LOCUS       NM_011985               1446 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus matrix metallopeptidase 23 (Mmp23), transcript variant
            1, mRNA.
ACCESSION   NM_011985
VERSION     NM_011985.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Tocchi A and Parks WC.
  TITLE     Functional interactions between matrix metalloproteinases and
            glycosaminoglycans
  JOURNAL   FEBS J 280 (10), 2332-2341 (2013)
   PUBMED   23421805
  REMARK    Review article
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin
            J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D and
            Ottolenghi C.
  TITLE     Foxl2 functions in sex determination and histogenesis throughout
            mouse ovary development
  JOURNAL   BMC Dev Biol 9, 36 (2009)
   PUBMED   19538736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z and Hebrok M.
  TITLE     Matrix metalloproteinases 2 and 9 are dispensable for pancreatic
            islet formation and function in vivo
  JOURNAL   Diabetes 54 (3), 694-701 (2005)
   PUBMED   15734845
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Johansson N, Ahonen M and Kahari VM.
  TITLE     Matrix metalloproteinases in tumor invasion
  JOURNAL   Cell Mol Life Sci 57 (1), 5-15 (2000)
   PUBMED   10949577
  REMARK    Review article
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Pei D.
  TITLE     CA-MMP: a matrix metalloproteinase with a novel cysteine array, but
            without the classic cysteine switch
  JOURNAL   FEBS Lett 457 (2), 262-270 (1999)
   PUBMED   10471791
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627405.17, AK146510.1 and
            AA217682.1.
            
            [WARNING] On Oct 17, 2023 this sequence was replaced by
            NM_011985.4.
            
            On Feb 18, 2016 this sequence version replaced NM_011985.2.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded protein contains an N-terminal
            cysteine array and a novel immunoglobulin-fold domain at the
            C-terminus. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            processing. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF085742.1, BC107357.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AL627405.17        151628-151821       c
            195-1433            AK146510.1         2-1240
            1434-1446           AA217682.1         339-351
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.85 cM"
     gene            1..1446
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /note="matrix metallopeptidase 23"
                     /db_xref="GeneID:26561"
                     /db_xref="MGI:MGI:1347361"
     exon            1..357
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            358..494
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            495..634
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            635..802
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            803..967
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1078
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1205
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1434
                     /gene="Mmp23"
                     /gene_synonym="CA-MMP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaatcgca ccgggggatg cggacggttc cagacttaac gagtcggttc cttatttgag
       61 ccagcgcagc cgggtcctct cttcaccata gggctgtaac tcgagccgtc cgccgcccat
      121 ccccttccca ctccgcccca gctctgcgat ccaggtccct acgtcgcgcg gccccttgtg
      181 gccctaaccc gactggagtc tgccatgggc tgccgggcct gtctccgtcc ggaggcgtcc
      241 ggcgcggtac agggccgctg gttgggggct gccctgagcg ggttgtgcct tctctccgcg
      301 ttggcgttgc tggagtggct aggggcgccg accgagaccg cctggagggc agctcaggga
      361 aatgtagatg cgccaaatgt gggcagctcc actgcccagg tacccagact gttgaccatg
      421 tcggtaaccc gaagacgccg ctacacgctg acaccggcca ggctgcgctg ggaccacttc
      481 aacctcacat acagagttct ttccttcccc cggaatcttt taagcccgga agagacgcga
      541 aggggcctgg ctgctgcctt tcgaatgtgg agtgatgttt ccccattcag tttccgtgag
      601 gtggcccctg aacgtcccag tgacctcaag ataggtttct acccagtcaa ccacaccgac
      661 tgcttggtct ctgcagtgca ccactgcttt gatggtccca caggtgaact ggcccacgct
      721 ttcttcccac cccacggtgg cattcacttt gatgacagcg agtactgggt cttgggcccc
      781 acacgctaca gttggaagaa aggtgtttgg ctcacaaacc tggtgcacgt ggcagcccat
      841 gagattggcc atgcactggg cctgatgcac tcacagcaag atcaggcgct catgcacctc
      901 aatgccacat tgcgaggctg gaaggcactg tcccaggatg aactgtgggg gttacaccga
      961 ctctatggct gcctggaccg gatttttgtg tgtgcatcct gggcacgaaa gggattttgt
     1021 gatgtccgcc agaggctcat gaagaggctc tgccccagaa gctgtgattt ctgttatgaa
     1081 ttcccatttc ccacggtggc caccaccaca tcacccacca gaacgaaaac aaggttggtg
     1141 agagagggta ggaacatgac cttccactgt ggacagaaga tcctacacaa gaaagggaaa
     1201 gtatactggt acaaggacca ggaacccctg gagttctcct accctggcta tctggccctg
     1261 ggtgaggcac agctgagcat cattgccaac gcagtcaacg aaggcaccta cacatgtgtg
     1321 gtacgccggc accagcgtgt tctcagcacc tactcctgga gggtccgagt gaggaattga
     1381 cactgctcag agcctctgtg ctggaaggca gcagataaag cactttctct ctgaaaaaaa
     1441 aaaaaa
//
