LOCUS       NM_008609               4335 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus matrix metallopeptidase 15 (Mmp15), mRNA.
ACCESSION   NM_008609 XM_001002190 XM_001002202 XM_001002209 XM_001002215
            XM_001002221
VERSION     NM_008609.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4335)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4335)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   3  (bases 1 to 4335)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4335)
  AUTHORS   Varadinkova,S., Oralova,V., Clarke,M., Frampton,J., Knopfova,L.,
            Lesot,H., Bartos,P. and Matalova,E.
  TITLE     Expression dynamics of metalloproteinases during mandibular bone
            formation: association with Myb transcription factor
  JOURNAL   Front Cell Dev Biol 11, 1168866 (2023)
   PUBMED   37701782
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4335)
  AUTHORS   Jiang,D., Burger,C.A., Casasent,A.K., Albrecht,N.E., Li,F. and
            Samuel,M.A.
  TITLE     Spatiotemporal gene expression patterns reveal molecular
            relatedness between retinal laminae
  JOURNAL   J Comp Neurol 528 (5), 729-755 (2020)
   PUBMED   31609468
REFERENCE   6  (bases 1 to 4335)
  AUTHORS   Perez,S.E., Cano,D.A., Dao-Pick,T., Rougier,J.P., Werb,Z. and
            Hebrok,M.
  TITLE     Matrix metalloproteinases 2 and 9 are dispensable for pancreatic
            islet formation and function in vivo
  JOURNAL   Diabetes 54 (3), 694-701 (2005)
   PUBMED   15734845
REFERENCE   7  (bases 1 to 4335)
  AUTHORS   Johansson,N., Ahonen,M. and Kahari,V.M.
  TITLE     Matrix metalloproteinases in tumor invasion
  JOURNAL   Cell Mol Life Sci 57 (1), 5-15 (2000)
   PUBMED   10949577
  REMARK    Review article
REFERENCE   8  (bases 1 to 4335)
  AUTHORS   Seldin,M.F., Gustavson,M.D. and Apte,S.S.
  TITLE     Mapping of two mouse membrane-type matrix metalloproteinase
            (MT-MMP) genes, Mmp15 and Mmp16, to mouse chromosomes 8 and 4,
            respectively
  JOURNAL   Genomics 50 (2), 295-297 (1998)
   PUBMED   9653660
REFERENCE   9  (bases 1 to 4335)
  AUTHORS   Itoh,S., Abe,Y., Kubo,A., Okuda,M., Shimoji,M., Nakayama,K. and
            Kamataki,T.
  TITLE     Isolation of a promoter region in mouse cytochrome P450 3A
            (Cyp3A16) gene and its transcriptional control
  JOURNAL   Biochim Biophys Acta 1350 (2), 155-158 (1997)
   PUBMED   9048885
REFERENCE   10 (bases 1 to 4335)
  AUTHORS   Tanaka,M., Sato,H., Takino,T., Iwata,K., Inoue,M. and Seiki,M.
  TITLE     Isolation of a mouse MT2-MMP gene from a lung cDNA library and
            identification of its product
  JOURNAL   FEBS Lett 402 (2-3), 219-222 (1997)
   PUBMED   9037199
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY732226.1 and BC047278.1.
            
            On Feb 12, 2016 this sequence version replaced NM_008609.3.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. A deficiency of the encoded protein in mice is compatible
            with normal development and postnatal growth. [provided by RefSeq,
            Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047278.1, D86332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY732226.1         2-42
            42-4335             BC047278.1         1-4294
FEATURES             Location/Qualifiers
     source          1..4335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..4335
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /note="matrix metallopeptidase 15"
                     /db_xref="GeneID:17388"
                     /db_xref="MGI:MGI:109320"
     exon            1..723
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            724..872
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1001
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1309
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1471
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1725
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1864
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2015
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2131
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..4320
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4299..4304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /note="hexamer: AATAAA"
     polyA_site      4320
                     /gene="Mmp15"
                     /gene_synonym="MT-MMP 2; MT2-MMP"
                     /note="major polyA site"
ORIGIN      
        1 ggggacgccg ggcgctggct agctggctgg cgggctcgtc gctctgtcgg gccggttccc
       61 tgcgcccctc ccgggactgc ctggggatcc aggcccgatt gggcgcggca gctagtggag
      121 tcgccagagg gaagcgcgca ctctgggcag cgcggaggac cttgggcatg gacagagagt
      181 gcagggcgcg cagggggcgc cgcgggaccg ggcggccgga gcgctgagcc agacaaaggc
      241 tctggagttc tgcttgctct cgggggccgg ggccagggcg caccgcgccg acgctgcgag
      301 actctgcggc gtgcagctcg gccggtcccc ttctccagcg ggcgagtccc cgcgtgcccc
      361 gacctgccct gcccgcttct cacccggttt gggaattggc agaggggacc tgagctcctc
      421 aggcaggcac cgggagccgg aggtccgccg cgcgcccgcg gggccgggag ccagggagcg
      481 tcgcaagttt cccagccgcg tgcgaggacg cggtgcgggc cagccagcta gccccgcgtg
      541 cagcgctcag gaccgggctg actgcctagg agcatgggca gcgaccggag cgcactcgga
      601 cgtccaggct gcactggcag ctgcctcagc agccgagctt cgctgctccc gctgctactg
      661 gtgcttctgg actgtctggg ccatggtaca gcgtctaaag acgccgaagt gtacgccgcg
      721 gagaactggc tgcggctcta tggctaccta ccccagccca gccgccacat gtccaccatg
      781 cgctctgccc agatcctggc ctccgccctt gccgagatgc agagtttcta tgggatccct
      841 gtcacgggtg tgcttgatga agagacgaaa acgtggatga agcggccccg atgtggggtt
      901 cctgatcagt ttggggtaca tgtgaaagcc aacctgcgtc gacggcggaa acgttacacc
      961 ctgacaggaa aggcatggaa caattaccac ctgaccttca gcatccagaa ctacactgag
     1021 aagctgggct ggtacaactc catggaggcg gtgcgcaggg ctttccaagt gtgggagcag
     1081 gtcacaccat tggtcttcca ggaagtatcc tatgatgaca ttcggctacg aaggcgagcg
     1141 gaggctgaca tcatggtact ctttgcctct ggcttccatg gcgacagctc accgtttgat
     1201 ggcgtgggtg gctttctggc ccacgcttat ttccccggcc ctggtctggg tggggacacc
     1261 catttcgacg cagatgaacc ctggaccttc tccagcactg acctgcatgg aatcagcctc
     1321 tttctggtgg ccgtgcatga gctgggccat gccctggggc tagaacactc aagtaacccc
     1381 agcgctatta tggcaccctt ctaccagtgg atggataccg acaacttcca gctgcccgaa
     1441 gatgaccttc ggggcatcca gcagctgtat ggctccccag atggtaagcc acagcccacc
     1501 cggcctctcc ccactgtgag gccccggcgg ccaggacggc cagatcacca gccacctcgg
     1561 cctccccagc caccacatcc aggtgggaag ccagaaaggc cccccaaacc agggccccca
     1621 ccccagcccc gagccacaga gaggcctgac cagtatggcc ccaacatctg cgatggcaac
     1681 ttcgacacag tggctgtgct ccgcggagag atgtttgtgt tcaagggccg ctggttctgg
     1741 cgagtcaggc acaaccgcgt tctagacaac taccccatgc caattggcca cttctggcgc
     1801 ggtctgccgg ggaacatcag tgctgcctac gagcgccagg atggacattt tgtcttcttc
     1861 aaaggtaacc gctactggct tttccgagaa gccaatctgg agcccggcta cccacagccg
     1921 ctgagcagct atggcacaga catcccctat gaccgcattg acacagccat ctggtgggag
     1981 cccacaggtc acaccttctt ctttcaagca gacaggtact ggcgcttcaa cgaggagaca
     2041 cagcatggag accctggcta ccccaagccc atcagtgtct ggcaggggat ccccacctct
     2101 cccaaagggg ccttcctcag caacgatgca gcctacacct acttctacaa gggcaccaag
     2161 tactggaaat tcaacaacga acgcctacgg atggaacccg gccaccccaa atccatcctg
     2221 cgggacttca tgggctgcca ggagcacgtg gagccccgat cgcgatggcc cgatgtggct
     2281 cgtccaccct tcaaccccaa cgggggtgcc gagcctgagg cagatggtga cagcaaggaa
     2341 gagaacgcgg gtgacaagga tgagggcagc cgcgtggtgg tgcagatgga ggaggtggtc
     2401 cggacagtga acgtggtgat ggtgttggtc cccttgctgc tgttgctctg tattctgggc
     2461 ctggcctttg ctctggtgca gatgcagcgc aagggcgccc ctcgcatgct gctctactgc
     2521 aagcgctcac tgcaggagtg ggtgtgatca ggtagcaccc gcagcacccg gtgctcaggt
     2581 ctgcagggac aggagacgtg tggatcccag atgctccctc ggcgcggcag gatgccctcc
     2641 tagccacaca catccccctg ccagccttgc cccccacccc cgtcctcctt tatttatgcc
     2701 caggtgcctc ttctttttgg caccctctct cagcctttgg ttccgctttc ctgactcggg
     2761 ccaggagatg ctttgagatc tcccggagtg tagtaccgcc ccaggcagga acgaagggac
     2821 agaggctcac acctctggaa gatggcagag ggctgggaag cttctctggc tctggctttt
     2881 cagcctgaac ctctcctccc acgacaagaa ctgtgtttgc cttgaaggag cccacctcgg
     2941 gctctgccct cctgaatttg ccttagggag agtatatgct cccccccctg gggggggcac
     3001 cctgataacc ttgagacttg gttccttctt cttaggctcc taagaagccc agaagcctaa
     3061 aagccctacc ccatcctagc attctgcagc tcctacttgc cccgggcctg cagcttcttt
     3121 cctctaggaa ggggccctgg acatgtctca cctaggacca aagggagcct gccaagctcc
     3181 cctcccaatg ctagtgacta gctcctcctt ccctaggctg cccatattct ctttcagtgc
     3241 cccataggtc tccggaggct gggcactccc cgcccgcccc cacccccagc ttctgcagtc
     3301 cttgtcccaa ctcttaatga catggggcag acacacccac tagggtacca gaggtccctg
     3361 ggcagtgtgt gtgattgtgg atgctcagca ggtcacagac caagcttatg ggcttcctcc
     3421 cttccagatt cctgtcccca cacaacacta ctaggctcag gccagcagct caccccacac
     3481 agagtctgtg gaacccccaa aggaatccac taaggcctgg gaagtctgtc ctaagggtga
     3541 aaggggccct cccttcctct tctcatcctg gagtcagcag gaggcttctg tgggaaatgg
     3601 tactgtacag ctgtggctct gtctcctctg cctccctaaa gccttgagca gtaaagggct
     3661 gccagccagg atcctctggg tcaccgccgc tttccaagtg gtggattctt atagcctggc
     3721 actagaggtg acagatcgga ggggcatgtc ctgcagcact ctagatgtcc cctctgcaga
     3781 acctgagagt cagcaagggg tggggcgtcc acccccccac tccccatcgt ttagttctgt
     3841 agataatcag cactgattaa atgtccagcc agcgagcgtg gctgcacttg tacgctcaga
     3901 cccaagcatg ccgcaaggaa gacctgcttg gcagggtcgg ggccaagcga ggatgccgag
     3961 gaataccctc ctcccagttt ggtaggacct ttgggatgga gtccaggaag gtcagggaag
     4021 agtggggggg ggggggcagt aggagtctgg ttgggctgag gtttactggg tttacttaac
     4081 atttggtagt gataagagga gaggacagcc cagcttccca aatgactcca catctggcgg
     4141 tctggaagaa ccagacaagg ccgcccaatc gtcccaccca cctggattgg attttgggca
     4201 gcctgagagg tggcttgaac aagaactcag ggatgggtct ggagagaatt gtgtaacggg
     4261 gccactttac ctccagaatc ttccctccat gttcagagaa taaaatgcac tggaacctgc
     4321 aaaaaaaaaa aaaaa
//
