
                     /db_xref="MGI:MGI:2442631"
     exon            1..222
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..859
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /note="isoform a is encoded by transcript variant 1; mps
                     one binder kinase activator-like 1B; mob1 homolog 1B;
                     MOB1, Mps One Binder kinase activator-like 1B"
                     /codon_start=1
                     /product="MOB kinase activator 1A isoform a"
                     /protein_id="NP_663546.1"
                     /db_xref="CCDS:CCDS39533.1"
                     /db_xref="GeneID:232157"
                     /db_xref="MGI:MGI:2442631"
                     /translation="MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQA
                     VMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTN
                     IKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYA
                     HIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR"
     exon            223..389
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            390..483
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            484..617
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            618..781
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            782..4382
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /note="hexamer: AATAAA"
     polyA_site      4302
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /note="major polyA site"
     regulatory      4357..4362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
                     /note="hexamer: ATTAAA"
     polyA_site      4382
                     /gene="Mob1a"
                     /gene_synonym="4022402H07Rik; MOB1; MOB4B; Mobk1b;
                     Mobkl1b"
ORIGIN      
        1 gttccgcatt ttggctcgcg gagctgtggg aggcagcgcg gaggagcccg cggtcggtgc
       61 ttggtcgcgg cggctggaac tcggtaccaa acccgggccg tgaagcttcg gcagccctgt
      121 agagccgcgg accgtcctct gcctcccggt gcccgcggcg gcgccgagtc tgacggggcg
      181 ggggccacgg cccctcgggc tagcgaggat gagcttcctc ttcagcagcc gctcttcgaa
      241 aacattcaaa ccaaagaaga atatccctga agggtcccat cagtatgagc tcttgaagca
      301 tgcagaggcg actctcggaa gtggcaatct gaggcaagct gttatgttgc ctgagggaga
      361 ggacctcaat gaatggattg ctgttaatac tgtggatttc ttcaatcaga tcaacatgtt
      421 gtatggaacc attacagaat tctgcactga ggcaagctgc ccagtcatgt cggcaggtcc
      481 caggtatgaa taccactggg cagatggcac taatattaaa aagccaatta agtgttctgc
      541 accaaaatat attgactatt tgatgacttg ggttcaggat cagcttgatg acgaaactct
      601 ttttccttct aagattggtg tcccttttcc caaaaacttt atgtctgtgg caaagactat
      661 tctgaagcgt ctcttcaggg tttatgccca tatctaccac cagcactttg actccgtgat
      721 gcagctgcag gaggaggctc acctcaacac ctcctttaag cactttattt tctttgttca
      781 ggagtttaat ctgattgata ggcgtgagtt ggcaccactt caggaattaa ttgagaagct
      841 tggatctaaa gacagataaa tgtttcttct agaacacagt tatgctctcc ttctatctac
      901 tgctagcact ctctcattgc tgtctggtat ggactaaatg atactgacta caagaaacca
      961 ggatcaaaag atccattgtg tttgcagaga aaattgtccc aaaggtaggt tggccagata
     1021 gcttcagaac aatccaacga caacagctaa atccgaggtg ctgtgtggcc accctgttac
     1081 tgctagtgtc cttctttgtc ttagcccatg actaacctgt agtttgttgc tgagctttgt
     1141 ttaagaaaat gatttttccc atgtgacagc ataatggaca ttaagaattt tcagcagcaa
     1201 cttactagta agtttctaga acaaatgtct taacacagat cagtttgctt tgttttacaa
     1261 atcagtggtg ttctgtttct aaatcccatc gtttagagct tctgttttac tttggttcac
     1321 atttgtatac tgatgtttta tacgcaagag tgtatgtttt tagctaggca tgatggtcca
     1381 tgcctgttac ctgacaactg tggaggcaga ggagagggtc tcacatttga agctggtttg
     1441 agctacattg tgaaactgtt gctaaaaaaa gtttgtttta caaaatccac aaggcataaa
     1501 tcacaggcat atgtggactg agataaccaa agttatttta aatgacttta ttttctaaac
     1561 ttgtttggga ttgtcttcat gtctagatga ggagagtgca tggcttctga cggtgccttg
     1621 caggttctca tttgagactc ctcactcaga ttaatttcat atgtagcttg gggcagagat
     1681 caaaacaact ttcaaagctc tgagacacac ttggacctta aagccactgt gtgcattgct
     1741 gtttccttgc aggtcttgcg gggcagtagg aaaagtattc agactacttg attatttcct
     1801 aaatgattcc atgtttttat tgcaacttga aacttctgtt tctgtataga aatgcacaga
     1861 cttcatggca ataaggacga aggtcaaaaa ccacagaata gcttgtgagg ggtgggggtg
     1921 ttgtgtgtgt gtgacagcag gtctccttgg gcctgtgaga gctggagacc cagcaaagag
     1981 agtgagttga tagtaacttg gcttcattct gcgcacaggc tgcagtgacc tctagagctt
     2041 ctatcctact tgtctttgta tcaaaacttg aatttttcct catcctgtca ggataaaaga
     2101 ctcctctact cgggaagtgc ctgcttttca tgtggtcctc agatctagtc agctctggct
     2161 gcctcctcag atgtacatga catcccaggg attctggaca cttgcccggc aggcagagct
     2221 ggagttatca gcattgtgta tcagagctgg gacttacaca gtgctcattg gcctcctata
     2281 tggctttata aaagttagag ttgatgaggt ttttgttatt tattttgatt ccactagact
     2341 atactggaaa gtattgctta gaaactccag ttttaataac tcattttcag tatgttctta
     2401 agtatactca gaatttcaaa ggaactgttt tgattttact ttgcctgaaa ccacatatca
     2461 ctgttagagg aattcaaatt ggaatactga tttagaaaaa aaaggacagt ttggaaacag
     2521 ctcacaaccc aggagtatgc agaggtccag atatcagctg ttgtgcaagt gtatgaccgt
     2581 catctgcaga caggcttcta gatgacacca aggatgcatc acccctcagc cccagactcc
     2641 atttactttg atttgcttta gtctctgagg aatgaaattc tttctcaacc agggcccagt
     2701 catttttatg aattctgaca ccctcaaatc aaaggtccct cttttctctg catgtgattc
     2761 agggatagaa atgccctctc catgactgag ctccaaatgg agaagtgcta agatacggag
     2821 gaggcagctc actaatggaa tataaagcaa agtcttgttg gtggaaaaga atgtctccac
     2881 tttttgtggt gtccccctcc tctattttcc ttctgtcttt taaaatgaga acagtgctag
     2941 actcccaagc caacctgcct taatcagtgt gcacacattg cactgttgct cacctctgag
     3001 gcaaaaaccc gagaggaggc tgtctttctg tctttggcta gagggtcgat ttgtaacatc
     3061 tgaagaaatc agtctgtcct gggtttatct gcctactctc ctgctccccg cagctggagt
     3121 cagctgtcct gtctgattct gctccctgaa ctgtattgca gtggcttcca attgcctgga
     3181 gaattctgct ttagccctgt ggtgcttgaa cttccaggac tttgaaaaat ttggatattg
     3241 ggggctggag agatggcaca ttgtttaaag aattggctgt tcttccgaag gaattaggtt
     3301 caattcctag cacctgtatg gtggctcata agtgtgtgta actcaattcc agtggataca
     3361 actccctcat acaaacatgc atgcaggaca aacaccaatg cacattaagt taaaaaaaga
     3421 gaagaagaag ccttagacaa tgacagacta taaaatatag tcttgcttcc ttgtggtaca
     3481 ttttttgtgt taacagctac tagactgtta ttctgctgac cgagtaaagt gacttaccag
     3541 cagccagtta gccagctctc catgacttgt agcaaacagg cacagtcctg gtgatgaggt
     3601 ttgtactctt ggcttctctc tgagccccaa gatcatatta gatatagctt ctcagacatg
     3661 atgtcattac ctcaagcgca taaacaaatc aggacttaaa gagtgtagga cctacaagtg
     3721 tgtgtcctgt catggtgcca gggctcctct gctctctggc agccatcccc aggcagtatg
     3781 gagccctgga cagtgccagc ctgggcatga gcagctgagt acctttagca gccatgttct
     3841 ttcctcctga ggtcagtgag agttctgaca aagaaggaca cggtagtctt ttgatcttcc
     3901 tgattttaca ttcagttttg atgcaaggct ttgttgggct ttggagtaca tgtggcagca
     3961 gtaattttac tgaagcaact gcattgaaat tcattgaaat ggttttctcc tcagaatgta
     4021 tcaaataagt attctgtaaa gccattccgg atggccagca tgctatgggc tggttataga
     4081 acagcattct gtgttggtct gcatcaaaaa tagtttgcat aagatagtct tggttaccat
     4141 ctaaaataac ttaaaatatt cctcacataa aaaatttatg ttgtattttt aaaactttta
     4201 gggctttatc tatttttcta agtcgttaac tgtacttttt aaaaaagtat tttgtatcta
     4261 cttttgtaac ttcatcagaa taaactatat tgaaagcaaa aatgcctttg aagtgtgtta
     4321 acatgctttt gtttaaatat ggaaatgaga tttttgatta aatttggaga gttgtctttg
     4381 ca
//
