LOCUS       NM_021412               3411 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus matrix metallopeptidase 19 (Mmp19), transcript variant
            1, mRNA.
ACCESSION   NM_021412
VERSION     NM_021412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Lei,Z., Liu,W., Nie,Y., Yang,Y., Chen,G., Huang,L., Wu,H., Lei,Y.,
            Chen,L., Hu,Q., Rong,H., Yu,S., Song,Q., Tong,F. and Guo,J.
  TITLE     EpCAM Is Essential to Maintaining the Immune Homeostasis of
            Intestines via Keeping the Expression of pIgR in the Intestinal
            Epithelium of Mice
  JOURNAL   Front Immunol 13, 843378 (2022)
   PUBMED   35493520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Sah,R.K., Ma,J., Bah,F.B., Xing,Z., Adlat,S., Oo,Z.M., Wang,Y.,
            Bahadar,N., Bohio,A.A., Nagi,F.H., Feng,X., Zhang,L. and Zheng,Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Brauer,R., Tureckova,J., Kanchev,I., Khoylou,M., Skarda,J.,
            Prochazka,J., Spoutil,F., Beck,I.M., Zbodakova,O., Kasparek,P.,
            Korinek,V., Chalupsky,K., Karhu,T., Herzig,K.H., Hajduch,M.,
            Gregor,M. and Sedlacek,R.
  TITLE     MMP-19 deficiency causes aggravation of colitis due to defects in
            innate immune cell function
  JOURNAL   Mucosal Immunol 9 (4), 974-985 (2016)
   PUBMED   26555704
  REMARK    GeneRIF: this study shows that MMP-19 deficiency causes aggravation
            of colitis due to defects in innate immune cell function
REFERENCE   4  (bases 1 to 3411)
  AUTHORS   Nalvarte,I., Tohonen,V., Lindeberg,M., Varshney,M., Gustafsson,J.A.
            and Inzunza,J.
  TITLE     Estrogen receptor beta controls MMP-19 expression in mouse ovaries
            during ovulation
  JOURNAL   Reproduction 151 (3), 253-259 (2016)
   PUBMED   26700939
  REMARK    GeneRIF: Estrogen receptor beta target gene, where ERbeta requires
            a specific Sp1 site on the MMP-19 promoter to mediate ligand
            dependent transcription
REFERENCE   5  (bases 1 to 3411)
  AUTHORS   Kobielak,A. and Fuchs,E.
  TITLE     Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma
            in skin
  JOURNAL   Proc Natl Acad Sci U S A 103 (7), 2322-2327 (2006)
   PUBMED   16452166
REFERENCE   6  (bases 1 to 3411)
  AUTHORS   Perez,S.E., Cano,D.A., Dao-Pick,T., Rougier,J.P., Werb,Z. and
            Hebrok,M.
  TITLE     Matrix metalloproteinases 2 and 9 are dispensable for pancreatic
            islet formation and function in vivo
  JOURNAL   Diabetes 54 (3), 694-701 (2005)
   PUBMED   15734845
REFERENCE   7  (bases 1 to 3411)
  AUTHORS   Pendas,A.M., Folgueras,A.R., Llano,E., Caterina,J., Frerard,F.,
            Rodriguez,F., Astudillo,A., Noel,A., Birkedal-Hansen,H. and
            Lopez-Otin,C.
  TITLE     Diet-induced obesity and reduced skin cancer susceptibility in
            matrix metalloproteinase 19-deficient mice
  JOURNAL   Mol Cell Biol 24 (12), 5304-5313 (2004)
   PUBMED   15169894
  REMARK    GeneRIF: Mmp19-null mice develop a diet-induced obesity due to
            adipocyte hypertrophy and exhibit decreased susceptibility to skin
            tumors induced by chemical carcinogens.
REFERENCE   8  (bases 1 to 3411)
  AUTHORS   Nuttall,R.K., Sampieri,C.L., Pennington,C.J., Gill,S.E.,
            Schultz,G.A. and Edwards,D.R.
  TITLE     Expression analysis of the entire MMP and TIMP gene families during
            mouse tissue development
  JOURNAL   FEBS Lett 563 (1-3), 129-134 (2004)
   PUBMED   15063736
REFERENCE   9  (bases 1 to 3411)
  AUTHORS   Mueller,M.S., Harnasch,M., Kolb,C., Kusch,J., Sadowski,T. and
            Sedlacek,R.
  TITLE     The murine ortholog of matrix metalloproteinase 19: its cloning,
            gene organization, and expression
  JOURNAL   Gene 256 (1-2), 101-111 (2000)
   PUBMED   11054540
REFERENCE   10 (bases 1 to 3411)
  AUTHORS   Caterina,J.J., Shi,J., Kozak,C.A., Engler,J.A. and
            Birkedal-Hansen,H.
  TITLE     Characterization, expression analysis and chromosomal mapping of
            mouse matrix metalloproteinase-19 (MMP-19)
  JOURNAL   Mol Biol Rep 27 (2), 73-79 (2000)
   PUBMED   11092553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY135344.1, AK086808.1,
            AC131081.7, AK135651.1, AK003621.1 and AI503640.1.
            
            On Feb 17, 2016 this sequence version replaced NM_021412.2.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. Mice lacking the encoded protein develop a diet-induced
            obesity due to adipocyte hypertophy, exhibit decreased
            susceptibility to chemical carcinogen-induced skin tumors and early
            onset of tumoral angiogenesis. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154863.1, AF155221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               BY135344.1         3-260
            259-1854            AK086808.1         1-1596
            1855-1856           AC131081.7         140105-140106
            1857-2084           AK086808.1         1600-1827
            2085-2086           AC131081.7         140335-140336
            2087-2460           AK086808.1         1831-2204
            2461-2912           AK135651.1         372-823
            2913-3238           AK003621.1         99-424
            3239-3245           AI503640.1         170-176             c
            3246-3408           AK003621.1         432-594
            3409-3409           AI503640.1         5-5                 c
            3410-3411           AC131081.7         141660-141661
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.16 cM"
     gene            1..3411
                     /gene="Mmp19"
                     /note="matrix metallopeptidase 19"
                     /db_xref="GeneID:58223"
                     /db_xref="MGI:MGI:1927899"
     exon            1..190
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            191..276
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            277..407
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            408..623
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            624..869
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            870..995
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1160
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1288
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..3411
                     /gene="Mmp19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3389..3394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp19"
                     /note="hexamer: AATAAA"
     polyA_site      3411
                     /gene="Mmp19"
                     /note="major polyA site"
ORIGIN      
        1 aaagacctgg aggtaagagt cccttgctta gctctgctcc tccaaacttt cagaagtctc
       61 aggccagagg cagcttctgg agctcttgtc tgctgggatc atggactggc agcagctgtg
      121 gctggcattc ttacttccca tgacagtctc aggccgggct ctggggccta cagagaagga
      181 ggcagtcttg gattacctgt tgcagtatgg gtatctacag aaacctctag aaggagctga
      241 tgacttcagg ctggaagata tcacagaggc tttaagaact ttccaggaag catctggact
      301 gcccatttcc ggtcagatgg atgacgccac aagggcccgt atgaagcagc cccgttgtgg
      361 tctggaggat cccttcaacc agaaatctct taaatacctg cttctgggcc actggagaaa
      421 gaagaacttg acattccgca tcttcaatgt gccctccacc ctctcacttc ccagagtccg
      481 agcagccctg catcaagcct ttaagtactg gagcagcgtg gctcctctga ccttccggga
      541 ggtgaaagct ggttgggctg acattcgcct ctctttccat ggccgccaaa gcctgtactg
      601 ctccaatacc tttgatgggc ctggaaaggt cctggcccat gctgacatcc cagaacttgg
      661 gagtatacac tttgataaag atgaactctg gactgagggg acctatcaag gagtgaacct
      721 gcgcatcatt gcggcccatg aagtgggcca tgccctagga cttgggcact cccgatatac
      781 ccaggcactc atggctcctg tctatgctgg ctaccagccc ttcttcaagc tgcatccaga
      841 tgatgtggca gggatccagg ctctctatgg caagaggagc ccagagacaa gagatgagga
      901 ggaagagacc gagatgctca ctgtgtctcc agtgactgca aaacctggtc ccatgccaaa
      961 cccctgcagc ggtgaggtgg acgccatggt gctggggcct cgtgggaaga cttatgcttt
     1021 caagggcgac tatgtgtgga ctgtaacaga ttcagggcca ggccccttgt tccaaatatc
     1081 tgccctttgg gaggggcttc ctggaaacct agatgctgcc gtttactctc cccggacacg
     1141 acggactcat ttcttcaagg gaaacaaggt gtggcggtat gtggatttca agatgtctcc
     1201 tggctttccc atgaaattca acagagtaga gcccaacctg gatgcagctc tctactggcc
     1261 tgttaatcaa aaggtgttcc tgtttaaggg ctcaggatac tggcaatggg atgaactggc
     1321 cagaactgac cttagccgct accctaaacc aatcaaggaa ctgtttactg gagtgccaga
     1381 ccgaccctcg gcagctatga gctggcaaga tggccaagtc tactttttca agggcaaaga
     1441 gtattggcgc cttaaccagc aacttcgagt ggcaaagggc tatcccagaa atacgacaca
     1501 ctggatgcac tgtggttctc agactccaga cactaactca tcaaccgggg acgttactcc
     1561 ttcaaccaca gacacagtct tgggtaccac tccatcaacc atgggctcaa ccttggacat
     1621 tccctcagct acagactctg cctccctctc attctctgct aatgtcaccc tgctaggggc
     1681 ctgagaacta ttcagtggac actaggccta atgtccctag atactccact tctggatacc
     1741 acattcctgt gttcctagaa ggtgtccact taattctgaa tcagtctcca attcctgttt
     1801 cttcttgtca tatagctgtt tcaagtgtga catctagtct ctggtggagg gaaactgtca
     1861 atcaggaggg ggttttttgt tgctgttgtt ttttttttgt tttgttttgt tttgtttttg
     1921 acagtctctc tacatagcac tggctatggt tatcagctat cctgaaactc tctgtgtaga
     1981 tatgtagacc aggctgcctt gaactcacag atatccacct gcctctgcct cctgagcgct
     2041 gggattaaag gcctgtgcta catgcctagc attttttttt tttttagatt taaggcatgt
     2101 gttaccatgt ccgactgtca gctggggctt tagctgacag gaggaagcag ctaacagctg
     2161 ggtattgaat tcttccaaca taaagtgcaa aaaaatatca tggccagtaa actgagcttg
     2221 ggatttggag tccttgagcc acctgactat gtgtggcttt ggctagctaa ttaaccctgt
     2281 caaaccttgg attccctatt aacaaagtaa ggctaatatc aatgttacag gattgttata
     2341 ttagatgaaa atactgtatg tgaaatatct gacagactct ggaacatttg tgtttaggta
     2401 aaggctagct tcatgttcct ggaagagaac tgagttatct gggtatattc atgtatatgt
     2461 atgatatgta tgtgtgcatt atatatggta gtgtatgcca tataggtgcc atagcagatc
     2521 tttgtggcgg ggtggggtgg ggttggggga gtagattagc tttgtttcgt ggtgcaaaga
     2581 aagtaaaaag cagcaacagt agaggcgcat ctccccaggt gaattttcaa tgccatttta
     2641 ttcccaaatt ccttgttctt cctccctctt attacagatc tgctgctcag gggaaagata
     2701 tattttcttt actatgtctg ggaaaccagg aaatagatct tggtcaggag aatcagagga
     2761 gggagagtta gaatggtcag tagctgggcc cgaattctgg tttaggagga aagctacttt
     2821 aaaagacaga aggcacttgg ctacagtgca gccccaaaga ccaggctcct ctgagaaaaa
     2881 ggtcaaggag ccagcttttg gagagagggg agctgaggca gatgctgtgg tcctcctcca
     2941 ctgaggagag ggggaaagca gcatggaaga tggagccccc cgcagaggta gcaggattca
     3001 cgagtgtagg gtccaggaag aaaggccaac cagaagccca atcacccccg agtaaggagc
     3061 cggggaactt ctgtgccatt cctcctgcca aaaaactatc actgggtatg gtggtgcatg
     3121 cctttagtcc cggtactggg gaggcacagg caagcagatc cctgtgagtt caaggccagc
     3181 ctgggctaca aagtgagttg caggacagcc agggctacac aaagaagccc tgtcttgaga
     3241 gaccaaaacc ccaatctaac caaacaaaac caaaaacaaa ccaaaaaaca aaacccaaac
     3301 aaaacaggtt tttgggaatg ggttgtagtt cagaacactt gtctaatatg ggcaatgctc
     3361 tgggttccac ctcagcatta cagaaattaa taaaaaacta ttttgggcat a
//
