LOCUS       NM_001033339            3670 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus matrix metallopeptidase 25 (Mmp25), transcript variant
            1, mRNA.
ACCESSION   NM_001033339 XM_139838
VERSION     NM_001033339.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Kyprianou C, Christodoulou N, Hamilton RS, Nahaboo W, Boomgaard DS,
            Amadei G, Migeotte I and Zernicka-Goetz M.
  TITLE     Basement membrane remodelling regulates mouse embryogenesis
  JOURNAL   Nature 582 (7811), 253-258 (2020)
   PUBMED   32523119
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Soria-Valles C, Gutierrez-Fernandez A, Osorio FG, Carrero D,
            Ferrando AA, Colado E, Fernandez-Garcia MS, Bonzon-Kulichenko E,
            Vazquez J, Fueyo A and Lopez-Otin C.
  TITLE     MMP-25 Metalloprotease Regulates Innate Immune Response through
            NF-kappaB Signaling
  JOURNAL   J Immunol 197 (1), 296-302 (2016)
   PUBMED   27259858
  REMARK    GeneRIF: this study shows that Mmp25-null mice exhibit a defective
            innate immune response characterized by low sensitivity to
            bacterial LPS, hypergammaglobulinemia, and reduced secretion of
            proinflammatory molecules
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Itoh Y.
  TITLE     Membrane-type matrix metalloproteinases: Their functions and
            regulations
  JOURNAL   Matrix Biol 44-46, 207-223 (2015)
   PUBMED   25794647
  REMARK    Review article
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Newby AC.
  TITLE     Metalloproteinases promote plaque rupture and myocardial
            infarction: A persuasive concept waiting for clinical translation
  JOURNAL   Matrix Biol 44-46, 157-166 (2015)
   PUBMED   25636537
  REMARK    Review article
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Tocchi A and Parks WC.
  TITLE     Functional interactions between matrix metalloproteinases and
            glycosaminoglycans
  JOURNAL   FEBS J 280 (10), 2332-2341 (2013)
   PUBMED   23421805
  REMARK    Review article
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   Brown GD and Nazarali AJ.
  TITLE     Matrix metalloproteinase-25 has a functional role in mouse
            secondary palate development and is a downstream target of
            TGF-beta3
  JOURNAL   BMC Dev Biol 10, 93 (2010)
   PUBMED   20809987
  REMARK    GeneRIF: These data suggest MMP-25 is a direct transcriptional
            target for TGF-beta3 in mouse secondary palate development and
            could be a target for TGF-beta3 elsewhere as well.
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154766.2, AK089533.1,
            AK137491.1 and BC059059.1.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_001033339.5.
            
            On Feb 18, 2016 this sequence version replaced NM_001033339.3.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded precursor undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Feb
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154458.1, BC112379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC154766.2         47851-48110
            261-1169            AK089533.1         1-909
            1170-1989           AK137491.1         772-1591
            1990-2742           AK089533.1         1729-2481
            2743-3670           BC059059.1         3492-4419
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.87 cM"
     gene            1..3670
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /note="matrix metallopeptidase 25"
                     /db_xref="GeneID:240047"
                     /db_xref="MGI:MGI:2443938"
     exon            1..679
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..2263
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     matrix metalloproteinase-25"
                     /codon_start=1
                     /product="matrix metalloproteinase-25 isoform 1"
                     /protein_id="NP_001028511.1"
                     /db_xref="CCDS:CCDS28452.1"
                     /db_xref="GeneID:240047"
                     /db_xref="MGI:MGI:2443938"
                     /translation="MCFPGSQISPARLYYLVSAPWICTGSLTSSRLPRRRESGPLRVP
                     PRSVQAERILRLPAFGLPLLALLLVPLLPVRAQNPDAKVVSMGVEWLTRYGYLPPADP
                     VHAQMQSLEKLQDAIKVMQRFAGLPETGQMDPMTIKTMRKPRCSLPDVLGAAGLVRRR
                     RRYSLSGSVWKKRTLTWSIRSFSQKSQLSPQIVRTLLSYALAVWATESGLTFQEVNSQ
                     YQEPDIIIHFARAYHQDSYPFDGSGGTLAHAFFPGEHPISGDTHFDDEETWTFGSTDD
                     NGIDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPATYRLPQDDRDGLQQLYG
                     RVSQNPNARPTRKPLVPPPQPPAMPPDSPATPVPDRCEGNFDAVANIRGEIFLFKGPW
                     FWRLQPSGQLVSPRPAGLHRFWEGLPTHVKVIQAAYARPLDGRIILFSGPQFWVFQER
                     QLEGAARPLVEFGLPPGEDVDAVFSWPHNGKTYLIRGQKYWRYDEVAARPDPGYPRAL
                     SLWDGAPFAPDDVTISNTGDTYFFKGTHFWRFAEGSVKAESDSPQPIGPKWLDCPAPN
                     SDPRVTSPPKTTSKTRSCDCHCELNQASEQLSPLLLPLLPLVAGEVFSY"
     exon            680..812
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            813..948
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1238
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1415
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1500
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1583
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1736
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1994
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..3662
                     /gene="Mmp25"
                     /gene_synonym="F730048C11Rik; Leukolysin; MMP20; MT6-MMP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccctgc gacagagcat ggatctggga acagaaactt ttagactgag acggcggagt
       61 agaggacttg tcagccggct tgccccactg tagctggccc ttaagctcat aggagagtcc
      121 ctgcgtgccg gtggggaaca gggagagccc ctgaccctcc tcttggacac tgacgttgga
      181 agattgggct acttccccta ccgcgccctt aacgcttctc tgggtgagcc ccgcctcatc
      241 caggctccca ctagcatatt gggcagttgg cgcctcgccc aggctggacc tggaggagac
      301 aggagtaggg gacctctttg ccggacctct gtcccctcct gagccttctc cacgctctca
      361 ggacccccac tccccagcgc cacctggacc ctcgattatc gccgttcagc ccgtgatgtg
      421 cttcccagga tcccagatct ctcctgcccg tctctactac cttgtgtcgg ctccctggat
      481 ctgcaccggg tccctgacct cctccagact tccacggcgg cgggagtcag ggcctcttcg
      541 cgtgcctccg cggtccgtcc aagctgaacg catcttgagg ctgccggctt tcggtctccc
      601 gttgctggcg cttctgttgg ttccgctgct gccggtgcgc gctcagaatc ccgatgcgaa
      661 ggtcgtgagc atgggcgtgg aatggctgac tcgctatggc tacctgccac cggcggatcc
      721 tgtccacgcc cagatgcaga gtcttgagaa actgcaggat gcaatcaaag tcatgcagag
      781 atttgccgga ctacctgaga ctggacaaat ggacccaatg acaataaaga ccatgcgcaa
      841 gccccggtgc tccctgcctg atgtcctggg cgcagctggg ctggtcagac gccgacgtcg
      901 ctattctctg agtggcagtg tttggaagaa acgcaccctg acatggagta tccggtcctt
      961 ctctcagaaa tcccagttga gcccgcagat tgttcggacc ctcctgagct atgccctggc
     1021 tgtctgggct actgaatcag gccttacatt ccaggaggtg aattctcagt accaggagcc
     1081 tgacatcatt atccactttg ctcgggccta ccaccaggac agttacccct ttgacgggtc
     1141 tggtggcacg ttggctcacg ccttcttccc tggggagcac cctatctctg gagacacgca
     1201 ctttgatgat gaagagacct ggacttttgg gtcaacagat gataacggaa ttgacctatt
     1261 tgcagtagca gttcatgaat ttggccatgc cctaggcctt ggccactctt ctgcacccaa
     1321 ctccattatg cggcccttct accagggccc ggtgggtgac cctgccacat accgtttgcc
     1381 ccaggatgac cgtgacggac tgcagcagct ctatgggaga gtgtcccaaa atccaaatgc
     1441 caggcccaca aggaaacccc tggttccgcc tccccagcct ccagccatgc cccctgacag
     1501 ccccgccaca cctgtgcctg accgctgtga gggcaacttt gatgccgttg ccaacattcg
     1561 aggggaaatt ttcctcttca aaggcccatg gttttggcgc ctccaaccct caggacagct
     1621 ggtatcaccc cgccctgctg ggttgcaccg cttttgggag gggctgccaa cccatgtgaa
     1681 agtcatccag gctgcctatg cccgacccct agatggccga atcatcctct tcagcggccc
     1741 gcagttctgg gtgttccagg aacgacagct tgagggtgca gcgcggccac tggtagagtt
     1801 tgggctgccc ccaggagaag acgtggatgc tgtgttctca tggcctcaca atggcaagac
     1861 atacctgatc cgaggtcaaa agtactggcg gtatgacgag gtggccgccc gcccagaccc
     1921 tggctaccca cgtgccttga gtctctggga tggggcgccc tttgccccag acgatgtcac
     1981 catcagcaac acaggtgaca cttacttttt caagggcacc catttctggc gctttgcgga
     2041 gggcagtgtc aaagctgagt cagattcccc ccagcccatt gggcccaagt ggctggactg
     2101 ccctgccccc aactctgacc ctcgagtcac cagtcccccg aaaacgacat ccaaaacccg
     2161 aagctgtgat tgtcactgcg agctcaatca agcctcagag cagctgtcgc ccctcctgct
     2221 gcctctccta cccctagtgg ctggagaggt cttttcttac tgaaacctgg tccttccttg
     2281 tggacttcct atataaaagg aagacggagt ctcccgcagc ggggcctcac catctgtgct
     2341 ccgcgtccct catcccacgt gcacagagct gagagattcc tagtagaagc ccggggacgc
     2401 ctccagtgtt actgagtctg ctttctgtta gggtgcaggg agccgtggcc atagtgaggg
     2461 tggccgccag ggggtggtgt gcaccctctc catcgccaag aggggcgtgc ctgctgtagc
     2521 tactagaact agaaacccag cagaattgca gctcctcaaa ccagaattgc tcctccaaac
     2581 caaggtgaca ctaacaccca ggttatgtgc tgccttctgc tgagctaact ggctttctgg
     2641 gaatccccac tcctctaatt ctcaactagt cctactgatc acagtgggat ggtgactgta
     2701 ctctgactag atgcgttaaa caggaccagg acattgaacc ccagcatctc ctttagcctc
     2761 tgaatgttcc tgaatcttct taccatgatc tactccctcc atgtcccttc ataatcactg
     2821 ccacagggta gggacttagg ccaagcactg ccacctcctc tagggtgtgc gtcaagtctt
     2881 ggctgacaac agtgttgatg tggatggaat ttctccatgt ttggccctgc ttatctcctt
     2941 ttacgtcacc ctcatcccag aacacagcct agggtcatca ccctgaactc aggattgccc
     3001 cattcatttg gaagggatct tatgattcct gtctttgtca ctgattgctg tcctagcccc
     3061 ccccccccca gggtgcccaa tgagacacag tgagcagtga aaaaaaaacc tgaggtagct
     3121 tccttcaaac caacttcctc atagattcag gacctagatc attgcttctg tgcagaacct
     3181 catgggattt tttttttttc ccaagacagg gtttctctgt atagccctgg ctgtcctgaa
     3241 actcacactg tagaccaggc tggcctcgaa ctcagagata tggggcctct tcctactgag
     3301 tgctgggatt aaagatgtgc accgccacta tccagcatct catgggtatt caagaataaa
     3361 gatcattttc ccttgccctg aatccgcatt ctggggaggg ggccaagaat ctatatttag
     3421 gaatgaatgc atagacagct tgagtagttt acttagtaag gcaaaagaac caagtttagg
     3481 atggagagat ggctcagtgg ttaagggtac tggctgctct tccagaggtt cagagttcaa
     3541 ttcccggcaa ccacttggtg gctcacaacc atctgtaatg ggatccaatg ccctctttaa
     3601 tgtgtctgaa gacagagcta cagtctcata tacataaact aaatacatcc ttaaaaaaaa
     3661 aaaaaaaaaa
//
