LOCUS       NM_032007               1997 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus matrix metallopeptidase 1b (interstitial collagenase)
            (Mmp1b), mRNA.
ACCESSION   NM_032007
VERSION     NM_032007.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1997)
  AUTHORS   Varadinkova,S., Oralova,V., Clarke,M., Frampton,J., Knopfova,L.,
            Lesot,H., Bartos,P. and Matalova,E.
  TITLE     Expression dynamics of metalloproteinases during mandibular bone
            formation: association with Myb transcription factor
  JOURNAL   Front Cell Dev Biol 11, 1168866 (2023)
   PUBMED   37701782
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1997)
  AUTHORS   Niebler,S., Schubert,T., Hunziker,E.B. and Bosserhoff,A.K.
  TITLE     Activating enhancer binding protein 2 epsilon
            (AP-2epsilon)-deficient mice exhibit increased matrix
            metalloproteinase 13 expression and progressive osteoarthritis
            development
  JOURNAL   Arthritis Res Ther 17 (1), 119 (2015)
   PUBMED   25964075
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1997)
  AUTHORS   Tocchi,A. and Parks,W.C.
  TITLE     Functional interactions between matrix metalloproteinases and
            glycosaminoglycans
  JOURNAL   FEBS J 280 (10), 2332-2341 (2013)
   PUBMED   23421805
  REMARK    Review article
REFERENCE   4  (bases 1 to 1997)
  AUTHORS   Tsuzurahara,F., Soeta,S., Kawawa,T., Baba,K. and Nakamura,M.
  TITLE     The role of macrophages in the disappearance of Meckel's cartilage
            during mandibular development in mice
  JOURNAL   Acta Histochem 113 (2), 194-200 (2011)
   PUBMED   19853894
REFERENCE   5  (bases 1 to 1997)
  AUTHORS   Stankunas,K., Hang,C.T., Tsun,Z.Y., Chen,H., Lee,N.V., Wu,J.I.,
            Shang,C., Bayle,J.H., Shou,W., Iruela-Arispe,M.L. and Chang,C.P.
  TITLE     Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment
            for myocardial morphogenesis
  JOURNAL   Dev Cell 14 (2), 298-311 (2008)
   PUBMED   18267097
REFERENCE   6  (bases 1 to 1997)
  AUTHORS   Chen,L., Nakai,M., Belton,R.J. Jr. and Nowak,R.A.
  TITLE     Expression of extracellular matrix metalloproteinase inducer and
            matrix metalloproteinases during mouse embryonic development
  JOURNAL   Reproduction 133 (2), 405-414 (2007)
   PUBMED   17307908
REFERENCE   7  (bases 1 to 1997)
  AUTHORS   Wang,X., Inoue,S., Gu,J., Miyoshi,E., Noda,K., Li,W.,
            Mizuno-Horikawa,Y., Nakano,M., Asahi,M., Takahashi,M., Uozumi,N.,
            Ihara,S., Lee,S.H., Ikeda,Y., Yamaguchi,Y., Aze,Y., Tomiyama,Y.,
            Fujii,J., Suzuki,K., Kondo,A., Shapiro,S.D., Lopez-Otin,C.,
            Kuwaki,T., Okabe,M., Honke,K. and Taniguchi,N.
  TITLE     Dysregulation of TGF-beta1 receptor activation leads to abnormal
            lung development and emphysema-like phenotype in core
            fucose-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (44), 15791-15796 (2005)
   PUBMED   16236725
REFERENCE   8  (bases 1 to 1997)
  AUTHORS   Guyot,R., Magre,S., Leduque,P. and Le Magueresse-Battistoni,B.
  TITLE     Differential expression of tissue inhibitor of metalloproteinases
            type 1 (TIMP-1) during mouse gonad development
  JOURNAL   Dev Dyn 227 (3), 357-366 (2003)
   PUBMED   12815621
REFERENCE   9  (bases 1 to 1997)
  AUTHORS   Balbin,M., Fueyo,A., Knauper,V., Lopez,J.M., Alvarez,J.,
            Sanchez,L.M., Quesada,V., Bordallo,J., Murphy,G. and Lopez-Otin,C.
  TITLE     Identification and enzymatic characterization of two diverging
            murine counterparts of human interstitial collagenase (MMP-1)
            expressed at sites of embryo implantation
  JOURNAL   J Biol Chem 276 (13), 10253-10262 (2001)
   PUBMED   11113146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC169512.1.
            
            [WARNING] On Aug 13, 2024 this sequence was replaced by
            NM_032007.4.
            
            On Sep 28, 2006 this sequence version replaced NM_032007.2.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. This gene is located in a cluster of other matrix
            metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ278461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC169512.1         200599-200731       c
            134-375             AC169512.1         199575-199816       c
            376-524             AC169512.1         199338-199486       c
            525-650             AC169512.1         199009-199134       c
            651-809             AC169512.1         197578-197736       c
            810-924             AC169512.1         197362-197476       c
            925-1058            AC169512.1         183435-183568       c
            1059-1221           AC169512.1         181864-182026       c
            1222-1325           AC169512.1         181265-181368       c
            1326-1997           AC169512.1         180375-181046       c
FEATURES             Location/Qualifiers
     source          1..1997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..1997
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /note="matrix metallopeptidase 1b (interstitial
                     collagenase)"
                     /db_xref="GeneID:83996"
                     /db_xref="MGI:MGI:1933847"
     exon            1..133
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1426
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /EC_number="3.4.24.7"
                     /note="matrix metalloproteinase 1b (interstitial
                     collagenase); interstitial collagenase B; collagenase-like
                     B"
                     /codon_start=1
                     /product="interstitial collagenase B preproprotein"
                     /protein_id="NP_114396.3"
                     /db_xref="CCDS:CCDS22805.1"
                     /db_xref="GeneID:83996"
                     /db_xref="MGI:MGI:1933847"
                     /translation="MSSLPLLLLLWAASSYSFPVIQDGLQKNVKTVWKYLENYYNLGK
                     NMQAKNVNGKEVMAEKLRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPDVAPYAITHN
                     NPRWTKTHLTYSILNYTPYLSKAVVEDAIARAFRVWSDVTPLTFQRVFEEEGDIVLSF
                     HRGDHGDLYTFDGSKYHFAHAFLPGLGLGGNVHYDLDQKWTDNNEDFNLFYVTAHELG
                     HSLGLSHSNDEEALMFPSYTWSNKDFVLNQDDINRIQALYGPSPNPIQLTDATLDPCN
                     SGLTFDAIITYRGEVIFFKDRFYIRVISFLPEPLIDVIDLIWPNLPGKFDAAYEVSGV
                     DELRFFKGSKVWAVQEQNVLEGFPMDIQSFFGFPSNVTNIDAAVCEEETGKTYFFVDH
                     MYWRYDENTRSMDPGYPRLIAEDFPGIDYKVDDVIQKEDNFYFFHQSIQYRFNLKTRR
                     IDDSSDINTWFNC"
     exon            134..375
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            376..524
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            525..650
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            651..809
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            810..924
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1058
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1221
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1325
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1997
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1964..1969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /note="hexamer: AATAAA"
     polyA_site      1985
                     /gene="Mmp1b"
                     /gene_synonym="Mcol-B; Mcolb; MMP-1b"
                     /note="major polyA site"
ORIGIN      
        1 gtcactggtg attttcccag agaaaagctt cagcatgtct agccttcctt tgctgttgct
       61 tctctgggct gccagctcat acagtttccc tgtgattcag gatggactcc agaaaaatgt
      121 gaagacagtc tggaaatacc tggaaaacta ctacaacttg ggcaaaaaca tgcaagctaa
      181 aaacgtgaat ggcaaggagg tgatggctga aaagctgagg caaatgcagc agttatttgg
      241 gctgaaagta actggaaatt cagatcctga aaccctgaga gctatgaaga agcccaggtg
      301 tggggtgcct gatgtggccc catatgccat tactcacaac aatcctcgtt ggaccaaaac
      361 acatctgact tacagcattt taaactacac accatatttg tcaaaagcag ttgtggaaga
      421 tgccatcgcg agagccttta gagtctggag tgatgtgaca ccacttacgt tccaaagagt
      481 ctttgaggag gaaggcgata ttgtgctctc cttccacaga ggagaccatg gtgacctcta
      541 cacatttgat ggatctaaat atcactttgc tcatgctttt ctgccaggcc taggtttggg
      601 gggcaatgtt cattatgatc ttgatcagaa gtggaccgac aacaatgagg atttcaactt
      661 gttctatgtt acggctcatg aactgggtca ctcccttgga ctctcccatt ctaatgatga
      721 agaggcacta atgttcccca gctacacatg gagcaataaa gactttgtgc taaaccagga
      781 tgatattaat cgcatccagg ccttatatgg accttcccca aatcccatcc agttaacaga
      841 tgcaacactg gatccatgta atagtggtct aacctttgat gctataatta catatcgggg
      901 ggaggtgata ttctttaaag acaggttcta cattcgggta attagcttcc tgccagaacc
      961 tttgatcgat gtgatagacc ttatctggcc aaatctgcca ggtaaatttg atgcagctta
     1021 tgaagttagt ggggtagatg aactccgctt tttcaaaggc agcaaagtat gggctgttca
     1081 ggaacagaat gtactggaag gatttcccat ggacatccag agtttctttg gcttccctag
     1141 caatgtgaca aacattgatg ctgctgtttg tgaagaagag actggaaaaa catacttctt
     1201 tgttgaccac atgtactgga gatatgatga aaatacacgg tccatggatc caggttaccc
     1261 cagattaata gcagaagact ttcctggaat cgactataaa gttgatgatg ttatccagaa
     1321 agaggataat ttctatttct ttcaccaatc aattcaatac agatttaacc tcaaaacaag
     1381 aagaattgat gattccagtg atattaatac ttggttcaac tgctaaaata ttggcaactt
     1441 gttaccgagt taatgaaaat acatattcca tgatcttaaa gaagatattt ttctgaagag
     1501 tcaaatattt ttatatttta tttacctttc agtacttctg atacagagag caactaagta
     1561 ttgtgaaagt tttataaact ttcacagtac atagtctaat attttatgaa ctaaaacagt
     1621 ttagtaccat gattagtagc ctaagaaagt catattcatg gttgatgagt caaggaagaa
     1681 aagtatttgt acagtggata actctcactg tggtcctatg tatctccttt caagagagga
     1741 gggtaaacag agaaactctt accagagtaa atgtggctct gaatgaagga acccacgtac
     1801 acgagaggaa atgcattgct gctttggttt tggtgtttaa gagagaatct catagcccag
     1861 tggactctga gctcttctac ctctgattcc cacatgctga tattctgtaa tccctattgt
     1921 gcctagctaa gagacatttc ttgtccaaaa tatttaatat ttaaataaag ccactcttgt
     1981 ctctagtgtt ttataag
//
