LOCUS       NM_008611               2453 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus matrix metallopeptidase 8 (Mmp8), mRNA.
ACCESSION   NM_008611
VERSION     NM_008611.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2453)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2453)
  AUTHORS   Wang,T.Y., Weng,E.F., Hsu,Y.C., Shiu,L.P., Huang,T.W., Wu,H.C.,
            Hong,J.S. and Wang,S.M.
  TITLE     Inhibition of MMP8 effectively alleviates manic-like behavior and
            reduces neuroinflammation by modulating astrocytic CEBPD
  JOURNAL   J Neuroinflammation 21 (1), 61 (2024)
   PUBMED   38419037
  REMARK    GeneRIF: Inhibition of MMP8 effectively alleviates manic-like
            behavior and reduces neuroinflammation by modulating astrocytic
            CEBPD.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2453)
  AUTHORS   Cathomas,F., Lin,H.Y., Chan,K.L., Li,L., Parise,L.F., Alvarez,J.,
            Durand-de Cuttoli,R., Aubry,A.V., Muhareb,S., Desland,F., Shimo,Y.,
            Ramakrishnan,A., Estill,M., Ferrer-Perez,C., Parise,E.M.,
            Wilk,C.M., Kaster,M.P., Wang,J., Sowa,A., Janssen,W.G., Costi,S.,
            Rahman,A., Fernandez,N., Campbell,M., Swirski,F.K., Nestler,E.J.,
            Shen,L., Merad,M., Murrough,J.W. and Russo,S.J.
  TITLE     Circulating myeloid-derived MMP8 in stress susceptibility and
            depression
  JOURNAL   Nature 626 (8001), 1108-1115 (2024)
   PUBMED   38326622
  REMARK    GeneRIF: Circulating myeloid-derived MMP8 in stress susceptibility
            and depression.
REFERENCE   4  (bases 1 to 2453)
  AUTHORS   Varadinkova,S., Oralova,V., Clarke,M., Frampton,J., Knopfova,L.,
            Lesot,H., Bartos,P. and Matalova,E.
  TITLE     Expression dynamics of metalloproteinases during mandibular bone
            formation: association with Myb transcription factor
  JOURNAL   Front Cell Dev Biol 11, 1168866 (2023)
   PUBMED   37701782
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2453)
  AUTHORS   Cordoba-Jover,B., Ribera,J., Portoles,I., Lecue,E.,
            Rodriguez-Vita,J., Perez-Sisques,L., Mannara,F.,
            Solsona-Vilarrasa,E., Garcia-Ruiz,C., Fernandez-Checa,J.C.,
            Casals,G., Rodriguez-Revenga,L., Alvarez-Mora,M.I.,
            Arteche-Lopez,A., Diaz de Bustamante,A., Calvo,R., Pujol,A.,
            Azkargorta,M., Elortza,F., Malagelada,C., Pinyol,R.,
            Huguet-Pradell,J., Melgar-Lesmes,P., Jimenez,W. and Morales-Ruiz,M.
  TITLE     Tcf20 deficiency is associated with increased liver fibrogenesis
            and alterations in mitochondrial metabolism in mice and humans
  JOURNAL   Liver Int 43 (8), 1822-1836 (2023)
   PUBMED   37312667
REFERENCE   6  (bases 1 to 2453)
  AUTHORS   Johansson,N., Ahonen,M. and Kahari,V.M.
  TITLE     Matrix metalloproteinases in tumor invasion
  JOURNAL   Cell Mol Life Sci 57 (1), 5-15 (2000)
   PUBMED   10949577
  REMARK    Review article
REFERENCE   7  (bases 1 to 2453)
  AUTHORS   Nagase,H. and Woessner,J.F. Jr.
  TITLE     Matrix metalloproteinases
  JOURNAL   J Biol Chem 274 (31), 21491-21494 (1999)
   PUBMED   10419448
  REMARK    Review article
REFERENCE   8  (bases 1 to 2453)
  AUTHORS   Balbin,M., Fueyo,A., Knauper,V., Pendas,A.M., Lopez,J.M.,
            Jimenez,M.G., Murphy,G. and Lopez-Otin,C.
  TITLE     Collagenase 2 (MMP-8) expression in murine tissue-remodeling
            processes. Analysis of its potential role in postpartum involution
            of the uterus
  JOURNAL   J Biol Chem 273 (37), 23959-23968 (1998)
   PUBMED   9727011
REFERENCE   9  (bases 1 to 2453)
  AUTHORS   Iwama,A., Zhang,P., Darlington,G.J., McKercher,S.R., Maki,R. and
            Tenen,D.G.
  TITLE     Use of RDA analysis of knockout mice to identify myeloid genes
            regulated in vivo by PU.1 and C/EBPalpha
  JOURNAL   Nucleic Acids Res 26 (12), 3034-3043 (1998)
   PUBMED   9611252
REFERENCE   10 (bases 1 to 2453)
  AUTHORS   Lawson,N.D., Khanna-Gupta,A. and Berliner,N.
  TITLE     Isolation and characterization of the cDNA for mouse neutrophil
            collagenase: demonstration of shared negative regulatory pathways
            for neutrophil secondary granule protein gene expression
  JOURNAL   Blood 91 (7), 2517-2524 (1998)
   PUBMED   9516153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY204369.1, AK137468.1 and
            BY548872.1.
            
            On Nov 15, 2007 this sequence version replaced NM_008611.3.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme that degrades types I, II and III collagens. Mice lacking
            the encoded protein exhibit abnormalities in the inflammatory
            responses to various agents. This gene is located in a cluster of
            other matrix metalloproteinase genes on chromosome 9. [provided by
            RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089336.1, AK155901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BY204369.1         2-32
            32-2013             AK137468.1         4-1985
            2014-2453           BY548872.1         17-456
FEATURES             Location/Qualifiers
     source          1..2453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..2453
                     /gene="Mmp8"
                     /note="matrix metallopeptidase 8"
                     /db_xref="GeneID:17394"
                     /db_xref="MGI:MGI:1202395"
     exon            1..215
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1505
                     /gene="Mmp8"
                     /EC_number="3.4.24.34"
                     /note="neutrophil collagenase; collagenase-2; matrix
                     metalloproteinase-8"
                     /codon_start=1
                     /product="neutrophil collagenase preproprotein"
                     /protein_id="NP_032637.3"
                     /db_xref="CCDS:CCDS22808.1"
                     /db_xref="GeneID:17394"
                     /db_xref="MGI:MGI:1202395"
                     /translation="MFRLKTLPLLIFLHTQLANAFPVPEHLEEKNIKTAENYLRKFYN
                     LPSNQFRSSRNATMVAEKLKEMQRFFSLAETGKLDAATMGIMEMPRCGVPDSGDFLLT
                     PGSPKWTHTNLTYRIINHTPQLSRAEVKTAIEKAFHVWSVASPLTFTEILQGEADINI
                     AFVSRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDSEETWTQDSKNYNLFLVAAHE
                     FGHSLGLSHSTDPGALMYPNYAYREPSTYSLPQDDINGIQTIYGPSDNPIQPTGPSTP
                     KACDPHLRFDATTTLRGEIYFFKDKYFWRRHPQLRTVDLNFISLFWPFLPNGLQAAYE
                     DFDRDLVFLFKGRQYWALSGYDLQQGYPRDISNYGFPRSVQAIDAAVSYNGKTYFFIN
                     NQCWRYDNQRRSMDPGYPKSIPSMFPGVNCRVDAVFLQDSFFLFFSGPQYFAFNFVSH
                     RVTRVARSNLWLNCS"
     exon            216..454
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            455..603
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            604..729
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            730..891
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1009
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1143
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1297
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1401
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..2453
                     /gene="Mmp8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp8"
     polyA_site      2453
                     /gene="Mmp8"
ORIGIN      
        1 ataagggacc agacaagagc agtgattggc aggggatgct gtgagcttga gggcacttgc
       61 cagaggggca gaggaaggca ggagaggttg tcttggaaga taagattatg tttcgcctga
      121 agacacttcc attactgatc ttcctccaca cacagcttgc caatgccttc ccagtacctg
      181 aacacctgga agagaaaaat ataaaaactg ctgagaatta cctacgaaaa ttctacaact
      241 taccaagcaa tcaattccgg tcttcgagga atgccacgat ggttgcagag aagcttaaag
      301 agatgcagcg cttcttcagc ttagcagaga ctgggaagtt agatgcagct acaatgggga
      361 ttatggaaat gcctcgatgt ggagtgcctg actctggtga tttcttgcta accccaggaa
      421 gtcccaagtg gacacacact aacctgacct acaggattat aaaccatacg ccacagctgt
      481 caagggctga agtgaaaaca gcaattgaga aagcttttca cgtctggagt gtagcatcgc
      541 ccctgacctt caccgagatc ttacagggag aagcagacat caacattgct ttcgtctcaa
      601 gagaccatgg tgacaattct ccatttgatg gacccaatgg aatccttgcc catgcctttc
      661 aaccaggcca aggtattgga ggagatgctc attttgattc agaagaaacg tggactcaag
      721 attccaaaaa ttacaaccta tttctcgtgg ctgctcatga atttggacat tctttgggac
      781 tctctcactc cactgatcct ggtgccttga tgtacccaaa ctatgcttac agggaaccca
      841 gcacctattc actacctcaa gatgatatca atggcattca gacaatctat ggaccttcag
      901 acaaccccat ccaacctact gggcccagca cacccaaagc ctgtgacccc cacctgagat
      961 ttgatgctac taccacactc cgtggggaga tttacttctt taaagacaag tacttctgga
     1021 gacggcatcc tcagctgaga acagttgacc tcaatttcat atctctgttc tggcccttcc
     1081 tacccaacgg tcttcaggct gcttatgaag attttgacag agacctagtt ttcctattta
     1141 aaggcagaca gtactgggct ctaagtggct atgacctgca gcaaggttac cccagagata
     1201 tatccaacta tggattccca aggagtgtcc aagccattga tgcagctgtt tcctataacg
     1261 ggaagacata cttcttcata aacaaccagt gctggagata tgacaatcaa agaagatcca
     1321 tggacccagg ttaccccaaa agcataccaa gcatgttccc aggagtaaac tgtagagtcg
     1381 atgcagtttt cctgcaggac tccttcttcc tcttcttcag tggaccacaa tattttgcat
     1441 ttaattttgt cagtcacaga gtcactagag ttgcaagaag caatttatgg cttaactgtt
     1501 catagagttg agcaatgtca aatgtccttg cacgcaccct atgaggacaa aaagggaagc
     1561 tcagtctgta tactcatccc acgtgtcctg cccagacttt cctcagtggt aactaactct
     1621 gcagccctct tcgaagaacc agcgtttgta atctggcatt cccagccatg gctaactcct
     1681 tctgcatatt ccgtccctgg ttcgtgaatg catcacaaag agagcaagcc gtttactacc
     1741 ttactcttca ctatttcatt atctgctctt ctgccttcta aaaccttttg ttttattact
     1801 tgcttatcta gcttcaaatg ttcctaaatc tcttcaaaca gggaatctag cattggattt
     1861 tcattacaaa tgaagattat aaacacatag atattatccc cttatctgta cagaaaaaaa
     1921 gtgctgttat ttcctccgtt ggaaaaatat gaaaaatatg taatgtgtgt tgaatcatgc
     1981 ccctctgcat gccagaaaaa aaaaaaaaaa aaacattgaa atcttaaccc cagctgttta
     2041 tctagctgtt aaccagagtc tttgaagata taatgaatta tgtgtaaatg acaagacagc
     2101 cttaaacagg gttaggatga gccataagtg catacatatg ttcttataaa acggagtgag
     2161 aggtgtggat gtcactcaga gattaaagtt ttttcctaac atgttttatt ctgaggagat
     2221 ttgggaagaa tcagcagagg tatgggcaca tgatagaaga gaccaagcaa agagaaccag
     2281 acactggagg gctgtatcta taaatctatt tgccaataag ttcccaggca gaggcaggta
     2341 ggaggggttt aaaaaaaagg accattcctt tctcaagcac attccagaat tgaggcactt
     2401 gttgatatgg gttttctggc ttttgtgaaa aaataaagtt gttattctgc tct
//
