LOCUS       NM_008613               1774 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus meiosis-specific nuclear structural protein 1 (Mns1),
            transcript variant 1, mRNA.
ACCESSION   NM_008613
VERSION     NM_008613.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Lu,H., Twan,W.K., Ikawa,Y., Khare,V., Mukherjee,I., Schou,K.B.,
            Chua,K.X., Aqasha,A., Chakrabarti,S., Hamada,H. and Roy,S.
  TITLE     Localisation and function of key axonemal microtubule inner
            proteins and dynein docking complex members reveal extensive
            diversity among vertebrate motile cilia
  JOURNAL   Development 151 (14) (2024)
   PUBMED   39007638
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Cao,H., Xu,H., Zhou,Y., Xu,W., Lu,Q., Jiang,L., Rong,Y., Zhang,Q.
            and Yu,C.
  TITLE     BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice
  JOURNAL   Cell Mol Life Sci 80 (6), 152 (2023)
   PUBMED   37198331
  REMARK    GeneRIF: BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Boschen,K.E., Gong,H., Murdaugh,L.B. and Parnell,S.E.
  TITLE     Knockdown of Mns1 Increases Susceptibility to Craniofacial Defects
            Following Gastrulation-Stage Alcohol Exposure in Mice
  JOURNAL   Alcohol Clin Exp Res 42 (11), 2136-2143 (2018)
   PUBMED   30129265
  REMARK    GeneRIF: Prenatal alcohol exposure Mns1(-/-) fetuses with severe
            eye defects also presented with craniofacial dysmorphologies
            characteristic of fetal alcohol syndrome and midline tissue loss in
            the brain, palate, and nasal septum
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Vadnais,M.L., Lin,A.M. and Gerton,G.L.
  TITLE     Mitochondrial fusion protein MFN2 interacts with the
            mitostatin-related protein MNS1 required for mouse sperm flagellar
            structure and function
  JOURNAL   Cilia 3, 5 (2014)
   PUBMED   24876927
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Zhou,J., Yang,F., Leu,N.A. and Wang,P.J.
  TITLE     MNS1 is essential for spermiogenesis and motile ciliary functions
            in mice
  JOURNAL   PLoS Genet 8 (3), e1002516 (2012)
   PUBMED   22396656
  REMARK    GeneRIF: These results demonstrate that MNS1 is essential for
            spermiogenesis, the assembly of sperm flagella, and motile ciliary
            functions.
            GeneRIF: MNS1 is an integral component of sperm flagella. Mice
            lacking MNS1 exhibit male sterility as evidenced by abnormal
            assembly of flagella. MNS1-deficient mice also display defects in
            left-right asymmetry patterning of internal organs and
            hydrocephalus.
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Schwab,K., Patterson,L.T., Aronow,B.J., Luckas,R., Liang,H.C. and
            Potter,S.S.
  TITLE     A catalogue of gene expression in the developing kidney
  JOURNAL   Kidney Int 64 (5), 1588-1604 (2003)
   PUBMED   14531791
REFERENCE   10 (bases 1 to 1774)
  AUTHORS   Furukawa,K., Inagaki,H., Naruge,T., Tabata,S., Tomida,T.,
            Yamaguchi,A., Yoshikuni,M., Nagahama,Y. and Hotta,Y.
  TITLE     cDNA cloning and functional characterization of a meiosis-specific
            protein (MNS1) with apparent nuclear association
  JOURNAL   Chromosome Res 2 (2), 99-113 (1994)
   PUBMED   8032679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT954326.5 and AC111135.10.
            
            On Aug 8, 2022 this sequence version replaced NM_008613.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046624.1, AK132772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               CT954326.5         136596-136713
            119-340             CT954326.5         137274-137495
            341-468             AC111135.10        110748-110875
            469-571             AC111135.10        112112-112214
            572-801             AC111135.10        114434-114663
            802-1018            AC111135.10        115056-115272
            1019-1126           AC111135.10        115357-115464
            1127-1384           AC111135.10        118486-118743
            1385-1510           AC111135.10        122683-122808
            1511-1774           AC111135.10        124218-124481
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     gene            1..1774
                     /gene="Mns1"
                     /note="meiosis-specific nuclear structural protein 1"
                     /db_xref="GeneID:17427"
                     /db_xref="MGI:MGI:107933"
     exon            1..118
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1591
                     /gene="Mns1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="meiosis-specific nuclear structural protein 1
                     isoform 1"
                     /protein_id="NP_032639.1"
                     /db_xref="CCDS:CCDS40684.1"
                     /db_xref="GeneID:17427"
                     /db_xref="MGI:MGI:107933"
                     /translation="MATKKRALSFSEKHQKLVDEKFRKSLNIQVMNKLERQAKNQVVQ
                     NENDEKVERQRFLRVLQNEQFELDMEEAIQKAEANKMLRDRQLEQEERLANELARLKH
                     ESLKDKKMRQQVRENSIELRELEQKLKAAYMNKERAAQIVEKDAMKYEQMKRDAEIER
                     IMMEEHDRLLKEESAKQERRNKERAQYYLDLEKQLEDQERRKQEAYEQLLKEKLMIDE
                     IVRKIYEEDQVERQQKLEKKNAIQKYIEEFQRAQDFWRQKKREEMEEENRKIIEFANI
                     QEQREGERMARVHEIEEKRVQRQNLLMKQLEETLRQRDDLEQVRQELYQEEQAEIIKL
                     KVKEEAELRLRRQREMKQDFEDQMALKELILQAAKEEEETFKKAMLAKFAEDDRIELM
                     NAQKQRMKQLEHKRAVEKLIEERRSQFLADKQRELEELQLQQRRQGCINEIIEEERLR
                     LLKEHAAKLLGYLPKGVFKREDDVDMLGEEFRKAYQKRDGV"
     exon            119..340
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..468
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..571
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..801
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1018
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1126
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1384
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1510
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1774
                     /gene="Mns1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mns1"
                     /note="hexamer: ATTAAA"
     polyA_site      1774
                     /gene="Mns1"
                     /note="major polyA site"
ORIGIN      
        1 aaacttaacc cagcgtgcac aggtatccgc tgccgtggct gctgctccgg aagacgcgtt
       61 tgcaactgag gcagagaccc atcctgccgg aggaggaggt ttaaagccaa ccgagatggc
      121 gaccaaaaag agagctttga gctttagtga aaagcatcag aagttagtag atgaaaaatt
      181 ccgcaaatca ttgaacatac aagtcatgaa taagttagag aggcaagcca agaaccaagt
      241 ggtgcaaaat gaaaacgacg agaaggtgga acgccagagg ttcctcagag tgctgcagaa
      301 tgagcagttt gagctcgaca tggaagaagc catccaaaaa gcagaagcaa acaagatgct
      361 gagggatcga cagcttgagc aggaagagag acttgcaaac gaactggcca gactgaagca
      421 cgagagtctg aaggataaga agatgaggca gcaagtgaga gagaacagca ttgagctcag
      481 agagttggag cagaaactga aagccgccta catgaacaaa gagagagcag cccagatcgt
      541 ggagaaggac gccatgaagt atgagcagat gaaacgtgat gcggagatag aaaggatcat
      601 gatggaggag cacgataggc tgctgaagga agagagcgcc aagcaagagc ggcggaacaa
      661 ggagagggca cagtactacc tggacctgga gaagcagctg gaagatcaag agaggaggaa
      721 gcaggaggca tacgagcagc tgctgaagga gaaactcatg atagacgaaa ttgtcaggaa
      781 gatctacgag gaagaccagg tggaaagaca gcaaaaatta gaaaaaaaga atgcaattca
      841 gaagtatatt gaagaattcc agagggcaca agacttctgg agacaaaaga agcgtgagga
      901 gatggaggaa gagaaccgga aaatcataga gtttgcaaac atacaggagc aaagagaagg
      961 cgagcggatg gccagagttc acgagatcga ggaaaagagg gtccagcgtc agaatttgct
     1021 gatgaagcag ctggaggaaa cactgcggca gcgggatgac ctggagcaag tgcggcagga
     1081 gctgtaccag gaggagcagg cagagatcat caaactgaaa gtgaaagaag aagcagagct
     1141 gagactgagg aggcagaggg agatgaagca agactttgaa gaccaaatgg cactgaagga
     1201 actcatactg caggctgcaa aagaggagga agagaccttt aagaaagcca tgctggccaa
     1261 gtttgccgaa gatgaccgca ttgagctcat gaatgcccag aaacagcgaa tgaagcagct
     1321 ggagcacaaa cgcgccgtgg agaaactcat tgaagaacgc cggagccagt tcctcgcaga
     1381 caaacaacgt gagctggagg aattgcaact acagcaaagg cggcagggct gcatcaatga
     1441 gattattgaa gaagagaggc tgagactcct caaagaacat gctgcaaagt tactaggcta
     1501 tctccccaaa ggagtgttta aaagagaaga cgatgttgac atgcttggtg aagagttcag
     1561 gaaggcctat cagaaaaggg atggagtctg aagccgagtc ttcatagcaa ggccgggcga
     1621 gacctggagt gctcagatgc tgccactaga tgtcagcgta actgctgttt tacagttggt
     1681 gacagtaggc cctggtctat ctgcatgttc taaaacatcc tcctatttca tcatgtatac
     1741 agtttgacaa aaattaaaca cattagtact ttaa
//
