LOCUS       NM_027613               4636 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus multimerin 1 (Mmrn1), transcript variant 1, mRNA.
ACCESSION   NM_027613 XM_284198 XM_909131
VERSION     NM_027613.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4636)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4636)
  AUTHORS   Leatherdale,A., Parker,D., Tasneem,S., Wang,Y., Bihan,D., Bonna,A.,
            Hamaia,S.W., Gross,P.L., Ni,H., Doble,B.W., Lillicrap,D.,
            Farndale,R.W. and Hayward,C.P.M.
  TITLE     Multimerin 1 supports platelet function in vivo and binds to
            specific GPAGPOGPX motifs in fibrillar collagens that enhance
            platelet adhesion
  JOURNAL   J Thromb Haemost 19 (2), 547-561 (2021)
   PUBMED   33179420
  REMARK    GeneRIF: Multimerin 1 supports platelet function in vivo and binds
            to specific GPAGPOGPX motifs in fibrillar collagens that enhance
            platelet adhesion.
REFERENCE   3  (bases 1 to 4636)
  AUTHORS   Chaprov,K.D., Goloborshcheva,V.V., Tarasova,T.V., Teterina,E.V.,
            Korokin,M.V., Soldatov,V.O., Pokrovskiy,M.V., Kucheryanu,V.G.,
            Morozov,S.G. and Ovchinnikov,R.K.
  TITLE     Increased Expression of the Multimerin-1 Gene in alpha-Synuclein
            Knokout Mice
  JOURNAL   Dokl Biol Sci 494 (1), 260-263 (2020)
   PUBMED   33083886
  REMARK    GeneRIF: Increased Expression of the Multimerin-1 Gene in
            alpha-Synuclein Knokout Mice.
REFERENCE   4  (bases 1 to 4636)
  AUTHORS   Liron,T., Raphael,B., Hiram-Bab,S., Bab,I.A. and Gabet,Y.
  TITLE     Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying
            mutated alpha-synuclein and multimerin-1 genes
  JOURNAL   J Cell Physiol 233 (1), 371-377 (2018)
   PUBMED   28266709
  REMARK    GeneRIF: C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying
            mutated alpha-synuclein and multimerin-1 genes, have an altered
            bone phenotype.
REFERENCE   5  (bases 1 to 4636)
  AUTHORS   Lacko,L.A., Hurtado,R., Hinds,S., Poulos,M.G., Butler,J.M. and
            Stuhlmann,H.
  TITLE     Altered feto-placental vascularization, feto-placental malperfusion
            and fetal growth restriction in mice with Egfl7 loss of function
  JOURNAL   Development 144 (13), 2469-2479 (2017)
   PUBMED   28526753
REFERENCE   6  (bases 1 to 4636)
  AUTHORS   Reheman,A., Tasneem,S., Ni,H. and Hayward,C.P.
  TITLE     Mice with deleted multimerin 1 and alpha-synuclein genes have
            impaired platelet adhesion and impaired thrombus formation that is
            corrected by multimerin 1
  JOURNAL   Thromb Res 125 (5), e177-e183 (2010)
   PUBMED   20138333
  REMARK    GeneRIF: Our data suggest that multimerin 1 supports platelet
            adhesive functions and thrombus formation, which will be important
            to verify by generating and testing selective multimerin 1
            deficient mice.
REFERENCE   7  (bases 1 to 4636)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   8  (bases 1 to 4636)
  AUTHORS   Specht,C.G. and Schoepfer,R.
  TITLE     Deletion of multimerin-1 in alpha-synuclein-deficient mice
  JOURNAL   Genomics 83 (6), 1176-1178 (2004)
   PUBMED   15177571
REFERENCE   9  (bases 1 to 4636)
  AUTHORS   Braghetta,P., Ferrari,A., De Gemmis,P., Zanetti,M., Volpin,D.,
            Bonaldo,P. and Bressan,G.M.
  TITLE     Overlapping, complementary and site-specific expression pattern of
            genes of the EMILIN/Multimerin family
  JOURNAL   Matrix Biol 22 (7), 549-556 (2004)
   PUBMED   14996434
REFERENCE   10 (bases 1 to 4636)
  AUTHORS   Leimeister,C., Steidl,C., Schumacher,N., Erhard,S. and Gessler,M.
  TITLE     Developmental expression and biochemical characterization of Emu
            family members
  JOURNAL   Dev Biol 249 (2), 204-218 (2002)
   PUBMED   12221002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014984.1, AK137556.1, AK036724.1 and BB035031.1.
            
            On or before Jul 24, 2009 this sequence version replaced
            XM_909131.2, XM_284198.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036724.1, BC137623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               AK014984.1         254-824
            572-2657            AK137556.1         411-2496
            2658-4277           AK036724.1         2497-4116
            4278-4629           AK137556.1         4117-4468
            4630-4631           BB035031.1         221-222
            4632-4636           AK137556.1         4471-4475
FEATURES             Location/Qualifiers
     source          1..4636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 29.22 cM"
     gene            1..4636
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /note="multimerin 1"
                     /db_xref="GeneID:70945"
                     /db_xref="MGI:MGI:1918195"
     exon            1..822
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..3877
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="multimerin-1 isoform a precursor"
                     /protein_id="NP_081889.1"
                     /db_xref="CCDS:CCDS51799.1"
                     /db_xref="GeneID:70945"
                     /db_xref="MGI:MGI:1918195"
                     /translation="MLGLKFLVLLSILWGRVFRLTNTQHSWTAPKDEDASLTPNPASA
                     SVSEILSLQVLSATQNPSTQGPAAAERSSEDDVLLQSTSQPSETSTPPDGRSQTSLEK
                     TGTAVVSLPLSLQDKPSIKPSTGAGTVMLANATLKFLQSFSRKSDQQEVSTKSAGDMG
                     NRSARETHLRRSDNSRNQRPSYQKPSFETTRGKNWCAHVHTKLSPTVILDTGSHLPSG
                     RGSCGWYSSGLCSRRSQKTSNAVYRMQHKIVTSLEWRCCPGYIGPNCQLKVEEQQQLA
                     HSNQAESHTAVDQGRAQQQKQDCGDPAMIQKLAEQLSQQERKLSLLQKKVDNASLVAD
                     DMRNAYLSLEGKVGEDNSRQFQSFLKALKSKSIEDLLKNIVKEQFKVFQDDMQETTAQ
                     IFKTVSSLSEDLESTRQAVLQVNQSFVSSTAQKDFAFMQENQPTWKDITDLKNSIMNI
                     RQEMALTCEKPVKELEAKQAHLEGALRQEHSQIVLYHQSLNETLSKMQEAHTQLLSVL
                     QVSGTENVATEESLNSNVTKYISVLQETASKQGLMLLQMLSDLHVQESKISNLTILLE
                     MEKESARGECEEMLSKCRHDFKFQLKDTEENLHVLNQTLSEVIFPMDIKVDKMSEQLN
                     DLTYDMEILQPLLEQRSSLQHQVIHKPKEATVTRRELQNLIGAINQLNVLTKELTKRH
                     NLLRNEVQSRGEAFERRISEHALETEDGLNKTMTVINNAIDFVQDNYVLKETLSAMTY
                     NPKVCECNQNMDNILTFVSEFQHLNDSIQTLVNNKEKYNFILQIAKALTAIPKDEKLN
                     QLNFQNIYQLFNETTSQVNKCQQNMSHLEENMLSVTKTAKEFETRLQGIESKVTKTLI
                     PYYISFKKGGILSNERDVDLQLKVLNTRFKALEAKSIHLSVSFSLLNKTVRELSMACR
                     NASTGTCGQNALIPRWTKGSLPGSQSSQKSLTELVESIVEIKTQAALSNLTWNVDRLL
                     SDTLANIVKPQKQIKLQKKPNTLKKTVNMTTILIGRTQRNTDTIIHPVAQEHSSCSSF
                     PCQNGGTCISGRSNFICACRHPFMGDTCTVKIKEDDAVAPDFSKGSYRYAPMVAFFVS
                     HTHGMTAPGPILFNDLSVNYGASYNPRTGKFRIPYLGVYIFKYTIESFSAHISGFFVV
                     DGVDKLRFESENADNEIHCDRVLTGDALFELNYGQEVWLRLVKGTIPIKYPPVTTFSG
                     YLLYRT"
     exon            823..942
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1049
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1151
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1325
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..3302
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3455
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..4636
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4606..4611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /note="hexamer: AATAAA"
     polyA_site      4633
                     /gene="Mmrn1"
                     /gene_synonym="4921530G03Rik; Emilin4; Mmrn"
                     /note="major polyA site"
ORIGIN      
        1 cttctcagag gtccctcacc actccattga tccatcctag gagggtcaca gatcgcagag
       61 caaccacaga aacaggaaaa cgaacttcct gagtgcactg caaacacaga aacctgtttc
      121 ctttgcgcac atcaaattgt caaaacccaa ttttgaaact ttcagtacgg aattggctat
      181 cagaaaggct ggaagaactt cgtctctcga ttccccatga atttttgtgc ctaaatttac
      241 tgccatgctg ggactaaagt ttcttgtcct gctttctatt ttatggggca gggtcttcag
      301 gcttaccaac actcaacatt catggactgc gcctaaggat gaagacgcct cactgacccc
      361 gaaccccgct tcagcttctg taagtgaaat actgagcctc caagtgctct cggccactca
      421 gaacccctcc actcagggtc ctgcagctgc tgagagatct tctgaagacg atgttctcct
      481 acagtcaaca tcacagccct ctgagacaag cacccctcct gacgggagaa gccaaacatc
      541 cctagagaag acagggacag cagtggtatc cctgcctctc tctcttcagg acaaacccag
      601 catcaagccc agcaccggag caggaactgt catgcttgct aatgccacgt tgaaattcct
      661 tcagagtttt tccagaaagt ctgatcaaca agaagtctcc actaagtcgg ctggcgacat
      721 gggaaacagg tctgcaaggg aaacacacct caggagaagt gacaacagca gaaatcaaag
      781 acccagctat caaaaaccca gttttgaaac aactagaggg aagaattggt gtgctcatgt
      841 tcataccaag ttatccccga cagtgatact ggacactggc tctcatttac caagtggaag
      901 aggttcttgt ggctggtaca gcagtggact ctgttccaga agatctcaga agacatccaa
      961 tgctgtctat agaatgcagc ataagattgt cacctcatta gaatggagat gctgtcctgg
     1021 atacataggt ccaaactgtc agctcaaagt ggaagaacag cagcagctgg cacacagtaa
     1081 ccaggctgaa agtcacaccg ctgttgacca aggaagagct cagcagcaga agcaagactg
     1141 tggtgaccca gccatgattc aaaaactggc agagcagctg agccaacagg agaggaagct
     1201 gtcgcttctg cagaagaagg ttgacaatgc ttctctggtg gcagatgaca tgaggaatgc
     1261 atacctctca ctagaaggga aagttggaga ggacaacagc aggcaatttc aatcttttct
     1321 aaaagctcta aaatcaaaga gtattgagga tctgctaaag aacatcgtaa aagaacaatt
     1381 taaagtcttc caagatgata tgcaggagac gactgcccag atcttcaaga ctgtgtcaag
     1441 tctatcagag gacttggaaa gtaccaggca ggcagttcta caagtgaacc agtcctttgt
     1501 ttcatcaaca gcccagaaag actttgcttt catgcaagaa aatcagccca cgtggaagga
     1561 catcacagat ctaaagaaca gcatcatgaa catcaggcag gaaatggcct tgacctgtga
     1621 gaagcctgtc aaggaactgg aagcaaaaca agctcatttg gaaggagcac taagacagga
     1681 gcactcacag attgttctgt accaccaatc cctcaatgaa actctctcta aaatgcagga
     1741 agcacacaca cagctgttat cagttctaca agtatcagga acagagaatg tcgccactga
     1801 ggaatccctc aacagtaatg tcactaagta tatatctgta ctacaggaga cagcaagcaa
     1861 gcaaggtctg atgctgctgc agatgctcag tgatttgcat gtccaagaga gcaagatcag
     1921 caaccttacc atccttttgg agatggagaa agaatcagcc aggggagaat gtgaggaaat
     1981 gctatctaaa tgcaggcatg actttaaatt tcaactcaag gacacagagg aaaatctgca
     2041 tgtgttaaat caaacactgt ctgaggttat ctttcccatg gacatcaagg tggataaaat
     2101 gagtgagcag ctgaatgatt tgacatatga catggagatc cttcagcctt tgctggagca
     2161 gaggtcgtcg cttcaacacc aggttataca caagccaaag gaagccacag ttactcgcag
     2221 agagctacaa aacctgatcg gtgccatcaa ccaactgaac gttcttacca aagaacttac
     2281 aaaaagacac aacttactga gaaatgaagt gcagagccgt ggtgaagcct ttgagagacg
     2341 catcagtgag catgccttag aaacagaaga tggcctaaat aagacaatga ctgttataaa
     2401 caatgccatc gattttgttc aagataacta tgtgttaaag gagactttaa gtgctatgac
     2461 atataatccc aaggtttgtg agtgtaacca aaatatggac aatattttaa catttgtttc
     2521 tgaattccag catttgaatg attctattca gactttggtc aataacaaag agaagtataa
     2581 ttttattttg caaattgcta aagcccttac agcgattcct aaagatgaga aactaaacca
     2641 gttaaacttt caaaatattt atcaactatt caatgaaacc acttcccagg tgaacaaatg
     2701 tcagcaaaac atgagtcatt tagaagaaaa tatgctttca gtaacaaaga ctgccaaaga
     2761 gtttgaaact cgtttgcaag gcattgaatc taaagtgacc aagacactca taccttacta
     2821 tatttcattt aaaaaaggtg gcatcctatc aaatgagaga gatgttgatc ttcagctgaa
     2881 ggtactaaat accagattta aggcactgga agcaaagtcc atccatcttt ccgtgagttt
     2941 ctctttgctt aataaaactg tccgtgagct ttcaatggca tgccgtaatg cttctacagg
     3001 tacctgtgga cagaatgcac tcatacccag gtggaccaaa ggctcactgc caggcagtca
     3061 gagttctcag aaaagtctga cagaacttgt ggaatcaata gttgaaatta aaactcaagc
     3121 cgccctatct aatttaactt ggaatgttga ccgattgtta tctgacactc tggcaaatat
     3181 tgtcaagcct caaaagcaga taaaattgca gaagaaaccc aacacactta agaaaacggt
     3241 gaacatgacc accattctga taggccgaac acaaaggaac acagacacca ttatacatcc
     3301 tgtagcacag gaacattcca gctgcagcag cttcccgtgc cagaatggtg gcacatgcat
     3361 cagcgggaga tccaacttca tctgcgcttg ccggcacccg ttcatgggtg acacttgcac
     3421 cgtgaagatc aaggaagatg atgcagtagc accagatttt tccaaaggat cttacagata
     3481 tgctccgatg gtggcgtttt tcgtatctca cactcacgga atgacggcac ctggtcctat
     3541 cctgttcaat gatctaagcg tcaactatgg ggcctcatat aacccaagga ctggcaagtt
     3601 cagaattcca taccttggag tgtatatttt caaatacacc attgagtcat tcagtgctca
     3661 tatctccggt ttttttgtgg tggatggagt agacaaactt agatttgagt ctgaaaatgc
     3721 tgacaatgag atacactgtg acagagtttt gactggggat gccttatttg aattaaatta
     3781 cggacaggaa gtgtggttgc gacttgtaaa aggaacaatt ccaatcaaat atccccctgt
     3841 gaccacgttc agtggttact tgttatatcg cacctaagtt tgtgtgagag gtagactctc
     3901 acctctctac tccagcatgc tctccttttc atttatcctt acatgcacat cagctctgtt
     3961 gtactatttc tacactaaat gagatatgtc attgaagagc ctgaatgttt atttcacaaa
     4021 atgatttgga tgtcctgtac agagggggtc ctttctccta aggagacaca gaggcataga
     4081 aacccaatgt gaccattacc cacaagcatg tgtctgccac cgcgggcatg cctacctgtg
     4141 ctcctttcct gtgagtcttt ccagtgtaga ataaaatgtc acagcagatt tcccaaagaa
     4201 acttaaattt tgttatattc tgtgtttata actctagaaa agaatttcct aagataacaa
     4261 acttaaataa ataattcaaa gaaaaaatcc cattttttaa cttctaaatt tgctttactg
     4321 ttgagttgat cagttttata aaataaattt gcatttgtgt tcaaaactaa gaaaagtaaa
     4381 ttataaatat gaagtatgct taaatattat ctttgcaaga ttggaaaatg gagacataac
     4441 taatgcctat ttagacattt tacatctaat tttgtgtgtg ctacttctct gcctccatta
     4501 gataacatgt gcatgaagac aagtacaaca cttttctatt catattcttc tattatactg
     4561 ttgtgaggaa atttgggttt ccttttgtgt attcttgctc ttaataataa agggatttaa
     4621 agatggactc tgaggg
//
