LOCUS       NM_010808               4306 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus matrix metallopeptidase 24 (Mmp24), mRNA.
ACCESSION   NM_010808
VERSION     NM_010808.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4306)
  AUTHORS   Pilat,D., Paumier,J.M., Louis,L., Manrique,C., Garcia-Gonzalez,L.,
            Stephan,D., Bernard,A., Pardossi-Piquard,R., Checler,F.,
            Khrestchatisky,M., Di Pasquale,E., Baranger,K. and Rivera,S.
  TITLE     Suppression of MT5-MMP Reveals Early Modulation of Alzheimer's
            Pathogenic Events in Primary Neuronal Cultures of 5xFAD Mice
  JOURNAL   Biomolecules 14 (12), 1645 (2024)
   PUBMED   39766352
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4306)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4306)
  AUTHORS   Sanz,R.L., Ferraro,G.B., Kacervosky,J., Salesse,C., Gowing,E.,
            Hua,L., Rambaldi,I., Beaubien,F., Holmbeck,K., Cloutier,J.F.,
            Levesque,M., Murai,K. and Fournier,A.E.
  TITLE     MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66
            Receptor Ectodomain Shedding
  JOURNAL   J Neurosci 38 (3), 518-529 (2018)
   PUBMED   29196321
REFERENCE   4  (bases 1 to 4306)
  AUTHORS   Baranger,K., Bonnet,A.E., Girard,S.D., Paumier,J.M.,
            Garcia-Gonzalez,L., Elmanaa,W., Bernard,A., Charrat,E., Stephan,D.,
            Bauer,C., Moschke,K., Lichtenthaler,S.F., Roman,F.S., Checler,F.,
            Khrestchatisky,M. and Rivera,S.
  TITLE     MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of
            5xFAD Mice and APP Trafficking in vitro
  JOURNAL   Front Mol Neurosci 9, 163 (2017)
   PUBMED   28119565
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4306)
  AUTHORS   Willem,M., Tahirovic,S., Busche,M.A., Ovsepian,S.V., Chafai,M.,
            Kootar,S., Hornburg,D., Evans,L.D., Moore,S., Daria,A., Hampel,H.,
            Muller,V., Giudici,C., Nuscher,B., Wenninger-Weinzierl,A.,
            Kremmer,E., Heneka,M.T., Thal,D.R., Giedraitis,V., Lannfelt,L.,
            Muller,U., Livesey,F.J., Meissner,F., Herms,J., Konnerth,A.,
            Marie,H. and Haass,C.
  TITLE     eta-Secretase processing of APP inhibits neuronal activity in the
            hippocampus
  JOURNAL   Nature 526 (7573), 443-447 (2015)
   PUBMED   26322584
  REMARK    GeneRIF: APP carboxy-terminal fragment generation is mediated in
            part by membrane-bound matrix metalloproteinases such as MT5-MMP,
            referred to as eta-secretase activity
REFERENCE   6  (bases 1 to 4306)
  AUTHORS   Johansson,N., Ahonen,M. and Kahari,V.M.
  TITLE     Matrix metalloproteinases in tumor invasion
  JOURNAL   Cell Mol Life Sci 57 (1), 5-15 (2000)
   PUBMED   10949577
  REMARK    Review article
REFERENCE   7  (bases 1 to 4306)
  AUTHORS   Wang,X., Yi,J., Lei,J. and Pei,D.
  TITLE     Expression, purification and characterization of recombinant mouse
            MT5-MMP protein products
  JOURNAL   FEBS Lett 462 (3), 261-266 (1999)
   PUBMED   10622708
REFERENCE   8  (bases 1 to 4306)
  AUTHORS   Kajita,M., Kinoh,H., Ito,N., Takamura,A., Itoh,Y., Okada,A.,
            Sato,H. and Seiki,M.
  TITLE     Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded
            by a novel major transcript: isolation of complementary DNA clones
            for human and mouse mt4-mmp transcripts
  JOURNAL   FEBS Lett 457 (3), 353-356 (1999)
   PUBMED   10471807
REFERENCE   9  (bases 1 to 4306)
  AUTHORS   Pei,D.
  TITLE     Identification and characterization of the fifth membrane-type
            matrix metalloproteinase MT5-MMP
  JOURNAL   J Biol Chem 274 (13), 8925-8932 (1999)
   PUBMED   10085137
REFERENCE   10 (bases 1 to 4306)
  AUTHORS   Kinoh,H., Hayashita,H., Kajita,M., Okada,A. and Seiki,M.
  TITLE     Assignment of the genes for membrane-type-4 matrix
            metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human
            chromosome band 12q24.3 and membrane-type-5 matrix
            metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human
            chromosome band 20q11.2-->q12, respectively, by radiation hybrid
            and in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 97-98 (1999)
   PUBMED   10640822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL929233.9, CD355182.1,
            CF540062.1, CD348827.1, BQ745403.1, CA320413.1 and BM947491.1.
            
            On Feb 18, 2016 this sequence version replaced NM_010808.3.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. Mice lacking the encoded protein do not develop neuropathic
            pain with mechanical allodynia after sciatic nerve injury, display
            enhanced sensitivity to noxious thermal stimuli under basal
            conditions, and develop hyperalgesia during inflammation. [provided
            by RefSeq, Feb 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB021226.1, AJ010262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL929233.9         84218-84219
            3-162               CD355182.1         1-160
            163-716             CF540062.1         1-554
            717-1176            CD348827.1         206-665
            1177-1762           BQ745403.1         28-613
            1763-1772           CA320413.1         513-522
            1773-2137           BM947491.1         104-468
            2138-4306           AL929233.9         125074-127242
FEATURES             Location/Qualifiers
     source          1..4306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     gene            1..4306
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /note="matrix metallopeptidase 24"
                     /db_xref="GeneID:17391"
                     /db_xref="MGI:MGI:1341867"
     exon            1..296
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1988
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /note="matrix metalloproteinase-24; membrane type 5-MMP;
                     matrix metalloproteinase-21; membrane-type matrix
                     metalloproteinase 5"
                     /codon_start=1
                     /product="matrix metalloproteinase-24 preproprotein"
                     /protein_id="NP_034938.3"
                     /db_xref="CCDS:CCDS16955.1"
                     /db_xref="GeneID:17391"
                     /db_xref="MGI:MGI:1341867"
                     /translation="MPRSRGGRAAPGQASRWSGWRAPGRLLPLLPALCCLAAAAGAGK
                     PAGADAPFAGQNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQT
                     TIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKA
                     IRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHA
                     YFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPF
                     YQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERHPRP
                     PRPPLGDRPSTPGAKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIE
                     QFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGID
                     TALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYY
                     TYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCKQKEVERRKERRLPQDDVDIMVTI
                     DDVPGSVNAVAVVVPCTLSLCLLVLLYTIFQFKNKAGPQPVTYYKRPVQEWV"
     exon            297..445
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            446..562
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            563..867
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1029
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1244
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1383
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1650
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..4306
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3521..3526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /note="hexamer: AGTAAA"
     polyA_site      3542
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /note="major polyA site"
     regulatory      4285..4290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /note="hexamer: AATAAA"
     polyA_site      4306
                     /gene="Mmp24"
                     /gene_synonym="MMP-21; MT5-MMP; MT5MMP; MTMMP5"
                     /note="major polyA site"
ORIGIN      
        1 aggcgggcca ggcgcgcgtc cgcggcgccg tgactcggcg gctccgcagc ggctgcagcg
       61 ggaggacccg gccggagccg ccgccgccgc cgccgccatc gcagccgggc ggccgggccc
      121 ccgccgccgg gatgccgagg agccggggcg gccgcgctgc gccgggccag gcctcgcgct
      181 ggagcggctg gcgggccccg gggcggctgc tgccgctgct gcccgcgctc tgctgcctcg
      241 cggcggcggc gggggccggg aagccggccg gggcggacgc gcccttcgct gggcagaact
      301 ggttaaaatc atatggctat ctgcttccct atgagtcgcg ggcatctgcg ttgcattctg
      361 ggaaggcctt gcagtccgcg gtctccacta tgcagcagtt ttacgggatc ccagtcaccg
      421 gtgtgttgga tcagacaaca atcgagtgga tgaagaaacc tcgatgtggc gtccctgatc
      481 atccccactt gagcaggagg aggagaaata agcgatatgc cctaactgga cagaagtgga
      541 ggcagaaaca catcacctac agcattcaca attatacccc aaaggtgggt gagctggaca
      601 cacggaaggc tattcgtcag gctttcgatg tgtggcagaa ggtgactcca ctgacctttg
      661 aagaggtgcc ataccatgag atcaaaagtg accggaagga ggcagacatc atgatcttct
      721 ttgcttctgg tttccatggt gacagctccc catttgatgg ggaaggggga ttcctagccc
      781 atgcctactt tcctggccca gggatcggag gagacactca ctttgattca gatgaaccct
      841 ggacgctagg aaatgccaac catgatggca atgacctctt cctggtggcc gtgcatgaac
      901 tgggccatgc actgggcttg gagcactcta atgaccccag tgctatcatg gctcccttct
      961 accaatacat ggagacacac aacttcaagc taccgcagga cgatctccag ggcatccaga
     1021 agatttacgg acccccagct gagcctctgg agcccacaag gcccctccct acactcccgg
     1081 tccgcaggat ccactcgcca tctgagagga agcacgagcg gcacccaagg cccccacggc
     1141 cgcctcttgg ggaccggcca tccactccag gtgccaaacc caacatctgc gatggcaact
     1201 tcaacacagt ggccctcttc cgaggggaga tgtttgtgtt caaggatcgc tggttctggc
     1261 gcctgcgcaa taaccgggtg caggaaggct accccatgca gatcgaacag ttctggaagg
     1321 gcctgcccgc ccgcatagac gcagcctatg aaagagctga cgggagattc gtcttcttca
     1381 aaggagacaa gtactgggtt ttcaaagaag tgacggtgga acctgggtac ccccacagct
     1441 tgggggagct gggaagctgc ctgccccgtg aaggaattga cacagctctg cgctgggaac
     1501 ctgtgggcaa aacctacttc ttcaaaggcg aacgatactg gcgctacagc gaggagcggc
     1561 gagccacaga ccctggctac cccaagccca tcaccgtgtg gaagggcatc ccgcaggctc
     1621 cgcaaggggc cttcatcagc aaggaaggat attacaccta cttctacaaa ggccgggact
     1681 actggaagtt tgacaaccag aaactgagcg tggagccagg ctacccacgc aacatcctgc
     1741 gtgactggat gggctgcaag cagaaggagg tagagcggcg taaggagcgg aggctgcccc
     1801 aggatgatgt ggacatcatg gtgaccatcg atgacgtgcc aggctctgtg aacgctgtgg
     1861 ctgtggttgt cccctgcaca ctgtccctct gcctcctggt gctgctctac actatcttcc
     1921 aattcaagaa caaggcgggt cctcagcccg tcacctacta taagcggccg gtccaggagt
     1981 gggtatgagc agcccagaac cctctctgtc tacccggtct ggccagccag gcccttcctc
     2041 accagggtct gaggggcagc tctagccact gcccactggg gccagcaggg ccctaggcca
     2101 ggttcgtgtg tagctgaagt ggtgggtgca ctggtctagg ctgagtgcgg ggcagggagt
     2161 gatggtggct atgccccagg ttgggtagct ggcacccagc tgccagcctt ctgtcctggg
     2221 cagacctctc tctactcaag ggaataggcc aggccctgtc aggaggcaag gatggtgcca
     2281 ggaggtgccc ctgaggtcat tgcatcctgt ggtgtctgca agataccaca gctccagtcc
     2341 tggctgggac ccagccctct gaggcaagcc agcactagct ctcaccccca ccccaagatg
     2401 ccaccaatcc cagtcccctc tgccaacacc tgctggtcag atgtcccctc atccctaccc
     2461 tactatcctc caaggctgca gtgcccctga tgccaacaga gtgggcaaaa gcctgggttt
     2521 cccctgctag cccatagagg attcctcagg aaacctgttc cacccgccag gtctcctctg
     2581 agactcagaa cttagggtca catgctgcag gcaaggctgt ggcccagctg gatctcacaa
     2641 ggacccagct gtcatgtcgt gaatatttaa atgtcctgtc actactgttt aaagtcccat
     2701 tttgcaaagg ctacttgagg ctttaggtca gctagaggtg actgtcttgg tgatgaggcc
     2761 agtatggtgg cccttccttg ggcactaagg accacggtgc tgcaaaggcc actcgggcat
     2821 cctgatacta gcgggcatcc tgttcaggag gctcaacagc tgcaggagct gaccctggtt
     2881 ctgggggcgg atgcaagttt gtgaccattc tctactcccc ttcattaatg ttgtcccctg
     2941 ccctgctcca gcctgtcctc tgtggcctgg gggctcggcc tgactacagg taaagcagag
     3001 aggattctag agccaccctt gtcatcttct cagagtaagg gaccagggca gccttttaag
     3061 ttctccatct acatccccag tgaccctgag gcaactcagc tccagcctgg agtcggtgtt
     3121 tgtgctccta tcttgaccct ggcagcccag gtctctgggt ccatcttcct gcactgctct
     3181 tagaaaaagg gtcctcttcc cagctggtag cagccccagg ctttggggtt tcccccaact
     3241 ccctaaccca aactaccttt ttgttgtttg ttttaacctg aggcccttct tcacatctga
     3301 cagttcctaa gtcttggttt ggcttgctcc aaaaccactg ggtgcaagtg tcactcactg
     3361 gctctctgcc aaacccaacg gtggtatgag gcggccatca gggtgctagt gggtcacaga
     3421 taccaactct gacctctgag cctgcatggg ctttgcccct gccctgtggt ctctcgccct
     3481 gtagcacaga cagagactct tgatgccctg ggagttgttg agtaaaatct cttgtcccag
     3541 aagcacctat gtgggtccac tgtgtcccat ctcaccattg tgttcttgct cattttggcc
     3601 aagggcaggc tccctggggc aggcggggaa caactgcaga gatttagtga ttcataggtt
     3661 tgtacagcgt tttatacttt gcaaagcact ttattagctc acagctgtcc actcacatga
     3721 aactcctgta ggctctgaga gaggctgagg gtagcactca tcttaccctc agatgaagca
     3781 caaggaggtc ttattatctg cccctgccat ccaggtggcc ctggctgggt cttgtgtccc
     3841 catcagtggg cccttccagg gtccgagaaa actgtctctt ctagtcctct cctctgggcc
     3901 tccctccccc agtcccctgg tccctctcct caggttggtg ctcacttctt gaaagctcta
     3961 ggccccgcag gctccctgtt ggctcctggc attccaaggc cagttgcgaa agagcagggg
     4021 atggaggcag gcagcccagg ctgcagatgt gagggacaca gggccgggcc cagagagggc
     4081 tcagcctaga ggcttccaat cttggattct tctgcctgcg gtcatctgtt tgtccatcag
     4141 cccaggtcag agcagtcaga ggggcaaagt actagagccc ccagagctca gcttcccctc
     4201 ggcctgggtg acatcacagc atctcagtgt cggtcacatt ttaaactgat cagcctttgt
     4261 acaatgtttt ttaaatcatt tctaaataaa acagaaatac agtgtt
//
