LOCUS       NM_019944               1456 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus motor neuron and pancreas homeobox 1 (Mnx1), mRNA.
ACCESSION   NM_019944
VERSION     NM_019944.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1456)
  AUTHORS   Hayakawa-Yano,Y., Furukawa,T., Matsuo,T., Ogasawara,T., Nogami,M.,
            Yokoyama,K., Yugami,M., Shinozaki,M., Nakamoto,C., Sakimura,K.,
            Koyama,A., Ogi,K., Onodera,O., Takebayashi,H., Okano,H. and Yano,M.
  TITLE     Qki5 safeguards spinal motor neuron function by defining the motor
            neuron-specific transcriptome via pre-mRNA processing
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2401531121 (2024)
   PUBMED   39226364
REFERENCE   2  (bases 1 to 1456)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1456)
  AUTHORS   Li,M., Xu,J., Zou,Y., Lu,J., Ou,A., Ma,X., Zhang,J., Xu,Y., Fu,L.,
            Liu,J., Wang,X., Zhou,L. and Guo,J.
  TITLE     Motor neuron-specific RhoA knockout delays degeneration and
            promotes regeneration of dendrites in spinal ventral horn after
            brachial plexus injury
  JOURNAL   Neural Regen Res 18 (12), 2757-2761 (2023)
   PUBMED   37449641
REFERENCE   4  (bases 1 to 1456)
  AUTHORS   Thomasen,P.B., Salasova,A., Kjaer-Sorensen,K., Woloszczukova,L.,
            Lavicky,J., Login,H., Tranberg-Jensen,J., Almeida,S., Beel,S.,
            Kavkova,M., Qvist,P., Kjolby,M., Ovesen,P.L., Nolte,S.,
            Vestergaard,B., Udrea,A.C., Nejsum,L.N., Chao,M.V., Van Damme,P.,
            Krivanek,J., Dasen,J., Oxvig,C. and Nykjaer,A.
  TITLE     SorCS2 binds progranulin to regulate motor neuron development
  JOURNAL   Cell Rep 42 (11), 113333 (2023)
   PUBMED   37897724
REFERENCE   5  (bases 1 to 1456)
  AUTHORS   Lee,Y., Yeo,I.S., Kim,N., Lee,D.K., Kim,K.T., Yoon,J., Yi,J.,
            Hong,Y.B., Choi,B.O., Kosodo,Y., Kim,D., Park,J. and Song,M.R.
  TITLE     Transcriptional control of motor pool formation and motor circuit
            connectivity by the LIM-HD protein Isl2
  JOURNAL   Elife 12, e84596 (2023)
   PUBMED   37869988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1456)
  AUTHORS   Benini,J., Ehlers,E.M. and Ehlers,S.
  TITLE     Different types of pulmonary granuloma necrosis in immunocompetent
            vs. TNFRp55-gene-deficient mice aerogenically infected with highly
            virulent Mycobacterium avium
  JOURNAL   J Pathol 189 (1), 127-137 (1999)
   PUBMED   10451499
REFERENCE   7  (bases 1 to 1456)
  AUTHORS   Briscoe,J., Sussel,L., Serup,P., Hartigan-O'Connor,D.,
            Jessell,T.M., Rubenstein,J.L. and Ericson,J.
  TITLE     Homeobox gene Nkx2.2 and specification of neuronal identity by
            graded Sonic hedgehog signalling
  JOURNAL   Nature 398 (6728), 622-627 (1999)
   PUBMED   10217145
REFERENCE   8  (bases 1 to 1456)
  AUTHORS   Sharma,K., Sheng,H.Z., Lettieri,K., Li,H., Karavanov,A., Potter,S.,
            Westphal,H. and Pfaff,S.L.
  TITLE     LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for
            motor neurons
  JOURNAL   Cell 95 (6), 817-828 (1998)
   PUBMED   9865699
REFERENCE   9  (bases 1 to 1456)
  AUTHORS   Kenny,D.A., Jurata,L.W., Saga,Y. and Gill,G.N.
  TITLE     Identification and characterization of LMO4, an LMO gene with a
            novel pattern of expression during embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 95 (19), 11257-11262 (1998)
   PUBMED   9736723
REFERENCE   10 (bases 1 to 1456)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE648171.1 and BC132283.1.
            
            On Apr 11, 2009 this sequence version replaced NM_019944.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BE648171.1         50-136
            88-1456             BC132283.1         1-1369
FEATURES             Location/Qualifiers
     source          1..1456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.04 cM"
     gene            1..1456
                     /gene="Mnx1"
                     /gene_synonym="HB9; Hlxb9; MNR2"
                     /note="motor neuron and pancreas homeobox 1"
                     /db_xref="GeneID:15285"
                     /db_xref="MGI:MGI:109160"
     exon            1..886
                     /gene="Mnx1"
                     /gene_synonym="HB9; Hlxb9; MNR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1410
                     /gene="Mnx1"
                     /gene_synonym="HB9; Hlxb9; MNR2"
                     /note="homeobox protein HB9; homeobox gene HB9"
                     /codon_start=1
                     /product="motor neuron and pancreas homeobox protein 1"
                     /protein_id="NP_064328.2"
                     /db_xref="CCDS:CCDS19150.1"
                     /db_xref="GeneID:15285"
                     /db_xref="MGI:MGI:109160"
                     /translation="MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLATTVSGPGRG
                     GSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLAAHCALLPKPGFLGAGG
                     GGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYG
                     HPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGASTFQLDQWLRAST
                     AGMILPKMPDFSSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVAT
                     SLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGTGKGGSEEKTEEELM
                     GPPVSGDKASGRRLRDLRDSDPDEDEDDEEEDNFPYSNGAGAHAASSDCSSEDDSPPP
                     RLGGPGHQPLPQ"
     exon            887..1047
                     /gene="Mnx1"
                     /gene_synonym="HB9; Hlxb9; MNR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1456
                     /gene="Mnx1"
                     /gene_synonym="HB9; Hlxb9; MNR2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacgaggac cgcaaagagg aggcgcctgg acgatggtcg ctctcagctg agtttccggc
       61 tgcgacttta ttggcaaaaa atcgcagtaa caataccggc cccaaggctg gccaccgcca
      121 cgctcagtct ccgtaagccc gcacacgact gcatcgccca cccttggacc ctgattgtca
      181 gctccaatcg agccgatgga aaaatccaaa aatttccgca tcgacgccct gctggccgtg
      241 gatcccccgc gagccgcctc cacgcagagc gcgcctctgg ccttggtcac ttccctcgcg
      301 actacagtat ctggtcccgg ccgcggcggc agcggcggcg gggggaccag tagcggggcg
      361 agccgtagct gcagtcccgc atcctcggag gccactgcag cgcccggtga ccggctgaga
      421 gctgagagcc cgtcgccccc acgcttgctg gctgcacact gcgcgctgct gcccaagccc
      481 ggattcctgg gcgccggagg aggcggcggc gcggcgggtg ggccgggcac tccccaccac
      541 cacgcgcacc ctggtgcagc agccgccgcg gctgccgctg ccgctgccgc ggctgccggt
      601 ggcctggcac tggggctgca cccggggggc gcacagggcg gcgcgggcct ccctgcacag
      661 gcggctctct atggacaccc ggtctacagt tattcggcag cagctgcagc ggccgcgcta
      721 gctggccagc acccggcgct ttcctactca taccctcagg tgcagggcgc gcaccctgcg
      781 caccctgccg accccatcaa gctgggtgcc agcaccttcc aactggacca gtggctgcgc
      841 gcgtctactg cgggcatgat cctgcccaag atgccggact tcagctccca ggcgcagtcg
      901 aacctcttgg ggaagtgccg aaggcctcgc acggccttca ccagccagca gctgttggag
      961 ctggaacacc agttcaagct caacaagtac ctgtctcgac ccaagcgttt tgaggtggct
     1021 acctcgctca tgctcaccga gactcaggtg aagatttggt tccagaaccg ccgaatgaaa
     1081 tggaaacgca gcaaaaaggc caaagagcag gctgcgcagg aggcggagaa gcagaagggc
     1141 ggcggcgggg gcaccggcaa aggcggcagt gaggagaaga cggaagagga gctgatgggg
     1201 cctccggttt cgggggacaa ggcaagcggc cgtcgcctgc gggacttgcg ggacagtgac
     1261 cctgatgagg acgaggatga tgaagaagag gacaacttcc cgtacagcaa tggtgccggt
     1321 gcccatgctg cctcatccga ctgctcatct gaggacgact cgcctcctcc aagactaggc
     1381 gggcctggac accaacctct gccccagtag ttgcctccag ggcggaagca gggatgcgaa
     1441 agatggctac ctgggg
//
