LOCUS       NM_001320300            3528 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus matrix metallopeptidase 28 (epilysin) (Mmp28),
            transcript variant 3, mRNA.
ACCESSION   NM_001320300 XM_011248682
VERSION     NM_001320300.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3528)
  AUTHORS   Long ME, Gong KQ, Volk JS, Eddy WE, Chang MY, Frevert CW, Altemeier
            WA, Gale M Jr, Liles WC and Manicone AM.
  TITLE     Matrix metalloproteinase 28 is regulated by TRIF- and type I
            IFN-dependent signaling in macrophages
  JOURNAL   Innate Immun 24 (6), 357-365 (2018)
   PUBMED   30068264
  REMARK    GeneRIF: this study shows that Mmp28 is regulated by TRIF- and type
            I IFN-dependent signaling in macrophages
REFERENCE   2  (bases 1 to 3528)
  AUTHORS   Maldonado M, Salgado-Aguayo A, Herrera I, Cabrera S, Ortiz-Quintero
            B, Staab-Weijnitz CA, Eickelberg O, Ramirez R, Manicone AM, Selman
            M and Pardo A.
  TITLE     Upregulation and Nuclear Location of MMP28 in Alveolar Epithelium
            of Idiopathic Pulmonary Fibrosis
  JOURNAL   Am J Respir Cell Mol Biol 59 (1), 77-86 (2018)
   PUBMED   29373068
  REMARK    GeneRIF: MMP28 is upregulated in epithelial cells from Idiopathic
            pulmonary fibrosis lungs.
REFERENCE   3  (bases 1 to 3528)
  AUTHORS   Manicone AM, Gharib SA, Gong KQ, Eddy WE, Long ME, Frevert CW,
            Altemeier WA, Parks WC and Houghton AM.
  TITLE     Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema
            Pathogenesis
  JOURNAL   Am J Pathol 187 (6), 1288-1300 (2017)
   PUBMED   28399390
REFERENCE   4  (bases 1 to 3528)
  AUTHORS   Cho KI, Yoon D, Qiu S, Danziger Z, Grill WM, Wetsel WC and Ferreira
            PA.
  TITLE     Loss of Ranbp2 in motoneurons causes disruption of
            nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3
            and Mmp28, and development of amyotrophic lateral sclerosis-like
            syndromes
  JOURNAL   Dis Model Mech 10 (5), 559-579 (2017)
   PUBMED   28100513
  REMARK    GeneRIF: results demonstrate that Ranbp2 controls
            nucleocytoplasmic, chemokine and metalloproteinase 28 signaling,
            and proteostasis of substrates that are crucial to motoneuronal
            homeostasis and whose impairments by loss of Ranbp2 drive ALS-like
            syndromes
REFERENCE   5  (bases 1 to 3528)
  AUTHORS   Gharib SA, Johnston LK, Huizar I, Birkland TP, Hanson J, Wang Y,
            Parks WC and Manicone AM.
  TITLE     MMP28 promotes macrophage polarization toward M2 cells and augments
            pulmonary fibrosis
  JOURNAL   J Leukoc Biol 95 (1), 9-18 (2014)
   PUBMED   23964118
  REMARK    GeneRIF: MMP28 promotes macrophage polarization toward M2 cells and
            augments pulmonary fibrosis.
            Erratum:[J Leukoc Biol. 2016 Nov;100(5):1225. PMID: 27799442]
REFERENCE   6  (bases 1 to 3528)
  AUTHORS   Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi
            J, Keski-Oja J, Wang Y, Skerrett SJ and Parks WC.
  TITLE     Epilysin (MMP-28) restrains early macrophage recruitment in
            Pseudomonas aeruginosa pneumonia
  JOURNAL   J Immunol 182 (6), 3866-3876 (2009)
   PUBMED   19265166
  REMARK    GeneRIF: Epilysin serves as a negative regulator of early
            macrophage recruitment, a novel function that may have evolved as a
            mechanism to restrain unnecessary and untimely inflammation.
REFERENCE   7  (bases 1 to 3528)
  AUTHORS   Smith L, Wagner TE, Huizar I and Schnapp LM.
  TITLE     uPARAP expression during murine lung development
  JOURNAL   Gene Expr Patterns 8 (7-8), 486-493 (2008)
   PUBMED   18639653
REFERENCE   8  (bases 1 to 3528)
  AUTHORS   Werner SR, Mescher AL, Neff AW, King MW, Chaturvedi S, Duffin KL,
            Harty MW and Smith RC.
  TITLE     Neural MMP-28 expression precedes myelination during development
            and peripheral nerve repair
  JOURNAL   Dev Dyn 236 (10), 2852-2864 (2007)
   PUBMED   17823957
  REMARK    GeneRIF: These results suggest that MMP-28 plays an evolutionarily
            conserved role in neural development and is likely to modulate the
            axonal-glial extracellular microenvironment.
REFERENCE   9  (bases 1 to 3528)
  AUTHORS   Illman SA, Keski-Oja J, Parks WC and Lohi J.
  TITLE     The mouse matrix metalloproteinase, epilysin (MMP-28), is
            alternatively spliced and processed by a furin-like proprotein
            convertase
  JOURNAL   Biochem J 375 (Pt 1), 191-197 (2003)
   PUBMED   12803542
  REMARK    GeneRIF: Epilysin is alternatively spliced and processed by a
            furin-like proprotein convertase.
REFERENCE   10 (bases 1 to 3528)
  AUTHORS   Illman SA, Keski-Oja J and Lohi J.
  TITLE     Promoter characterization of the human and mouse epilysin (MMP-28)
            genes
  JOURNAL   Gene 275 (1), 185-194 (2001)
   PUBMED   11574168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663096.16, BY308224.1, BC145048.1 and AK051258.1.
            
            On Feb 19, 2016 this sequence version replaced XM_011248682.1.
            
            Transcript Variant: This variant (3) uses an alternate, in-frame
            splice site in the 3' coding region, compared to variant 1. It
            encodes isoform 3, which is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY065653.1, BC145048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL663096.16        58823-58825         c
            4-124               BY308224.1         1-121
            125-1790            BC145048.1         1-1666
            1791-2994           AK051258.1         1703-2906
            2995-2995           AL663096.16        37086-37086         c
            2996-3144           AK051258.1         2908-3056
            3145-3145           AL663096.16        36936-36936         c
            3146-3528           AK051258.1         3058-3440
FEATURES             Location/Qualifiers
     source          1..3528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.39 cM"
     gene            1..3528
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /note="matrix metallopeptidase 28 (epilysin)"
                     /db_xref="GeneID:118453"
                     /db_xref="MGI:MGI:2153062"
     exon            1..293
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1745
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; matrix metalloproteinase 28 (epilysin)"
                     /codon_start=1
                     /product="matrix metalloproteinase-28 isoform 3 precursor"
                     /protein_id="NP_001307229.1"
                     /db_xref="CCDS:CCDS83860.1"
                     /db_xref="GeneID:118453"
                     /db_xref="MGI:MGI:2153062"
                     /translation="MVAGVSLLLRALPLLLWGCQDAQPTQHGLPELRQEAEAFLEKYG
                     YLSEQGSKAPASAQFRNAIREFQWISQLPLSGVLDQATLRQMTRPRCGVADTDSHATW
                     TERISTLLAGHRAKMRRKKRFAKPGNKWYKQHLSYRLVNWPERLPEPAVRGAVRAAFQ
                     LWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLANAFDGPGGALAHAFLPRRGEAHF
                     DGDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKKLGRDALLSWDDV
                     LAVQSLYGKPLGRSVATQLPGKVFTDFEAWDPHNSQSRRPETRGPKYCHSSFDAITVD
                     GQWRLYVFKGSYFWEVTVDGNVSEPRPLQKRWPGLPPGIEAAAVSLEDGDFYFFKGNR
                     CWRFQGTKSVWGFAQLCRAGGLPRHPDAALFFPPLRRLVLFKGSRYYVLAQGGMQVEP
                     YYPRSLRDWAGVPEEVSGALPRPDGSIIFFRDDHYWHLDQAKLRVTSSGRWATELSWM
                     GCWNANSGGALF"
     exon            294..373
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /inference="alignment:Splign:2.1.0"
     exon            374..561
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /inference="alignment:Splign:2.1.0"
     exon            562..786
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1032
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1182
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1350
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..3528
                     /gene="Mmp28"
                     /gene_synonym="D130023P12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcggtcc tccggttgac tgacccacag gcaggcatcg cgggtgccgg acaacctcgg
       61 gcggcggtgg aaccaggcgc tagggaccct ggggacctgg tgggtccgca cgcgggccgc
      121 gacgaactgg catccgtggg agtcgggcac agctgaccac caccccccag cagctcgctg
      181 cgatggtggc tggcgtgagt ctcctgctgc gcgccctgcc gctgctgctg tggggctgcc
      241 aggacgcaca gcccacccag cacggactcc cggagctgcg ccaggaggca gaggcattcc
      301 tggagaagta tggatacctc agtgagcagg gctccaaagc cccagcctcc gcacagttca
      361 ggaacgccat cagagagttc cagtggatat cccagctgcc cctcagtggt gtgctggacc
      421 aggccacact gcgccagatg acccgcccac gctgtggggt tgcggatact gacagtcatg
      481 ccacttggac agagaggatc agtaccctgc ttgctggaca ccgagccaaa atgaggcgta
      541 agaaacgctt tgcaaagcca ggtaacaaat ggtacaagca gcatctttcc taccgcctgg
      601 tgaactggcc tgagcgcctg cccgagccag ctgttcgagg ggccgtgcgc gctgccttcc
      661 agctgtggag taatgtgtca gcactggagt tctgggaagc cccagccacg ggccctgccg
      721 acatccgcct caccttcttc caaggagacc acaatgatgg gctggccaac gccttcgatg
      781 gcccaggggg tgccctggca cacgcctttc tgccccggcg gggcgaagcg catttcgacg
      841 gagacgagcg ctggtctctg agccgccgcc gtgggcgcaa cttgttcgtg gtgctggcgc
      901 acgaaatcgg ccacacgctc ggtctcacgc actcgcccgc gccacgggcg cttatggcgc
      961 cctactacaa gaagctgggc cgcgacgcct tgctcagctg ggacgatgtg ctggcggtgc
     1021 agagcctgta cggaaagcct ctgggacgct cagtagccac ccaactcccc ggaaaggtgt
     1081 tcactgactt tgaggcctgg gacccccaca actcccagag cagacgcccg gaaaccagag
     1141 gtcctaaata ctgccactct tcctttgatg ccatcactgt agatgggcaa tggcgactgt
     1201 atgtcttcaa agggagttac ttctgggaag tcacagttga tggcaatgtt tcagagcctc
     1261 gtccactaca gaaaagatgg ccaggactgc cacctggtat tgaggctgct gcagtgtctt
     1321 tggaagatgg agacttctac ttctttaaag ggaatcgttg ttggaggttc cagggcacga
     1381 agtccgtgtg ggggttcgca cagctctgcc gggcaggtgg tctaccccga cacccggacg
     1441 cagctctctt cttcccgcct ctgcgccgcc tagtcctctt caagggttcc cgctactacg
     1501 tgctagctca aggagggatg caagtggagc cctactatcc ccgcagcctg cgagactggg
     1561 ccggtgtccc cgaggaggtc agcggcgccc tgccaaggcc ggatggctcc attatcttct
     1621 tcagagatga ccactattgg catttggatc aagccaaact gcgggtgacc agctccggtc
     1681 gctgggctac cgagctgtcc tggatgggct gttggaatgc caactcagga ggtgccctgt
     1741 tctgaaggct ccccatcact gaatgaaccg tggttgctgc ctcctgagag gtgggtcctg
     1801 tctaggaagc ccctggactt tgcaagaacc tcttgagcag taaggactcc aagcaggaaa
     1861 tcaatcagca tttgttctcc gggatggaaa gagaactagg gttcccatag ccttttccct
     1921 caaagacctt tttccttccc actagtgtgt gtatgtggga aggtggtgaa gatgaaggtt
     1981 ctggtgaaga tgtcccatgc ccacagtgct gagtcccagg aagatgcaaa actcagctga
     2041 ggttggagac tgtatctgca ggaccctccc tttcagtgcc tttcaggctc agttcttggg
     2101 gaatcacctg ctatttcatc agagacttca ccccagctcc taccctcagc aagctgggat
     2161 gtagtgaagc ctcgaggatc cccactgtca gaggctctct tttggttcag gatgcagagc
     2221 aggagggaat gtgttcctcc tgagcccgac ttgttgtctg ggctaatgaa gaagcacccc
     2281 ccagctggtc aacgtagagg tgcagcagac ttccctagat agaattgtct acccttctca
     2341 atagaagcac atgggtactg ggtgctggag acacaaggac catgcactta catccaaccc
     2401 agctgtgtat ggttatcatg gagagacagg gtgaacctct cttcaaaatt caggacattt
     2461 tcaccccatt tgcctccaag ttggacatct tgagcatcag gaagatgaaa gagggccctt
     2521 gggggtccgc tcaagatgta gcctccattg cgatcttcag gctgcgtgaa gcccgtttgc
     2581 ccgcaatggc cccgttctcc aaggccacac agccagcatt ccgaagctca tgcagtctag
     2641 caagaatagc tgggattcct ggagaaggaa ccagccccct gccttcccct tttgtctcag
     2701 cctgtctcag tattaatttt agcatctgga tctccagccc tctctcctcc ctctccacct
     2761 accagtgcac acacacacac acgcacaatg accaccaaca gccagctctc agggagggga
     2821 gaatccggca agagagcagc ccgaagttcc ccagaggcat tgctggccac gcgccctcct
     2881 ttcttctctg tgcagtggac agaatggcct ttgactgccc ttggatgcaa gtgctttgta
     2941 ctgccctgtc ccagggaaaa catggaggaa cctccctgct agcccactgc tgtctgggtt
     3001 gtacccagcg ggagagaaag gagagtctca tctttatcac tctattccac ctcaagcgac
     3061 tctgattgga gactttattg ctgattagaa ggaaagaggc aatttattaa gagggctaag
     3121 gacaccccga ggctatcttt ctccagggta agccggagag aggccagagg acctgaaaac
     3181 gatgcaggca aggttgtgtt gaaggcgtga gggtcaggag ggctgtaggt gctgggtact
     3241 gtctggggag gagtgcctag tttcttctat agttccgcaa gacaacagat ggaaccgtga
     3301 accgacggtg ggccttctca ccggtaggag gcgctaagga tggcggcttg aagggacagt
     3361 tctgtggaac tcactagaga tagaagagtt tggagcattg cgggctcgga ggctgggagt
     3421 caatgagctc agagttgccg gtggcctctg ccttacccag gtcagggtgc tcaagaatac
     3481 agtgctccac gtaggccggg tggctgtgca gagtcttgca tttcttgc
//
