LOCUS       NM_008608               3801 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus matrix metallopeptidase 14 (membrane-inserted)
            (Mmp14), mRNA.
ACCESSION   NM_008608
VERSION     NM_008608.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3801)
  AUTHORS   Feng,W., Hong,N., Wu,Y., Huang,J., Zhang,Q., Liu,G., Qian,Z.,
            Chen,Y., Jin,L., Ding,X., Zhao,P., Chen,A.F. and Yu,Y.
  TITLE     Deficiency of Sox7 leads to congenital aortic stenosis via abnormal
            valve remodeling
  JOURNAL   J Mol Cell Cardiol 199, 81-94 (2025)
   PUBMED   39746830
REFERENCE   2  (bases 1 to 3801)
  AUTHORS   Sabeh,F., Li,X.Y., Olson,A.W., Botvinick,E., Kurup,A.,
            Gimenez,L.E., Cho,J.S. and Weiss,S.J.
  TITLE     Mmp14-dependent remodeling of the pericellular-dermal collagen
            interface governs fibroblast survival
  JOURNAL   J Cell Biol 223 (9) (2024)
   PUBMED   38990714
  REMARK    GeneRIF: Mmp14-dependent remodeling of the pericellular-dermal
            collagen interface governs fibroblast survival.
REFERENCE   3  (bases 1 to 3801)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3801)
  AUTHORS   Li,X., Cao,Q., Xu,C., Wang,J., Pan,T., Liu,Q., Xie,P. and Hu,Z.
  TITLE     Exosomal lncRNA-MIAT promotes neovascularization via the
            miR-133a-3p/MMP-X1 axis in diabetic retinopathy
  JOURNAL   Exp Eye Res 243, 109912 (2024)
   PUBMED   38670210
  REMARK    GeneRIF: Exosomal lncRNA-MIAT promotes neovascularization via the
            miR-133a-3p/MMP-X1 axis in diabetic retinopathy.
REFERENCE   5  (bases 1 to 3801)
  AUTHORS   Yeung,C.C., Garva,R., Pickard,A., Lu,Y., Mallikarjun,V., Swift,J.,
            Taylor,S.H., Rai,J., Eyre,D.R., Chaturvedi,M., Itoh,Y., Meng,Q.J.,
            Mauch,C., Zigrino,P. and Kadler,K.E.
  TITLE     Mmp14 is required for matrisome homeostasis and circadian rhythm in
            fibroblasts
  JOURNAL   Matrix Biol 124, 8-22 (2023)
   PUBMED   37913834
  REMARK    GeneRIF: Mmp14 is required for matrisome homeostasis and circadian
            rhythm in fibroblasts.
REFERENCE   6  (bases 1 to 3801)
  AUTHORS   Apte,S.S., Fukai,N., Beier,D.R. and Olsen,B.R.
  TITLE     The matrix metalloproteinase-14 (MMP-14) gene is structurally
            distinct from other MMP genes and is co-expressed with the TIMP-2
            gene during mouse embryogenesis
  JOURNAL   J Biol Chem 272 (41), 25511-25517 (1997)
   PUBMED   9325265
REFERENCE   7  (bases 1 to 3801)
  AUTHORS   Tanaka,M., Sato,H., Takino,T., Iwata,K., Inoue,M. and Seiki,M.
  TITLE     Isolation of a mouse MT2-MMP gene from a lung cDNA library and
            identification of its product
  JOURNAL   FEBS Lett 402 (2-3), 219-222 (1997)
   PUBMED   9037199
REFERENCE   8  (bases 1 to 3801)
  AUTHORS   Kinoh,H., Sato,H., Tsunezuka,Y., Takino,T., Kawashima,A., Okada,Y.
            and Seiki,M.
  TITLE     MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A),
            is expressed with its substrate in mouse tissue during
            embryogenesis
  JOURNAL   J Cell Sci 109 (Pt 5), 953-959 (1996)
   PUBMED   8743942
REFERENCE   9  (bases 1 to 3801)
  AUTHORS   Okada,A., Bellocq,J.P., Rouyer,N., Chenard,M.P., Rio,M.C.,
            Chambon,P. and Basset,P.
  TITLE     Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed
            in stromal cells of human colon, breast, and head and neck
            carcinomas
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2730-2734 (1995)
   PUBMED   7708715
REFERENCE   10 (bases 1 to 3801)
  AUTHORS   Sato,H., Takino,T., Okada,Y., Cao,J., Shinagawa,A., Yamamoto,E. and
            Seiki,M.
  TITLE     A matrix metalloproteinase expressed on the surface of invasive
            tumour cells
  JOURNAL   Nature 370 (6484), 61-65 (1994)
   PUBMED   8015608
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from W75261.1, AK165014.1 and
            AC206013.3.
            
            On Feb 11, 2016 this sequence version replaced NM_008608.3.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. Mice lacking the encoded protein exhibit craniofacial
            dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft
            tissues. [provided by RefSeq, Feb 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076638.1, AK163601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 W75261.1           12-17
            7-2542              AK165014.1         2-2537
            2543-3801           AC206013.3         171125-172383
FEATURES             Location/Qualifiers
     source          1..3801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.79 cM"
     gene            1..3801
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /note="matrix metallopeptidase 14 (membrane-inserted)"
                     /db_xref="GeneID:17387"
                     /db_xref="MGI:MGI:101900"
     exon            1..376
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..2017
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /EC_number="3.4.24.80"
                     /note="type 1 matrix metalloprotease 14; membrane-type-1
                     matrix metalloproteinase; matrix metalloproteinase 14
                     (membrane-inserted); Membrane type 1-MMP"
                     /codon_start=1
                     /product="matrix metalloproteinase-14 preproprotein"
                     /protein_id="NP_032634.3"
                     /db_xref="CCDS:CCDS36922.1"
                     /db_xref="GeneID:17387"
                     /db_xref="MGI:MGI:101900"
                     /translation="MSPAPRPSRSLLLPLLTLGTALASLGWAQGSNFSPEAWLQQYGY
                     LPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADLATMMAMRRPRCGVPDKFGTE
                     IKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWESATPLRFR
                     EVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSA
                     EPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDR
                     RGIQQLYGSKSGSPTKMPPQPRTTSRPSVPDKPKNPAYGPNICDGNFDTVAMLRGEMF
                     VFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDE
                     ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEEFRAVDSEYP
                     KNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC
                     PSGGRPDEGTEEETEVIIIEVDEEGSGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHG
                     TPKRLLYCQRSLLDKV"
     exon            377..525
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     exon            526..648
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     exon            649..956
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1118
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1279
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1418
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1569
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1685
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..3801
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3767..3772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /note="hexamer: AATAAA"
     polyA_site      3787
                     /gene="Mmp14"
                     /gene_synonym="MMP-X1; MT-MMP-1; MT1-MMP; sabe"
                     /note="major polyA site"
ORIGIN      
        1 gctgtgggag aagggaggga ccaaaggaga gcagagaggg cttccaactc agttcgccga
       61 ctaagcagaa gaaagatcaa aaaacggaaa agagaagagc aaacagacat ttccaggagc
      121 aattccctca cctccaagcc gaccgcgctc taggaatcca cattccgttc ctttagaaga
      181 caaaggcgcc ccaagagagg cggcgcgacc ccagggcgtg ggccccgccg cggagcccgc
      241 accgcccggc gccccgacgc cggggaccat gtctcccgcc cctcgaccct cccgcagcct
      301 cctgctcccc ctgctcacgc ttggcacggc gctcgcctcc ctcggctggg cccaaggcag
      361 caacttcagc cccgaagcct ggctgcagca gtatggctac ctacctccag gggacctgcg
      421 tacccacaca caacgctcac cccagtcact ctcagctgcc attgccgcca tgcaaaagtt
      481 ctatggttta caagtgacag gcaaggctga tttggcaacc atgatggcca tgaggcgccc
      541 tcgctgtggt gttccggata agtttgggac tgagatcaag gccaatgttc ggaggaagcg
      601 ctatgccatt cagggcctca agtggcagca taatgagatc actttctgca ttcagaatta
      661 cacccctaag gtgggcgagt atgccacatt cgaggccatt cggaaggcct tccgagtatg
      721 ggagagtgcc acgccactgc gcttccgaga agtgccctat gcctacatcc gggagggaca
      781 tgagaagcag gctgacatca tgatcttgtt tgctgagggt ttccacggcg acagtacacc
      841 ctttgatggt gaaggagggt tcctggctca tgcctacttc ccaggcccca atattggagg
      901 ggatacccac tttgattctg ccgagccctg gactgtccaa aatgaggatc taaatgggaa
      961 tgacatcttc ttggtggctg tgcatgagtt ggggcatgcc ctaggcctgg aacattccaa
     1021 tgatccctcc gccatcatgg ccccctttta ccagtggatg gacacagaga acttcgtgtt
     1081 gcctgatgac gatcgccgtg gcatccagca actttatgga agcaagtcag ggtcacccac
     1141 aaagatgccc cctcaaccca gaactacctc tcggccctct gtcccagata agcccaaaaa
     1201 ccccgcctat gggcccaaca tctgtgacgg gaactttgac accgtggcca tgctccgagg
     1261 agagatgttt gtcttcaagg agcgatggtt ctggcgggtg aggaataacc aagtgatgga
     1321 tggataccca atgcccattg gccaattctg gaggggcctg cctgcatcca tcaatactgc
     1381 ctacgagagg aaggatggca aatttgtctt cttcaaagga gataagcact gggtgtttga
     1441 cgaagcctcc ctggaacccg ggtaccccaa gcacattaag gagctgggcc gagggctgcc
     1501 cacggacaag atcgatgcag ctctcttctg gatgcccaat gggaagacct acttcttccg
     1561 gggcaataag tactaccggt tcaatgaaga attcagggca gtggacagcg agtaccctaa
     1621 aaacatcaaa gtctgggaag gaatccctga atctcccagg gggtcattca tgggcagtga
     1681 tgaagtcttc acatacttct acaagggaaa caaatactgg aagttcaaca accagaagct
     1741 gaaggtagag ccagggtatc ccaagtcagc tctgcgggac tggatgggct gcccttcggg
     1801 gggccggccc gatgagggga ctgaggagga gacggaggtg atcatcattg aggtggatga
     1861 ggagggcagt ggagctgtga gtgcggccgc cgtggtcctg ccggtactac tgctgctcct
     1921 ggtactggca gtgggcctcg ctgtcttctt cttcagacgc catgggacgc ccaagcgact
     1981 gctttactgc cagcgttcgc tgctggacaa ggtctgaccc ccaccactgg cccacccgct
     2041 tctaccacaa ggactttgcc tctgaaggcc agtggctaca ggtggtagca ggtgggctgc
     2101 tctcacccgt cctgggctcc ctccctccag cctcccttct cagtccctaa ttggcctctc
     2161 ccaccctcac cccagcattg cttcatccat aagtgggtcc cttgagggct gagcagaaga
     2221 cggttggcct ctggccctca agggaatctc acagctcggt gtgtgttcag ccctagttga
     2281 atgttgtcaa ggctctgcac ttgaaggcaa gaccctctga ccttataggc aacggccaaa
     2341 tggggccatc tgcttctttt ccatccccct aactacatac cttaaatctc tgaactctga
     2401 cctcaggagg ctctgggcat atgagcccta tatgtaccaa gtgtacctag ttggctgcct
     2461 cccgccactc tgactaaaag gaatcttaag agtgtacgtt tggaggtgga aagattgttc
     2521 agtttaccct aaagactttg ataagaaaga gaaagaaaga aagaaagaaa gaaagaaaga
     2581 aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga
     2641 aagaaagaaa gaaaagctca cagagagtct ggtggcttgg acagccaagt tcctctccac
     2701 aaagatctgc ctctatccaa cccagtctgg agaacttcca aaggagcctg agccattaag
     2761 gactaaatgg gtttgaggaa acccttggca aacccgaccc ctgacccctg aatgttagcc
     2821 ttgaatgtca agttcaaggc tggaagagct gaaaccaggg ggaaaggtcc cgggtggagt
     2881 gaggtcaagg ggagacagca ggacctgaag gatgagcctc acagctcaaa gcagacaaag
     2941 accttgttca aatgcaagtc actggggctg ggacccaaag agagcagtca gagagggcag
     3001 gacacgaagg gtagtggtgg cagtgtatgc ctgggagtct gcacagactg cagtgcacac
     3061 acgggacact agtccccagg agtgggcaca tcttattgga tgtctcagaa agggccttaa
     3121 gggaagccac actggccact ttctgtcccc ttgctcacag tgtagaaggc aagggtagga
     3181 attgatacag gagtgagaag aacatgcata cagggactca atggagacca gagaaggctg
     3241 tcagcagcct gggcttgctt agacttcctc actgccctag tgaggcaggt gtctgggtgc
     3301 tgttggttag ggtggcctcc ctttcctgat gcaggcaccc ctcagcccat tttacctatg
     3361 tcctgccctt cctcttcccc gcccagttga cccatttgaa gtctccttca gccactgaag
     3421 gcggtcatgg tactggggac ttgggagagt gagaccctgt ggagggagag gcgaggagag
     3481 gagagaaatg tctgggtggg ggttggggat aggggtgaac ggtgctggaa gcccagctaa
     3541 atttctgtct tgtttgggtt ttttttttgt tttgtttaat gtatattttt attataatta
     3601 ttatatatga atgccattca aatcgttcct ttttgttaac aaggggcatg gggaggggtg
     3661 gggggtggag gggggctgag gcgactgacc ccagaaacct gcagggcggg gctgggtcag
     3721 tgctctctaa ggacattttt tgaccttgtt caacctttcc aagaagaata aactgtgttt
     3781 cacattcttt gtgtgactcg a
//
