LOCUS       NM_010813               4601 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus max binding protein (Mnt), mRNA.
ACCESSION   NM_010813
VERSION     NM_010813.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4601)
  AUTHORS   Nguyen,H.V., Vandenberg,C.J., Robati,M.R., Ng,A.P. and Cory,S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   2  (bases 1 to 4601)
  AUTHORS   Nguyen,H.V., Vandenberg,C.J., Ng,A.P., Robati,M.R., Anstee,N.S.,
            Rimes,J., Hawkins,E.D. and Cory,S.
  TITLE     Development and survival of MYC-driven lymphomas require the MYC
            antagonist MNT to curb MYC-induced apoptosis
  JOURNAL   Blood 135 (13), 1019-1031 (2020)
   PUBMED   31978211
REFERENCE   3  (bases 1 to 4601)
  AUTHORS   Campbell,K.J., Vandenberg,C.J., Anstee,N.S., Hurlin,P.J. and
            Cory,S.
  TITLE     Mnt modulates Myc-driven lymphomagenesis
  JOURNAL   Cell Death Differ 24 (12), 2117-2126 (2017)
   PUBMED   28800127
  REMARK    GeneRIF: Although mnt heterozygosity clearly slowed lymphomagenesis
            in vavP-MYC10 and Emu-myc mice, the change(s) in cellular
            properties responsible for this effect remain to be identified.
REFERENCE   4  (bases 1 to 4601)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 4601)
  AUTHORS   Link,J.M., Ota,S., Zhou,Z.Q., Daniel,C.J., Sears,R.C. and
            Hurlin,P.J.
  TITLE     A critical role for Mnt in Myc-driven T-cell proliferation and
            oncogenesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19685-19690 (2012)
   PUBMED   23150551
  REMARK    GeneRIF: results redefine the physiological relationship between
            Mnt and Myc and requirements for Myc-driven oncogenesis
REFERENCE   6  (bases 1 to 4601)
  AUTHORS   Yingling,J., Toyo-Oka,K. and Wynshaw-Boris,A.
  TITLE     Miller-Dieker syndrome: analysis of a human contiguous gene
            syndrome in the mouse
  JOURNAL   Am J Hum Genet 73 (3), 475-488 (2003)
   PUBMED   12905154
  REMARK    Review article
REFERENCE   7  (bases 1 to 4601)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4601)
  AUTHORS   Hirotsune,S., Pack,S.D., Chong,S.S., Robbins,C.M., Pavan,W.J.,
            Ledbetter,D.H. and Wynshaw-Boris,A.
  TITLE     Genomic organization of the murine Miller-Dieker/lissencephaly
            region: conservation of linkage with the human region
  JOURNAL   Genome Res 7 (6), 625-634 (1997)
   PUBMED   9199935
REFERENCE   9  (bases 1 to 4601)
  AUTHORS   Meroni,G., Reymond,A., Alcalay,M., Borsani,G., Tanigami,A.,
            Tonlorenzi,R., Lo Nigro,C., Messali,S., Zollo,M., Ledbetter,D.H.,
            Brent,R., Ballabio,A. and Carrozzo,R.
  TITLE     Rox, a novel bHLHZip protein expressed in quiescent cells that
            heterodimerizes with Max, binds a non-canonical E box and acts as a
            transcriptional repressor
  JOURNAL   EMBO J 16 (10), 2892-2906 (1997)
   PUBMED   9184233
  REMARK    Erratum:[EMBO J 1997 Oct 1;16(19):6055]
REFERENCE   10 (bases 1 to 4601)
  AUTHORS   Hurlin,P.J., Queva,C. and Eisenman,R.N.
  TITLE     Mnt, a novel Max-interacting protein is coexpressed with Myc in
            proliferating cells and mediates repression at Myc binding sites
  JOURNAL   Genes Dev 11 (1), 44-58 (1997)
   PUBMED   9000049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA327080.1, BC054534.1 and AW491765.1.
            
            On Dec 11, 2007 this sequence version replaced NM_010813.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77356.1, AK147933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                CA327080.1         5-78
            75-4572             BC054534.1         1-4498
            4573-4601           AW491765.1         1-29                c
FEATURES             Location/Qualifiers
     source          1..4601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.76 cM"
     gene            1..4601
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /note="max binding protein"
                     /db_xref="GeneID:17428"
                     /db_xref="MGI:MGI:109150"
     exon            1..478
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..2181
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /note="myc antagonist MNT"
                     /codon_start=1
                     /product="max-binding protein MNT"
                     /protein_id="NP_034943.3"
                     /db_xref="CCDS:CCDS25037.1"
                     /db_xref="GeneID:17428"
                     /db_xref="MGI:MGI:109150"
                     /translation="MSIETLLEAARFLEWQAQQQQRAREEQERLRLEREREREQEQKR
                     ASNLARLAHALPVEEPRIEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQS
                     LPPPPPLPPAAQPLPLAPRQPALVSTPGLSIKEPVTLPTRPQVPTPAPLLPDAKTTVA
                     PTGSPKPLQPLPAPILTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEAKSSEQKKRP
                     GGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRK
                     EKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTA
                     SEGEDNVDEEMEGDRAGLGPPKLNHRPQPELLKSALPTPSTAPAPLPTHPHPHPHPVA
                     LSPAHLPVQQQQPPQQKTPLPAPPPPPATPTQTLVPAPAHLVATAGGGSTVIAHTATT
                     HASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLG
                     SQLPLYPQPVAVSQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQL
                     VGQTVLNPVTMVTMPSFPVSTLKLA"
     exon            479..1064
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1106
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1218
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1411
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..4586
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4532..4537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /note="hexamer: AATAAA"
     regulatory      4550..4555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /note="hexamer: AATAAA"
     polyA_site      4551
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /note="major polyA site"
     polyA_site      4586
                     /gene="Mnt"
                     /gene_synonym="bHLHd3; Rox"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcc gggggcagcg cggctccttc ccttgttgtg tgtgtcggtg cctcctcgcc
       61 atcttgttgc aaagcccttt cttgtcggcg ggactccggg ggccgcgggg cgggaggcat
      121 cggaagggag gaagaggaag aaggaaggaa gaaggcagtg ccgccttttt tattttttgc
      181 atcaaaattt ttttaatttg caaattttta ttttgcaaat attttgggag acattgattt
      241 ttctccccgt gctcccccgt tcttttctga ggagtgcgct gcgccgccca gccctgtcgc
      301 cccccggagg tgatccctcc ctcctgccgg cccgccagcc tgacctgtgc ttggctcgcg
      361 ggccgcagcc tcggccccgg cgcgcccccg gctgctctcg ccgcgatgag catagagacg
      421 ctactggagg cggcccgctt cctggaatgg caagcgcagc aacaacagag agcacgtgag
      481 gagcaggagc gccttcgcct ggagcgggaa cgtgagagag agcaggagca gaagagggca
      541 agtaacttgg ccaggttggc ccatgccctg cctgtggagg aaccccgaat cgaggctcca
      601 ccactgcctt tgtctccacc ggcaccacca cccgcaccac caccaccact tgccacccct
      661 gctccactga ctgtcattcc tattcctgta gtgaccaatt ccccgcagtc tctaccccca
      721 cctccacctc taccccccgc agcccagcct cttcccctgg cacctcgtca gccagccctg
      781 gtcagcaccc ctggactcag cattaaggag ccagtcaccc tgcccaccag accacaggtg
      841 cccacccctg ctcccctcct gcctgatgcg aagaccacag ttgcgcccac tggcagcccc
      901 aagcctttgc agcccctccc tgcgcccatc ctgaccattg caccacaccc tggagtccag
      961 ccgcagctgg ctccccagca accacccccg cccacgcttg ggaccctgaa gttggcaccg
     1021 gctgaagaag ccaaatccag tgaacagaag aaaaggcctg gagggatcgg aaccagagaa
     1081 gtccacaaca aattggagaa gaacaggagg gcccatctga aggaatgttt tgagaccctg
     1141 aagcgcaaca tccccaacgt ggacgacaag aagacttcga atctgagcgt gctgcggacg
     1201 gcgctgcggt acatccagtc cctgaagagg aaggagaaag agtatgagca tgagatggag
     1261 cgccttgcgc gggagaagat cgccacccag cagcggctgg cagagctcaa gcatgagctg
     1321 agtcagtgga tggacgtgct ggagatagat cgtgtgctcc ggcagacagg ccagcctgag
     1381 gacgaccagg cgtccacctc cacagcctcc gagggcgagg acaacgttga cgaggagatg
     1441 gagggagacc gggcaggcct gggcccacct aagctgaacc atcgtcccca gccggagctg
     1501 ctgaaatccg ccctgccaac ccccagcacc gcccctgcgc ctctgcctac ccatccgcac
     1561 cctcaccccc acccagtggc cctgtctcct gcccaccttc ctgtgcagca gcagcagcca
     1621 ccacagcaaa agacccctct gccagcccct cctcccccac ctgccacccc aacccagacg
     1681 ctagtgccag ctccggccca tctggtggcc acggctgggg gcggctccac ggtcattgcc
     1741 cacacagcca cgacccatgc ctcagtcatc cagactgtga accatgttct gcaggggccg
     1801 gggggcaagc atatcgccca catcgccccc tccgccccca gccctgctgt gcagctggca
     1861 cccgccacac cccccatcgg ccacatcaca gtgcaccctg ccaccctcaa ccatgtggcc
     1921 caccttggct cccagttgcc cttgtaccca cagcctgtgg ccgtgagcca gccagtggcc
     1981 gtgagccaca tcgcccacac cctgtcgcac cagcaagtaa atggcacagc cgggctgggg
     2041 cccccagcca ctgtcatggc aaagccagct gtgggggccc aggtggtgca ccacccccag
     2101 ctggtgggcc aaacagtgct caaccctgtg actatggtca ccatgccctc ctttccggtc
     2161 agcacactca agctggcttg agaatgaggc cacttaggcc cccagtgggg gcagggaagg
     2221 ggacctgact gcccctaatc ccacccacca gctccacaca ttccagccag gcccaggccc
     2281 gccccaccca caccaccccc aggcctcctt aggggaaggg ggtgcagaga ctctgagcca
     2341 ggggaaggga ggggccccca gggagttggc tgcaggcagg aagtcctgct gcaggaggac
     2401 ttggcagaca ggaggatgct tttggtggac attcttgcct acccagcctg gtgccagttc
     2461 tggtgccgct ccatctccct gttttgtccc ctggaagtct gcactgtggc ttacgttctc
     2521 tgccttcccc ttccctggcc tgccttcctg tgctgttgct gctattgctc tgtctgggga
     2581 ggtggctgag ctctccggct tcccctcccc agcctcagag tcctgtggga cctctggata
     2641 ggaaacaggg agccccagaa agatgggaga tgggtgggga ggggcccacc tctgagtgca
     2701 ggtgacagat cctaagatct ggagtcaggt taggacaagt gaaggcctgg gcctgggcca
     2761 ctctgaccca cctgtggtca ctgtgattgg ctacagtaga aactgttcag aatgagtccc
     2821 aaccaacaat aaacgaggtc ctggctgttg tcaaggttcc cgagcctgcc cctggggtgg
     2881 ggcttcccta gtgcttcccc cggccctggt ttaggtactg cctgcagctt gggaggtgtg
     2941 gaccagcaag ggctctagga gctaaggtac actgtggagg tatcccgggg ctcttcccat
     3001 tctccctccc tctcggtgcc agtgttgaga cccctccctt cctggtgggg ctgcagtgtc
     3061 tatggtggaa agggcctttg ctggggaaga caaggcacag catgtgtttg atggagagcg
     3121 ggggtgctgt gcttcggggg tgctgtgtct cctgcctctg cttctgcaga ccgctttggc
     3181 ttctcttttt aagtggatat ttattacaag tggccttgtg tcagacactc agttactcgc
     3241 gtgcgcattc aggccctcac tggacactca ccaatggcct ttccgtgtgg ggcaggaagc
     3301 aagtgcccct aaggtgcgaa gtttgcactg ggggcttagg cagtccaggg gccagagggg
     3361 aggactcagg gtccttcaga tgacattgtg agcagacact gaggccagcg aaggtcctga
     3421 atacattctc ccttgaaata atgactcctc aggtgcctca gagctcacag gtcctcctgg
     3481 ccctggaaac ctcccagggc actttattat tattatttgt ctcctggggt agggaatggt
     3541 agctaggacc aggtctcaac cccagcacag gaatcccaac aaactggctg ccttcctgtg
     3601 gctgctgcca gccacctcta cccacattct gactctgggg gccacctcca ctctctgctc
     3661 tgtgttgtga caaggggcag agtctggtgc tggctgggtc agaccacttg tcccattaac
     3721 ccttctctgt gtctcgaggc cagttgcaga gttgacagca tcgtgttggc ccccaggcct
     3781 gcacagatac ctcatcatcc acccagccct ccccccatcc ccccggcagg ggttcctcca
     3841 gatctagtgc cgaatgacta tgtccagatt ggtggtgatg ggtgttgtcg ctgtttttgt
     3901 tgtttgtgac tgctgtgtgc ccaagtgggc agccacctcc cagccctttc ttgggcatct
     3961 cccctttgag agctgttagg accacatctg tcctcacgct gtgggaccgc ctggcccttc
     4021 ccttcctatc ccttccagcc tgggacacac acacacatac acacacctta cctctcatgc
     4081 gtgttttacc tgtgctgttt ggagtggctc actgcctggg atctttacct cggggaggaa
     4141 aaggggagag tggttccctt ggggccaaag aagggcaggg gatacctgga ggggagttgg
     4201 gtcaccacag tctctctcta ggaacagctg cttctccccc caccccaatc ccagggtccc
     4261 actcccaatc cccaaagagg tggcccttgt ttacagtgag gacttggtca ctgtgtctct
     4321 gtttcctgaa atatgaattg tagcgacccc agactgtaga gatttttatg tgtttgggta
     4381 catctgctgt gtgggaaaaa aaaaaaacta caaaaaccct aattttgtac atattgtatt
     4441 tttactattg aactgtactc tagtggctgt tcatgctctg agtttaggta ttgagacatg
     4501 aatactatcc atgtaataag cacttgcctg gaataaaata taaaactgaa ataaatctgc
     4561 actgaaacct gagacggagc tcccaaaaaa aaaaaaaaaa a
//
