LOCUS       NM_019471               1734 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus matrix metallopeptidase 10 (Mmp10), mRNA.
ACCESSION   NM_019471
VERSION     NM_019471.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Chang,L., Gao,J., Yu,Y., Liao,B., Zhou,Y., Zhang,J., Ma,X., Hou,W.,
            Zhou,T. and Xu,Q.
  TITLE     MMP10 alleviates non-alcoholic steatohepatitis by regulating
            macrophage M2 polarization
  JOURNAL   Int Immunopharmacol 124 (Pt B), 111045 (2023)
   PUBMED   37844469
  REMARK    GeneRIF: MMP10 alleviates non-alcoholic steatohepatitis by
            regulating macrophage M2 polarization.
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Ishimura,T., Ishii,A., Yamada,H., Osaki,K., Toda,N., Mori,K.P.,
            Ohno,S., Kato,Y., Handa,T., Sugioka,S., Ikushima,A., Nishio,H.,
            Yanagita,M. and Yokoi,H.
  TITLE     Matrix metalloproteinase-10 deficiency has protective effects
            against peritoneal inflammation and fibrosis via transcription
            factor NFkappaBeta pathway inhibition
  JOURNAL   Kidney Int 104 (5), 929-942 (2023)
   PUBMED   37652204
  REMARK    GeneRIF: Matrix metalloproteinase-10 deficiency has protective
            effects against peritoneal inflammation and fibrosis via
            transcription factor NFkappaBeta pathway inhibition.
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Varadinkova,S., Oralova,V., Clarke,M., Frampton,J., Knopfova,L.,
            Lesot,H., Bartos,P. and Matalova,E.
  TITLE     Expression dynamics of metalloproteinases during mandibular bone
            formation: association with Myb transcription factor
  JOURNAL   Front Cell Dev Biol 11, 1168866 (2023)
   PUBMED   37701782
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1734)
  AUTHORS   Bobadilla Munoz,M., Orbe,J., Abizanda,G., Machado,F.J.D., Vilas,A.,
            Ullate-Agote,A., Extramiana,L., Baraibar Churio,A., Aranguren,X.L.,
            Cantero,G., Sainz Amillo,N., Rodriguez,J.A., Ramos Garcia,L.,
            Romero Riojas,J.P., Vallejo-Illarramendi,A., Paradas,C., Lopez de
            Munain,A., Paramo,J.A., Prosper,F. and Perez-Ruiz,A.
  TITLE     Loss of the matrix metalloproteinase-10 causes premature features
            of aging in satellite cells
  JOURNAL   Front Cell Dev Biol 11, 1128534 (2023)
   PUBMED   37228645
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1734)
  AUTHORS   Dharavath,B., Butle,A., Pal,A., Desai,S., Upadhyay,P., Rane,A.,
            Khandelwal,R., Manavalan,S., Thorat,R., Sonawane,K., Vaish,R.,
            Gera,P., Bal,M., D'Cruz,A.K., Nair,S. and Dutt,A.
  TITLE     Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue
            cancer
  JOURNAL   Commun Biol 6 (1), 57 (2023)
   PUBMED   36650344
  REMARK    GeneRIF: Role of miR-944/MMP10/AXL- axis in lymph node metastasis
            in tongue cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1734)
  AUTHORS   Madlener,M. and Werner,S.
  TITLE     cDNA cloning and expression of the gene encoding murine
            stromelysin-2 (MMP-10)
  JOURNAL   Gene 202 (1-2), 75-81 (1997)
   PUBMED   9427548
REFERENCE   7  (bases 1 to 1734)
  AUTHORS   Sanz,L., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Molecular characterization of a novel transcription factor that
            controls stromelysin expression
  JOURNAL   Mol Cell Biol 15 (6), 3164-3170 (1995)
   PUBMED   7760812
REFERENCE   8  (bases 1 to 1734)
  AUTHORS   Gack,S., Vallon,R., Schmidt,J., Grigoriadis,A., Tuckermann,J.,
            Schenkel,J., Weiher,H., Wagner,E.F. and Angel,P.
  TITLE     Expression of interstitial collagenase during skeletal development
            of the mouse is restricted to osteoblast-like cells and
            hypertrophic chondrocytes
  JOURNAL   Cell Growth Differ 6 (6), 759-767 (1995)
   PUBMED   7669731
REFERENCE   9  (bases 1 to 1734)
  AUTHORS   Sympson,C.J., Talhouk,R.S., Alexander,C.M., Chin,J.R., Clift,S.M.,
            Bissell,M.J. and Werb,Z.
  TITLE     Targeted expression of stromelysin-1 in mammary gland provides
            evidence for a role of proteinases in branching morphogenesis and
            the requirement for an intact basement membrane for tissue-specific
            gene expression
  JOURNAL   J Cell Biol 125 (3), 681-693 (1994)
   PUBMED   8175886
  REMARK    Erratum:[J Cell Biol 1996 Feb;132(4):following 752]
REFERENCE   10 (bases 1 to 1734)
  AUTHORS   Gack,S., Vallon,R., Schaper,J., Ruther,U. and Angel,P.
  TITLE     Phenotypic alterations in fos-transgenic mice correlate with
            changes in Fos/Jun-dependent collagenase type I expression.
            Regulation of mouse metalloproteinases by carcinogens, tumor
            promoters, cAMP, and Fos oncoprotein
  JOURNAL   J Biol Chem 269 (14), 10363-10369 (1994)
   PUBMED   8144618
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK020292.1.
            
            On Dec 18, 2013 this sequence version replaced NM_019471.2.
            
            Summary: This gene encodes a member of the matrix metalloproteinase
            family of extracellular matrix-degrading enzymes that are involved
            in tissue remodeling, wound repair, progression of atherosclerosis
            and tumor invasion. The encoded preproprotein undergoes proteolytic
            processing to generate a mature, zinc-dependent endopeptidase
            enzyme. The lack of encoded protein in mice promotes experimental
            lung cancer formation, exacerbates experimental colitis and
            promotes development of inflammation-associated colonic dysplasia.
            This gene is located in a cluster of other matrix metalloproteinase
            genes on chromosome 9. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020292.1, Y13185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1734              AK020292.1         2-1735
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..1734
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /note="matrix metallopeptidase 10"
                     /db_xref="GeneID:17384"
                     /db_xref="MGI:MGI:97007"
     exon            1..157
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1483
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /EC_number="3.4.24.22"
                     /note="stromelysin-2; transin-2; matrix metalloproteinase
                     10"
                     /codon_start=1
                     /product="stromelysin-2 preproprotein"
                     /protein_id="NP_062344.1"
                     /db_xref="CCDS:CCDS22807.1"
                     /db_xref="GeneID:17384"
                     /db_xref="MGI:MGI:97007"
                     /translation="MEPLAILALLSLPICSAYPLHGAVTQGHPSMDLAQQYLEKYYNF
                     KKNEKQIFKRKDSSPVVKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGVPDVGGFST
                     FPGSPKWRKSHITYRIVNYTPDLPRQSVDSAIEKALKVWEEVTPLTFSRISEGEADIM
                     ISFAVGEHGDFYPFDGPGQSLAHAYPPGPGFYGDVHFDDDEKWTLAPSGTNLFLVAAH
                     ELGHSLGLFHSDKKESLMYPVYRFSTSPANFHLSQDDIEGIQSLYGAGPSSDATVVPV
                     LSVSPRPETPDKCDPALSFDSVSTLRGEVLFFKDRYFWRRSHWNPEPEFHLISAFWPT
                     LPSDLDAAYEAHNTDSVLIFKGSQFWAVRGNEVQAGYPKGIHTLGFPPTVKKIDAAVF
                     EKEKKKTYFFVGDKYWRFDETRHVMDKGFPRQITDDFPGIEPQVDAVLHEFGFFYFFR
                     GSSQFEFDPNARTVTHILKSNSWLLC"
     exon            158..402
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..551
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..677
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..842
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..984
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1118
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1278
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1382
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1734
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /note="putative"
     polyA_site      1734
                     /gene="Mmp10"
                     /gene_synonym="MMP-10; SL-2"
                     /note="putative"
ORIGIN      
        1 atggaaacca ggtgctagag aaggatcggt ttttaaagta aagactgtct gtatggagcc
       61 actagccatc ctggcactgc tgagcctacc aatctgctca gcgtatcctc tgcatggggc
      121 agtgacacaa ggccacccaa gcatggatct tgctcagcaa tacctagaaa aatactacaa
      181 ctttaaaaaa aatgagaaac aaattttcaa aagaaaggac agtagtcctg ttgtcaaaaa
      241 aattcaagaa atgcagaagt tcctcgggtt ggagatgaca gggaagctgg actccaacac
      301 tatggagctg atgcacaagc ccaggtgtgg tgttcctgat gttggtggct tcagtacctt
      361 cccaggttcg ccaaaatgga ggaaatccca catcacctac aggattgtga attatacacc
      421 agatttgcca agacagagtg tggattctgc cattgagaaa gctttgaagg tctgggagga
      481 ggtgacccca ctcactttct ccaggatctc tgaaggagag gctgacataa tgatctcctt
      541 tgcagttgga gaacacggag acttttaccc ttttgatggg ccaggacaga gtctggctca
      601 tgcctaccca cctggccctg gattttatgg agatgttcac ttcgatgatg atgagaaatg
      661 gacacttgca ccctcaggga ccaacttatt cctggttgca gcccatgaac ttggccactc
      721 cctgggtctc tttcattccg acaagaaaga atctctgatg tacccagtct acaggttctc
      781 cacaagccca gctaacttcc acctttctca agatgatata gagggcattc aatccctgta
      841 tggagccggt ccctcctccg atgccacagt ggttcctgtg ttgtctgtct ctccaagacc
      901 tgagacccca gacaaatgtg atcctgcttt gtcctttgat tcagtcagca cgctgagagg
      961 ggaagtccta ttctttaaag acaggtactt ctggcgcaga tcccattgga atcccgagcc
     1021 tgaatttcat ttgatatcag cattttggcc cactcttcct tcagacttag atgctgccta
     1081 tgaggctcac aacacggaca gtgttctgat ttttaaagga agtcagttct gggcagtccg
     1141 aggaaatgaa gtccaagcag gctacccaaa ggggatccac actctcggtt ttcctcccac
     1201 cgtgaagaag attgatgcag ctgtttttga aaaggagaag aagaaaacgt acttctttgt
     1261 aggggacaaa tactggagat ttgatgagac aagacatgtt atggataaag gcttcccaag
     1321 acagataaca gatgattttc caggaattga gccacaagtt gatgctgtgt tacacgaatt
     1381 tgggtttttt tatttcttcc gaggatcatc acagttcgag tttgacccca atgccaggac
     1441 ggtgacacac atactgaaga gcaacagctg gctgctgtgc tgatcatcat gacaagacat
     1501 atacaaccct gtaaaatgag tctcatgact tcccacctac tttattatgt gtcagaatga
     1561 ttagttgctc ctgcatgttc tgtggctccg gatgagcgca gcagatgtct ttcataatga
     1621 gtcacaaagc atcacctgag cacagaagtg aaattttctc actgcagtag gtgagaggat
     1681 gcatccatcc ccatgggtat tttattattt aataaagagc tttatttttg aacc
//
