LOCUS       NM_008606               2304 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus matrix metallopeptidase 11 (Mmp11), transcript variant
            1, mRNA.
ACCESSION   NM_008606
VERSION     NM_008606.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   Varadinkova,S., Oralova,V., Clarke,M., Frampton,J., Knopfova,L.,
            Lesot,H., Bartos,P. and Matalova,E.
  TITLE     Expression dynamics of metalloproteinases during mandibular bone
            formation: association with Myb transcription factor
  JOURNAL   Front Cell Dev Biol 11, 1168866 (2023)
   PUBMED   37701782
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Alcantara,M.C., Suzuki,K., Acebedo,A.R., Kajioka,D., Hirohata,S.,
            Kaisho,T., Hatano,Y., Yamagata,K., Takahashi,S. and Yamada,G.
  TITLE     Androgen-regulated MafB drives cell migration via MMP11-dependent
            extracellular matrix remodeling in mice
  JOURNAL   iScience 25 (12), 105609 (2022)
   PUBMED   36465133
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Drake,K.A., Chaney,C.P., Das,A., Roy,P., Kwartler,C.S., Rakheja,D.
            and Carroll,T.J.
  TITLE     Stromal beta-catenin activation impacts nephron progenitor
            differentiation in the developing kidney and may contribute to
            Wilms tumor
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32541007
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   D'Ignazio,L., Michel,M., Beyer,M., Thompson,K., Forabosco,A.,
            Schlessinger,D. and Pelosi,E.
  TITLE     Lhx8 ablation leads to massive autophagy of mouse oocytes
            associated with DNA damage
  JOURNAL   Biol Reprod 98 (4), 532-542 (2018)
   PUBMED   29329412
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Noel,A., Santavicca,M., Stoll,I., L'Hoir,C., Staub,A., Murphy,G.,
            Rio,M.C. and Basset,P.
  TITLE     Identification of structural determinants controlling human and
            mouse stromelysin-3 proteolytic activities
  JOURNAL   J Biol Chem 270 (39), 22866-22872 (1995)
   PUBMED   7559421
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   Sanz,L., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Molecular characterization of a novel transcription factor that
            controls stromelysin expression
  JOURNAL   Mol Cell Biol 15 (6), 3164-3170 (1995)
   PUBMED   7760812
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Lefebvre,O., Regnier,C., Chenard,M.P., Wendling,C., Chambon,P.,
            Basset,P. and Rio,M.C.
  TITLE     Developmental expression of mouse stromelysin-3 mRNA
  JOURNAL   Development 121 (4), 947-955 (1995)
   PUBMED   7743938
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Sympson,C.J., Talhouk,R.S., Alexander,C.M., Chin,J.R., Clift,S.M.,
            Bissell,M.J. and Werb,Z.
  TITLE     Targeted expression of stromelysin-1 in mammary gland provides
            evidence for a role of proteinases in branching morphogenesis and
            the requirement for an intact basement membrane for tissue-specific
            gene expression
  JOURNAL   J Cell Biol 125 (3), 681-693 (1994)
   PUBMED   8175886
  REMARK    Erratum:[J Cell Biol 1996 Feb;132(4):following 752]
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Lefebvre,O., Wolf,C., Limacher,J.M., Hutin,P., Wendling,C.,
            LeMeur,M., Basset,P. and Rio,M.C.
  TITLE     The breast cancer-associated stromelysin-3 gene is expressed during
            mouse mammary gland apoptosis
  JOURNAL   J Cell Biol 119 (4), 997-1002 (1992)
   PUBMED   1429845
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY100700.1, AK142169.1 and
            CD742452.1.
            
            On Apr 19, 2015 this sequence version replaced NM_008606.2.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of endopeptidases that are involved in remodeling
            extracellular matrix during, for example, embryonic development and
            tumor progression. The encoded protein undergoes post-translational
            proteolytic processing by furin endopeptidase to form an active
            enzyme. Subcutaneous introduction of cells expressing the encoded
            protein into nude mice results in increased tumor incidence. Mice
            lacking the encoded protein exhibit a decreased incidence of
            chemically-induced tumors. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052854.1, AK142169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY100700.1         2-28
            28-2286             AK142169.1         1-2259
            2287-2304           CD742452.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.62 cM"
     gene            1..2304
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /note="matrix metallopeptidase 11"
                     /db_xref="GeneID:17385"
                     /db_xref="MGI:MGI:97008"
     exon            1..169
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1528
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /note="matrix metalloproteinase 11; stromelysin 3"
                     /codon_start=1
                     /product="stromelysin-3 preproprotein"
                     /protein_id="NP_032632.1"
                     /db_xref="CCDS:CCDS23937.1"
                     /db_xref="GeneID:17385"
                     /db_xref="MGI:MGI:97008"
                     /translation="MARAACLLRAISRVLLLPLPLLLLLLLLLPSPLMARARPPESHR
                     HHPVKKGPRLLHAALPNTLTSVPASHWVPSPAGSSRPLRCGVPDLPDVLNARNRQKRF
                     VLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIM
                     IDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAA
                     HEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQMAPTSPAPTLS
                     SQAGTDTNEIALLEPETPPDVCETSFDAVSTIRGELFFFKAGFVWRLRSGRLQPGYPA
                     LASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVH
                     AALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRSTDWRGVPSEIDAAFQDAEGY
                     AYFLRGHLYWKFDPVKVKVLEGFPRPVGPDFFDCAEPANTFR"
     exon            170..399
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..543
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /inference="alignment:Splign:2.1.0"
     exon            544..677
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..919
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1136
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1394
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..2288
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /note="hexamer: ATTAAA"
     polyA_site      2288
                     /gene="Mmp11"
                     /gene_synonym="MMP-11; SL-3; ST3; Stmy3"
                     /note="major polyA site"
ORIGIN      
        1 aggggcggcg gcccggcctg gcccagcagg cccagcagcc ccggggcgga tggcacgggc
       61 cgcctgtctc ctccgcgcga tttcgcgcgt cctcctgctc ccgctgcctc tgctgctcct
      121 gttgctgctg ctcctgccgt cgccgctgat ggcccgggcc aggccaccgg agagtcaccg
      181 tcatcaccct gtgaagaaag ggcctcggct cctgcatgca gctctgccta ataccttgac
      241 atctgtcccc gcgtctcatt gggtccctag tcctgccggt agctccaggc ctctacgatg
      301 tggtgtgccc gacctgcctg atgtactgaa tgcccggaac cgacagaagc gcttcgtcct
      361 gtcaggagga cgctgggaga agacagacct cacctatagg atcctccggt tcccatggca
      421 gcttgtaagg gagcaagtcc ggcagacagt ggcagaggcc ctccaggtat ggagtgaagt
      481 gaccccactc actttcactg aggtgcacga gggacgcgct gacatcatga tcgacttcgc
      541 caggtactgg catggtgaca acttgccgtt tgacgggcct gggggcatcc tggcccatgc
      601 cttcttccct aagacccacc gagaagggga tgtccacttt gactatgatg aaacttggac
      661 tattggggac aaccagggaa ctgacctgct gcaagtggcg gctcatgaat ttggccatgt
      721 tctggggcta caacacacca cagcagctaa ggccctcatg tcccctttct acaccttccg
      781 ctaccctctg agccttagcc cagatgaccg aaggggcatc cagcacctct atgggcggcc
      841 ccagatggcc cccacctccc ccgccccaac tttgagctcc caggctggga cagataccaa
      901 tgagattgca ctgctggagc cggaaacccc gccagatgtc tgtgagactt ccttcgacgc
      961 ggtttccacc atccgaggag agctcttctt cttcaaggca ggctttgtgt ggaggctgcg
     1021 cagtgggcga ctgcagcccg ggtatcctgc tttggcctct cggcactggc aaggactgcc
     1081 cagccctgtg gatgcagctt ttgaggatgc ccagggccag atttggttct tccaaggtgc
     1141 tcagtactgg gtatatgatg gtgagaagcc agtcctaggc cctgcaccac tctccaagct
     1201 gggcctgcaa gggtccccag ttcatgccgc cttggtctgg ggtcctgaga agaacaagat
     1261 ctacttcttc cgaggtggag actattggcg tttccacccc agaacccagc gagtggacaa
     1321 tcccgtgccc cggcgctcca ctgactggcg aggggtacct tctgagattg atgctgcctt
     1381 ccaggatgct gagggctatg cctacttcct tcgtggccat ctctactgga agtttgatcc
     1441 cgtgaaggtg aaggtcctag aaggctttcc tcgccccgta ggtcctgact tctttgactg
     1501 tgctgagcct gccaatactt tccgctgaca acactttgga tgcattcagg ggtactgact
     1561 cctgccaggg cacttagatc atgtaagaga cccacagcca tatctgtggc tctgggcttc
     1621 aggcatggga cagacagggc ctatgtctcc tcaggggagt gggttggggt gcagccactg
     1681 tttgtaggaa cgaccatgct ggtcatggtc acctgccaac aattgtctca gactaggcaa
     1741 aggctttggt gttacttaaa aataagggag gttttgggct ggcaatattt cagctaccaa
     1801 taatccacag tcagcctggt tgcccaaggt ctccatctct gtccctcaaa gtagaacccc
     1861 cacacaaact caggaatcac ctgcaatgag gttcctgttg ggagtggtgt tggtaatgag
     1921 atgcccaggg taccatgctg cccctgctaa gcaactggac cagtatcttt cctggtaagt
     1981 cagctctgga gagatagtga actgatcata ttctggcagg tgattcagac aagtgcttcc
     2041 tggaactcag gccaaaaggt acacagccag ccaaggaggc agctgcttcc tcccagagac
     2101 acggaacctc aaaggcccca catacctcac agccttgccc caggccattt ctttctgggg
     2161 ccctcttcct agcacaggta ccctctaagc catgtacatg tgtatacagt gtataaagac
     2221 ttttttaaaa aaacaaaaaa caaaacccaa aaaagccaag actgtcatta aacatgagtg
     2281 ttttctaaaa aaaaaaaaaa aaaa
//
