LOCUS       NM_001142937            3684 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus modulator of apoptosis 1 (Moap1), transcript variant
            2, mRNA.
ACCESSION   NM_001142937
VERSION     NM_001142937.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3684)
  AUTHORS   Chang,H.C., Tao,R.N., Tan,C.T., Wu,Y.J., Bay,B.H. and Yu,V.C.
  TITLE     The BAX-binding protein MOAP1 associates with LC3 and promotes
            closure of the phagophore
  JOURNAL   Autophagy 17 (11), 3725-3739 (2021)
   PUBMED   33783314
REFERENCE   2  (bases 1 to 3684)
  AUTHORS   Tan,C.T., Chang,H.C., Zhou,Q., Yu,C., Fu,N.Y., Sabapathy,K. and
            Yu,V.C.
  TITLE     MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1
            and suppresses Nrf2 signaling
  JOURNAL   EMBO Rep 22 (1), e50854 (2021)
   PUBMED   33393215
  REMARK    GeneRIF: MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases
            Keap1 and suppresses Nrf2 signaling.
REFERENCE   3  (bases 1 to 3684)
  AUTHORS   Zhao,H., Mohamed,N.E., Chan,S.J., Tan,C.T., Tao,R., Yu,V.C. and
            Wong,P.T.
  TITLE     Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of
            Apoptosis 1-Deficient Mice
  JOURNAL   Mol Neurobiol 56 (3), 2185-2201 (2019)
   PUBMED   30003515
  REMARK    GeneRIF: These data suggest that MOAP-1 is required in the
            regulation of stress response in the dorsal raphe nucleus.
            Crosstalk between BDNF and 5-HT appears to play an important role
            in this stress response.
REFERENCE   4  (bases 1 to 3684)
  AUTHORS   Tan,C.T., Zhou,Q.L., Su,Y.C., Fu,N.Y., Chang,H.C., Tao,R.N.,
            Sukumaran,S.K., Baksh,S., Tan,Y.J., Sabapathy,K., Yu,C.D. and
            Yu,V.C.
  TITLE     MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid
            Recruitment to Mitochondria
  JOURNAL   Cell Rep 16 (1), 174-185 (2016)
   PUBMED   27320914
  REMARK    GeneRIF: These findings reveal a role for MOAP-1 in Fas signaling
            in the liver by promoting MTCH2-mediated tBid recruitment to
            mitochondria.
REFERENCE   5  (bases 1 to 3684)
  AUTHORS   Tan,K.O., Fu,N.Y., Sukumaran,S.K., Chan,S.L., Kang,J.H., Poon,K.L.,
            Chen,B.S. and Yu,V.C.
  TITLE     MAP-1 is a mitochondrial effector of Bax
  JOURNAL   Proc Natl Acad Sci U S A 102 (41), 14623-14628 (2005)
   PUBMED   16199525
  REMARK    GeneRIF: MAP-1 is a direct mitochondrial target of Bax.
REFERENCE   6  (bases 1 to 3684)
  AUTHORS   Tan,K.O., Tan,K.M., Chan,S.L., Yee,K.S., Bevort,M., Ang,K.C. and
            Yu,V.C.
  TITLE     MAP-1, a novel proapoptotic protein containing a BH3-like motif
            that associates with Bax through its Bcl-2 homology domains
  JOURNAL   J Biol Chem 276 (4), 2802-2807 (2001)
   PUBMED   11060313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132315.4 and AU080670.1.
            
            On Dec 23, 2011 this sequence version replaced NM_001142937.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.91556.1, AU080670.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC132315.4         102527-102542       c
            17-624              AU080670.1         1-608
            625-3684            AC132315.4         98711-101770        c
FEATURES             Location/Qualifiers
     source          1..3684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.14 cM"
     gene            1..3684
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /note="modulator of apoptosis 1"
                     /db_xref="GeneID:64113"
                     /db_xref="MGI:MGI:1915555"
     exon            1..119
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /inference="alignment:Splign:2.1.0"
     exon            120..3684
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1284
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /codon_start=1
                     /product="modulator of apoptosis 1"
                     /protein_id="NP_001136409.1"
                     /db_xref="CCDS:CCDS26122.1"
                     /db_xref="GeneID:64113"
                     /db_xref="MGI:MGI:1915555"
                     /translation="MTLRLLEDWCRGMDMNPRKALLVAGIPPTCGVADIEEALQAGLA
                     PLGEHRLLGRMFRRDENKNVALIGLTVETGSALVPKEIPAKGGVWRVIFKPPDTDSDF
                     LCRLNEFLKGEGMTMGELTRVLGNRNDPLGLDPGIMIPEIRAPMLAQALNEALKPTLQ
                     YLRYKKLSVFSGRDPPGPGEEEFESWMFHTSQVMKTWQVSDVEKRRRLIESLRGPAFE
                     IIRVLKINNPFITVAECLKTLETIFGIIDNPRALQVKYLTTYQKTDEKLSAYVLRLEP
                     LLQKLVQKGAIEKEVVNQARLDQVIAGAVHKSVRRELGLPEGSPAPGLLQLLTLIKDK
                     EAEEEEVLLQAELEGYCT"
     regulatory      1776..1781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /note="hexamer: AATAAA"
     polyA_site      1784
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /note="major polyA site"
     regulatory      1943..1948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /note="hexamer: ATTAAA"
     polyA_site      1962
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /note="hexamer: AATAAA"
     regulatory      3651..3656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
                     /note="hexamer: AATAAA"
     polyA_site      3661
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
     polyA_site      3680
                     /gene="Moap1"
                     /gene_synonym="Map-1; MmMOAP1; Pnma4"
ORIGIN      
        1 gcttcgcgcc gcctccagag gcggttgtct gttccctgag gcgtttgctg cggtcgttct
       61 tctgccctcg gccgggaggc gggcgcgggg agcccgggtc tctcctaaac cccgcaaagg
      121 ctcccggacc tctgcgtgtt aaagagacga gcacgcacat cactgtaagc ggcggcggcg
      181 gcggcggcgc cctggtcgaa ttagaattta aatactctga gcaccatgac actgagactt
      241 ctagaagact ggtgcagagg gatggatatg aatcctcgga aagcactatt ggttgccggc
      301 atccctccga cctgcggagt ggcagacata gaggaggccc tgcaggctgg ccttgctccc
      361 ttaggggaac acagactgct tgggaggatg ttcaggaggg atgagaacaa gaatgtagcc
      421 ctgattgggc ttacagtaga gactggcagt gccctggtcc ccaaggaaat acctgcaaaa
      481 ggaggtgtct ggagagtgat ctttaagcct cctgatactg atagtgactt tttgtgcaga
      541 ttaaatgagt ttttaaaggg ggagggcatg acgatgggtg aattaaccag agttcttggg
      601 aatcggaatg accctctcgg cctagacccg ggcataatga tccctgaaat tcgagcaccc
      661 atgttagcac aggcattaaa tgaggccctt aagcctaccc tgcagtatct gaggtacaaa
      721 aagctgagtg tgttctcagg cagggatcct ccaggaccag gtgaggaaga atttgaatct
      781 tggatgtttc atacttccca agtaatgaaa acatggcagg tgtcagatgt agagaaaaga
      841 aggcggttga tagagagcct tagaggtcca gcatttgaaa ttattcgagt cctcaagata
      901 aacaacccct tcattacagt tgcagaatgc ctgaagacgc ttgagacaat atttgggatt
      961 attgataatc ctagagcatt gcaggtcaaa taccttacta cttatcagaa gactgatgaa
     1021 aagctgtctg cctatgttct aaggttggag cctttattgc agaaactggt tcagaaagga
     1081 gcaattgaga aagaagttgt gaatcaggcc cgtctagacc aagtcattgc tggggcagtc
     1141 cacaaatcag ttcgaagaga gcttgggctg ccggagggta gcccagcccc aggcttactg
     1201 cagttgctga cactgataaa agataaggag gccgaagaag aagaggtcct ccttcaggcc
     1261 gaattagaag gctattgcac ttgacccaag acccaaggct gtcatgagca gaacaagatg
     1321 gaagagctca ttgcagagat cagcccatcc actctttatg ctgccaaagt aactcgccct
     1381 ttgtcgtgtt gtttactgaa tgtctcccca atgttttact gataaaaatg atgtcattct
     1441 acactgataa ttatttaaat caaaagacca ttctgctagt acagtgtccc agcaagtcaa
     1501 aagtttatat gcatgtttaa tagtcatatg tgatggtgct atcagttatc aatagttttc
     1561 aggtgttgcc cacatttatg ctgaagaccc tgagccaagg ctggttaaga tatttagttt
     1621 cttttattaa aatcagttat cgattctgtg caatcaaaaa gcacaactga atgctgtggt
     1681 cagttctaca actagtttta ggtttgtgac tatctgatat gttgccaaaa cgtctgcttc
     1741 taaatatcat tttcttggag taataaagaa atgataataa aatatttgat ctttgtatac
     1801 attgtaatac tacatttgaa ggaaaataat tttttggctt tgtttttaag acagtttctc
     1861 tgtgcagctt tagctgtgct ggaacccact ctatagaccc agggtagtct caaactcaga
     1921 aatgtgcctc ctgagtgctg gaattaaagg cctgcacaac tacactaggc tgaacaaaag
     1981 tttttatagt gtgaatctga aagccactga aattacagac ttagttcttt gaactcttgg
     2041 cacctagggg ataggaactt gcttgtttga caggaaccag actataaaca gattgtggcg
     2101 agtagtaggc ccatcaatat tgaattttga gggagaaagg gaagatgaag gtttgtgttt
     2161 ttccaaccct ggtgctacac acctataacc ccagtgctta acaagtaaag ccaaagtcag
     2221 gaagactggc ctctcaaggc cagccagaac tacagaggga ggccctacct ccaaagagaa
     2281 aactacatac agggaaacta agatcacctg ggaaatggat gtatgcccaa gacgaagcag
     2341 gcagtaatga gagctgttct ggttcttgca aagctgctgt tctctctact aagggaggga
     2401 actacacaaa gaatcaaggc cagactgtca ccgtgtgtac atgtagtctt gggagtgtga
     2461 tagattactc tgagttagga atacatggaa agtttcctta tgttctccac tgcagaatgg
     2521 catgtggact cttgagagct gtgattctgc tcatgtttgt atagtggctt aagatacatt
     2581 atgcactgtc ctgcaggtca ctcatttgct gcctcggtga gaaactttac attttgtata
     2641 gacacacaag cattaataaa tgccacgcct cttctgtatg tgagacccta agctgagggg
     2701 gtaaactcga caggataatc cctgctttga aggtttattc agactcagta ttaatggctg
     2761 acattggatg tatccttggc cagcgactaa gtactagctg aagaagaagc tgtctcttcc
     2821 cacctcccat tttatgaata agatgaggca cagaaaaata acttgtctgt ggttttacag
     2881 gtagtaatgt ggctagcccc tggctccagg tctttttatt ctgggtagat cataggctca
     2941 gagatcttta ggtgctggtc tttgacgcat atatatatat atatatccca taacatttgg
     3001 cagtggtggc aacagacagg tggagaagag tgccacctag tgttatagct ctaggggcct
     3061 aggatgctag acccttaatt aagcattata gatcttgtgg aagcctctag taaccccacc
     3121 ctttgctcta aaatactaag ttattgggta gacctcatta caagtattat agctgttgta
     3181 tagacttggg aagttattat tccttcgcct tgccagtgtt aaatcgtaca ggtctcgggg
     3241 tgtctgagac ttgtaaaaat cacagaagct ctctgaaacc tccagtgaca agggcctgct
     3301 ggttttcatt tccagctctt tacagccttc tctcctttat ctctgcctct tcggttgtca
     3361 caacagccag ccacacagcc attttccagc tctgcctgcc actccactgt ctgctgttgc
     3421 tgccactctc ctggctttat attgccatct tagcctcaca actaagaagt aagctagaaa
     3481 taggaaagga gggctggaga ggtggctcct cgggtaagag caccgactgc tcttccagag
     3541 gtcctgagtt caaatcccag caaccacatg gtggctcaca accatctgta atgggatctg
     3601 atgctgcctt ctggtgtgac tgaaaacagt tacagtgtac tcataaataa aataaatctt
     3661 tttaaaaaat ggcaaggaaa cact
//
