LOCUS       NM_146234               4109 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus membrane magnesium transporter 1 (Mmgt1), mRNA.
ACCESSION   NM_146234
VERSION     NM_146234.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4109)
  AUTHORS   Guna,A., Volkmar,N., Christianson,J.C. and Hegde,R.S.
  TITLE     The ER membrane protein complex is a transmembrane domain insertase
  JOURNAL   Science 359 (6374), 470-473 (2018)
   PUBMED   29242231
REFERENCE   2  (bases 1 to 4109)
  AUTHORS   Spierings,D.C., McGoldrick,D., Hamilton-Easton,A.M., Neale,G.,
            Murchison,E.P., Hannon,G.J., Green,D.R. and Withoff,S.
  TITLE     Ordered progression of stage-specific miRNA profiles in the mouse
            B2 B-cell lineage
  JOURNAL   Blood 117 (20), 5340-5349 (2011)
   PUBMED   21403133
REFERENCE   3  (bases 1 to 4109)
  AUTHORS   Kozomara,A. and Griffiths-Jones,S.
  TITLE     miRBase: integrating microRNA annotation and deep-sequencing data
  JOURNAL   Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
   PUBMED   21037258
REFERENCE   4  (bases 1 to 4109)
  AUTHORS   Goytain,A. and Quamme,G.A.
  TITLE     Identification and characterization of a novel family of membrane
            magnesium transporters, MMgT1 and MMgT2
  JOURNAL   Am J Physiol Cell Physiol 294 (2), C495-C502 (2008)
   PUBMED   18057121
  REMARK    GeneRIF: These experiments suggest that MMgT proteins may provide
            regulated pathways for Mg(2+) transport in the Golgi and post-Golgi
            organelles of epithelium-derived cells.(MMgT1 PROTEIN, MOUSE)
REFERENCE   5  (bases 1 to 4109)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   6  (bases 1 to 4109)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 4109)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC048362.14.
            
            On Jan 25, 2019 this sequence version replaced NM_146234.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036253.1, AK049689.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC048362.14        151665-151824       c
            161-213             AC048362.14        149270-149322       c
            214-317             AC048362.14        144958-145061       c
            318-4109            AC048362.14        139392-143183       c
FEATURES             Location/Qualifiers
     source          1..4109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 30.06 cM"
     gene            1..4109
                     /gene="Mmgt1"
                     /gene_synonym="9630048L06Rik; Emc5; mir-5116; Mir5116;
                     Tmem32"
                     /note="membrane magnesium transporter 1"
                     /db_xref="GeneID:236792"
                     /db_xref="MGI:MGI:2384305"
     exon            1..160
                     /gene="Mmgt1"
                     /gene_synonym="9630048L06Rik; Emc5; mir-5116; Mir5116;
                     Tmem32"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..477
                     /gene="Mmgt1"
                     /gene_synonym="9630048L06Rik; Emc5; mir-5116; Mir5116;
                     Tmem32"
                     /note="transmembrane protein 32"
                     /codon_start=1
                     /product="ER membrane protein complex subunit 5"
                     /protein_id="NP_666346.1"
                     /db_xref="CCDS:CCDS30147.1"
                     /db_xref="GeneID:236792"
                     /db_xref="MGI:MGI:2384305"
                     /translation="MAPSLWKGLVGVGLFALAHAAFSAAQHRSYMRLTEKEDESLPID
                     IVLQTLLAFAVTCYGIVHIAGEFKDMDATSELKNKTFDTLRNHPSFYVFNHRGRVLFR
                     PSDATNSSNLDALSSNTSLKLRKFDSLRR"
     exon            161..213
                     /gene="Mmgt1"
                     /gene_synonym="9630048L06Rik; Emc5; mir-5116; Mir5116;
                     Tmem32"
                     /inference="alignment:Splign:2.1.0"
     exon            214..317
                     /gene="Mmgt1"
                     /gene_synonym="9630048L06Rik; Emc5; mir-5116; Mir5116;
                     Tmem32"
                     /inference="alignment:Splign:2.1.0"
     exon            318..4109
                     /gene="Mmgt1"
                     /gene_synonym="9630048L06Rik; Emc5; mir-5116; Mir5116;
                     Tmem32"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtggacgc ccgccggtga aaggaggagt acctctgccg cccttcgtct ccttttgttg
       61 ggctgccgct ccttctgaat catggcgccg tcgctgtgga aggggcttgt aggtgtcggg
      121 ctttttgccc tagcccacgc tgccttttca gctgcgcagc atcgttctta tatgcgacta
      181 acagaaaagg aagatgaatc attaccaata gatatagttc ttcagacact tctggccttt
      241 gcagttacct gttatggcat agttcatatc gcaggggagt tcaaagacat ggatgccact
      301 tcagaattaa agaataagac atttgatacc ttaaggaatc acccatcttt ttatgtgttt
      361 aaccatcgtg gtcgagtgct gttccggcct tcagatgcaa caaattcttc aaacctagat
      421 gcattgtcct ctaatacatc gttgaagtta cgaaagtttg actcactgcg ccgttaagct
      481 ttttacaaat taaataacag gacagacaca gaattgagta ttggagtttg gggtgtaaaa
      541 cactcccccc aagatcagta tttatattgc tatttcagag ctagttaaac taatctatgg
      601 gcccttgttt atatattatc gatccgatca aatggagtat gaattatctg tgaaatgagt
      661 ctttgaactt tcgtatagag ttcttttgtt gatttgaaac aattcccatg ttttgtaaaa
      721 gtcactgttt caaacataat tccctgaaaa aatgttcgga tttttgtgat tatttatttt
      781 catagatttc ttttcttttg cactacagtt tttaggaatc ctggaaatac catataccat
      841 ctgtgttttg cagcacaaga atcaaatggt cttcagttct tatcagacca acttctttaa
      901 gaagaccaaa atggtgactt tacagttttt ctttggtccc ctaaaaagtg actctacttt
      961 tacagatact tgccaatttt tactttatta atggtttctc tccggactcc actccctgat
     1021 actgtctaac ataagctgtc ttgtttcatc atttctagga ttctgtgtgc agtgagcaat
     1081 ttttgtgtca gaaattctat cataacatat atatttaaca agctcatctt gctgtaaaac
     1141 tactcatgtt cttttgttgt aaaattttca ctgattgtat aatgtaagac tagttgaaag
     1201 tagaccaaaa agacaacttg tgacttcatt atcttgcctg agtagaatag tattgattga
     1261 ggaaaactga tcgtcattag ccagtctcac tcattataag tctgttggtt tatgttgtac
     1321 taaactagtg aattagtgaa agtaaaggaa atggctcatt ttatctaaag gcacatgtgc
     1381 aaagaaactg ggccaaatat gttctaaata tttggagttc atctatttga attctcttag
     1441 aaaattcagg tcatttagga agttggttct cagcttctga ctgagagctg gcctggagct
     1501 tcccatcttc actctgcggt gctgaggggg aggatgacat gccattggat gcttttcaga
     1561 aacagtagtt tactctgaca acattggagt agctttttca gctagaaagc taagaagctc
     1621 aacattactg tagagattat tgcttcccac gagcatgaac acattacttg tgttaaactc
     1681 tataggtgta aagggaatca ctgcggattt tgataggaac cccgcctgat gctttttggt
     1741 ttgtttcagg cagggtcttc atatcgagaa gctcttttac ttggtagcat tttttgatta
     1801 ggaatgaacc tcagcctttc tgcccagtca tacagagcct caaaggccaa ggttattttg
     1861 tcatttcttt gttggttttg gtttttgttt gtaaacagga ttccgtataa cctgagctag
     1921 cctcaaatgt actatgtagc cgaggatgat cctcatgcct ccaccgtgtc agtgctaaga
     1981 ttataggtgc tgtcactaca cctggttttt tgagatcctg ggcactgaac ccagggcctc
     2041 atgcatgcta ggcaagcact ataccagctg aactacatcc caggcccttg acattgaatt
     2101 atgattcttg agctctgttt tgctaactaa gtctatggag cattgactgt tctctaatga
     2161 gaacaaactt ggaaatctgc tgattaccta caataattta gacataggct aaaagtgtga
     2221 agtcaagcca ggtgtggtgg catgtgcttg taatcctagc acttacaagg ctgaaacagg
     2281 atcacaagtt tagggcagaa ctgggctatc ttaatgaacc cctgtcttaa ccccaacccc
     2341 caaaaagcga acccaaggac taatgcgata gctaaatcaa aatggcgtgc aggacgcatg
     2401 ctgtacatca ggcttttctg ccatactcct cgactattac ttgactgaag agcctcttgt
     2461 tttcttctcc ttggagactg ttttcccttc ttaatgtgtt ttcataacaa tgttactgag
     2521 aatctgcgtg ttttgtactt ccattcttta aaggatgtat aattgccaga tgtggctcat
     2581 gcctataata ctaacactca ggaggctaag gcaggaaagt tttcacacag gttcaagacc
     2641 agaattagat acacagtgag accttatctt taaagaagtt atacaaattt taaagggtac
     2701 aattaagtaa ctttaaatat actcacaaaa ttatgcaacc acttgataaa tctaggccat
     2761 ttcactcctc tccaagaagc cctgtattct ttagtagtca cctctgattt cctcccagtt
     2821 tgtcccacgt aggtcctagg aaaccaatag tttattatat gcataatctg atcatttact
     2881 ataaatgagt taatgcaata tttagtcact tagtttcata aatatggttt cctacgtggg
     2941 ataaatgctc attctgagaa ctcagaaccc agtacagtga cagaaagtgt ctgggtttgt
     3001 aaatctggta ggaagcttgc ctagcacgtg cgagacccta ggctcactca cagtatccca
     3061 ggaaaaaaaa aagctagttg ataaatcaat ggatttaaag agggaaagcc agatacctgg
     3121 cagactctag agttaatctt attaaataga gtacttttcc tcctagccaa acattcattc
     3181 tatactactg cttctaactt acattctagt tcctcccagc tctgctttgg ttttgccaag
     3241 acagggtttc tctgtgtagc cctggctatt ctggaactca ctttgtagac caggctagac
     3301 tccaactcac agagatccac ctgcctctgc cttccaagtg ttgggattaa aggcgtgcac
     3361 catcagtgcc cagcccattc tcgtttctac aatggatatt aaaatgtctt cttgtcttct
     3421 cagccaagaa aatcctgctt aaaaaaatgc taaaacattt ggccgataac tgacatggta
     3481 aatttattta gacgtgtcca cctttggaca gcttgcatac ctcagaccag gtaaatagcc
     3541 ccaggttttt aaatcgactt cattgaattt ctgctatctt cttgaaatat ggtactatac
     3601 gactaagtca gatttgggtg tgttgtaaca gtgctaagtg tgctcagtag aattttattt
     3661 acagtactgt gtgatagtcc attactgcct agggtagttg aaaaccagtg atctgagcta
     3721 gtgctaggta aacctatagc tgacatgatt tcagtcacac tcaaaaatag gagacatgta
     3781 cccagcaaag ttctccagaa tgcaggaaca cacttcataa ccagggaact agccaaatcc
     3841 tatgggctaa tagctcagct gcagggaata aagattgtga attggtggca agtatgcaca
     3901 ataactccct aataattgct tcctaagcac ttgtggcata cttttgagtg acataacagc
     3961 attttcttgg ctgtacatga ccggtttcca tgatgtattg aatactgttg tttgtgagcc
     4021 ttgatgcctg taacaccaat aaacccattg ttgaatatat tttctctctt taaatgacct
     4081 tgccttgtcc aataaataag cgattgtct
//
