LOCUS       NM_001289463            5872 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus membrane metallo endopeptidase (Mme), transcript
            variant 3, mRNA.
ACCESSION   NM_001289463 XM_006501096
VERSION     NM_001289463.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5872)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5872)
  AUTHORS   Erin,N. and Akdeniz,O.
  TITLE     ADAM10 and Neprilysin level decreases in immune cells of mice
            bearing metastatic breast carcinoma: Possible role in cancer
            inflammatory response
  JOURNAL   Int Immunopharmacol 127, 111384 (2024)
   PUBMED   38141405
  REMARK    GeneRIF: ADAM10 and Neprilysin level decreases in immune cells of
            mice bearing metastatic breast carcinoma: Possible role in cancer
            inflammatory response.
REFERENCE   3  (bases 1 to 5872)
  AUTHORS   Esser,N., Mongovin,S.M., Mundinger,T.O., Barrow,B.M. and Zraika,S.
  TITLE     Neprilysin deficiency reduces hepatic gluconeogenesis in high
            fat-fed mice
  JOURNAL   Peptides 168, 171076 (2023)
   PUBMED   37572792
  REMARK    GeneRIF: Neprilysin deficiency reduces hepatic gluconeogenesis in
            high fat-fed mice.
REFERENCE   4  (bases 1 to 5872)
  AUTHORS   Chen,Y. and Burnett,J.C. Jr.
  TITLE     Biochemistry, Therapeutics, and Biomarker Implications of
            Neprilysin in Cardiorenal Disease
  JOURNAL   Clin Chem 63 (1), 108-115 (2017)
   PUBMED   28062615
  REMARK    Review article
REFERENCE   5  (bases 1 to 5872)
  AUTHORS   Bayes-Genis,A., Barallat,J. and Richards,A.M.
  TITLE     A Test in Context: Neprilysin: Function, Inhibition, and Biomarker
  JOURNAL   J Am Coll Cardiol 68 (6), 639-653 (2016)
   PUBMED   27491909
  REMARK    Review article
REFERENCE   6  (bases 1 to 5872)
  AUTHORS   Turner,A.J. and Nalivaeva,N.N.
  TITLE     Proteinase dysbalance in pathology: the neprilysin (NEP) and
            angiotensin-converting enzyme (ACE) families
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 52 (4), 40-48 (2006)
   PUBMED   17543197
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5872)
  AUTHORS   Weil,M., Itin,A. and Keshet,E.
  TITLE     A role for mesenchyme-derived tachykinins in tooth and mammary
            gland morphogenesis
  JOURNAL   Development 121 (8), 2419-2428 (1995)
   PUBMED   7545574
REFERENCE   8  (bases 1 to 5872)
  AUTHORS   Kalled,S.L., Siva,N., Stein,H. and Reinherz,E.L.
  TITLE     The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is
            similar in non-lymphoid organs but differs within the hematopoietic
            system: absence on murine T and B lymphoid progenitors
  JOURNAL   Eur J Immunol 25 (3), 677-687 (1995)
   PUBMED   7705396
REFERENCE   9  (bases 1 to 5872)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   10 (bases 1 to 5872)
  AUTHORS   Chen,C.Y., Salles,G., Seldin,M.F., Kister,A.E., Reinherz,E.L. and
            Shipp,M.A.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121993.2, AK033824.1, AK031446.1 and AC121840.3.
            
            On Jan 22, 2014 this sequence version replaced XM_006501096.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033824.1, BC034092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC121993.2         36115-36205         c
            92-3782             AK033824.1         3-3693
            3783-4390           AK031446.1         3634-4241
            4391-5872           AC121840.3         121375-122856       c
FEATURES             Location/Qualifiers
     source          1..5872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.97 cM"
     gene            1..5872
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /note="membrane metallo endopeptidase"
                     /db_xref="GeneID:17380"
                     /db_xref="MGI:MGI:97004"
     exon            1..228
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            229..398
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..2491
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /EC_number="3.4.24.11"
                     /note="common acute lymphoblastic leukemia antigen;
                     enkephalinase; atriopeptidase; neutral endopeptidase
                     24.11; skin fibroblast elastase"
                     /codon_start=1
                     /product="neprilysin"
                     /protein_id="NP_001276392.1"
                     /db_xref="CCDS:CCDS17381.1"
                     /db_xref="GeneID:17380"
                     /db_xref="MGI:MGI:97004"
                     /translation="MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVT
                     MIALYATYDDGICKSSDCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSS
                     RYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLKL
                     LPDIYGWPVASDNWDQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIH
                     FDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKV
                     MELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFTNEIMSTV
                     NINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRN
                     AFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREV
                     FIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYREDEYF
                     ENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFS
                     AQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVY
                     QYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNH
                     KQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSY
                     MNPERKCRVW"
     exon            399..434
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            435..596
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            597..677
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            678..773
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            774..892
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            893..958
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1093
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1195
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1332
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1426
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1555
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1654
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1735
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1839
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1898
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2018
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2152
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2218
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2314
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2391
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..5872
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /note="hexamer: AATAAA"
     polyA_site      3582
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /note="major polyA site"
     polyA_site      5143
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /note="major polyA site"
     regulatory      5852..5857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /note="hexamer: ATTATA"
     polyA_site      5872
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /note="major polyA site"
ORIGIN      
        1 gacctgagaa tgtggggagg ggaaggggcc gagaaggcga cctggaggag gaccctggga
       61 gtgatgtcag gtcacctcca ggttcatttt catagcttcc tgcagcctcc gcccaggagt
      121 tctgtttggt gaccgagagc agcgctgcca aattgcaccg gggttcattt gggggctggg
      181 aattggccat tccgctgtac agacactgtt tttattttaa aaaacaagat tttaggtgat
      241 gggaagatca gaaagtcaga tggatataac tgatatcaat gctccaaagc caaagaagaa
      301 acagcgatgg actcccctgg agatcagcct ctctgtgctt gtcttgctcc tgactatcat
      361 agcggtgaca atgatcgctc tctatgcaac ctatgatgat ggcatttgca aatcatcaga
      421 ctgcataaaa tcagctgctc gactgattca gaatatggat gcctctgttg agccatgtac
      481 agacttcttc aagtatgctt gtggaggctg gttgaaacgc aacgtcattc ccgagaccag
      541 ttcccgatac agtaattttg acattttaag agatgagcta gaagtcattt tgaaagatgt
      601 ccttcaagaa cccaaaactg aagacatagt agcagtgcag aaagcaaaaa ccttgtacag
      661 atcgtgtata aatgagtctg ctattgatag cagaggcgga caacctctac tcaaactgtt
      721 accagatata tatgggtggc cagtagcatc agataactgg gatcaaacat atggcacttc
      781 ttggacagct gagaaatcca ttgcacaact gaattctaaa tatgggaaaa aggtcctcat
      841 taattttttt gttggcactg atgataagaa ttctacccag catataattc attttgacca
      901 gcctcgactt ggcctccctt ccagagacta ctatgagtgc actggaatat ataaagaggc
      961 ttgcacagca tatgtggatt ttatgatttc tgtggccaga ctgattcgtc aggaacaaag
     1021 tttgcctatt gatgaaaacc agctctcttt ggaaatgaat aaagttatgg aattggaaaa
     1081 agaaattgcc aatgctacaa ctaaaccaga agaccgaaat gacccaatgc tgctttataa
     1141 caaaatgaca ttggccaagc tgcagaacaa cttttccctg gaggtcaatg ggaagtcatt
     1201 cagctggtca aatttcacaa atgaaatcat gtcaactgtg aatattaata ttcaaaatga
     1261 ggaagaagtt gttgtctatg ctccagaata tttaaccaaa cttaagccta ttcttaccaa
     1321 atattctccc agagatcttc aaaatttaat gtcctggagg ttcataatgg atcttgtaag
     1381 cagcctcagc cgaaactaca aggagtccag aaatgctttc cgcaaggccc tttatgggac
     1441 tacatcagaa actgcaacat ggagacggtg tgctaactac gtcaatggga atatggagaa
     1501 tgctgtgggg aggctttatg tggaagcggc ttttgctgga gagagcaagc acgtggttga
     1561 agacttgatt gcacaaatcc gggaagtttt tattcagact ttggatgacc ttacttggat
     1621 ggatgctgag acaaaaaaga aagctgaaga aaaggccttg gcaattaaag aaaggattgg
     1681 ctatcctgat gacatcattt ccaatgagaa caaactgaat aatgagtatc ttgagttgaa
     1741 ctacagggaa gatgaatact ttgagaacat aattcaaaat ttgaaattca gccaaagcaa
     1801 gcagctaaag aagctccgag aaaaagtgga caaagatgag tggataagtg gagcagctgt
     1861 agtcaatgca ttttattcct caggccgaaa tcagatagtc ttccccgctg gcattttgca
     1921 gcccccattc ttcagtgctc agcaatccaa ctcattgaac tatgggggca tcggcatggt
     1981 cattggacat gaaatcacac atggatttga tgacaatgga agaaatttca ataaagatgg
     2041 agacctcgtt gactggtgga cgcagcagtc ggcaaataat tttaaagacc aatcccagtg
     2101 tatggtatac cagtatggaa acttttcctg ggacctagca ggtggacagc atctcaatgg
     2161 aattaataca ctaggagaaa acattgctga taatggaggt attggccaag catacagagc
     2221 ctatcagaat tatgttaaaa agaatggtga agaaaaatta ctccctggac ttgacctcaa
     2281 tcacaaacaa ctatttttcc tgaactttgc ccaggtgtgg tgtgggacct accggccaga
     2341 gtatgcagtc aattctatta aaacagatgt acacagtcct ggaaatttca ggatcattgg
     2401 gactttgcag aactctgccg agtttgcaga tgcctttcat tgccgcaaga attcatacat
     2461 gaatccagaa aggaaatgtc gggtttggtg atcttcacaa gatactgaac atccacggca
     2521 agatttgcca aagccacgga aacaggaact cttccctcag agaaactggg ccccggaagt
     2581 ttcttcagct tcctgggggg caattcacag agacgagcat gagctaacat aaatgaaatt
     2641 agattattaa atctgctgtg aatgaaaggg gagggagcct acgatctagc aaatcaatca
     2701 cttcactgtg taaataatga ttactttcca acggtagtac taccgttcac ttctgtttct
     2761 cacacagact gcagctttca tgttgtctgt agagaacagt gttaacactt aaagcagact
     2821 atgacttctg atcaaaagga ggacgatgct cagtacagca gggcaccaaa gcacagattt
     2881 gcccctcagc actcactttt gtttgcaaca ttcatgctcc ttccaaactc tcccaaagaa
     2941 ctcccataca gactgtggcc ttcaggctcg tgcagttttg aactcatttt accatacata
     3001 agttattcat tcatcccaca tcaatttagt ttgaacactc ttagagctta aactagagta
     3061 tctgaaacgg ttcccctatt tcacccactt tagtgatgtt gagattcttg aacccccctg
     3121 cagatctttg agcaatttct tgctcttgct gcccctcaga ctcagtcttt taaaggattt
     3181 gtagtaatgt ataaagaata attctatatt taattattaa ctacatttat gactgaataa
     3241 accattgcta taggtaatca ttgaatattg aagttatatg gccaagatag ttttgaagat
     3301 ctgtaacatg atatacagac gaaaatttga gactctttaa atctgtaaat catattgatg
     3361 aaaagcttta agtacaaact ctgggggtga gcattaccat tggacgggtg tcttgagata
     3421 cataatagtt gtggtttaca aacagcattt tcaagattaa gtctgtccct agtggctaag
     3481 aaagggtcta actgtatctg tgttgctcca tgaatgctta gccttcaggt ttgtcatcag
     3541 atgaaaatat tttgataata aattgacgtt gtgagcccct tactaggcct gtgtgcacgc
     3601 catgccacct agctttagaa agcctatgtc tgaatcgaga tgggcagcct ccactgtacc
     3661 tgcttcttga attctacagc tcatggactc taattggatt tcctgaggca ctcatatgcc
     3721 ttccttgtcc ttctgcttac tttagtgatt ttcactattc agtataaatt ttacaaagat
     3781 tcatttctac agtccttatt tttatcaaaa ggtgaaaatg aaaacatttc tatccaaact
     3841 cttagttttc atgccttgtg agaaaagccc acttgcttgt aaaagtgtta cagtacaata
     3901 tgtaaaattg tatagaacaa aaactacagt tcagcgaact gatattctct gaacacagca
     3961 ccctagctaa aatctataag aaatggaaca ctgtagcttt ctgccatcat catataactg
     4021 ctaggcatac attatccaga tctccagcat tatgcactag ctctgcccca ttttgtcttt
     4081 cagtcatgca ttacttccta tcttacttct ctctgcctta catttgtaaa atttagctgt
     4141 atgattggtt tatatgtgaa tctatcattg ttgaataagg ttctgttgtg tgactatact
     4201 acaaatattc catcttatta ttgatggact tttaaggact ccatgaactc ctgtctattc
     4261 tggttttgga ttgttacaaa tgatataact atgcattatg aactgtgctt atatattcac
     4321 ctttacttga attatcattg gaatcacttt cccaaaccta tccaaaacta tcataaattt
     4381 taaagacacg gtttcagact gtgtggttac aaacatcctt atctttttcc cttttaaaac
     4441 aaacactatt gtcatgaata atacttatat gactgtttct ttgaaatcaa tttaaacata
     4501 cttgagtact atgaatggtg gtagtagaag atttcagtta aacagctatc tctgggttat
     4561 tttcatttat gtcctgtcat agcagccaaa gagacagaag tgaagagtca atggccacta
     4621 gcatctccac tggtagttca ttaaaggatc aagcttccaa acctatgtaa cagcaactct
     4681 ggtgcctaga ttcctgctgt atatacagca tacagcatat tctttgagct aagggatttt
     4741 aacataaaag ttaaaatggt aattttttcc ctattactcg ggcatccaga tatcagtggt
     4801 tgtagctggt actcagaacc ctatgttctt tcttaattcc taccagccat ttgtcacatt
     4861 acttaagagt tacatataat attatacata aatttgcttc caccgtattt aagttctgat
     4921 cggggagagt ttgttgtaca cttgagagct gttgtagctc atcagtgaag atgaagctcc
     4981 tggcagtatg tgttggcaag gagtctgctt ccataacata gtgtctgtgt gcaaggcaaa
     5041 aggatgctcc ccaggaagtt gaggatttgt tctagttcta ctgccaaagt gaccttgggc
     5101 acatgtatat cccttggggc ttctgcctct tttactccaa aaagaagaca gtaagattcc
     5161 agcagttcat accaatgctg ccttcccttt aacctgttac ccaggaaaca aggaccaaaa
     5221 ttctaacaag cttggggctg tgatactgtt actattaggc atgatgatag gacagacact
     5281 tgcaaacttt cttaagtgtt cataattcct atagcaatag atggagctct tagagtagaa
     5341 ggcatctgtc agtttagaaa gaaaataaca ttctaagatt ctactgtgtc aaaagaagta
     5401 tattcagaat ttttaaaatt aggtcctatt ctctaggata gaaaataaca aacattttca
     5461 taatgttgtt tctatgacta gttgactgtt ccaatttcac caatatgcat gtaaacatac
     5521 acacaccatt tatgccttga aaaatattaa gataaaatag gacattgttt tctatgcagt
     5581 cttatatttc cttcatagtt tcaaactaaa tctttttaaa caaataatat gaagtatttt
     5641 accaacattt tattttaaag ataaccagtt ttctgattag gtgtttcata tggctaccaa
     5701 atgttatcag gagtcacaat tataattgga ttatgctgaa gccaaatgtg caaatgtgaa
     5761 gagctggacc actcaggtga cttggtgaca gaggagccac atgtgactgt tgtcaaaata
     5821 gcatgtttat tgcattctaa ctttttctct aattatattt tcttagtgtc aa
//
