LOCUS       NM_010810               1068 bp    mRNA    linear   ROD 24-MAR-2023
DEFINITION  Mus musculus matrix metallopeptidase 7 (Mmp7), transcript variant
            1, mRNA.
ACCESSION   NM_010810
VERSION     NM_010810.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1068)
  AUTHORS   Xiao Y, Lian H, Zhong XS, Krishnachaitanya SS, Cong Y, Dashwood RH,
            Savidge TC, Powell DW, Liu X and Li Q.
  TITLE     Matrix metalloproteinase 7 contributes to intestinal barrier
            dysfunction by degrading tight junction protein Claudin-7
  JOURNAL   Front Immunol 13, 1020902 (2022)
   PUBMED   36275703
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1068)
  AUTHORS   Lei Z, Liu W, Nie Y, Yang Y, Chen G, Huang L, Wu H, Lei Y, Chen L,
            Hu Q, Rong H, Yu S, Song Q, Tong F and Guo J.
  TITLE     EpCAM Is Essential to Maintaining the Immune Homeostasis of
            Intestines via Keeping the Expression of pIgR in the Intestinal
            Epithelium of Mice
  JOURNAL   Front Immunol 13, 843378 (2022)
   PUBMED   35493520
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1068)
  AUTHORS   Westermann-Clark E, Soundararajan R, Fukumoto J, Patil SS, Stearns
            TM, Saji S, Czachor A, Hernandez-Cuervo H, Breitzig M,
            Krishnamurthy S, Lockey RF and Kolliputi N.
  TITLE     Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects
            in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis
  JOURNAL   Biomolecules 12 (2), 283 (2022)
   PUBMED   35204783
  REMARK    GeneRIF: Matrix Metalloproteinase 7 Expression and Apical
            Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary
            Fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1068)
  AUTHORS   Fernandez Vallone V, Leprovots M, Ribatallada-Soriano D, Gerbier R,
            Lefort A, Libert F, Vassart G and Garcia MI.
  TITLE     LGR5 controls extracellular matrix production by stem cells in the
            developing intestine
  JOURNAL   EMBO Rep 21 (7), e49224 (2020)
   PUBMED   32468660
REFERENCE   5  (bases 1 to 1068)
  AUTHORS   Yang Y, Ma L, Wang C, Song M, Li C, Chen M, Zhou J and Mei C.
  TITLE     Matrix metalloproteinase-7 in platelet-activated macrophages
            accounts for cardiac remodeling in uremic mice
  JOURNAL   Basic Res Cardiol 115 (3), 30 (2020)
   PUBMED   32270301
  REMARK    GeneRIF: Matrix metalloproteinase-7 in platelet-activated
            macrophages accounts for cardiac remodeling in uremic mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1068)
  AUTHORS   Dunsmore SE, Saarialho-Kere UK, Roby JD, Wilson CL, Matrisian LM,
            Welgus HG and Parks WC.
  TITLE     Matrilysin expression and function in airway epithelium
  JOURNAL   J Clin Invest 102 (7), 1321-1331 (1998)
   PUBMED   9769324
REFERENCE   7  (bases 1 to 1068)
  AUTHORS   Yamazaki K, Okada T, Mori Y and Tanaka I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   8  (bases 1 to 1068)
  AUTHORS   Rudolph-Owen LA, Hulboy DL, Wilson CL, Mudgett J and Matrisian LM.
  TITLE     Coordinate expression of matrix metalloproteinase family members in
            the uterus of normal, matrilysin-deficient, and
            stromelysin-1-deficient mice
  JOURNAL   Endocrinology 138 (11), 4902-4911 (1997)
   PUBMED   9348221
REFERENCE   9  (bases 1 to 1068)
  AUTHORS   Wilson CL, Heppner KJ, Labosky PA, Hogan BL and Matrisian LM.
  TITLE     Intestinal tumorigenesis is suppressed in mice lacking the
            metalloproteinase matrilysin
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1402-1407 (1997)
   PUBMED   9037065
REFERENCE   10 (bases 1 to 1068)
  AUTHORS   Wilson CL, Heppner KJ, Rudolph LA and Matrisian LM.
  TITLE     The metalloproteinase matrilysin is preferentially expressed by
            epithelial cells in a tissue-restricted pattern in the mouse
  JOURNAL   Mol Biol Cell 6 (7), 851-869 (1995)
   PUBMED   7579699
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL603630.11 and AK144515.1.
            
            [WARNING] On Jun 15, 2023 this sequence was replaced by
            NM_010810.6.
            
            On Feb 10, 2016 this sequence version replaced NM_010810.4.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. Mice lacking the encoded protein are deficient in
            functional cryptdins. This gene is located in a cluster of other
            matrix metalloproteinase genes on chromosome 9. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L36244.1, AK144515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL603630.11        137172-137175
            5-1063              AK144515.1         2-1060
            1064-1068           AL603630.11        144663-144667
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..1068
                     /gene="Mmp7"
                     /gene_synonym="MAT; MMP-7"
                     /note="matrix metallopeptidase 7"
                     /db_xref="GeneID:17393"
                     /db_xref="MGI:MGI:103189"
     exon            1..153
                     /gene="Mmp7"
                     /gene_synonym="MAT; MMP-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..840
                     /gene="Mmp7"
                     /gene_synonym="MAT; MMP-7"
                     /EC_number="3.4.24.23"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; matrilysin, uterine; matrin; pump-1 protease;
                     uterine metalloproteinase; matrix metalloproteinase 7"
                     /codon_start=1
                     /product="matrilysin isoform 1 preproprotein"
                     /protein_id="NP_034940.2"
                     /db_xref="CCDS:CCDS40531.1"
                     /db_xref="GeneID:17393"
                     /db_xref="MGI:MGI:103189"
                     /translation="MAAMQLTLFCFVCLLPGHLALPLSQEAGDVSAHQWEQAQNYLRK
                     FYPHDSKTKKVNSLVDNLKEMQKFFGLPMTGKLSPYIMEIMQKPRCGVPDVAEYSLMP
                     NSPKWHSRIVTYRIVSYTSDLPRIVVDQIVKKALRMWSMQIPLNFKRVSWGTADIIIG
                     FARRDHGDSFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWTDGEDAGVNFLFAATHE
                     FGHSLGLSHSSVPGTVMYPTYQRDYSEDFSLTKDDIAGIQKLYGKRNTL"
     exon            154..380
                     /gene="Mmp7"
                     /gene_synonym="MAT; MMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            381..529
                     /gene="Mmp7"
                     /gene_synonym="MAT; MMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            530..658
                     /gene="Mmp7"
                     /gene_synonym="MAT; MMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            659..820
                     /gene="Mmp7"
                     /gene_synonym="MAT; MMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1068
                     /gene="Mmp7"
                     /gene_synonym="MAT; MMP-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacatcaaa gtagctctga gaacaatcgc ctgttgatgg cagctatgca gctcaccctg
       61 ttctgctttg tgtgtctgct gccaggccac ctggccctgc cactgtccca ggaagctgga
      121 gatgtgagcg cacatcagtg ggaacaggct cagaattatc ttagaaaatt ttaccctcat
      181 gactctaaaa caaagaaggt caatagtcta gtggacaacc tcaaggaaat gcagaagttc
      241 tttggcctgc ccatgactgg aaaactctcc ccctacatca tggaaataat gcagaaacct
      301 aggtgtggag tgccagatgt tgcagaatac tcactaatgc caaacagtcc aaaatggcat
      361 tccagaattg tcacctacag aattgtatcc tatacttcag acttacctcg gatcgtagtg
      421 gatcaaatcg tgaaaaaagc tctcagaatg tggagtatgc agatcccact gaacttcaag
      481 agggttagtt gggggactgc ggatatcata attggcttcg caaggagaga tcatggagac
      541 agcttcccct ttgatgggcc agggaacact ctaggtcatg ccttcgcacc tgggccaggc
      601 ctaggcggag atgctcactt tgacaaggat gagtactgga ctgatggtga ggacgcagga
      661 gtgaacttcc tgtttgctgc cacccatgaa tttggccact ctctgggtct gagtcactct
      721 tctgttcccg gtactgtgat gtaccctacc tatcaaagag actactcaga agacttcagt
      781 cttacaaagg acgacattgc aggcattcag aagttatatg gaaagaggaa cacgctgtga
      841 tagatgcaga cagatcacag aaacggtctg cactcactgg gtcctccatt gcatccctca
      901 gctggcatga acaaacgccc ttcctgagct gcacctgttt ccctcttcct tgtgctgtgg
      961 atgggttttg cacatccctc tgagggtcat cttgacggaa tgattctgac taatctcagg
     1021 taacatgaag ttgcgagaca tcaacaataa atgtcatgtg cacaaata
//
