LOCUS       NM_152944               1858 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus matrix metallopeptidase 21 (Mmp21), transcript variant
            1, mRNA.
ACCESSION   NM_152944
VERSION     NM_152944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Zhou,J., Liu,L., Hu,X., Feng,R., Zhao,N., Zhang,L., Hu,W.,
            Zhang,J., Huang,S., Liu,L., Li,W., Shan,Y. and Jin,J.
  TITLE     Matrix metalloproteinase-21 promotes metastasis via increasing the
            recruitment and M2 polarization of macrophages in HCC
  JOURNAL   Cancer Sci 114 (2), 423-435 (2023)
   PUBMED   35398966
  REMARK    GeneRIF: Matrix metalloproteinase-21 promotes metastasis via
            increasing the recruitment and M2 polarization of macrophages in
            HCC.
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Perles,Z., Moon,S., Ta-Shma,A., Yaacov,B., Francescatto,L.,
            Edvardson,S., Rein,A.J., Elpeleg,O. and Katsanis,N.
  TITLE     A human laterality disorder caused by a homozygous deleterious
            mutation in MMP21
  JOURNAL   J Med Genet 52 (12), 840-847 (2015)
   PUBMED   26429889
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Akawi,N., McRae,J., Ansari,M., Balasubramanian,M., Blyth,M.,
            Brady,A.F., Clayton,S., Cole,T., Deshpande,C., Fitzgerald,T.W.,
            Foulds,N., Francis,R., Gabriel,G., Gerety,S.S., Goodship,J.,
            Hobson,E., Jones,W.D., Joss,S., King,D., Klena,N., Kumar,A.,
            Lees,M., Lelliott,C., Lord,J., McMullan,D., O'Regan,M., Osio,D.,
            Piombo,V., Prigmore,E., Rajan,D., Rosser,E., Sifrim,A., Smith,A.,
            Swaminathan,G.J., Turnpenny,P., Whitworth,J., Wright,C.F.,
            Firth,H.V., Barrett,J.C., Lo,C.W., FitzPatrick,D.R. and Hurles,M.E.
  CONSRTM   DDD study
  TITLE     Discovery of four recessive developmental disorders using
            probabilistic genotype and phenotype matching among 4,125 families
  JOURNAL   Nat Genet 47 (11), 1363-1369 (2015)
   PUBMED   26437029
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Guimier,A., Gabriel,G.C., Bajolle,F., Tsang,M., Liu,H., Noll,A.,
            Schwartz,M., El Malti,R., Smith,L.D., Klena,N.T., Jimenez,G.,
            Miller,N.A., Oufadem,M., Moreau de Bellaing,A., Yagi,H.,
            Saunders,C.J., Baker,C.N., Di Filippo,S., Peterson,K.A.,
            Thiffault,I., Bole-Feysot,C., Cooley,L.D., Farrow,E.G., Masson,C.,
            Schoen,P., Deleuze,J.F., Nitschke,P., Lyonnet,S., de Pontual,L.,
            Murray,S.A., Bonnet,D., Kingsmore,S.F., Amiel,J., Bouvagnet,P.,
            Lo,C.W. and Gordon,C.T.
  TITLE     MMP21 is mutated in human heterotaxy and is required for normal
            left-right asymmetry in vertebrates
  JOURNAL   Nat Genet 47 (11), 1260-1263 (2015)
   PUBMED   26437028
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   6  (bases 1 to 1858)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   7  (bases 1 to 1858)
  AUTHORS   Tocchi,A. and Parks,W.C.
  TITLE     Functional interactions between matrix metalloproteinases and
            glycosaminoglycans
  JOURNAL   FEBS J 280 (10), 2332-2341 (2013)
   PUBMED   23421805
  REMARK    Review article
REFERENCE   8  (bases 1 to 1858)
  AUTHORS   Boyd,S., Virolainen,S., Parssinen,J., Skoog,T., van Hogerlinden,M.,
            Latonen,L., Kyllonen,L., Toftgard,R. and Saarialho-Kere,U.
  TITLE     MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell
            cancer
  JOURNAL   Exp Dermatol 18 (12), 1044-1052 (2009)
   PUBMED   19601983
  REMARK    GeneRIF: MMP-21 does not associate with invasion of squamous cell
            cancer but may be involved in keratinocyte differentiation.
REFERENCE   9  (bases 1 to 1858)
  AUTHORS   Ahokas,K., Lohi,J., Illman,S.A., Llano,E., Elomaa,O., Impola,U.,
            Karjalainen-Lindsberg,M.L. and Saarialho-Kere,U.
  TITLE     Matrix metalloproteinase-21 is expressed epithelially during
            development and in cancer and is up-regulated by transforming
            growth factor-beta1 in keratinocytes
  JOURNAL   Lab Invest 83 (12), 1887-1899 (2003)
   PUBMED   14691307
REFERENCE   10 (bases 1 to 1858)
  AUTHORS   Marchenko,G.N., Marchenko,N.D. and Strongin,A.Y.
  TITLE     The structure and regulation of the human and mouse matrix
            metalloproteinase-21 gene and protein
  JOURNAL   Biochem J 372 (Pt 2), 503-515 (2003)
   PUBMED   12617721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC106861.2 and AC127348.4.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. Mice harboring certain mutations in this gene
            exhibit congenital heart defects. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY124569.1, BC106861.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1772              BC106861.2         1-1772
            1773-1858           AC127348.4         115430-115515
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 77.24 cM"
     gene            1..1858
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /note="matrix metallopeptidase 21"
                     /db_xref="GeneID:214766"
                     /db_xref="MGI:MGI:2664387"
     exon            1..177
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1722
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; matrix metalloproteinase-21"
                     /codon_start=1
                     /product="matrix metalloproteinase-21 isoform 1 precursor"
                     /protein_id="NP_694423.1"
                     /db_xref="CCDS:CCDS21933.1"
                     /db_xref="GeneID:214766"
                     /db_xref="MGI:MGI:2664387"
                     /translation="MLAASVLRLTLPLCWLVAPQPTQPERLFHSRDRSDLEPSPLSQA
                     KPIADLHDAQSFLLKYGWSEIPSPKESAGVPVGFTLAQAVRRFQKANRLPASGELDSP
                     TLAAMNKPRCGVPDTRLPPRAALPTPPALLTSLGLRPRARQKRFLQMLFPKPDGQQED
                     ASDTGASRAFSKKTLTWRLVGDAYSSQLSGDEQRYIFRLAFRMWSEVTPLDFREDRTA
                     PGTMVDIKLGFGRGRHLGCPRVFDGSGQEFAHAWRLGEIHFDDDEHFTPLSSDTGISL
                     LKVAVHEIGHVLGLPHTYRVGSIMQPNYIPQEPAFELDWADRKAIQRLYGSCKGSFDT
                     VFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPTQS
                     IDAYVHVWSWGKDERYFFKGSQYWRYDSENDQAHTEDEQGRSYPKLISEGFPGIPSPL
                     DTAFYDRRQQLIYFFKESLVFAFDVNRNQVLNSYPKKMSQVFPAIMPQNHPFRNLDSA
                     YYSYAHNSIFFFKGNSYWKVVSDKDKQQNTRLPLNGLFPKKPVSEKWFDVCDVHTSTL
                     NM"
     exon            178..709
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            710..849
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            850..991
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1249
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1422
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1858
                     /gene="Mmp21"
                     /gene_synonym="b2b2458Clo; b2b873Clo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccagtg aagccatgct tgctgcctct gtcttgcgtc tgacactgcc gctctgctgg
       61 ctagttgcac cccagcccac ccagcctgag aggctcttcc acagccggga ccgttcggac
      121 ctggagccat ctcccctgag ccaggccaag cccattgctg acctccatga tgctcagagc
      181 ttcctattga aatatggctg gtcagagata cctagcccaa aggagtcagc aggagtccct
      241 gtgggattca ccttggctca agctgtacgt agattccaga aggcgaacag actgccagcc
      301 agtggggaat tggactcacc tacactggcc gctatgaaca agccacgctg tggggttcct
      361 gacacacggc tgccccctcg ggctgccctg ccaaccccac cagccctgct gacctcttta
      421 ggtctccggc ccagggccag acaaaagcgc tttcttcaaa tgctgttccc caagccagat
      481 gggcaacagg aggatgcctc agacactggg gccagcaggg ccttctccaa gaagacactg
      541 acctggaggc tggtgggaga tgcctacagc agccaactct ctggggatga gcagaggtac
      601 atctttagac tggccttcag gatgtggagt gaggtgacac cactggactt ccgggaggac
      661 cgcactgccc ctggcaccat ggtggacata aagctgggtt ttgggagagg ccggcacctg
      721 ggctgtccac gggtgtttga cgggagtgga caggagtttg cacatgcctg gcgcctgggt
      781 gagatccact ttgatgacga cgagcacttc actcctctct ccagtgacac aggcatcagc
      841 cttctcaaag tagctgtcca tgaaattggc cacgtcctcg gattgcctca cacctacagg
      901 gtgggatcca taatgcaacc aaactacatt ccccaggagc ctgcctttga gttggactgg
      961 gcagacagaa aagcaattca aagactatat ggttcgtgca aggggtcatt tgatacagtg
     1021 tttgactgga tccgcaagga gaggaaccaa tatggtgagg tgagggtgag attcaacacg
     1081 tacttcttcc gcaacagctg gtactggctc tacgaaaacc gcaacaacag gactcgctac
     1141 ggggaccccc tccaaatcct cactggctgg cgtgggatcc ccacgcagag catcgatgcc
     1201 tacgtccatg tctggtcatg gggaaaagac gagcgctact ttttcaaagg aagccaatac
     1261 tggagatatg acagtgagaa tgaccaggca cacacagaag acgaacaagg aaggagctac
     1321 cctaaactga tctcagaagg attccctggc atccccagcc ccctggacac ggccttttac
     1381 gatcggaggc agcagttaat ttacttcttc aaggagtctc tagtatttgc atttgatgtc
     1441 aaccgaaacc aagtacttaa ttcttatcca aagaagatga gccaagtgtt tccagcaata
     1501 atgcctcaaa accacccatt cagaaacctc gattcagcgt actactccta tgcacacaac
     1561 tccatcttct tcttcaaagg caactcgtac tggaaagtag ttagtgacaa ggacaaacag
     1621 cagaacaccc ggctgcctct gaatggctta tttccaaaaa aacctgtttc cgagaagtgg
     1681 tttgatgttt gtgatgttca cacctctacc ctgaacatgt aaagaagaaa atcaagacta
     1741 ggacttagga acagttttaa gggaacgtgt cagccttctc tgcaaagaaa acaaacctga
     1801 ttcttaatag ctaaagcaaa tatggcttcc taagctaaac caaacaagaa agcattac
//
