LOCUS       NM_010809               1801 bp    mRNA    linear   ROD 22-JAN-2023
DEFINITION  Mus musculus matrix metallopeptidase 3 (Mmp3), mRNA.
ACCESSION   NM_010809
VERSION     NM_010809.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1801)
  AUTHORS   Feng T, Tong H, Ming Z, Deng L, Liu J, Wu J, Chen Z, Yan Y and Dai
            J.
  TITLE     Matrix metalloproteinase 3 restricts viral infection by enhancing
            host antiviral immunity
  JOURNAL   Antiviral Res 206, 105388 (2022)
   PUBMED   35940311
  REMARK    GeneRIF: Matrix metalloproteinase 3 restricts viral infection by
            enhancing host antiviral immunity.
REFERENCE   2  (bases 1 to 1801)
  AUTHORS   Kumper M, Zamek J, Steinkamp J, Pach E, Mauch C and Zigrino P.
  TITLE     Role of MMP3 and fibroblast-MMP14 in skin homeostasis and repair
  JOURNAL   Eur J Cell Biol 101 (4), 151276 (2022)
   PUBMED   36162272
  REMARK    GeneRIF: Role of MMP3 and fibroblast-MMP14 in skin homeostasis and
            repair.
REFERENCE   3  (bases 1 to 1801)
  AUTHORS   Kageyama Y, Nakamura M, Igari Y, Yamaguchi S, Oguchi A, Murakawa Y,
            Hattori Y and Sasano Y.
  TITLE     Expression of matrix metalloproteinase-3 and -10 is up-regulated in
            the periodontal tissues of aged mice
  JOURNAL   J Periodontal Res 57 (4), 733-741 (2022)
   PUBMED   35502585
  REMARK    GeneRIF: Expression of matrix metalloproteinase-3 and -10 is
            up-regulated in the periodontal tissues of aged mice.
REFERENCE   4  (bases 1 to 1801)
  AUTHORS   Lei Z, Liu W, Nie Y, Yang Y, Chen G, Huang L, Wu H, Lei Y, Chen L,
            Hu Q, Rong H, Yu S, Song Q, Tong F and Guo J.
  TITLE     EpCAM Is Essential to Maintaining the Immune Homeostasis of
            Intestines via Keeping the Expression of pIgR in the Intestinal
            Epithelium of Mice
  JOURNAL   Front Immunol 13, 843378 (2022)
   PUBMED   35493520
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1801)
  AUTHORS   Abdallah EAA and El-Refaei MF.
  TITLE     Caffeic acid phenethyl ester mitigates infertility: A crucial role
            of metalloproteinase and angiogenic factor in cadmium-induced
            testicular damage
  JOURNAL   J Biochem Mol Toxicol 36 (2), e22960 (2022)
   PUBMED   34791780
  REMARK    GeneRIF: Caffeic acid phenethyl ester mitigates infertility: A
            crucial role of metalloproteinase and angiogenic factor in
            cadmium-induced testicular damage.
REFERENCE   6  (bases 1 to 1801)
  AUTHORS   Sanz L, Moscat J and Diaz-Meco MT.
  TITLE     Molecular characterization of a novel transcription factor that
            controls stromelysin expression
  JOURNAL   Mol Cell Biol 15 (6), 3164-3170 (1995)
   PUBMED   7760812
REFERENCE   7  (bases 1 to 1801)
  AUTHORS   Gack S, Vallon R, Schmidt J, Grigoriadis A, Tuckermann J, Schenkel
            J, Weiher H, Wagner EF and Angel P.
  TITLE     Expression of interstitial collagenase during skeletal development
            of the mouse is restricted to osteoblast-like cells and
            hypertrophic chondrocytes
  JOURNAL   Cell Growth Differ 6 (6), 759-767 (1995)
   PUBMED   7669731
REFERENCE   8  (bases 1 to 1801)
  AUTHORS   Li F, Strange R, Friis RR, Djonov V, Altermatt HJ, Saurer S,
            Niemann H and Andres AC.
  TITLE     Expression of stromelysin-1 and TIMP-1 in the involuting mammary
            gland and in early invasive tumors of the mouse
  JOURNAL   Int J Cancer 59 (4), 560-568 (1994)
   PUBMED   7960227
REFERENCE   9  (bases 1 to 1801)
  AUTHORS   Hammani K, Henriet P and Eeckhout Y.
  TITLE     Cloning and sequencing of a cDNA encoding mouse stromelysin 1
  JOURNAL   Gene 120 (2), 321-322 (1992)
   PUBMED   1398148
REFERENCE   10 (bases 1 to 1801)
  AUTHORS   Brenner CA, Adler RR, Rappolee DA, Pedersen RA and Werb Z.
  TITLE     Genes for extracellular-matrix-degrading metalloproteinases and
            their inhibitor, TIMP, are expressed during early mammalian
            development
  JOURNAL   Genes Dev 3 (6), 848-859 (1989)
   PUBMED   2744464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115689.22 and AK148467.1.
            
            [WARNING] On Jun 15, 2023 this sequence was replaced by
            NM_010809.3.
            
            On Aug 27, 2015 this sequence version replaced NM_010809.1.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded protein is activated by the removal
            of an N-temrinal activation peptide to generate a zinc-dependent
            endopeptidase with a broad range of substrates such as
            proteoglycans, laminin, fibronectin, elastin, and collagens. This
            gene is located in a cluster of other matrix metalloproteinase
            genes on chromosome 9. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63162.1, BC006725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC115689.22        150237-150259       c
            24-688              AK148467.1         2-666
            689-689             AC115689.22        148452-148452       c
            690-1798            AK148467.1         668-1776
            1799-1801           AC115689.22        140106-140108       c
FEATURES             Location/Qualifiers
     source          1..1801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..1801
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /note="matrix metallopeptidase 3"
                     /db_xref="GeneID:17392"
                     /db_xref="MGI:MGI:97010"
     exon            1..187
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..432
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..581
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..707
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..872
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1017
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1151
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1311
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1415
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1801
                     /gene="Mmp3"
                     /gene_synonym="EMS-2; MMP-3; SL-1; SLN-1; SLN1; Stmy1;
                     STR-1; Str1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgggctta agaaggtgga cctagaagga ggcagcagag aacctactga aggtggtaca
       61 gagctgtggg aagtcaatga aaatgaaggg tcttccggtc ctgctgtggc tgtgtgtggt
      121 tgtgtgctca tcctacccat tgcatgacag tgcaagggat gatgatgctg gtatggagct
      181 tctgcagaaa tacctagaaa actactatgg ccttgcaaaa gatgtgaagc aatttattaa
      241 gaaaaaggac agtagtctta ttgtcaaaaa aattcaagaa atgcagaagt tcctcgggtt
      301 ggagatgaca gggaagctgg actccaacac tatggagctg atgcataagc ccaggtgtgg
      361 tgttcctgat gttggtggct tcagtacctt cccaggttcg ccaaaatgga ggaaatccca
      421 catcacctac aggattgtga attatacacc ggatttgcca agacagagtg tggattctgc
      481 cattgaaaaa gctttgaagg tctgggagga ggtgacccca ctcactttct ccaggatctc
      541 tgaaggagag gctgacataa tgatctcctt tgcagttgga gaacatggag actttgtccc
      601 ttttgatggg cctggaacag tcttggctca tgcctatgca cctggaccag ggattaatgg
      661 agatgctcac tttgacgatg atgaacgatg gacagaggat gtcactggta ccaacctatt
      721 cctggttgct gctcatgaac ttggccactc cctgggactc taccactcag ccaaggctga
      781 agctctgatg tacccagtct acaagtcctc cacagacttg tcccgtttcc atctctctca
      841 agatgatgta gatggtattc agtccctcta tggaactccc acagcatccc ctgatgtcct
      901 cgtggtaccc accaagtcta actctctgga acctgagaca tcaccaatgt gcagctctac
      961 tttgttcttt gatgcagtca gcaccctccg gggagaagtc ctgtttttta aagacaggca
     1021 cttttggcgc aaatctctca ggactcctga gcctgaattt tatttgatct cttcattttg
     1081 gccatctctt ccatccaaca tggatgctgc atatgaggtt actaacagag acactgtttt
     1141 catttttaaa ggaaatcagt tctgggctat acgagggcac gaggagctag caggttatcc
     1201 taaaagcatt cacaccctgg gtctccctgc aaccgtgaag aagatcgatg ctgccatttc
     1261 taataaagag aaaaggaaga cctacttctt tgtagaggac aaatactgga ggtttgatga
     1321 gaagaaacaa tccatggagc caggatttcc caggaagata gctgaggact ttccaggtgt
     1381 tgactcaagg gtggatgctg tctttgaagc atttgggttt ctctacttct tcagtggatc
     1441 ttcgcagttg gaatttgacc caaatgccaa aaaagtgacc cacatattga agagcaatag
     1501 ctggtttaat tgttaaaaag agatccaagg aaggcatcct gtgttttaac tgatgcttat
     1561 agttcttcat ctgagtcttt gtgaaaggaa gtgctttgtt cagcatgtgc tatggcagaa
     1621 ccaaacagga gctatggatg acaccagtca acgtcaagtt gtcaaaggat gttcagaagc
     1681 actgtgtagc ttacactgtg tcccaaggag aggagggaag gcactcctgg gccacaaaca
     1741 agtgtctgaa ctgtgtagat ggtttgtttt atttaataaa gattgtgtgt cgtttattaa
     1801 a
//
