LOCUS       NM_011846               4477 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus matrix metallopeptidase 17 (Mmp17), mRNA.
ACCESSION   NM_011846
VERSION     NM_011846.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4477)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 4477)
  AUTHORS   Vornewald,P.M., Forman,R., Yao,R., Parmar,N., Lindholm,H.T.,
            Lee,L.S.K., Martin-Alonso,M., Else,K.J. and Oudhoff,M.J.
  TITLE     Mmp17-deficient mice exhibit heightened goblet cell effector
            expression in the colon and increased resistance to chronic
            Trichuris muris infection
  JOURNAL   Front Immunol 14, 1243528 (2023)
   PUBMED   37869014
  REMARK    GeneRIF: Mmp17-deficient mice exhibit heightened goblet cell
            effector expression in the colon and increased resistance to
            chronic Trichuris muris infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4477)
  AUTHORS   Sahun-Espanol,A., Clemente,C., Jimenez-Loygorri,J.I.,
            Sierra-Filardi,E., Herrera-Melle,L., Gomez-Duran,A., Sabio,G.,
            Monsalve,M., Boya,P. and Arroyo,A.G.
  TITLE     p38 MAPK priming boosts VSMC proliferation and arteriogenesis by
            promoting PGC1alpha-dependent mitochondrial dynamics
  JOURNAL   Sci Rep 12 (1), 5938 (2022)
   PUBMED   35396524
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4477)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4477)
  AUTHORS   English,W.R., Puente,X.S., Freije,J.M., Knauper,V., Amour,A.,
            Merryweather,A., Lopez-Otin,C. and Murphy,G.
  TITLE     Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis
            factor-alpha convertase activity but does not activate pro-MMP2
  JOURNAL   J Biol Chem 275 (19), 14046-14055 (2000)
   PUBMED   10799478
REFERENCE   6  (bases 1 to 4477)
  AUTHORS   Johansson,N., Ahonen,M. and Kahari,V.M.
  TITLE     Matrix metalloproteinases in tumor invasion
  JOURNAL   Cell Mol Life Sci 57 (1), 5-15 (2000)
   PUBMED   10949577
  REMARK    Review article
REFERENCE   7  (bases 1 to 4477)
  AUTHORS   Itoh,Y., Kajita,M., Kinoh,H., Mori,H., Okada,A. and Seiki,M.
  TITLE     Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a
            glycosylphosphatidylinositol-anchored proteinase
  JOURNAL   J Biol Chem 274 (48), 34260-34266 (1999)
   PUBMED   10567400
REFERENCE   8  (bases 1 to 4477)
  AUTHORS   Kajita,M., Kinoh,H., Ito,N., Takamura,A., Itoh,Y., Okada,A.,
            Sato,H. and Seiki,M.
  TITLE     Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded
            by a novel major transcript: isolation of complementary DNA clones
            for human and mouse mt4-mmp transcripts
  JOURNAL   FEBS Lett 457 (3), 353-356 (1999)
   PUBMED   10471807
REFERENCE   9  (bases 1 to 4477)
  AUTHORS   Kinoh,H., Hayashita,H., Kajita,M., Okada,A. and Seiki,M.
  TITLE     Assignment of the genes for membrane-type-4 matrix
            metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human
            chromosome band 12q24.3 and membrane-type-5 matrix
            metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human
            chromosome band 20q11.2-->q12, respectively, by radiation hybrid
            and in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 97-98 (1999)
   PUBMED   10640822
REFERENCE   10 (bases 1 to 4477)
  AUTHORS   Puente,X.S., Pendas,A.M., Llano,E., Velasco,G. and Lopez-Otin,C.
  TITLE     Molecular cloning of a novel membrane-type matrix metalloproteinase
            from a human breast carcinoma
  JOURNAL   Cancer Res 56 (5), 944-949 (1996)
   PUBMED   8640782
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114657.9, BC051917.1 and
            AK079221.1.
            
            On Feb 13, 2016 this sequence version replaced NM_011846.4.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. Mice lacking the encoded protein exhibit dysfunctional
            vascular smooth muscle cells and altered extracellular matrix in
            the vessel wall leading to an increased susceptibility to
            angiotensin-II-induced thoracic aortic aneurysm. [provided by
            RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051917.1, AK143521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC114657.9         67214-67258
            46-3502             BC051917.1         1-3457
            3503-3503           AC114657.9         91225-91225
            3504-3534           BC051917.1         3459-3489
            3535-4114           AK079221.1         3262-3841
            4115-4290           AK079221.1         3843-4018
            4291-4292           AC114657.9         92013-92014
            4293-4477           AK079221.1         4021-4205
FEATURES             Location/Qualifiers
     source          1..4477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.18 cM"
     gene            1..4477
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /note="matrix metallopeptidase 17"
                     /db_xref="GeneID:23948"
                     /db_xref="MGI:MGI:1346076"
     exon            1..280
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            281..413
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..543
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            544..827
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1004
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1104
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1187
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1340
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1598
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..4477
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3513..3518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /note="hexamer: AATAAA"
     polyA_site      3534
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
                     /note="major polyA site"
     polyA_site      4198
                     /gene="Mmp17"
                     /gene_synonym="MT4-MMP; MT4MMP; MTMMP4"
ORIGIN      
        1 ggaggcgggc gggcgcgcgg ctcagtcccg cggagcggag cggtgcgggc gcggagccga
       61 gcgaggcgcg gagctggctg ctggcgggtg cggggaccct cgccacccga cctgggagag
      121 cgggatggga cgccgcccgc ggggacctgg gtccccccgg ggacctggcc ctccacgccc
      181 cgggccgggg ctgccaccac tgctgcttgt actggcgctg gcggcccatg ggggctgcgc
      241 agcgcccgcg ccccgcgcgg aggacctcag cctcggggtg gagtggctaa gcaggtttgg
      301 ctacctgccg cctgcagatc cggcatcagg gcagctacag acccaggagg aactgtccaa
      361 agcgattact gccatgcagc agtttggtgg tctggagacc actggcatcc tagatgaggc
      421 cactctggcc ctgatgaaaa cccctcgatg ctcccttccg gacctgcccc ctggggccca
      481 atcgagaagg aagcggcaga ctccaccccc aaccaaatgg agcaagagga acctttcttg
      541 gagggtccgg acattcccac gggactcacc cctgggccgg gatactgtgc gtgcactcat
      601 gtactacgcc ctcaaagtct ggagtgacat cacacccttg aacttccacg aggtagcggg
      661 caacgcggcg gacatccaga tcgacttctc caaggccgac cacaatgacg gctacccctt
      721 cgatggccct ggtggcacgg tggcccacgc attcttccct ggtgaccacc acacggcagg
      781 ggacacccac tttgatgacg atgagccatg gaccttccgt tcctcagatg cccacgggat
      841 ggacctgttt gcagtggccg tccatgagtt tggtcatgcc attggtctga gccatgttgc
      901 cgccccaagc tccatcatgc aaccgtacta ccagggcccc gtgggtgacc cgctacgcta
      961 tggacttccc tatgaggaca gggtgcgtgt ctggcagttg tacggtgtgc gggaatccgt
     1021 gtcccctact gcccagctgg ataccccaga gcccgaggag ccacccctcc tgccagagcc
     1081 ccccaacaat cggtctagca ctccgcccca gaaggacgtg cctcacaggt gcactgccca
     1141 ctttgatgct gtggcccaga ttcgaggcga agcattcttt ttcaaaggca agtatttctg
     1201 gaggctgacc cgggaccgac acttggtgtc gctgcagccg gctcaaatgc atcgcttctg
     1261 gcggggcctg ccgctgcacc tggacagtgt ggacgccgtg tatgagcgta ccagtgacca
     1321 caagattgtc ttcttcaaag gagacagata ctgggtgttt aaggacaaca acgtagagga
     1381 agggtacccg cgacctgtct ccgacttcag cctcccgcca ggtggcatcg atgctgtctt
     1441 ctcctgggcc cacaatgaca ggacttattt ctttaaggac cagctgtact ggcgctatga
     1501 tgaccacaca cggcgcatgg accctggcta ccctgcccag ggacccctgt ggagaggtgt
     1561 ccccagcatg ttggatgatg ccatgcgctg gtctgatggt gcatcctatt tcttccgagg
     1621 ccaggagtac tggaaagtgc tggatggcga gctggaagca gcccccgggt acccacagtc
     1681 tacagcccgc gactggctgg tatgcggtga gccgctggcg gatgcggagg atgtagggcc
     1741 tggaccccag ggccgcagtg gggcccaaga tggtctggca gtatgttcct gcacttcaga
     1801 cgcacacagg ttggcactgc catctctgct gcttctgact ccactgctgt ggggcctgtg
     1861 aacctcagtc tctgccaagg catcctgagg gcagtgctag ccttgcggat caaggagcca
     1921 aggggagcag ggacacactg gccagtactc agcaggactt gtgctccaag cttccggtcc
     1981 ctcgctcctt ccttccttcc ttccttgaac ccaggggtgc tgtgccatct gctggagtgg
     2041 tctccagctg ggacaggacg tcccaccaag ggcatccatg cacaccttgc ctacctggag
     2101 cagccatagg cagctcccct tccctcctct gcacatcatg ctgcttcgtt gcaccttgcc
     2161 gggctgccca agcccagctg tcacaacccc aggatgcctt gtctgcacct gagcggctct
     2221 gatggcatct gcacgtgggc tgatgagggg caaacagggg ttcctcgtgg tatccgtagg
     2281 ggccaccatg cctgtttcac aagtaagaga gttgatgccc cgatggggga acagggtggg
     2341 agaaaggcac ctacccagaa gtctgatcca ctgccgtttg cagcagccag cgccgtatct
     2401 gctgggatag gggaccagtc acactcagga tctgcccaca gattcccaga tgctggccag
     2461 gggccttgct ccaaccacca ggagcacagc cacctctccc cgtcctagat aggttagcca
     2521 tggaggctgt gtcctgttat ctccctctct ttggccagga gagcattgtg ggtctccctc
     2581 gggtgctgtt gatgggggtg gggggcgccc atagagatat ttcttcatct gtcagtaccc
     2641 attgcttcag caagatgccc ccatatagtt ctggcctgag accctgcagc ttggactcac
     2701 agctgtcccc tccccagctg cagaagggct tctaacacct ggaataaagg tgggcgttca
     2761 gtttagggaa ggaggatggt tgggggagcc cagggtgata gcaaggggga gctgcaggga
     2821 taagtgtcag ggtcctcggg gagtcatgac aatgttaccg cctaacttgg agatgtagga
     2881 gctgtgcacg gattgcttct ctgggtgaca aacctccatg gtccagaaag gggctgaggt
     2941 tgaacccaag atgggttaat gagctccaga aaggaacagc caagttcaaa ggttctggga
     3001 caagacgggc ctgaggaaca gggccaccca ggtaggcgtg gctgtagggt aagcagtttc
     3061 tgtcattggg cacgagatga aaattagtga tcacacgcac atacccccct ccccaactgg
     3121 cccggtccca tctcaggtaa gaaaggcttc tgtctacccc aggccaggtt tgagtgttgt
     3181 caggatgagt gagcagctag cggggcctaa gtttctaccc tccatttccc aagcctggcc
     3241 acaccctaga cccacctgtc agactaggca ggacagagtc aggggtaggg gcatctgagg
     3301 tttccctgtc ttggaagcca ccctactctg ccctcatatc aaagcacgct cctatgatgt
     3361 cccatgttgt ccaccagcct gcaggacaca gatgtcctat acagcaacag ggaagggtcc
     3421 aaaaatcttt gtcacatagc actgaaagcc aggcccgcag gctggagctg tctagatgct
     3481 ggtgtcacac tcattttaaa acccaaactc ttaataaaaa ttttgtacac tggacaggtt
     3541 gacagctcag tggtaaggtt ttggggttga tctcctcctg tacaactccc ccaccaccac
     3601 ccccaaaatt ctctgtacct ctggtcttgg gctaaatggt cagtgggaac agagttctct
     3661 gaactgccct cccatgccct gcctgcctcc attgctgcat tcggaggtct tgcagggaga
     3721 gcagaacaga ttgggtgcta ataatgcatg gattcctgca ggcttcgctc tgcagttgga
     3781 cagaatgcat tgctggggcc cctgtggttt atgatgtcgc tgcccttaca gaggcttcag
     3841 gaagaacata agagcatctg ccccgcccac aggctgctgg atatgatgca gactctgggc
     3901 acgtactgtc ccatgcttcc tatgggatat gactccccct gaggcgtgct ctccagaaaa
     3961 cctcgggaat tccaggctat catctatttt gagcctcctt catcatcccg atcaccttct
     4021 ctccgggcaa aaagctaacc cagtgccagg tttcccaaat gctgactcct acccaacctc
     4081 tgcatctgat cagcctacct gaagcttccg gagaccacag cctgcggcaa cgtctggcgt
     4141 gacaccacat ggtgtccctt tctagacaag ttgtggctaa acacatattt ctctgtcatt
     4201 ctgacttctg tggtctgtga gtcctgggct gagctggccc tctgcactta ggtggatggc
     4261 cctcctgtga ccacggtgaa actccaggaa agaggtctga ggactcgcac catccaggga
     4321 gggcctagta gccatcaagg gtagtcatgg gctcttgagc cttataagca aacacgtgct
     4381 ctgtgtttgg gaagaggatc aaggaacccc tgtgtggctt caagggccag gtcacagcct
     4441 acccaattct cattttacaa caaggcatga cgtcttt
//
