LOCUS       NM_029797                866 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus meiotic nuclear divisions 1 (Mnd1), transcript variant
            1, mRNA.
ACCESSION   NM_029797
VERSION     NM_029797.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 866)
  AUTHORS   Tran,T.N., Martinez,J. and Schimenti,J.C.
  TITLE     A predicted deleterious allele of the essential meiosis gene MND1,
            present in ~ 3% of East Asians, does not disrupt reproduction in
            mice
  JOURNAL   Mol Hum Reprod 25 (10), 668-673 (2019)
   PUBMED   31393579
  REMARK    GeneRIF: Assuming the mouse model accurately reflects the impact of
            this variant in humans, rs140107488 appears to be a benign allele
            that can be eliminated or de-prioritized in clinical genomic
            analyses of infertility patients.
REFERENCE   2  (bases 1 to 866)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   3  (bases 1 to 866)
  AUTHORS   Zhao,W. and Sung,P.
  TITLE     Significance of ligand interactions involving Hop2-Mnd1 and the
            RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian
            dysgenesis
  JOURNAL   Nucleic Acids Res 43 (8), 4055-4066 (2015)
   PUBMED   25820426
REFERENCE   4  (bases 1 to 866)
  AUTHORS   Bugreev,D.V., Huang,F., Mazina,O.M., Pezza,R.J., Voloshin,O.N.,
            Camerini-Otero,R.D. and Mazin,A.V.
  TITLE     HOP2-MND1 modulates RAD51 binding to nucleotides and DNA
  JOURNAL   Nat Commun 5, 4198 (2014)
   PUBMED   24943459
  REMARK    GeneRIF: HOP2-MND1 enhances the interaction of RAD51 with
            nucleotide cofactors and modifies its DNA-binding specificity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 866)
  AUTHORS   Pezza,R.J., Voloshin,O.N., Volodin,A.A., Boateng,K.A.,
            Bellani,M.A., Mazin,A.V. and Camerini-Otero,R.D.
  TITLE     The dual role of HOP2 in mammalian meiotic homologous recombination
  JOURNAL   Nucleic Acids Res 42 (4), 2346-2357 (2014)
   PUBMED   24304900
REFERENCE   6  (bases 1 to 866)
  AUTHORS   Pezza,R.J., Petukhova,G.V., Ghirlando,R. and Camerini-Otero,R.D.
  TITLE     Molecular activities of meiosis-specific proteins Hop2, Mnd1, and
            the Hop2-Mnd1 complex
  JOURNAL   J Biol Chem 281 (27), 18426-18434 (2006)
   PUBMED   16675459
REFERENCE   7  (bases 1 to 866)
  AUTHORS   Petukhova,G.V., Pezza,R.J., Vanevski,F., Ploquin,M., Masson,J.Y.
            and Camerini-Otero,R.D.
  TITLE     The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in
            meiotic recombination
  JOURNAL   Nat Struct Mol Biol 12 (5), 449-453 (2005)
   PUBMED   15834424
  REMARK    GeneRIF: data reveal an interplay among Hop2, Mnd1 and Rad51 and
            Dmc1 in the formation of the first recombination intermediates
            during meiosis [Mnd1]
REFERENCE   8  (bases 1 to 866)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 866)
  AUTHORS   Tsubouchi,H. and Roeder,G.S.
  TITLE     The Mnd1 protein forms a complex with hop2 to promote homologous
            chromosome pairing and meiotic double-strand break repair
  JOURNAL   Mol Cell Biol 22 (9), 3078-3088 (2002)
   PUBMED   11940665
  REMARK    GeneRIF: Characterization of the MND1 gene in Saccharomyces
            cerevisiae and identification of a potential homolog in mouse.
REFERENCE   10 (bases 1 to 866)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154875.8.
            
            On Dec 21, 2021 this sequence version replaced NM_029797.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027741.1, BI411755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC154875.8         18513-18628
            117-182             AC154875.8         32526-32591
            183-240             AC154875.8         36064-36121
            241-389             AC154875.8         40124-40272
            390-464             AC154875.8         57789-57863
            465-579             AC154875.8         69241-69355
            580-624             AC154875.8         80691-80735
            625-866             AC154875.8         86116-86357
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.46 cM"
     gene            1..866
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /note="meiotic nuclear divisions 1"
                     /db_xref="GeneID:76915"
                     /db_xref="MGI:MGI:1924165"
     exon            1..116
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..731
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /note="isoform 1 is encoded by transcript variant 1;
                     meiotic nuclear division protein 1 homolog; meiotic
                     nuclear divisions 1 homolog"
                     /codon_start=1
                     /product="meiotic nuclear division protein 1 homolog
                     isoform 1"
                     /protein_id="NP_084073.2"
                     /db_xref="CCDS:CCDS38464.1"
                     /db_xref="GeneID:76915"
                     /db_xref="MGI:MGI:1924165"
                     /translation="MSKKRGLSGEEKRTRMMEIFFETKDVFQLKDLEKLAPKEKGITA
                     MSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEALNSQLSEGSQKHAD
                     LQKSIEKARVGRQETEERAMLAKELSSFRDQRQQLKAEVEKYRECDPQVVEEIREANK
                     VAKEAANRWTDNIFAIKSWAKRKFGFEESKIDKNFGIPEDFDYID"
     exon            117..182
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /inference="alignment:Splign:2.1.0"
     exon            183..240
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /inference="alignment:Splign:2.1.0"
     exon            241..389
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /inference="alignment:Splign:2.1.0"
     exon            390..464
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /inference="alignment:Splign:2.1.0"
     exon            465..579
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /inference="alignment:Splign:2.1.0"
     exon            580..624
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /inference="alignment:Splign:2.1.0"
     exon            625..866
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="Mnd1"
                     /gene_synonym="2610034E18Rik; Gaj"
                     /note="major polyA site"
ORIGIN      
        1 agtcctacca gggccgccag gggtcgttgc atctcccctg cacttcctcc ggtccttccc
       61 accccacgcg gttgttggcg ccagactcaa acagggaggc cgcctcgcgc agcatgtcaa
      121 agaaaagagg actgagtggg gaggaaaaga gaacccggat gatggagata ttttttgaga
      181 caaaagatgt attccagctg aaagacctgg agaagcttgc tcccaaagag aaaggcataa
      241 ccgccatgtc agtgaaggaa gtccttcaga gcctagtgga tgacggtatg gttgactgcg
      301 agaggatcgg gacgtccaat tactattggg cttttccgag caaggctctt catgccagga
      361 agcgcaagtt ggaggctctg aactctcagc tgtcagaggg aagccagaag catgcagact
      421 tacagaagag cattgagaaa gcaagagttg gccggcaaga gacggaagaa cgagccatgc
      481 ttgcaaaaga actttcttca tttcgagacc aaaggcaaca acttaaggca gaagtggaaa
      541 aatatcgaga atgtgaccca caggttgtgg aagagatacg tgaagcaaat aaagtagcta
      601 aagaagccgc caatcgatgg actgataaca tatttgcaat aaaatcctgg gccaaaagaa
      661 aatttgggtt tgaagaaagt aaaattgata aaaactttgg aattccagaa gactttgact
      721 acatagacta aaatgttggt gctaaacaag gatctgggag cttgtgaata tgtcaaggtt
      781 taaacagcta actaatgtta cccagttatc atctatctgc taattgttta ccgttttgaa
      841 gctttaaata aagtatacaa taagga
//
