LOCUS       NP_001344264             750 aa            linear   ROD 04-OCT-2024
DEFINITION  neprilysin [Mus musculus].
ACCESSION   NP_001344264 XP_006501158
VERSION     NP_001344264.1
DBSOURCE    REFSEQ: accession NM_001357335.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 750)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 750)
  AUTHORS   Erin,N. and Akdeniz,O.
  TITLE     ADAM10 and Neprilysin level decreases in immune cells of mice
            bearing metastatic breast carcinoma: Possible role in cancer
            inflammatory response
  JOURNAL   Int Immunopharmacol 127, 111384 (2024)
   PUBMED   38141405
  REMARK    GeneRIF: ADAM10 and Neprilysin level decreases in immune cells of
            mice bearing metastatic breast carcinoma: Possible role in cancer
            inflammatory response.
REFERENCE   3  (residues 1 to 750)
  AUTHORS   Esser,N., Mongovin,S.M., Mundinger,T.O., Barrow,B.M. and Zraika,S.
  TITLE     Neprilysin deficiency reduces hepatic gluconeogenesis in high
            fat-fed mice
  JOURNAL   Peptides 168, 171076 (2023)
   PUBMED   37572792
  REMARK    GeneRIF: Neprilysin deficiency reduces hepatic gluconeogenesis in
            high fat-fed mice.
REFERENCE   4  (residues 1 to 750)
  AUTHORS   Chen,Y. and Burnett,J.C. Jr.
  TITLE     Biochemistry, Therapeutics, and Biomarker Implications of
            Neprilysin in Cardiorenal Disease
  JOURNAL   Clin Chem 63 (1), 108-115 (2017)
   PUBMED   28062615
  REMARK    Review article
REFERENCE   5  (residues 1 to 750)
  AUTHORS   Bayes-Genis,A., Barallat,J. and Richards,A.M.
  TITLE     A Test in Context: Neprilysin: Function, Inhibition, and Biomarker
  JOURNAL   J Am Coll Cardiol 68 (6), 639-653 (2016)
   PUBMED   27491909
  REMARK    Review article
REFERENCE   6  (residues 1 to 750)
  AUTHORS   Turner,A.J. and Nalivaeva,N.N.
  TITLE     Proteinase dysbalance in pathology: the neprilysin (NEP) and
            angiotensin-converting enzyme (ACE) families
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 52 (4), 40-48 (2006)
   PUBMED   17543197
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 750)
  AUTHORS   Weil,M., Itin,A. and Keshet,E.
  TITLE     A role for mesenchyme-derived tachykinins in tooth and mammary
            gland morphogenesis
  JOURNAL   Development 121 (8), 2419-2428 (1995)
   PUBMED   7545574
REFERENCE   8  (residues 1 to 750)
  AUTHORS   Kalled,S.L., Siva,N., Stein,H. and Reinherz,E.L.
  TITLE     The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is
            similar in non-lymphoid organs but differs within the hematopoietic
            system: absence on murine T and B lymphoid progenitors
  JOURNAL   Eur J Immunol 25 (3), 677-687 (1995)
   PUBMED   7705396
REFERENCE   9  (residues 1 to 750)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   10 (residues 1 to 750)
  AUTHORS   Chen,C.Y., Salles,G., Seldin,M.F., Kister,A.E., Reinherz,E.L. and
            Shipp,M.A.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121993.2 and AC121840.3.
            
            On Oct 26, 2017 this sequence version replaced XP_006501158.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.3847.1,
                                           SRR10223969.3733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.97 cM"
     Protein         1..750
                     /product="neprilysin"
                     /EC_number="3.4.24.11"
                     /note="common acute lymphoblastic leukemia antigen;
                     enkephalinase; atriopeptidase; neutral endopeptidase
                     24.11; skin fibroblast elastase"
                     /calculated_mol_wt=85571
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Region          16..23
                     /region_name="Stop-transfer sequence.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Site            29..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Region          77..748
                     /region_name="M13"
                     /note="Peptidase family M13 includes neprilysin and
                     endothelin-converting enzyme I; cd08662"
                     /db_xref="CDD:341056"
     Site            order(107,537,542..545,564,580..581,584..585,588,647,690,
                     693..694,711..712,718)
                     /site_type="active"
                     /db_xref="CDD:341056"
     Site            145
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            211
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            285
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            325
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            628
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     CDS             1..750
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /coded_by="NM_001357335.1:416..2668"
                     /db_xref="CCDS:CCDS17381.1"
                     /db_xref="GeneID:17380"
                     /db_xref="MGI:MGI:97004"
ORIGIN      
        1 mgrsesqmdi tdinapkpkk kqrwtpleis lsvlvlllti iavtmialya tyddgickss
       61 dciksaarli qnmdasvepc tdffkyacgg wlkrnvipet ssrysnfdil rdelevilkd
      121 vlqepktedi vavqkaktly rscinesaid srggqpllkl lpdiygwpva sdnwdqtygt
      181 swtaeksiaq lnskygkkvl inffvgtddk nstqhiihfd qprlglpsrd yyectgiyke
      241 actayvdfmi svarlirqeq slpidenqls lemnkvmele keianattkp edrndpmlly
      301 nkmtlaklqn nfslevngks fswsnftnei mstvniniqn eeevvvyape yltklkpilt
      361 kysprdlqnl mswrfimdlv sslsrnykes rnafrkalyg ttsetatwrr canyvngnme
      421 navgrlyvea afageskhvv edliaqirev fiqtlddltw mdaetkkkae ekalaikeri
      481 gypddiisne nklnneylel nyredeyfen iiqnlkfsqs kqlkklrekv dkdewisgaa
      541 vvnafyssgr nqivfpagil qppffsaqqs nslnyggigm vigheithgf ddngrnfnkd
      601 gdlvdwwtqq sannfkdqsq cmvyqygnfs wdlaggqhln gintlgenia dnggigqayr
      661 ayqnyvkkng eekllpgldl nhkqlfflnf aqvwcgtyrp eyavnsiktd vhspgnfrii
      721 gtlqnsaefa dafhcrknsy mnperkcrvw
//
