LOCUS       NM_001081235            6859 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus meningioma 1 (Mn1), mRNA.
ACCESSION   NM_001081235 XM_485667
VERSION     NM_001081235.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6859)
  AUTHORS   Lehman,N.L., Spassky,N., Sak,M., Webb,A., Zumbar,C.T.,
            Usubalieva,A., Alkhateeb,K.J., McElroy,J.P., Maclean,K.H.,
            Fadda,P., Liu,T., Gangalapudi,V., Carver,J., Abdullaev,Z.,
            Timmers,C., Parker,J.R., Pierson,C.R., Mobley,B.C., Gokden,M.,
            Hattab,E.M., Parrett,T., Cooke,R.X., Lehman,T.D., Costinean,S.,
            Parwani,A., Williams,B.J., Jensen,R.L., Aldape,K. and Mistry,A.M.
  TITLE     Astroblastomas exhibit radial glia stem cell lineages and
            differential expression of imprinted and X-inactivation escape
            genes
  JOURNAL   Nat Commun 13 (1), 2083 (2022)
   PUBMED   35440587
  REMARK    Erratum:[Nat Commun. 2023 Jan 31;14(1):507. doi:
            10.1038/s41467-023-36255-z.. PMID: 36720866]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6859)
  AUTHORS   Riedel,S.S., Lu,C., Xie,H.M., Nestler,K., Vermunt,M.W., Lenard,A.,
            Bennett,L., Speck,N.A., Hanamura,I., Lessard,J.A., Blobel,G.A.,
            Garcia,B.A. and Bernt,K.M.
  TITLE     Intrinsically disordered Meningioma-1 stabilizes the BAF complex to
            cause AML
  JOURNAL   Mol Cell 81 (11), 2332-2348 (2021)
   PUBMED   33974912
  REMARK    GeneRIF: Intrinsically disordered Meningioma-1 stabilizes the BAF
            complex to cause AML.
REFERENCE   3  (bases 1 to 6859)
  AUTHORS   Libbrecht,C., Xie,H.M., Kingsley,M.C., Haladyna,J.N., Riedel,S.S.,
            Alikarami,F., Lenard,A., McGeehan,G.M., Ernst,P. and Bernt,K.M.
  TITLE     Menin is necessary for long term maintenance of meningioma-1 driven
            leukemia
  JOURNAL   Leukemia 35 (5), 1405-1417 (2021)
   PUBMED   33542482
  REMARK    GeneRIF: Menin is necessary for long term maintenance of
            meningioma-1 driven leukemia.
REFERENCE   4  (bases 1 to 6859)
  AUTHORS   Sharma,A., Jyotsana,N., Gabdoulline,R., Heckl,D., Kuchenbauer,F.,
            Slany,R.K., Ganser,A. and Heuser,M.
  TITLE     Meningioma 1 is indispensable for mixed lineage leukemia-rearranged
            acute myeloid leukemia
  JOURNAL   Haematologica 105 (5), 1294-1305 (2020)
   PUBMED   31413090
  REMARK    GeneRIF: Meningioma 1 is indispensable for mixed lineage
            leukemia-rearranged acute myeloid leukemia.
REFERENCE   5  (bases 1 to 6859)
  AUTHORS   George,M.R., Duan,Q., Nagle,A., Kathiriya,I.S., Huang,Y., Rao,K.,
            Haldar,S.M. and Bruneau,B.G.
  TITLE     Minimal in vivo requirements for developmentally regulated cardiac
            long intergenic non-coding RNAs
  JOURNAL   Development 146 (23) (2019)
   PUBMED   31784461
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6859)
  AUTHORS   Zhang,X., Dowd,D.R., Moore,M.C., Kranenburg,T.A.,
            Meester-Smoor,M.A., Zwarthoff,E.C. and MacDonald,P.N.
  TITLE     Meningioma 1 is required for appropriate osteoblast proliferation,
            motility, differentiation, and function
  JOURNAL   J Biol Chem 284 (27), 18174-18183 (2009)
   PUBMED   19386590
  REMARK    GeneRIF: important role for MN1 in maintaining the appropriate
            maturation and function of calvarial osteoblasts
REFERENCE   7  (bases 1 to 6859)
  AUTHORS   Liu,W., Lan,Y., Pauws,E., Meester-Smoor,M.A., Stanier,P.,
            Zwarthoff,E.C. and Jiang,R.
  TITLE     The Mn1 transcription factor acts upstream of Tbx22 and
            preferentially regulates posterior palate growth in mice
  JOURNAL   Development 135 (23), 3959-3968 (2008)
   PUBMED   18948418
  REMARK    GeneRIF: Mn1 and Tbx22 function in a novel molecular pathway
            regulating mammalian palate development.
REFERENCE   8  (bases 1 to 6859)
  AUTHORS   Carella,C., Bonten,J., Sirma,S., Kranenburg,T.A., Terranova,S.,
            Klein-Geltink,R., Shurtleff,S., Downing,J.R., Zwarthoff,E.C.,
            Liu,P.P. and Grosveld,G.C.
  TITLE     MN1 overexpression is an important step in the development of
            inv(16) AML
  JOURNAL   Leukemia 21 (8), 1679-1690 (2007)
   PUBMED   17525718
  REMARK    GeneRIF: MN1 overexpression is associated with the development of
            myeloproliferative disease
REFERENCE   9  (bases 1 to 6859)
  AUTHORS   Kawagoe,H. and Grosveld,G.C.
  TITLE     Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in
            conjunction with overexpression of HOXA9
  JOURNAL   Blood 106 (13), 4269-4277 (2005)
   PUBMED   16105979
  REMARK    GeneRIF: leukemogenic effect of MN1-ets variant gene 6 in our
            knock-in mice is pleiotropic, and the type of secondary mutation
            determines disease outcome
REFERENCE   10 (bases 1 to 6859)
  AUTHORS   Meester-Smoor,M.A., Vermeij,M., van Helmond,M.J., Molijn,A.C., van
            Wely,K.H., Hekman,A.C., Vermey-Keers,C., Riegman,P.H. and
            Zwarthoff,E.C.
  TITLE     Targeted disruption of the Mn1 oncogene results in severe defects
            in development of membranous bones of the cranial skeleton
  JOURNAL   Mol Cell Biol 25 (10), 4229-4236 (2005)
   PUBMED   15870292
  REMARK    GeneRIF: Mn1 is an important factor in development of membranous
            bones
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122226.3 and AC124749.5.
            
            On Nov 3, 2022 this sequence version replaced NM_001081235.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR10223971.6056.1, SRR10223970.7757.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AC122226.3         161922-162306
            386-4450            AC122226.3         162462-166526
            4451-6859           AC124749.5         81853-84261
FEATURES             Location/Qualifiers
     source          1..6859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.86 cM"
     gene            1..6859
                     /gene="Mn1"
                     /note="meningioma 1"
                     /db_xref="GeneID:433938"
                     /db_xref="MGI:MGI:1261813"
     exon            1..385
                     /gene="Mn1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..4450
                     /gene="Mn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             733..4626
                     /gene="Mn1"
                     /note="probable tumor suppressor protein MN1"
                     /codon_start=1
                     /product="transcriptional activator MN1"
                     /protein_id="NP_001074704.1"
                     /db_xref="CCDS:CCDS39214.1"
                     /db_xref="GeneID:433938"
                     /db_xref="MGI:MGI:1261813"
                     /translation="MFGLDQFEPQINSRHAGQGEGNFNEAGLSMNAHFKAPAFHAGPP
                     TGPVDPAISALGEPPILGLNMEPYGFHARSHSELHAGGLQAQPVHGFFGGQQPHHSHP
                     GGHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFAESYEHMAESQ
                     GPEGFGPQRPGNLPDFHSSGTSGHAVPAPCLPLDQSPNRAASFHGLSASSGSDSHSLE
                     PRRVTNQGAVDSLEYNYPSEPPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAM
                     PRASGMVGLSKMHSQPPQPPPQQQQPQHGVFFERFGGARKMPVGLEPAVGSRHPLMQP
                     PQQAPPPPQQPPPQQQPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQ
                     HAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDF
                     PGSAGVDRCASWNGSMHNGTLDNQLSPSAYPGLPGEFTPPVPDSFSSGPPLQHPGPDH
                     QSLQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLG
                     HPGDVGQGGLVHGGSVGGLAQTNFEREGGSAGAGRLSGFEQQAPHLAQESAWFPGPHP
                     PGDLLPRRMGGAGLPTDCGPHDPALAPPPAPGGSGVLFRGSLQEPLRMPGEGHVPALA
                     SPGLQFGGSLAGLGQLQSPGAGVGLPNAPSERRPPPPDFPAPALGGQPGFPFGSGSRQ
                     ATPHSAPGVNSPPSAGSGSSGAGGGAYPPQPDFQPSQRNSASKLGALSLGSFNKPSSK
                     DNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNEPDSAVAAGNP
                     GSDYFPGGTTPGAPGPGGPSGTSGGGSKASGPPNPPIQGDSTSLSPNYTLESTSGNDG
                     KPVPGGSGRGRGRRKRDSGHVSPGTFFDKYSTAPDSGGAPGVSPGQQQAPGSAAGGSS
                     VNEARGPTPHEKALTSPSWGKGAELLLGDQPDLMASLDSTAKSDGSSPHVGEFASDEV
                     STSYANEDEVSSSSDNTTALAKASRSPLVTSSPKLPPRGVGAGEHTPKASALGLGILS
                     TSTSTPDSYGGGVGTGHPGTPGLEQVRTPTSSSGAQPPDEIHPLEILQAQIQLQRQQF
                     SISEDQPLGLKGSKKAECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHST
                     TWYMPPDKALVDGGDEDKTLAPWEKAKSQNPNNKEAHDHPTNKASATQPGSHLQCLTV
                     HCTDGDPKARTSVPTWRSLHSDISNRFGTFVAALT"
     exon            4451..6859
                     /gene="Mn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6838..6843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mn1"
                     /note="hexamer: AATAAA"
     polyA_site      6859
                     /gene="Mn1"
                     /note="major polyA site"
ORIGIN      
        1 ctcccggcgc cggcgagagg cagacgcgga gcggaatccc ggacctcgca gcgcctcgcc
       61 cgccccgcgc gccctgctcg cccgcgcggc ccattcccgg gtccgagggg acccgtggag
      121 tgcggaggcg ggaaccacag cttcggaacc gccggcccca cgcctcccct cccgcgcgcg
      181 gcccgagact cccgcgaact cgcgcggcga ccggcgatcg agcccgagcc gcggagccgc
      241 ggagccgcgc gtctcccgca gcctgcgttc ccgctccggc gcccgcgtct actgctgtga
      301 atccagcacc ggcgatgagg agcggagcag cccgtcttcc gagccgctga ggctttcgcc
      361 gccgatcgcc cgcggccgac cggagctcgt cggcctccag gtctcctctc cgcataccca
      421 cccgcgaccg tgccatcgac ccggggcatg ggccccccga caaggctcca ggaggcgccg
      481 cggcctcgca agacgtgaga ggcccgcttg ggtcgatttc gaggttccga agagcagcgg
      541 agagagctcc tagccagcgc ccgcgcgctg ggccgggcgg cagtgagcgc tgcgccccgc
      601 ggtgcagaac gtcccggagc gccggaacct cggctgaggc gagtacctgg ccggaggcgc
      661 gcggcggagc aggctgtcat gccctattga tcccctcccg cccccccccc gccccccccg
      721 cccccgccaa gtatgtttgg gctggaccaa ttcgagcccc agatcaacag ccggcacgct
      781 ggtcagggcg aggggaactt taacgaagcc ggactgagca tgaacgccca ctttaaggct
      841 cctgccttcc acgccgggcc tcctactggc cccgtggacc ctgcaataag cgctctgggc
      901 gaacccccga tcttgggctt gaacatggag ccctacggct ttcatgcgcg cagccactcc
      961 gagctgcacg caggggggct gcaggcgcag cctgtgcatg gcttcttcgg cggtcagcag
     1021 cctcaccaca gccatcccgg aggccatcac ccgcaccagc atcaccccca ctttgggggc
     1081 aacttcggtg gtccggatcc aggtgcctca tgtctgcacg ggggccggct gcttggctac
     1141 ggaggtgcag cgggcggcct gggcagccag cctcccttcg cagagagtta tgagcacatg
     1201 gcggagagcc aggggccgga gggcttcggc ccgcagcggc caggaaacct cccggacttc
     1261 catagttcgg gcacctcggg ccacgccgtg cctgccccgt gcctgcctct ggaccagagc
     1321 cctaaccggg ctgcctcttt tcacggcctg tccgcctcta gcggctcgga ttctcacagc
     1381 ctggagcccc ggagggtgac gaaccaagga gccgtagatt ccctggaata caattacccg
     1441 agcgagccgc cctcaggaca ttttgacatg ttttcaccct ctgactctga agggcagctg
     1501 ccacattatg ctgcgggtcg ccaggttccc gggggcgctt tcccgggtgc ttctgccatg
     1561 cctagagcct caggcatggt gggtttgtcc aaaatgcaca gccagccacc ccagccgcct
     1621 ccacaacagc agcaaccgca gcacggagtg ttcttcgaga ggtttggcgg ggcccgaaag
     1681 atgcctgtgg gtctggagcc tgcagtgggc tccaggcacc cgctaatgca gcctccccag
     1741 caggccccac cacccccgca gcagccgccc ccgcagcagc agccgccgcc accgggactt
     1801 ctggttcgac agaattcttg ccctcctgcg ctcccgcggc cccagcaggg tgaggctggc
     1861 acacccagtg gcggcctgca ggacgggggc cccatgctgc ccagtcaaca tgctcagttc
     1921 gagtatccca tccatcggct agagaaccgg agcatgcacc catattctga gcctgtcttc
     1981 agcatgcagc atccccctcc tcagcaggcg cccaaccaga ggctgcagca tttcgatgcg
     2041 cccccttaca tgaacgtggc caagaggccg cgttttgact ttccgggcag cgcaggcgtg
     2101 gaccgctgcg cctcgtggaa tggcagcatg cataacggta ccctagacaa ccaactctct
     2161 ccctctgcct acccaggcct cccaggcgag ttcacaccgc ctgtgccgga cagcttttcc
     2221 tcgggaccac ccttgcagca cccggggccg gaccaccagt ccctgcagca gcagcagcag
     2281 cagcaacaac agcagcagca gcagcaacaa caacagcagc aacagcagca gcagcaacag
     2341 caacgccaga atgcggccct catgattaaa cagatggcgt cccggaacca gcagcagcgg
     2401 ttgcgacagc ccaacctggc ccagctaggc catcctgggg acgtgggcca gggcggcctg
     2461 gtccacggag gttccgtggg cggcttggcc cagacgaact ttgagcgcga agggggcagc
     2521 gcaggtgccg ggcgcctgag tggctttgag cagcaggcgc cccacctggc gcaggagagc
     2581 gcgtggttcc cgggtccaca ccctcccggc gacctgctgc cccggaggat gggcggcgcg
     2641 gggttgccga ctgactgcgg cccgcacgac cctgctctgg cgcctccccc tgctccaggt
     2701 ggctcagggg tgcttttccg aggctctttg caggagcctc tgaggatgcc aggagaaggc
     2761 cacgtgcccg cactggcctc gcccgggctg cagtttgggg gcagcttagc tggcctaggc
     2821 cagttgcagt cgcccggtgc cggtgtggga ctgccaaacg ctccgtcgga gcgacggcct
     2881 ccgcctccgg acttccccgc gccagctctc gggggccagc cgggctttcc attcggttca
     2941 ggcagccggc aggccactcc gcacagcgct ccaggcgtga attcgccccc gagcgcgggc
     3001 agcggcagct ccggtgctgg cgggggcgct tacccgccgc agccagattt ccaacccagc
     3061 cagcgcaact cggccagtaa gctgggcgca ctgtcgttgg ggtctttcaa caagcccagc
     3121 tctaaggaca acctgttcgg ccagagctgc ctggctgcgc tctccactgc ttgccagaac
     3181 atgattgcca gcctgggtgc tcctaacctc aacgtgactt tcaacaagaa gaacccaccc
     3241 gaggggaaga ggaaactgag ccagaacgag cccgacagcg cggttgcagc cggtaacccg
     3301 ggctcggatt acttccccgg agggactact cctggggccc ctggacccgg aggcccttcc
     3361 gggaccagtg gtggtggctc caaagcctca ggaccgccca accctcccat ccagggggac
     3421 agcaccagtc tctcccccaa ttataccctg gaatcaacgt cgggtaacga tggcaagcct
     3481 gtccctgggg gcagtggccg gggaagggga cgcagaaaac gggacagtgg tcatgtgagc
     3541 cccgggacct tcttcgacaa atattccaca gctccagaca gtgggggcgc accaggggtg
     3601 agcccggggc agcagcaggc tcctggctca gccgctgggg gaagctcagt gaacgaggcc
     3661 cgaggcccca caccccatga gaaggccctt acgtccccat cgtggggcaa aggagccgag
     3721 cttctccttg gggaccagcc ggacctcatg gcgtccctgg acagcacagc caaatcagat
     3781 ggtagttccc cgcacgtggg tgagttcgcc tctgatgagg tgagcacaag ttatgcgaac
     3841 gaggacgaag tgtcatccag ttctgacaac actacagccc tggccaaagc cagccgaagt
     3901 cccctggtga ccagctcacc gaaactccct cctcgagggg tgggcgctgg ggaacacaca
     3961 ccgaaggctt ccgccctggg cctgggcatc ctgtctacct ctacctcaac ccctgacagc
     4021 tatggtgggg gcgtgggcac cggacatccc ggcacaccag gcctggagca ggtccggacc
     4081 ccaacgagca gcagcggtgc gcagcctcct gacgagattc atcccctgga gatcctccaa
     4141 gcccagatcc agctgcagag acaacaattt agcatctcgg aggaccagcc cctggggctc
     4201 aagggcagca aaaaagccga gtgtgctgta ggggcctcag gagcacagaa cggtgacagc
     4261 gagttgggta gctgctgctc cgaagcagtc aagagcgcca tgagtactat cgacctggac
     4321 tccctgatgg cagaacacag cactacctgg tacatgccac ctgacaaggc cctggtggat
     4381 ggtggagatg aggacaagac gctggcgccc tgggagaagg ccaagtccca gaaccccaac
     4441 aacaaagaag cccatgacca ccccaccaac aaggcctcag ccacccagcc cggcagccac
     4501 ctgcagtgcc tgactgtcca ctgcacagat ggtgacccca aggcccgcac ctccgtaccc
     4561 acctggcggt ctctgcactc tgatatctcc aaccgatttg ggacatttgt ggccgccctg
     4621 acttgagccc acgggagccg atgccctaac catcaccacg aggggcctcc gtggctgagc
     4681 agactcttta caatattttt tttctttctt tctttctttc tttttttttt tttttttttt
     4741 ttttcttttt gggtctaggt tggtactttc ttagtggcac tcagaatgga aagggttcat
     4801 tgaaaggggc cggggaaggt gatcaaagga acctcaaaaa agttatctga aggaaaccat
     4861 gtgtgccaca ccgtgacaca cctgtgtcat cctccgcagc aaatgctgtg ctggtgggcg
     4921 caaacctttt tcctgctaga gaacccccat ttcctgtact cggcgtgtgt tctagaaggc
     4981 tcttgctttg tttaagcctg gacaggggta cctggaaacc cccccccccc ctttaaattc
     5041 ttttccctcc ctcttttcta tttgtccatc cctatggaga tcttggaaga ttgtgtcctg
     5101 gagcactccc cgggtggatg tagcagggtc atgccagtgt cgactggtga catggagcag
     5161 ctggaggcgc cttcacacac cgggggagtt ttctgtgctc cctgagaact tgcagagaga
     5221 ggtcttttcc tgattggccc ttagcattca ctaagcttcc attcctctca ttgggagcag
     5281 tccctctggt cccttctggg ttgtgagttg gatgctggtg tcatgggcac cctctccttc
     5341 actgaggcta ccgttgcgcc ctctgccttc tctgtggcct tgtgaccctc aaagggcaca
     5401 agggagggtc tgccagttgt ctaagggact tactggccct gttctcccag atggcagcca
     5461 gggtgcctca gttccacctc gcatagcatc cctaagtgaa tccatccctg ggaggaggga
     5521 ttgaggcagc caaattcagg ctgagacact cttcggtcct gcacagatcc tagaggggag
     5581 gagagtaaat tgagtggctt tgtgatgcct gttcccgaga ctcacgttcc ctttgtggga
     5641 tgtctcctgc cctttggatt tggtttcatt ctgatttaca agcagagccc tgcccagtgt
     5701 gtccccctgg gagagacgct tctgcctaag tggaggggag cagagattgc tgagctgatg
     5761 tagataaatc tacagcttag ggtgtgctct gtaccccgcc aacctatgtg gcccactatg
     5821 gctatgctgt ggggccctgc atccctggga gggtcagtca ggccagagcc agttcagttt
     5881 ttgttgttag tgtgtctctt caattactcc tttctgagcc ccacctgaac tcgacagaca
     5941 cccttccctt tcttagtaag aggtccgaag gcttggctct ctccagatac ccgtattgtt
     6001 tgtgtcaagg gactttcaac tgtgggagcc ccttgccaaa agctggctat ctccctcaag
     6061 tcctctcctc ctcctcgtgg ctaagtcctg agcccccagg atctgcactt gttgcctggg
     6121 cgttgtgatg gggctcagag ggcagacaca ggtggtatgg gctggtggag caggaagggc
     6181 cctctgtttt gtgcccaaag cagtgaaggg atggcttctc tcctccatgg gccacaggag
     6241 catcctccag gcttcggtct ctcagagttg gtgacatgta gctagctgtc tgagagtgcc
     6301 agcctttcag tccccaaaca agaatgacag ttttcagtgc ttaaggctgg ggatgagtgt
     6361 gctaatggct gtcagcaaac ttcccggtat caactcagtc cagtgttatc tgtgctcact
     6421 ccccacgacc ctggggtgga gcagctttta aaatagcctt aagcaaaagg acatcatcgt
     6481 gtcattaaat ttggtttagc aggaagaata aaagtagaag aaaaccatgc ccgaagcgca
     6541 ggagcctggg aacactgtaa tcagtccgca gccaactcca gtagagagaa ggaaatcgct
     6601 attgcacatg tataatatga acccttaacc ctgcggtgcg gtgcgcgaac ctgtaagctt
     6661 tttttgactc ttaaaaccat ttctgaatgc ttggttggaa gacagtgact gacaatagct
     6721 catgaaactg agtggtattt ttctttcttt ctttttttta aatatgtaaa gttgagtctt
     6781 ccgtattcac gcatactgta tatacgtgta tatgttttgc tgagcagctt aaataacaat
     6841 aaatacaacg ttaacggtg
//
