LOCUS       NM_008605               3607 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus matrix metallopeptidase 12 (Mmp12), transcript variant
            1, mRNA.
ACCESSION   NM_008605
VERSION     NM_008605.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3607)
  AUTHORS   Buerger,M., Amor,M., Akhmetshina,A., Bianco,V., Perfler,B.,
            Zebisch,A., Weichhart,T. and Kratky,D.
  TITLE     Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion
            of Matrix Metalloproteinase 12
  JOURNAL   Int J Mol Sci 25 (20), 11001 (2024)
   PUBMED   39456786
  REMARK    GeneRIF: Limited Alleviation of Lysosomal Acid Lipase Deficiency by
            Deletion of Matrix Metalloproteinase 12.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3607)
  AUTHORS   Arosa,L., Camba-Gomez,M., Lorenzo-Martin,L.F., Clavain,L., Lopez,M.
            and Conde-Aranda,J.
  TITLE     RNA Expression of MMP12 Is Strongly Associated with Inflammatory
            Bowel Disease and Is Regulated by Metabolic Pathways in RAW 264.7
            Macrophages
  JOURNAL   Int J Mol Sci 25 (6), 3167 (2024)
   PUBMED   38542140
  REMARK    GeneRIF: RNA Expression of MMP12 Is Strongly Associated with
            Inflammatory Bowel Disease and Is Regulated by Metabolic Pathways
            in RAW 264.7 Macrophages.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3607)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3607)
  AUTHORS   Zhou,X., Zhang,C., Yang,S., Yang,L., Luo,W., Zhang,W., Zhang,X. and
            Chao,J.
  TITLE     Macrophage-derived MMP12 promotes fibrosis through sustained damage
            to endothelial cells
  JOURNAL   J Hazard Mater 461, 132733 (2024)
   PUBMED   37816293
  REMARK    GeneRIF: Macrophage-derived MMP12 promotes fibrosis through
            sustained damage to endothelial cells.
REFERENCE   5  (bases 1 to 3607)
  AUTHORS   Amor,M., Bianco,V., Buerger,M., Lechleitner,M., Vujic,N.,
            Dobrijevic,A., Akhmetshina,A., Pirchheim,A., Schwarz,B.,
            Pessentheiner,A.R., Baumgartner,F., Rampitsch,K., Schauer,S.,
            Klobucar,I., Degoricija,V., Pregartner,G., Kummer,D., Svecla,M.,
            Sommer,G., Kolb,D., Holzapfel,G.A., Hoefler,G., Frank,S.,
            Norata,G.D. and Kratky,D.
  TITLE     Genetic deletion of MMP12 ameliorates cardiometabolic disease by
            improving insulin sensitivity, systemic inflammation, and
            atherosclerotic features in mice
  JOURNAL   Cardiovasc Diabetol 22 (1), 327 (2023)
   PUBMED   38017481
  REMARK    GeneRIF: Genetic deletion of MMP12 ameliorates cardiometabolic
            disease by improving insulin sensitivity, systemic inflammation,
            and atherosclerotic features in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3607)
  AUTHORS   Gersten,K.M., Natsuka,S., Trinchera,M., Petryniak,B., Kelly,R.J.,
            Hiraiwa,N., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Lowe,J.B.
  TITLE     Molecular cloning, expression, chromosomal assignment, and
            tissue-specific expression of a murine
            alpha-(1,3)-fucosyltransferase locus corresponding to the human
            ELAM-1 ligand fucosyl transferase
  JOURNAL   J Biol Chem 270 (42), 25047-25056 (1995)
   PUBMED   7559635
REFERENCE   7  (bases 1 to 3607)
  AUTHORS   Bozza,M., Kolakowski,L.F. Jr., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., David,J.R. and Gerard,C.
  TITLE     Structural characterization and chromosomal location of the mouse
            macrophage migration inhibitory factor gene and pseudogenes
  JOURNAL   Genomics 27 (3), 412-419 (1995)
   PUBMED   7558021
REFERENCE   8  (bases 1 to 3607)
  AUTHORS   Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
  TITLE     Molecular cloning of the murine IL-1 beta converting enzyme cDNA
  JOURNAL   J Immunol 149 (10), 3254-3259 (1992)
   PUBMED   1431103
REFERENCE   9  (bases 1 to 3607)
  AUTHORS   Shapiro,S.D., Griffin,G.L., Gilbert,D.J., Jenkins,N.A.,
            Copeland,N.G., Welgus,H.G., Senior,R.M. and Ley,T.J.
  TITLE     Molecular cloning, chromosomal localization, and bacterial
            expression of a murine macrophage metalloelastase
  JOURNAL   J Biol Chem 267 (7), 4664-4671 (1992)
   PUBMED   1537850
REFERENCE   10 (bases 1 to 3607)
  AUTHORS   Denis,M., Cormier,Y., Fournier,M., Tardif,J. and Laviolette,M.
  TITLE     Tumor necrosis factor plays an essential role in determining
            hypersensitivity pneumonitis in a mouse model
  JOURNAL   Am J Respir Cell Mol Biol 5 (5), 477-483 (1991)
   PUBMED   1931076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY195619.1, AK171428.1,
            AK155841.1, AK155748.1 and BY539785.1.
            
            On Sep 29, 2006 this sequence version replaced NM_008605.2.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. Mice lacking the encoded protein have a diminished capacity
            to degrade extracellular matrix components, do not develop
            emphysema in response to long-term exposure to cigarette smoke, and
            exhibit impaired clearance and increased mortality upon bacterial
            infection. This gene is located in a cluster of other matrix
            metalloproteinase genes on chromosome 9. Alternate splicing
            generates multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155748.1, AK170976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY195619.1         1-32
            33-1832             AK171428.1         2-1801
            1833-2034           AK155841.1         1860-2061
            2035-3605           AK155748.1         2004-3574
            3606-3607           BY539785.1         399-400
FEATURES             Location/Qualifiers
     source          1..3607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..3607
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /note="matrix metallopeptidase 12"
                     /db_xref="GeneID:17381"
                     /db_xref="MGI:MGI:97005"
     exon            1..165
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1473
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /EC_number="3.4.24.65"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; matrix metalloproteinase 12; macrophage
                     metalloelastase; macrophage elastase"
                     /codon_start=1
                     /product="macrophage metalloelastase isoform 1
                     preproprotein"
                     /protein_id="NP_032631.3"
                     /db_xref="CCDS:CCDS22804.1"
                     /db_xref="GeneID:17381"
                     /db_xref="MGI:MGI:97005"
                     /translation="MSCTLLKGVCTMKFLMMIVFLQVSACGAAPMNDSEFAEWYLSRF
                     YDYGKDRIPMTKTKTNRNFLKEKLQEMQQFFGLEATGQLDNSTLAIMHIPRCGVPDVQ
                     HLRAVPQRSRWMKRYLTYRIYNYTPDMKREDVDYIFQKAFQVWSDVTPLRFRKLHKDE
                     ADIMILFAFGAHGDFNYFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFL
                     VAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFRLSADDIRNIQSLYGAPVKPPSLT
                     KPSSPPSTFCHQSLSFDAVTTVGEKIFFFKDWFFWWKLPGSPATNITSISSIWPSIPS
                     GIQAAYEIESRNQLFLFKDEKYWLINNLVPEPHYPRSIYSLGFSASVKKVDAAVFDPL
                     RQKVYFFVDKHYWRYDVRQELMDPAYPKLISTHFPGIKPKIDAVLYFKRHYYIFQGAY
                     QLEYDPLFRRVTKTLKSTSWFGC"
     exon            166..413
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     exon            414..562
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     exon            563..688
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     exon            689..850
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     exon            851..974
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1108
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1268
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1372
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..3607
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1811..1816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /note="hexamer: AATAAA"
     polyA_site      1829
                     /gene="Mmp12"
                     /gene_synonym="MME; Mmel"
                     /note="major polyA site"
ORIGIN      
        1 gttatataaa gtggggcttt aagggaactt gcagtcggag ggaacaggtt gatgagctgc
       61 actctgctga aaggagtctg cacaatgaaa tttctcatga tgattgtgtt cttacaggta
      121 tctgcctgtg gggctgctcc catgaatgac agtgaatttg ctgaatggta cttgtcaaga
      181 ttttatgatt atggaaagga cagaattcca atgacaaaaa caaaaaccaa tagaaacttc
      241 ctaaaagaaa aactccagga aatgcagcag ttctttgggc tagaagcaac tgggcaactg
      301 gacaactcaa ctctggcaat aatgcacatc cctcgatgtg gagtgcccga tgtacagcat
      361 cttagagcag tgccccagag gtcaagatgg atgaagcggt acctcactta caggatctat
      421 aattacactc cggacatgaa gcgtgaggat gtagactaca tatttcagaa agctttccaa
      481 gtctggagtg atgtgactcc tctaagattc agaaagcttc ataaagatga ggctgacatt
      541 atgatacttt ttgcatttgg agctcacgga gacttcaact attttgatgg caaaggtggt
      601 acactagccc atgcttttta tcctggacct ggtattcaag gagatgcaca ttttgatgag
      661 gcagaaacgt ggactaaaag ttttcaaggc acaaacctct tccttgttgc tgttcatgaa
      721 cttggccatt ccttggggct gcagcattcc aataatccaa agtcaataat gtaccccacc
      781 tacagatacc ttaaccccag cacatttcgc ctctctgctg atgacatacg taacattcag
      841 tccctctatg gagccccagt gaaaccccca tccttgacaa aacctagcag tccaccatca
      901 actttctgtc accaaagctt gagttttgat gctgtcacaa cagtgggaga gaaaatcttt
      961 ttctttaaag actggttctt ctggtggaag cttcctggga gtccagccac caacattact
     1021 tctatttctt ccatatggcc aagcatccca tctggtattc aagctgctta cgaaattgaa
     1081 agcagaaatc aacttttcct ttttaaagat gagaagtact ggttaataaa caacttagta
     1141 ccagagccac actatcccag gagcatatat tccctgggct tctctgcatc tgtgaagaag
     1201 gttgatgcag ctgtctttga cccacttcgc caaaaggttt atttctttgt ggataaacac
     1261 tactggaggt atgatgtgag gcaggagctc atggaccctg cttaccccaa gctgatttcc
     1321 acacacttcc caggaatcaa gcctaaaatt gatgcagtcc tctatttcaa aagacactac
     1381 tacatcttcc aaggagccta tcaattggaa tatgaccccc tgttccgtcg tgtcaccaaa
     1441 acattgaaaa gtacaagctg gtttggttgt taggaagaat gtagtgaagg gtgcttgctg
     1501 gtttttcagt tttataagta tatttattac atattcactc tatgctcagg gtgtaactat
     1561 gtggcaataa tgtaacagga aataagggga ggtgtacagg tcacacacac atagttacac
     1621 agaaaagtgc ttttacaaaa ttaacctctt ttaggaaact tttttcactt cattctattc
     1681 ttaattttga aagtgcatgg ttcagaggcc aactggttta tctgtaagtt gttttctaac
     1741 aaccttcaag tagaaatatt agaattactc tcttgtcttt actgaaatgt aacatgtttt
     1801 gttttcttta aataaattga aagaaagtgt ttgcctttta attttttctt taaaaaagtg
     1861 tgtgtgtgtg tgtgtgtgtg tgtgtgtatg ttgcctatgt gcatatttat gtaccacctg
     1921 ctggtagaag acagaagagg atgtcaggtc cctagaaaca ggagttatca tggttatggg
     1981 aaacattgtg ggtgctgggg attgaattca tatctcctaa aagagcagcc tgtgctcttt
     2041 gctcctgtgt catctctcca gccccagtta taatattttt cttgaaaagt caatcaattt
     2101 tgaaaataac tgtggtcttc taaataaaat ctttctgtga ctgtaccaag ccatcaatgg
     2161 agatgtgata gctataagaa gttgaagctt ggagtccttt taatcacttg tgtatgaaca
     2221 gcagtctaaa cccaagacaa gaaagcattc tctagccagc acatgactcc aaaggtagct
     2281 ccatatgacc acaagactga agaggaggta ggaggaaata aggcttctgt tcttgttaga
     2341 tgtgttgtgt ggctcatttc acatcagaaa gtgggttgta gcattgctat gtggccttac
     2401 aggacattaa atggaagcct ccttaagcac aggaggaact atgagtagca cacgctttgt
     2461 ttgtcacagg aaaaagacaa catggtgagc ctgccatgtc tgtgtcctgg tctgccttct
     2521 atcagtttta ttttctgtcc tgacatcttg gctccctatc ttctgtattg tgtatgctgt
     2581 agagatctca aagcttgtga gtttgtgaag tatgtccaat gttaaaactg actggtgtat
     2641 tgtccaagaa acagagaacc cttcatagca gattgtcatt caggcatttt tggagactga
     2701 aatgaactga aataggaatg acatgaggaa agggctcctt tgctccatgt gtcagatgtg
     2761 agtattaacc ttcgacatca acttcatgag atccagagtc atgtaagaga catgtgagca
     2821 ctacttcaaa gaaggtaaat ggtagggagc attgtcactc tcagagcagg tggcagatcg
     2881 atgacagtcc catcatggga aggacagcat tttgtcctta ataggatagg tcattaattt
     2941 tggttatgaa tttgcatttc ctgtacatag tgctcctgct caaactatca cccatggact
     3001 tacagcatac cttaccacca ccatagtatt ccacacaaca ttgtttctgt tcagggacct
     3061 catttcacag ccacagtaga gtcacattag gctcacattc atgttgatat tcatgctctg
     3121 cacagtcctg acacgggaaa aacatctgct ttatagactg ctgtaagcct ttgattgatt
     3181 tctagaatct ttatcttctc agtattagag actgaaccca gggccgtgtg tgtacaacaa
     3241 agcacgtgac ctttaagtta tgtcctagca gttaagattc tgaaaaggtc attttttctg
     3301 ctatttttat gctggtgttt ttgttacttt tatgaaaaaa aatatttgga ttacccttta
     3361 tttaatcatt ccaggtggca tggcttttag attattaatt ttagtgttga cagcaaacag
     3421 atatttaaag ccttaaatta atgctactat tctcataata attctgtcag cgtggatttt
     3481 ttcaggaaat gtattattta tattaaagtg ttatttagct gactcaatac ctaaaatatt
     3541 ttcataactt ctgctatggc aaatgtttcc tgagacagaa taacaaataa aaactcttca
     3601 aaatctg
//
