LOCUS       NM_008607               2675 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus matrix metallopeptidase 13 (Mmp13), mRNA.
ACCESSION   NM_008607
VERSION     NM_008607.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2675)
  AUTHORS   Hata,K., Wakamori,K., Hirakawa-Yamamura,A., Ichiyama-Kobayashi,S.,
            Yamaguchi,M., Okuzaki,D., Takahata,Y., Murakami,T., Uzawa,N.,
            Yamashiro,T. and Nishimura,R.
  TITLE     Serinc5 Regulates Sequential Chondrocyte Differentiation by
            Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes
  JOURNAL   J Cell Physiol 240 (1), e31490 (2025)
   PUBMED   39568258
REFERENCE   2  (bases 1 to 2675)
  AUTHORS   Houchen,C.J., Ghanem,S., Kaartinen,V. and Bumann,E.E.
  TITLE     TGF-beta signaling in the cranial neural crest affects late-stage
            mandibular bone resorption and length
  JOURNAL   Front Physiol 15, 1435594 (2024)
   PUBMED   39473613
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2675)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2675)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   5  (bases 1 to 2675)
  AUTHORS   Sieverts,M., Yee,C., Nemani,M., Parkinson,D.Y., Alliston,T. and
            Acevedo,C.
  TITLE     Spatial control of perilacunar canalicular remodeling during
            lactation
  JOURNAL   Sci Rep 14 (1), 14655 (2024)
   PUBMED   38918485
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2675)
  AUTHORS   Gack,S., Vallon,R., Schmidt,J., Grigoriadis,A., Tuckermann,J.,
            Schenkel,J., Weiher,H., Wagner,E.F. and Angel,P.
  TITLE     Expression of interstitial collagenase during skeletal development
            of the mouse is restricted to osteoblast-like cells and
            hypertrophic chondrocytes
  JOURNAL   Cell Growth Differ 6 (6), 759-767 (1995)
   PUBMED   7669731
REFERENCE   7  (bases 1 to 2675)
  AUTHORS   Schorpp,M., Mattei,M.G., Herr,I., Gack,S., Schaper,J. and Angel,P.
  TITLE     Structural organization and chromosomal localization of the mouse
            collagenase type I gene
  JOURNAL   Biochem J 308 (Pt 1) (Pt 1), 211-217 (1995)
   PUBMED   7755567
REFERENCE   8  (bases 1 to 2675)
  AUTHORS   Mattot,V., Raes,M.B., Henriet,P., Eeckhout,Y., Stehelin,D.,
            Vandenbunder,B. and Desbiens,X.
  TITLE     Expression of interstitial collagenase is restricted to skeletal
            tissue during mouse embryogenesis
  JOURNAL   J Cell Sci 108 (Pt 2), 529-535 (1995)
   PUBMED   7768998
REFERENCE   9  (bases 1 to 2675)
  AUTHORS   Gack,S., Vallon,R., Schaper,J., Ruther,U. and Angel,P.
  TITLE     Phenotypic alterations in fos-transgenic mice correlate with
            changes in Fos/Jun-dependent collagenase type I expression.
            Regulation of mouse metalloproteinases by carcinogens, tumor
            promoters, cAMP, and Fos oncoprotein
  JOURNAL   J Biol Chem 269 (14), 10363-10369 (1994)
   PUBMED   8144618
REFERENCE   10 (bases 1 to 2675)
  AUTHORS   Henriet,P., Rousseau,G.G. and Eeckhout,Y.
  TITLE     Cloning and sequencing of mouse collagenase cDNA. Divergence of
            mouse and rat collagenases from the other mammalian collagenases
  JOURNAL   FEBS Lett 310 (2), 175-178 (1992)
   PUBMED   1383028
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC125320.1, AK150728.1 and
            AC174457.2.
            
            On Mar 24, 2010 this sequence version replaced NM_008607.1.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family that plays a role in wound healing, skeletal development and
            bone remodeling. The encoded protein is activated by the removal of
            an N-terminal activation peptide to generate a zinc-dependent
            endopeptidase enzyme that can cleave various native collagens,
            including types I - IV, X and XIV. Mice lacking the encoded protein
            display profound defects in growth plate cartilage as well as a
            delay in the endochondral bone development. Lack of the encoded
            protein also impairs the wound healing process due to reduced
            keratinocyte migration and vascular density at the wound site. This
            gene is located in a cluster of other matrix metalloproteinase
            genes on chromosome 9. [provided by RefSeq, Jun 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125320.1, AK152916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1530              BC125320.1         1-1530
            1531-2670           AK150728.1         1518-2657
            2671-2675           AC174457.2         27533-27537         c
FEATURES             Location/Qualifiers
     source          1..2675
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..2675
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /note="matrix metallopeptidase 13"
                     /db_xref="GeneID:17386"
                     /db_xref="MGI:MGI:1340026"
     exon            1..164
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1460
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /note="collagenase 3; matrix metalloproteinase 13;
                     collagenase-1; interstitial collagenase"
                     /codon_start=1
                     /product="collagenase 3 preproprotein"
                     /protein_id="NP_032633.1"
                     /db_xref="CCDS:CCDS22803.1"
                     /db_xref="GeneID:17386"
                     /db_xref="MGI:MGI:1340026"
                     /translation="MHSAILATFFLLSWTPCWSLPLPYGDDDDDDLSEEDLVFAEHYL
                     KSYYHPATLAGILKKSTVTSTVDRLREMQSFFGLEVTGKLDDPTLDIMRKPRCGVPDV
                     GEYNVFPRTLKWSQTNLTYRIVNYTPDMSHSEVEKAFRKAFKVWSDVTPLNFTRIYDG
                     TADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLF
                     IVAAHELGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQFLYGPGDEDPNP
                     KHPKTPEKCDPALSLDAITSLRGETMIFKDRFFWRLHPQQVEAELFLTKSFWPELPNH
                     VDAAYEHPSRDLMFIFRGRKFWALNGYDILEGYPRKISDLGFPKEVKRLSAAVHFENT
                     GKTLFFSENHVWSYDDVNQTMDKDYPRLIEEEFPGIGNKVDAVYEKNGYIYFFNGPIQ
                     FEYSIWSNRIVRVMPTNSILWC"
     exon            165..406
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..555
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..681
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..843
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..961
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1095
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1255
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1359
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..2675
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /note="hexamer: AATAAA"
     polyA_site      2673
                     /gene="Mmp13"
                     /gene_synonym="Clg; MMP-13; Mmp1"
                     /note="major polyA site"
ORIGIN      
        1 cttgccctgg gaaggagaga ctccaggcac tgctgggcac catgcattca gctatcctgg
       61 ccaccttctt cttgttgagc tggactccct gttggtccct gccccttccc tatggtgatg
      121 atgatgatga tgacctgtct gaggaagacc ttgtgtttgc agagcactac ttgaaatcat
      181 actaccatcc tgcgactctt gcgggaatcc tgaagaagtc tacagtgacc tccacagttg
      241 acaggctccg agaaatgcaa tctttctttg gcttagaggt gactggcaaa cttgatgatc
      301 ccaccttaga catcatgaga aaaccaagat gtggagtgcc tgatgtgggt gaatacaatg
      361 ttttccctag aacactcaaa tggtcccaaa cgaacttaac ttacaggatt gtgaactata
      421 ctcctgatat gtcccattct gaagtggaga aggccttcag aaaagccttc aaggtctggt
      481 ctgatgtgac accactgaat ttcaccagaa tctatgatgg cactgctgac atcatgatat
      541 cttttgggac taaagaacat ggtgacttct acccatttga tggaccttct ggtcttctgg
      601 cacacgcttt tcctcctgga ccaaactatg gtggggatgc ccattttgat gatgatgaaa
      661 cctggacaag cagttccaaa ggctacaact tgtttattgt tgctgcccat gagcttggcc
      721 actccctagg tctggatcac tccaaggacc caggagccct gatgtttccc atctatacct
      781 acactggcaa aagccatttc atgcttcctg atgatgacgt tcaaggaatt cagtttcttt
      841 atggtccagg cgatgaagac cccaacccta agcatcccaa aacaccagag aagtgtgacc
      901 cagccctatc ccttgatgcc attaccagtc tccgaggaga aactatgatc tttaaagaca
      961 gattcttctg gcgcctgcac cctcagcagg ttgaggctga gctctttttg acaaagtcct
     1021 tttggccaga acttcccaac catgtggatg ctgcatatga acatccatcc cgtgacctta
     1081 tgtttatctt tagagggaga aaattctggg ctctgaatgg ttatgacatt ctggaaggtt
     1141 atcccagaaa aatatctgac ctgggattcc caaaagaggt gaagagactg agcgctgcgg
     1201 ttcactttga gaacacgggg aagaccctct tcttctctga gaaccacgtg tggagttatg
     1261 atgatgttaa ccagactatg gacaaagatt atccccgcct catagaagag gaattccctg
     1321 gaattggcaa caaagtagat gctgtctatg agaaaaatgg ctatatctac tttttcaatg
     1381 ggcccataca gtttgaatac agtatctgga gtaatcgcat tgtgagagtc atgccaacaa
     1441 attccatatt gtggtgttaa gcatctttaa aagttgttat ttatctccca gagagtattt
     1501 ggaatacttt cagatgtatg gggtgggggt ggggtggaga tatcagggga gagcttagtt
     1561 ctgtgaacga gcttcagtaa gttatctttg agcatacagt atctatatga ctatgcgtgg
     1621 ctggaaccac atggaagaat tttaaagtaa tgcaattgag aaccccaagg atcacctgat
     1681 tcttgcgtgc tatgaagaaa caagattgat aataacccac agcaaacatg gggtccatct
     1741 gcttttgaga gcatgcataa ttattaatat atttatttta aaaagcctaa cagacataaa
     1801 ataaatcata tttatataac tgaattgtct ttacaaaaaa gtataaactt agaaacttga
     1861 aaattgtgag gagttcatgt atggggagcc acagatgagc acagataaag ggaaatgcct
     1921 aaaaaatgca cgttaacgga caactttcca aagagagatt tcagcttttc actgcgagcg
     1981 ttcagattta catccacttt tatacaacca ataaaaaaat accaaagtca ctaaagaaag
     2041 gggataacag ccactacaag gacagtggag gtggccttac atttggctta atttttatgt
     2101 tggtcattac tcaaggctat gcacactggt agaagatatt gagagagaaa tggaggagat
     2161 ttctcttttt attaaatatt taggcattga aaagaccata gtgtgaaaag tcaaaattgc
     2221 tataagatac gtaagcaatg ccatagcttt ttcatgaatt atttgactat tttagaataa
     2281 aactaatgtt tcaaccttgt ttatctaccc acttgttcta atgacctata gactctttga
     2341 tacatagtct cttttctagt aacttgtgtg acaggggcta aggcagaaat attatgtaga
     2401 agtagatcca gctaagacac agcaagccag aataaagact gtgccagctg gtcagtcgcc
     2461 cttttgagac cactcctttg tgctccacca tgtttgttaa tccctctctg ctttccttag
     2521 cgagtaacac ttggtgctta ctgatgtgtg aaaagctatt gtgtcaagag acagtgttaa
     2581 ttaaactggg aaaatacaaa agaactgttt ttttgaataa tatgttagac tgtatttatg
     2641 ttgtttctaa taaaaataag tgttttcagc agata
//
