LOCUS       NM_001379519            3353 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus matrix metallopeptidase 16 (Mmp16), transcript variant
            4, mRNA.
ACCESSION   NM_001379519 XM_017320017
VERSION     NM_001379519.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   Feng,X., Diao,S., Liu,Y., Xu,Z., Li,G., Ma,Y., Su,Z., Liu,X., Li,J.
            and Zhang,Z.
  TITLE     Exploring the mechanism of artificial selection signature in
            Chinese indigenous pigs by leveraging multiple bioinformatics
            database tools
  JOURNAL   BMC Genomics 24 (1), 743 (2023)
   PUBMED   38053015
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Varadinkova,S., Oralova,V., Clarke,M., Frampton,J., Knopfova,L.,
            Lesot,H., Bartos,P. and Matalova,E.
  TITLE     Expression dynamics of metalloproteinases during mandibular bone
            formation: association with Myb transcription factor
  JOURNAL   Front Cell Dev Biol 11, 1168866 (2023)
   PUBMED   37701782
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3353)
  AUTHORS   Perez,S.E., Cano,D.A., Dao-Pick,T., Rougier,J.P., Werb,Z. and
            Hebrok,M.
  TITLE     Matrix metalloproteinases 2 and 9 are dispensable for pancreatic
            islet formation and function in vivo
  JOURNAL   Diabetes 54 (3), 694-701 (2005)
   PUBMED   15734845
REFERENCE   7  (bases 1 to 3353)
  AUTHORS   Rogers,M.S., Rohan,R.M., Birsner,A.E. and D'Amato,R.J.
  TITLE     Genetic loci that control the angiogenic response to basic
            fibroblast growth factor
  JOURNAL   FASEB J 18 (10), 1050-1059 (2004)
   PUBMED   15226265
  REMARK    Erratum:[FASEB J. 2015 Jan;29(1):354-5]
REFERENCE   8  (bases 1 to 3353)
  AUTHORS   Jung,J.C., Leco,K.J., Edwards,D.R. and Fini,M.E.
  TITLE     Matrix metalloproteinases mediate the dismantling of mesenchymal
            structures in the tadpole tail during thyroid hormone-induced tail
            resorption
  JOURNAL   Dev Dyn 223 (3), 402-413 (2002)
   PUBMED   11891989
REFERENCE   9  (bases 1 to 3353)
  AUTHORS   Johansson,N., Ahonen,M. and Kahari,V.M.
  TITLE     Matrix metalloproteinases in tumor invasion
  JOURNAL   Cell Mol Life Sci 57 (1), 5-15 (2000)
   PUBMED   10949577
  REMARK    Review article
REFERENCE   10 (bases 1 to 3353)
  AUTHORS   Seldin,M.F., Gustavson,M.D. and Apte,S.S.
  TITLE     Mapping of two mouse membrane-type matrix metalloproteinase
            (MT-MMP) genes, Mmp15 and Mmp16, to mouse chromosomes 8 and 4,
            respectively
  JOURNAL   Genomics 50 (2), 295-297 (1998)
   PUBMED   9653660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683877.10 and AL805957.12.
            
            On Apr 7, 2020 this sequence version replaced XM_017320017.2.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. Mice lacking the encoded protein exhibit retarded growth of
            the skeleton, especially in the cranium and long bones. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (4), as well as variants 1 and 3,
            encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR2680377.105089.1,
                                           SRR1660817.256093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AL683877.10        96399-96594
            197-403             AL683877.10        96753-96959
            404-552             AL805957.12        48511-48659
            553-675             AL805957.12        57133-57255
            676-980             AL805957.12        72430-72734
            981-1142            AL805957.12        112661-112822
            1143-1354           AL805957.12        115306-115517
            1355-1493           AL805957.12        154269-154407
            1494-1644           AL805957.12        171367-171517
            1645-1760           AL805957.12        172938-173053
            1761-3353           AL805957.12        176826-178418
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 7.08 cM"
     gene            1..3353
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /note="matrix metallopeptidase 16"
                     /db_xref="GeneID:17389"
                     /db_xref="MGI:MGI:1276107"
     exon            1..196
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            197..403
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..2095
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /note="matrix metalloproteinase-16; membrane-type matrix
                     metalloproteinase 3; Membrane type 3-MMP"
                     /codon_start=1
                     /product="matrix metalloproteinase-16 preproprotein"
                     /protein_id="NP_001366448.1"
                     /db_xref="GeneID:17389"
                     /db_xref="MGI:MGI:1276107"
                     /translation="MILLAFSSGRRLDFVHRSGVFFLQTLLWILCATVCGTEQYFNVE
                     VWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG
                     VPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQ
                     NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGG
                     DTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNF
                     KLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRRHDRPKPPRPPTGRPS
                     YPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSI
                     DAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPPHGIDSAIWWEDVGK
                     TYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYW
                     KFNNQILKVEPGYPRSILKDFMGCDGPTDRDKEGLSPPDDVDIVIKLDNTASTVKAIA
                     IVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV"
     exon            404..552
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            553..675
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            676..980
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1142
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1354
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1493
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1644
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1760
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..3353
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3327..3332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /note="hexamer: AATAAA"
     polyA_site      3353
                     /gene="Mmp16"
                     /gene_synonym="MT-MMP 3; MT3-MMP; Mt3mmp"
                     /note="major polyA site"
ORIGIN      
        1 agagaggagg gaaggagcag tggaggcagt gagctgggag cggctgaggc ccttcccgca
       61 gaaactgggg gcaccggcgg cgtaggaggt ggagaaggcg gaggacgcac gggctggagg
      121 cggcggctgc gactcggcgg cgctgggaat cggaaccgcg ggtgaacttg ggcgccacgt
      181 tccgggcgac ggccgggaaa cagggagtgg acattcggaa agagggagaa aacgcagggg
      241 agctcgtcca tccgttgagg cacagttcac tatgatctta ctcgcattca gctctggaag
      301 aaggttggat ttcgtgcatc gttcgggtgt gtttttcttg caaaccttgc tttggatttt
      361 atgtgctaca gtctgcggaa cggagcagta tttcaatgtg gaggtttggt tacaaaaata
      421 cggctacctt ccaccgactg accccagaat gtcagtgctg cgctctgcag agaccatgca
      481 gtcagctcta gctgccatgc agcagttcta tggcattaac atgacaggaa aagtggacag
      541 aaacacaatc gactggatga agaagcctcg atgcggtgta ccagaccaga caagaggcag
      601 ctctaaattc aacattcgtc gaaagcgcta cgcattaact ggacagaaat ggcaacacaa
      661 acatatcact tacagtataa agaacgtaac tccaaaagtt ggagatcctg agacccggag
      721 agcaattcgc cgtgcctttg atgtgtggca gaatgtaact cctctaacgt ttgaagaagt
      781 tccctacagt gaactagaaa acggcaaacg tgatgtggat ataaccatca tttttgcttc
      841 tggttttcat ggagacagtt ccccatttga tggggaggga ggatttttgg cacatgctta
      901 tttccctgga cccggaattg gaggcgacac ccattttgat tctgatgagc catggacact
      961 gggaaatccc aatcatgatg gaaacgattt atttcttgta gcagtccatg agctgggaca
     1021 tgctctagga ctggaacatt ccaacgaccc caccgctatc atggccccat tttatcagta
     1081 catggaaaca gacaacttca agcttcctaa tgatgattta cagggcatcc agaagatata
     1141 tggtccacct gacaagatcc ctccacctac aagacctcta ccgacagtgc ccccgcaccg
     1201 atctgttcct ccagcagacc caaggagaca tgacaggccc aaacctcctc ggcctcccac
     1261 tggcagaccc tcctatccag gagccaaacc caacatctgt gatgggaact tcaacactct
     1321 agctattctt cgaagggaga tgtttgtttt caaggaccag tggttttggc gagtgagaaa
     1381 caacagggtg atggatggat acccaatgca aattacttac ttctggcggg gccttcctcc
     1441 cagtattgat gcagtttatg aaaacagtga cggaaatttc gtcttcttta aaggcaacaa
     1501 atactgggtg ttcaaagaca caactcttca acctggttac cctcatgact tgattaccct
     1561 tgggaatgga atcccccctc atggtattga ttctgccata tggtgggaag atgttggcaa
     1621 aacctatttc ttcaaaggtg acaggtattg gagatatagt gaagaaatga aaaccatgga
     1681 ccctggttac cccaagccca tcaccatctg gaaggggatc cctgaatcac ctcagggagc
     1741 tttcgtccac aaagaaaatg gctttaccta tttctacaaa ggaaaggagt attggaaatt
     1801 caacaatcag atactcaaag tagaacctgg ttatccaaga tccatcctca aggactttat
     1861 gggctgtgat ggaccaacag accgagataa agaaggactc agcccaccag atgatgtaga
     1921 cattgtcatc aaactggaca acacagccag cactgtgaaa gccatagcta ttgtcattcc
     1981 ctgcatcttg gccttatgcc tccttgtatt ggtttacact gtgttccagt tcaagaggaa
     2041 aggaacaccc cgccacatac tgtactgtaa acgctctatg caagagtggg tgtgatgtag
     2101 ggatttcttt tttctttctt ttctgggagt ttgtggtaac ttgagattca agacaagagc
     2161 tgttatgctg tttcctagct aggagcaggc ttgtggcagc ctgatggagg ctgaccttcc
     2221 aaacctagat ggttgctggt cctgcacatg agtggaaata taatcatgga gaagcttccg
     2281 tgatgcacag tatctgctgt tctccagtcc tctgtctttc tttgtcattc agttctaggc
     2341 ctttcctctg cacgctcaat gcccagtaaa atttcaggat taactgaaga agaggaaata
     2401 tagaagaaaa gtttcttctt aattttttaa aaaatacatt tccttctgaa atctgagccc
     2461 atttctggga aagagaaaga aagagagaga aagagagaga gagagagaaa gaaaaacaaa
     2521 aagagcaaat caaaaaaccc ataggttttt gctttaaggc aaaagaagaa agagtttaaa
     2581 aaacaacaaa atccactatt gaactttcag gaaagtgtga agatccaaaa cagctttgtc
     2641 tccaaagaag atagctctgt gaccactatg gatagtctcc tgcacatcgt tttgtcaggt
     2701 gggagatctg gaacacatgc aggatgctag actgttggga cagtcatttt ccaacaaaca
     2761 aggggccaaa atatctgcaa tatagtaaca gccttaataa tacatgcatt tttcgttttc
     2821 tacagctgtt ctcaactatg tccacaatgt atcatcacct ccatactcat agctgtgttc
     2881 aaacaggacc tttcggttgt tttgaaatat ttctgaaccc cctcctgcct cctgacccag
     2941 aatcattgtg atgttcttcc cagttgtgtt aggcctttgt cccaggccgt ccattggtct
     3001 gtcagcaata ctccgcgcaa agcagagcaa gaagtattgt gtctctgaag gaaagaaggt
     3061 gatggttatt ttataaggat ctgttactct ttaatacatc agtggaaccc tttgagaact
     3121 atcggaccag cttacagagt caggatgatc agtcttgcaa tctggtcatt tgtagaactg
     3181 gccaaaaggg aaagccatca caggtttcga gaagttcaga tttgtaaagc ataccttaca
     3241 atcccatgta actctttaat gactgacagt actgcataaa tgcttttata acaacgatga
     3301 tgtgacttgc caaaactttt ctggcaaata aaaaagatat tttgttaaca gta
//
