LOCUS       NM_153127               3935 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus multimerin 2 (Mmrn2), mRNA.
ACCESSION   NM_153127
VERSION     NM_153127.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3935)
  AUTHORS   Pellicani,R., Poletto,E., Andreuzzi,E., Paulitti,A., Doliana,R.,
            Bizzotto,D., Braghetta,P., Colladel,R., Tarticchio,G.,
            Sabatelli,P., Bucciotti,F., Bressan,G., Iozzo,R.V., Colombatti,A.,
            Bonaldo,P. and Mongiat,M.
  TITLE     Multimerin-2 maintains vascular stability and permeability
  JOURNAL   Matrix Biol 87, 11-25 (2020)
   PUBMED   31422156
  REMARK    GeneRIF: Multimerin-2 maintains vascular stability and
            permeability.
REFERENCE   2  (bases 1 to 3935)
  AUTHORS   Liang,Q., Su,L., Zhang,D. and Jiao,J.
  TITLE     CD93 negatively regulates astrogenesis in response to MMRN2 through
            the transcriptional repressor ZFP503 in the developing brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (17), 9413-9422 (2020)
   PUBMED   32291340
  REMARK    GeneRIF: These results reveal that CD93 is a negative regulator of
            the onset of astrogenesis and provide insight into therapy for
            psychiatric disorders.
REFERENCE   3  (bases 1 to 3935)
  AUTHORS   Lacko,L.A., Hurtado,R., Hinds,S., Poulos,M.G., Butler,J.M. and
            Stuhlmann,H.
  TITLE     Altered feto-placental vascularization, feto-placental malperfusion
            and fetal growth restriction in mice with Egfl7 loss of function
  JOURNAL   Development 144 (13), 2469-2479 (2017)
   PUBMED   28526753
REFERENCE   4  (bases 1 to 3935)
  AUTHORS   Noy,P.J., Lodhia,P., Khan,K., Zhuang,X., Ward,D.G., Verissimo,A.R.,
            Bacon,A. and Bicknell,R.
  TITLE     Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and
            tumour growth
  JOURNAL   Oncogene 34 (47), 5821-5831 (2015)
   PUBMED   25745997
REFERENCE   5  (bases 1 to 3935)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   6  (bases 1 to 3935)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   7  (bases 1 to 3935)
  AUTHORS   Danussi,C., Spessotto,P., Petrucco,A., Wassermann,B., Sabatelli,P.,
            Montesi,M., Doliana,R., Bressan,G.M. and Colombatti,A.
  TITLE     Emilin1 deficiency causes structural and functional defects of
            lymphatic vasculature
  JOURNAL   Mol Cell Biol 28 (12), 4026-4039 (2008)
   PUBMED   18411305
REFERENCE   8  (bases 1 to 3935)
  AUTHORS   Doliana,R., Veljkovic,V., Prljic,J., Veljkovic,N., De Lorenzo,E.,
            Mongiat,M., Ligresti,G., Marastoni,S. and Colombatti,A.
  TITLE     EMILINs interact with anthrax protective antigen and inhibit toxin
            action in vitro
  JOURNAL   Matrix Biol 27 (2), 96-106 (2008)
   PUBMED   17988845
  REMARK    GeneRIF: Mmrn2 interacts with anthrax protective antigen.
REFERENCE   9  (bases 1 to 3935)
  AUTHORS   Braghetta,P., Ferrari,A., De Gemmis,P., Zanetti,M., Volpin,D.,
            Bonaldo,P. and Bressan,G.M.
  TITLE     Overlapping, complementary and site-specific expression pattern of
            genes of the EMILIN/Multimerin family
  JOURNAL   Matrix Biol 22 (7), 549-556 (2004)
   PUBMED   14996434
REFERENCE   10 (bases 1 to 3935)
  AUTHORS   Leimeister,C., Steidl,C., Schumacher,N., Erhard,S. and Gessler,M.
  TITLE     Developmental expression and biochemical characterization of Emu
            family members
  JOURNAL   Dev Biol 249 (2), 204-218 (2002)
   PUBMED   12221002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077884.1, AK134285.1 and AC160930.2.
            
            On Jan 18, 2007 this sequence version replaced NM_153127.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077884.1, AK134285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2218              AK077884.1         3-2220
            2219-3390           AK134285.1         2258-3429
            3391-3935           AC160930.2         24716-25260         c
FEATURES             Location/Qualifiers
     source          1..3935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 20.81 cM"
     gene            1..3935
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /note="multimerin 2"
                     /db_xref="GeneID:105450"
                     /db_xref="MGI:MGI:2385618"
     exon            1..275
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2943
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /note="elastin microfibril interfacer 3; Multimerin-2"
                     /codon_start=1
                     /product="multimerin-2 precursor"
                     /protein_id="NP_694767.3"
                     /db_xref="CCDS:CCDS36876.1"
                     /db_xref="GeneID:105450"
                     /db_xref="MGI:MGI:2385618"
                     /translation="MIPTLLLGFGVYLSWGLLGSWAQDPGTKFSHLNRPGMPEGWRLG
                     AEDTSRDPIRRNWCPYQKSRLVTFVAACKTEKFLVHSQQPCPQGAPDCQGVRVMYRVA
                     QKPVYQVQQKVLISVDWRCCPGFQGPDCQDHNPTANPEPTEPSGKLQETWDSMDGFEL
                     GHPVPEFNEIKVPQEQQENLLQNLQNDAQSVEDGFPGSWEAPPSNLTDEMTEANLTEF
                     EFPGRTSEHLLQPHIDAFLKAHFSPIWKNFNDSLHSLSQAIRNLSLDVEANHQAIKMI
                     QEGTVARADFQELGAKFEAKVQQNSQRLGQLWQDVEDQLHAQRRSVHHALSDVQAEVS
                     TKLKQLVKAQELPGANGSLVMASAAAAARPEPESLQARLGQLQRNLSALHMVTSQREE
                     ELQSTLKNMDSVLKQHAEEIKELYSESDETFDQISKVERQVEELLVNHTGLRELRVIL
                     MEKSLIMEENKEEIERQLLELNLTLQHLHAGHADLIKYVKDCNCQRVNSDVDVAPEGH
                     RDVMHTLEETQVSLDEQHQLDGSSLQALQSTVDAMSSAMDAYRGEGERARAERARIRS
                     QLRALDHAVEALKTAANGTRKEIRLLHGSFTALLEDALRHQAVLAALFGEEMIDEMSE
                     EAPRPLPLDYEQIRLALQDAASGLQEQAIGWEDLATRVEALEKAAGGFVEQHPQLAEG
                     LEPSHDSGREEEAMTLAELEQEIRRLSSDVKQIGQCCEASWAASLNSSLEDLHSMLLD
                     TQHGLRQHRQLFHNLFQNFQGLVASNISLDLGKLQAMLSKKDKKQPRGPGESRKRDKK
                     QVVMSTDAHAKGLELWETGSPVAFYAGSSEGATALQMVKFNTTSINVGSSYFPEHGYF
                     RAPKRGVYLFAVSITFGPGPGMGQLVFEGHHRVPVYSTEQRGGSTATTFAMVELQKGE
                     RAWFELIQGSATKGSQPGTAFGGFLMFKT"
     exon            276..404
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..511
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..592
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..766
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..2560
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..3935
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3915..3920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /note="hexamer: AATAAA"
     polyA_site      3935
                     /gene="Mmrn2"
                     /gene_synonym="Emilin3; EndoGlyx-1; ENDOGLYX1"
                     /note="major polyA site"
ORIGIN      
        1 tttgttgtcc tcgtgttttc ttttctttct gacatttcgc ttgaagacca catcaccagc
       61 aaatttgaga gtcacttgta aggctgagca tcagcacagg agcccctcac catgatcccg
      121 acactgctgc tgggctttgg ggtgtacctg agctggggac tgctagggtc ctgggcacag
      181 gaccccggta ccaagttctc ccatctcaat aggcccggca tgcctgaagg ctggagacta
      241 ggggctgagg ataccagcag agaccccatc agacggaact ggtgtcctta ccagaagtcc
      301 aggctagtca cctttgtagc tgcttgcaaa acagagaaat tcctggtcca ttcacagcag
      361 ccatgtccac agggagcccc tgactgccag ggagtcagag tcatgtatcg agtggcccag
      421 aagccagtgt accaggtcca gcagaaggtg ctgatctctg tggactggcg gtgctgccca
      481 gggttccagg gaccagactg ccaggaccac aatcccacag caaaccctga gcccacagag
      541 ccaagtggta aactccagga gacttgggac tcgatggatg gctttgaact tggtcaccct
      601 gtcccagagt ttaatgagat taaggtgcca caagaacaac aggaaaacct gcttcaaaat
      661 ctccagaatg atgcccagtc agtagaagat ggctttccag gctcttggga agccccaccc
      721 agcaacctca cagatgagat gacagaagcc aatctaacag aattcgagtt tcctggcagg
      781 acatcagagc acctgctgca gccccatatt gatgcattcc tgaaagcaca cttcagtccc
      841 atctggaaga acttcaacga cagcttgcac agcctctccc aggccatcag aaacttgtct
      901 cttgatgtgg aggccaatca ccaggccatc aagatgatcc aggagggcac agtggctagg
      961 gctgacttcc aagagcttgg tgccaagttt gaggccaagg tccagcagaa tagccagaga
     1021 ctgggccaac tgtggcagga tgtggaggac cagctgcatg cccagcgccg atcggtgcat
     1081 catgccctct ctgatgtcca ggctgaggtg agcaccaagt taaagcagct tgtcaaggct
     1141 caggaacttc caggggccaa tggcagcctg gtgatggcat ctgcagcagc ggcagcaagg
     1201 ccagagccag agagcctgca ggccaggcta gggcagctgc agagaaacct ctctgctctg
     1261 cacatggtca ctagccagag ggaggaggag ttgcagagca ccctcaagaa catggacagc
     1321 gtcctgaagc agcacgccga agagatcaaa gagctctatt ctgaatcgga tgagaccttc
     1381 gaccagatca gcaaggtaga gaggcaggtg gaggagctgc tggtgaacca caccgggctt
     1441 cgagagctgc gggtgatcct aatggaaaag tccctgatca tggaggagaa caaagaggag
     1501 atagagcggc aactgttgga actcaacctt accctgcagc atctgcatgc gggtcatgca
     1561 gacctcatta agtatgtcaa ggactgcaac tgccaaaggg tcaactctga cgtggatgtc
     1621 gctccggagg gccacaggga tgtcatgcac accctagaag agacccaagt gagcctggac
     1681 gaacagcacc agctagacgg ttcttctttg caggccctgc aaagcactgt agatgccatg
     1741 tcttcagcaa tggatgccta tagaggagag ggtgaacggg cccgggctga aagggcacgg
     1801 atacggagcc aactgcgggc tctggatcat gctgtggaag cgctgaagac agcggcgaat
     1861 ggaacccgca aagagatacg cctactgcac ggctccttca cagccctgct ggaggatgcc
     1921 ctgcgacatc aggccgtgct agctgcactc ttcggggagg agatgataga cgagatgtca
     1981 gaggaggccc ctcgccctct gccactggat tatgagcaga tccgcctagc cctgcaggac
     2041 gcggccagtg ggctacagga acaggcgatt ggttgggagg acttggccac ccgggtggag
     2101 gcattggaga aggccgcagg tggctttgtg gagcagcacc cacagttggc agagggactt
     2161 gagcccagcc acgactctgg gagagaggag gaagccatga ctttggcgga gctggagcag
     2221 gagattcggc gcctgagttc tgatgtcaag cagattgggc agtgctgtga ggcctcctgg
     2281 gctgcctccc tcaatagctc ccttgaagac ctacacagca tgctcttgga cacccagcac
     2341 ggcctgagac agcaccggca gctcttccac aacctcttcc agaacttcca aggtctggtg
     2401 gcaagcaaca tcagcctaga cttggggaag ctgcaggcca tgttgagtaa gaaagataag
     2461 aagcaaccga gaggcccagg agaatcccgg aagagggata agaagcaagt ggtgatgtct
     2521 acagatgcac acgccaaagg tctggagctc tgggagacag gctcccctgt ggccttctat
     2581 gccggttctt cagaaggggc cactgctctg cagatggtga agttcaacac cacatccatc
     2641 aatgtgggca gcagctactt tcctgaacat ggctacttcc gagctcccaa acgtggcgtc
     2701 tacttgtttg ctgtgagcat tacatttggc ccaggcccag gaatggggca gctggtattt
     2761 gaaggtcatc accgggttcc agtctacagt acggaacaga ggggcgggag cacagccacc
     2821 acttttgcta tggtagagct acaaaagggt gagagagcgt ggtttgagtt aatccaaggg
     2881 tcagcaacca aagggagcca accaggcact gcatttgggg gcttcctgat gttcaagacc
     2941 tgaaccctgg gctcggctca gcttgtatca gacatggtag atccgcctgc tgctcttaga
     3001 ctgaggctct ggccagcaaa ggctggagaa catctagtgg cctagctctt ccctggacac
     3061 cttctgcaaa gaccctgcgg ccagcagcac gtaccttctt ctggacacac aggttgggga
     3121 ggccagaata ctgctctctg gactgggccg gggcctggag tgggagctgg gatttccatg
     3181 ccttccccaa tggcacggct cggcttgtct ctgagacact tcctcagttc tacagctttt
     3241 ctttttctct cccttgtggt tggaaacttg tacacttacg cctttttcgg tttccacttt
     3301 tctgtgttag aaagtcactg tttctcagaa ggaatgtcta cagtgatggg tttgccatgc
     3361 agaaaggtcc cagattctct ttccaatgtc tcaaaaaaaa aaaaaaaaaa aaaaaaaaga
     3421 agaagaagaa gaaaatgaag attttttttt tacccccccc ccccccatga aactggaaac
     3481 aggtctccaa ttactacaga aaagctaatc aaaaacagtc tttctagttt cagaagggag
     3541 ccaacacatg gttgaattag ccctgggtcc agtctccagc actgtgcaca cctatggtct
     3601 cagcatatgg agtaagcatg aagttcagag ctatcctcag cttcataaca agttcaaggc
     3661 tagcctggga tatgggagac cctgtctcaa aacagcaaaa gaagttacat taactcccag
     3721 ccacactttg tctttgttta tttaatttta atatcacgcc ctgcttcact ctgtaaaggc
     3781 caacatatca aatagggaca atgttgtgca tggccttcac ccttcttatt catctatcaa
     3841 gactgtgcca accccagcat ctctaaggaa gggaaggagg gaaattaaac cctactggta
     3901 gtgaccgact ttggaataaa gtgatactct ccaaa
//
