LOCUS       NM_199467               4493 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus MMS22-like, DNA repair protein (Mms22l), transcript
            variant 1, mRNA.
ACCESSION   NM_199467 XM_131333
VERSION     NM_199467.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4493)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4493)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4493)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4493)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   5  (bases 1 to 4493)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   6  (bases 1 to 4493)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX296536.6, AK164069.1, CK639437.1, BC094429.1 and AK089531.1.
            
            On Sep 21, 2017 this sequence version replaced NM_199467.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available conservation
            data and which would result in a protein that is 276 aa longer at
            the N-terminal.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.1767278.1,
                                           SRR13422590.529738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BX296536.6         48603-48613
            12-624              AK164069.1         1-613
            625-667             CK639437.1         166-208
            668-1849            BC094429.1         1-1182
            1850-1850           AK089531.1         579-579
            1851-4493           BC094429.1         1184-3826
FEATURES             Location/Qualifiers
     source          1..4493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 10.36 cM"
     gene            1..4493
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /note="MMS22-like, DNA repair protein"
                     /db_xref="GeneID:212377"
                     /db_xref="MGI:MGI:2684980"
     exon            1..615
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..4174
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /codon_start=1
                     /product="protein MMS22-like"
                     /protein_id="NP_955761.2"
                     /db_xref="CCDS:CCDS18006.2"
                     /db_xref="GeneID:212377"
                     /db_xref="MGI:MGI:2684980"
                     /translation="MDGCSAASTFLTDSLELELGTEWCKPPCFSCAFDNREGKFSGES
                     YLASGALKRLILNLDPLPTNFEEDTVELFGFQWVTETALVYSCRELFHLFRQQIFNLE
                     SLVQVSCDFGKIATLHAKADSIRQQCVVFLHYIKVFIFRCLKVQEAESHSRPAHPYEA
                     LEAQLPSMLVDELRGLLLYIGHLAALPSVTVGAFVNQNQMKLFPPSWHLLHLYLDTHW
                     LVLEILHILGEKLKQVVYGRQFIGQAGDNLTNVSLFEEHCEHLFCDLICLSLNRFDKV
                     MPSEALLISHCPCSCVKELWVLLIHLLDHRRKWSVADSFWNWLNKLLRTLFEKSSDQR
                     RSSVSLTQAKDPLGFSWWISVHVASLYQIDRHGVSDKMKQMESNWSFIEELLKRSVTV
                     QDSILEEQLRMHLHCCLTLCDFWEPNISVVTILWEYYSKNLNSSFSISWLPLKGLTNI
                     IKSPLSMLTLVRNCCSDKQDPDLYKSSSSYIIFLCILAKVVKKAMRTSGPHPWKQVKG
                     RIYSKFHQKRMEELTEVGLQNFFSLFLLLAAVAEIEDVASHVLDLLRFLRPASMSSHG
                     ALVWKGQMAFLLMYAQKNLDIGVWAEKLSCEFQEKAKEFLVSKNDEMVQRHALWTLLC
                     IYIDGVQEVFETSSCLYPSHEHLLNDGFSMLLPACRESELRTVLNFLQAVLARIRSVH
                     QQLCQELQRENVDLTVQSSLSAKERPLAAVAGALWRHFFSFLKSQRMTQVVPLSQLAD
                     AAADFTLLAVDMPNTAPPDLQPQPVISIIQLFGWDDIIWPQVVARYLSHLLQNSTVYE
                     ALSQSSCVSSQSLTIRSWVRCVLQMHIKHLSDPDLLIDVNPEQAVEKEYMEQLAEMTR
                     LLFTLSEVKSVFSKAQIEQLPSPDDPKQALIQFLEAVGVTYRTLQTFSDKSAMVTKSL
                     EYLGEVLKYIKPYLGKKVSSAGLQLTYGIMGILVKSWAHIFATSKAQKLLFRIIDCLL
                     LPHTVLQQDKELPGPMLTAIQKTLPLYLQGICIVCCQSQNPNAYLNQLLRNVIEQYIG
                     RFLPTSPCVSDLGQHPVLLALRNPASVPSMTPLRKHTVHAIRKSYLEFKGSSPPPRLA
                     SVLAFVLQLFKDTEMGACDLELLLPGILKCLVLVNEPQVKKLATENLQCMVQTCQVGS
                     EGGPATQLTSLFRQFIQDYGMQYSYQVYSILETVATLNQHVVIQLIPTLTQSLKDSEL
                     KWGLGRNIAQREAYSRLLSGLGQVGQGEKQRLEK"
     exon            616..741
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            742..791
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            792..879
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1060
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1151
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1282
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1396
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1573
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1636
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1756
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1983
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2493
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2687
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2838
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2987
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3130
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3290
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3460
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3672
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3836
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3933
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4101
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4478
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4456..4461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /note="hexamer: ATTAAA"
     polyA_site      4478
                     /gene="Mms22l"
                     /gene_synonym="F730047E07Rik; Gm134"
                     /note="major polyA site"
ORIGIN      
        1 ggaatttcgc ctgcttccgg tttcctctgc ccggcgctgc gttccgcgtt ctaggtttgc
       61 gggggcctgc ggttttcccg cgcgctcgcc cgccccgaac gccgcgctgg gactgaggga
      121 gacggaggga ggcggcgggg ctgcgtgctc catccgggcc gtgcggggaa accagcctga
      181 ggaggtgcgc gagggcctca aaacccacgg cagcccggag ggagcgaggg cggcgttgga
      241 aggcttggcg gctccggcgc ctgcgggacg cccggaggat tctggacctg ttgccttcag
      301 cttctctgct ttcacgttgg tttccccggg tgctgagggc acattttgga tctccgaggt
      361 agctccttac cgtactttca gcctcttgca gcttgtcttc ggagcccgaa cgtaactgcc
      421 cggaaccgcg gtggcattgc agagcaggat gtaaataatg gatggctgtt cagcagcgtc
      481 gaccttcttg actgacagct tagagctgga gctggggaca gagtggtgca aacccccctg
      541 cttttcttgc gcttttgaca acagagaagg aaaattctct ggagagtcct accttgccag
      601 tggcgccctt aagcggttaa ttttaaatct tgatccatta ccaactaatt ttgaagagga
      661 tacagtagaa ctatttggct tccaatgggt tacagaaaca gcgctagtct attcctgtag
      721 agagctcttt catttattca ggcaacagat atttaacttg gagtccttgg tacaagtcag
      781 ctgtgatttt gggaaaatag ccaccttgca cgccaaagca gacagtatta ggcaacaatg
      841 tgtagtgttc cttcactaca ttaaagtttt catcttcagg tgtctgaaag tacaggaagc
      901 agagagccac agtcgccctg cccatcccta tgaggctttg gaagcccagc ttccctccat
      961 gttggtcgat gagctccgtg gattacttct gtacattgga catctagctg cacttcccag
     1021 tgttactgta ggagcgtttg taaatcaaaa ccagatgaag ctcttccctc catcatggca
     1081 tttattacat ctctatttag atacccactg gctggtgttg gaaatactgc atattctggg
     1141 agaaaaattg aaacaagttg tttatggtcg tcagtttatt ggtcaggcag gtgacaattt
     1201 aaccaatgtc agcctctttg aagaacattg tgaacatctt ttctgtgact taatatgcct
     1261 gtcactcaac agatttgaca aggtcatgcc ttcagaagca ctactgatta gtcactgccc
     1321 atgctcctgt gttaaagaat tatgggttct acttattcat cttttagacc acagaaggaa
     1381 atggtctgtt gcagattcat tttggaattg gttgaataaa ctacttagaa cactttttga
     1441 aaagtcaagt gaccaacgaa gatcttctgt gtctctaacc caggccaagg atccattagg
     1501 ctttagttgg tggattagtg ttcatgtagc atcattgtac cagattgatc gccatggtgt
     1561 gtcagacaaa atgaaacaga tggaatccaa ttggagcttt atagaagaac ttttgaaacg
     1621 gtccgtcact gttcaggata gtatactaga agaacaattg cgaatgcatc ttcattgttg
     1681 tttgacactt tgtgatttct gggagccaaa tatttcagtt gtcaccattt tatgggagta
     1741 ttattctaag aacctgaata gctccttcag tatttcctgg cttcctttga aaggccttac
     1801 caatattatc aagtctccac tgtcgatgct tacactggtg aggaactgct gtagtgataa
     1861 acaagaccct gacctctata agtccagcag cagttacatc atttttcttt gcattctggc
     1921 aaaagttgtt aagaaagcaa tgagaaccag cggccctcac ccttggaagc aagttaaagg
     1981 aagaatatat tctaagtttc atcaaaaaag aatggaagaa ctaactgaag ttggcctaca
     2041 gaactttttc agcctttttc tactgttagc agctgttgca gagatagaag atgtagcaag
     2101 ccatgtttta gacctccttc gtttcctcag gcctgcctcc atgtcatctc atggagccct
     2161 tgtttggaag ggtcagatgg catttctcct gatgtatgcc cagaaaaact tggacattgg
     2221 tgtttgggct gagaaactgt catgtgaatt ccaagagaaa gcaaaggaat tcttggtatc
     2281 taagaatgat gaaatggtac agagacatgc tctatggaca ctgctttgca tctatattga
     2341 tggtgttcaa gaagtatttg agaccagcag ttgcttgtat ccttctcatg agcatcttct
     2401 caatgatgga tttagcatgt tactgccagc ctgtcgagaa tctgaactta ggacagtcct
     2461 gaactttcta caagctgttc tggcgagaat caggagtgtt catcagcaat tgtgtcagga
     2521 acttcaaaga gagaatgtgg acctaactgt gcagtcttca ttatcggcta aagagcgccc
     2581 cctggctgcc gtcgctggtg cactgtggag gcatttcttt tcctttctca agagtcagag
     2641 aatgacacaa gttgtgcctc tctcccagct tgcagatgcc gctgcagatt ttactttgct
     2701 ggcagtggac atgccaaaca cagcaccacc agatcttcag ccacagccag ttatatcaat
     2761 aattcagctt tttggttggg atgatatcat ctggccccaa gttgtagcaa gatatttaag
     2821 tcatttgcta caaaatagca cagtatatga agcactttct cagtcaagtt gcgtgtcttc
     2881 tcagtcctta actataagat catgggtccg ttgtgttttg caaatgcaca taaaacacct
     2941 ctctgaccct gacttgctga ttgatgtgaa tcctgaacag gccgtggaaa aagagtacat
     3001 ggaacagctg gctgaaatga caagattact atttacactc tcagaagtaa agagtgtctt
     3061 ctcaaaggct caaatagagc aattacccag cccagacgat cccaagcaag cgcttattca
     3121 gttcctggag gctgttggtg tgacttacag gactctgcag acattttctg ataaatctgc
     3181 catggtcaca aagtccttag aataccttgg tgaagtatta aaatatataa agccttattt
     3241 ggggaaaaaa gtttccagtg cagggttgca gctgacttac gggataatgg gaattcttgt
     3301 taagtcatgg gcacacatct ttgccacctc taaagcacag aagctacttt ttcggataat
     3361 agactgtttg ttgctgccac atacagtgct acagcaagac aaggagctgc ctggacccat
     3421 gctgactgca attcagaaga cgcttcctct ctatctacag ggcatatgta ttgtatgctg
     3481 ccagtctcaa aatccaaatg cctacttgaa tcagttgctg aggaatgtca ttgagcagta
     3541 catagggagg tttctcccaa cctcgccctg tgtttcagat ctgggacagc accctgttct
     3601 gttggcactg agaaaccctg cctctgttcc ctcgatgacg cctctaagaa agcacactgt
     3661 ccatgccata aggaaatcct accttgagtt caaagggtcc tcaccccctc ctcgattagc
     3721 atccgtattg gccttcgtcc ttcagctctt caaggacacc gaaatgggtg cctgtgacct
     3781 tgagctgctc cttcctggca tcctgaaatg tttggtgttg gtaaatgaac cccaagttaa
     3841 aaagctggcc acagagaacc tgcagtgcat ggtacaaacc tgccaagtgg ggtcagaagg
     3901 aggacctgcc acccagctga cttctctgtt taggcagttc atccaggact atggtatgca
     3961 atacagttat caagtataca gcatcctaga gacagtagca acgctgaatc agcacgttgt
     4021 catccaattg attcctaccc tcactcagtc tctgaaggat tcagagctca aatggggcct
     4081 cggcagaaat attgcacaaa gggaagcata tagcagactt ttatctggcc taggacaggt
     4141 aggacagggc gagaagcaga gactggaaaa gtgacgaact gtgacgatgc tgctgccttc
     4201 ctgcctggga ggtctctgtc tacagctctg tgggctaccc cagctgctac tgtgattaat
     4261 tgtgtactgt tgtatcacaa ataattccct tcattgcctg catgtaggaa gtgtgtgtgt
     4321 gtgtgtgtgt gtgtgtgtgt gtacacgtgt gtgtacgtgt gtgtacatga ggagtgaagg
     4381 ctaattagta actgtataat aggacataag gaacactgta aaactctgct ctatcttgaa
     4441 gagattttta attaaattaa agattctttg aaacaaaaaa aaaaaaaaaa aaa
//
