LOCUS       NM_008612               2505 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus menage a trois 1 (Mnat1), mRNA.
ACCESSION   NM_008612
VERSION     NM_008612.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2505)
  AUTHORS   Kafer,G.R. and Cesare,A.J.
  TITLE     A Survey of Essential Genome Stability Genes Reveals That
            Replication Stress Mitigation Is Critical for Peri-Implantation
            Embryogenesis
  JOURNAL   Front Cell Dev Biol 8, 416 (2020)
   PUBMED   32548123
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2505)
  AUTHORS   Wang,J., Ni,J., Song,D., Ding,M., Huang,J., Li,W. and He,G.
  TITLE     MAT1 facilitates the lung metastasis of osteosarcoma through
            upregulation of AKT1 expression
  JOURNAL   Life Sci 234, 116771 (2019)
   PUBMED   31421084
  REMARK    GeneRIF: MAT1 serves as a promoter in the lung metastasis of
            osteosarcoma through increasing AKT1 expression.
REFERENCE   3  (bases 1 to 2505)
  AUTHORS   Helenius,K., Yang,Y., Tselykh,T.V., Pessa,H.K., Frilander,M.J. and
            Makela,T.P.
  TITLE     Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal
            domain Ser5 phosphorylation, transcription and mRNA turnover
  JOURNAL   Nucleic Acids Res 39 (12), 5025-5035 (2011)
   PUBMED   21385826
  REMARK    GeneRIF: Deletion of the TFIIH kinase subunit Mat1 in mouse
            fibroblasts leads to dramatically reduced RNA polymerase II Ser5
            phosphorylation.
REFERENCE   4  (bases 1 to 2505)
  AUTHORS   Patel,S.A. and Simon,M.C.
  TITLE     Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse
            embryonic stem cells and embryos
  JOURNAL   J Biol Chem 285 (20), 15587-15598 (2010)
   PUBMED   20231280
  REMARK    GeneRIF: investigated the function of the Cdk7.cyclin H.Mat1
            complex in murine embryonic stem (ES) cells and preimplantation
            embryos to determine whether it regulates the unique cell cycle
            structure and transcriptional network of pluripotent cells
REFERENCE   5  (bases 1 to 2505)
  AUTHORS   Stoller,J.Z., Huang,L., Tan,C.C., Huang,F., Zhou,D.D., Yang,J.,
            Gelb,B.D. and Epstein,J.A.
  TITLE     Ash2l interacts with Tbx1 and is required during early
            embryogenesis
  JOURNAL   Exp Biol Med (Maywood) 235 (5), 569-576 (2010)
   PUBMED   20463296
REFERENCE   6  (bases 1 to 2505)
  AUTHORS   Sano,M., Izumi,Y., Helenius,K., Asakura,M., Rossi,D.J., Xie,M.,
            Taffet,G., Hu,L., Pautler,R.G., Wilson,C.R., Boudina,S., Abel,E.D.,
            Taegtmeyer,H., Scaglia,F., Graham,B.H., Kralli,A., Shimizu,N.,
            Tanaka,H., Makela,T.P. and Schneider,M.D.
  TITLE     Menage-a-trois 1 is critical for the transcriptional function of
            PPARgamma coactivator 1
  JOURNAL   Cell Metab 5 (2), 129-142 (2007)
   PUBMED   17276355
  REMARK    GeneRIF: This study demonstrates a requirement for MAT1 in the
            operation of PGC-1 coactivators that control cell metabolism.
REFERENCE   7  (bases 1 to 2505)
  AUTHORS   Korsisaari,N., Rossi,D.J., Paetau,A., Charnay,P., Henkemeyer,M. and
            Makela,T.P.
  TITLE     Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells
            provides evidence that Mat1 is not required for general
            transcription
  JOURNAL   J Cell Sci 115 (Pt 22), 4275-4284 (2002)
   PUBMED   12376559
REFERENCE   8  (bases 1 to 2505)
  AUTHORS   Rossi,D.J., Londesborough,A., Korsisaari,N., Pihlak,A.,
            Lehtonen,E., Henkemeyer,M. and Makela,T.P.
  TITLE     Inability to enter S phase and defective RNA polymerase II CTD
            phosphorylation in mice lacking Mat1
  JOURNAL   EMBO J 20 (11), 2844-2856 (2001)
   PUBMED   11387217
REFERENCE   9  (bases 1 to 2505)
  AUTHORS   Gervais,V., Busso,D., Wasielewski,E., Poterszman,A., Egly,J.M.,
            Thierry,J.C. and Kieffer,B.
  TITLE     Solution structure of the N-terminal domain of the human TFIIH MAT1
            subunit: new insights into the RING finger family
  JOURNAL   J Biol Chem 276 (10), 7457-7464 (2001)
   PUBMED   11056162
REFERENCE   10 (bases 1 to 2505)
  AUTHORS   Fisher,R.P., Jin,P., Chamberlin,H.M. and Morgan,D.O.
  TITLE     Alternative mechanisms of CAK assembly require an assembly factor
            or an activating kinase
  JOURNAL   Cell 83 (1), 47-57 (1995)
   PUBMED   7553872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155859.1 and AK157721.1.
            
            On Mar 10, 2006 this sequence version replaced NM_008612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157721.1, AK155859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK155859.1         2-15
            15-2505             AK157721.1         2-2492
FEATURES             Location/Qualifiers
     source          1..2505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.37 cM"
     gene            1..2505
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /note="menage a trois 1"
                     /db_xref="GeneID:17420"
                     /db_xref="MGI:MGI:106207"
     exon            1..210
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1051
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /note="p35; RING finger protein MAT1; CDK7/cyclin-H
                     assembly factor"
                     /codon_start=1
                     /product="CDK-activating kinase assembly factor MAT1"
                     /protein_id="NP_032638.2"
                     /db_xref="CCDS:CCDS49087.1"
                     /db_xref="GeneID:17420"
                     /db_xref="MGI:MGI:106207"
                     /translation="MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAG
                     NCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEV
                     EEIVFNLTNNVDLENTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQEHEQ
                     RRLFIQKEEELQQALKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPRSM
                     KPVTFSTGIKMGQQISLAPIQKLEEALYEYQPLQIETCGPQVPEQELLGRLGYLNHVR
                     AASPQDLAGGYTSSLACHRALQDAFSGLFWQPR"
     exon            211..363
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /inference="alignment:Splign:2.1.0"
     exon            364..437
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /inference="alignment:Splign:2.1.0"
     exon            438..541
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /inference="alignment:Splign:2.1.0"
     exon            542..682
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /inference="alignment:Splign:2.1.0"
     exon            683..808
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /inference="alignment:Splign:2.1.0"
     exon            809..930
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /inference="alignment:Splign:2.1.0"
     exon            931..2505
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /note="hexamer: AATAAA"
     polyA_site      1369
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /note="major polyA site"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
                     /note="hexamer: AATAAA"
     polyA_site      1765
                     /gene="Mnat1"
                     /gene_synonym="E130115E11Rik; MAT1; P36"
ORIGIN      
        1 cattccggcc aagtgcctgt tggtagcagc ttagttgaca tctggtctgg gggttcttgt
       61 aggtggcagt ggctgaaatc cgtgtggagg aaaaaaaaaa atccaaagcc gaagagacgc
      121 catggacgac cagggctgcc ccaggtgtaa gaccaccaag taccggaacc cttctttgaa
      181 gctgatggtg aacgtgtgcg gacacactct gtgtgagagt tgtgtggact tactgtttgt
      241 aagaggagct ggaaactgtc ctgagtgtgg gactccactg agaaagagca acttcagggt
      301 acaactcttt gaagatccca ctgttgataa ggaggttgaa attcggaaaa aagtactaaa
      361 gatatacaat aaaagggaag aagattttcc tagtttaaga gagtataatg attttctgga
      421 agaagtggag gaaatcgttt tcaatttgac caacaatgtg gatttggaga acactaaaaa
      481 gaaaatggaa atatatcaaa aagaaaacaa agatgtcatt cagaaaaaca aattaaagct
      541 gacgcgggag caggaggagt tggaggaagc attggaggta gaacgccaag aacatgagca
      601 gcgacggctg ttcatacaaa aggaagaaga gctgcagcag gctctgaaaa ggaagaacaa
      661 gcaggccttt ttagatgagc tggagagctc cgacctccct gttgctctgc tcctggcgca
      721 gcataaagac agatcgaccc agctggaaat gcagctcgag aagcccagat ccatgaagcc
      781 agtgacgttt tccacaggaa ttaaaatggg tcaacagatt tcattagcac caatccaaaa
      841 gctggaagaa gctctttatg agtaccagcc cctgcagata gagacctgtg gcccacaagt
      901 tcctgagcaa gagctcttag gacggcttgg gtatttaaac cacgtccggg ctgcatctcc
      961 acaggatctt gctggcggct atacttcttc tcttgcttgt cacagagcgc tacaggatgc
     1021 gttcagtggg ctcttctggc agcccagata acctgtattt tctcatgtat aagatctgga
     1081 ttgtggagcc aaaccaaggg gtttgaaagt atagaggttt gtaaagttcc agccccgcag
     1141 ctgcacagca caccaccact gctgctgtgc tcaggtgttt attgcagtct ggaccaagct
     1201 gagaaatgtg ttgcatatag attcatggaa gaggtttatt ttttacttct gttctttaga
     1261 cagggatgaa gaacattaaa cctcatctga cagaaaagaa ataaatgatt tgcctatgtt
     1321 tggagttgac ttacacattt tataaaaaat aaagcctgac tttatggtac atttttgtgg
     1381 gatttttttt tcttcctcct cctccttgtg tttttctgga acatatttcc aaatgccttt
     1441 ttgattataa cattcagtgc tattatccaa gtctatattt tccctataaa aacttctttt
     1501 tccccttaat gtcgtattga tagtggtaca gacaagtgga gatgtttcat cttagcagca
     1561 ggccgtgtca agaaagcaca actgtgatgt ggctcttcct cagcagtaag agtctggggg
     1621 actgttttga gccatgcaaa gtgaggcaaa cctaatgtgg ttcccagctg tgagccacag
     1681 aaatgataaa ccagagcagg ccattaacct gctttaatgg cagattcaaa gatgtgagct
     1741 aataaaactt aatacatcaa tggcaccttt cactgctaat gtgagctcat tttatgatga
     1801 gatgttgaga ctggaaaagg taccatgtaa gtgaaatttc tctgcataaa ttatagactg
     1861 atgtagtttt ccacccacca aagcttcaag ggattttact gtgcttgtgg ttttgtgtag
     1921 tttgggtgtg tgttggtcag aagcatgagc atcccagcct gtgtgagtct gtcgcatggg
     1981 cccctgggta tggaacatag gcttttccag gaaattaaag gatattctat caaatttctg
     2041 tcacaacaaa tgctaacttt atggacataa gagttaaatg aatcaaatct ctggttatgt
     2101 tagtgttaat agtcatatgt aacaatacca tctttattgg gtggggatcc atttcagtgc
     2161 atcttgtggg accaaccttc cttgctagaa gtcacacttc tcatctttga taaatgagaa
     2221 aaccaagaag ttgaatatgc caagaatata tatgtaaatt agtaaaaagc tagaattagg
     2281 tcaagttact tcttaatcta aatccactat ggagtgagca tgtagtattc cttatgttag
     2341 ttaggttttt gctaattggt agttcaccct tctgtattca atctgtaaat ctgatgaaga
     2401 agtgatgaaa atgagcccac ggctagggct ttgctgcact cgtggacaga aatcaatata
     2461 cctacaattc atgaactaat taataaaact caagctttgt tttgc
//
