LOCUS       NM_175217               2168 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus monocyte to macrophage differentiation-associated 2
            (Mmd2), transcript variant 1, mRNA.
ACCESSION   NM_175217 XM_981505
VERSION     NM_175217.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2168)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2168)
  AUTHORS   Zhao,L., Thomson,E., Ng,E.T., Longmuss,E., Svingen,T.,
            Bagheri-Fam,S., Quinn,A., Harley,V.R., Harrison,L.C., Pelosi,E. and
            Koopman,P.
  TITLE     Functional Analysis of Mmd2 and Related PAQR Genes During Sex
            Determination in Mice
  JOURNAL   Sex Dev 16 (4), 270-282 (2022)
   PUBMED   35306493
  REMARK    GeneRIF: Functional Analysis of Mmd2 and Related PAQR Genes During
            Sex Determination in Mice.
REFERENCE   3  (bases 1 to 2168)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2168)
  AUTHORS   Perera,S.N., Williams,R.M., Lyne,R., Stubbs,O., Buehler,D.P.,
            Sauka-Spengler,T., Noda,M., Micklem,G., Southard-Smith,E.M. and
            Baker,C.V.H.
  TITLE     Insights into olfactory ensheathing cell development from a
            laser-microdissection and transcriptome-profiling approach
  JOURNAL   Glia 68 (12), 2550-2584 (2020)
   PUBMED   32857879
REFERENCE   5  (bases 1 to 2168)
  AUTHORS   Machado,C.B., Kanning,K.C., Kreis,P., Stevenson,D., Crossley,M.,
            Nowak,M., Iacovino,M., Kyba,M., Chambers,D., Blanc,E. and
            Lieberam,I.
  TITLE     Reconstruction of phrenic neuron identity in embryonic stem
            cell-derived motor neurons
  JOURNAL   Development 141 (4), 784-794 (2014)
   PUBMED   24496616
  REMARK    Erratum:[Development. 2014 Mar 15;141(6):1416]
REFERENCE   6  (bases 1 to 2168)
  AUTHORS   Bouma,G.J., Hudson,Q.J., Washburn,L.L. and Eicher,E.M.
  TITLE     New candidate genes identified for controlling mouse gonadal sex
            determination and the early stages of granulosa and Sertoli cell
            differentiation
  JOURNAL   Biol Reprod 82 (2), 380-389 (2010)
   PUBMED   19864314
REFERENCE   7  (bases 1 to 2168)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   8  (bases 1 to 2168)
  AUTHORS   Gonez,L.J., Naselli,G., Banakh,I., Niwa,H. and Harrison,L.C.
  TITLE     Pancreatic expression and mitochondrial localization of the
            progestin-adipoQ receptor PAQR10
  JOURNAL   Mol Med 14 (11-12), 697-704 (2008)
   PUBMED   18769639
  REMARK    GeneRIF: identification of progestin & adipoQ receptor, PAQR10, in
            a screen for genes differentially expressed in pancreatic
            beta-cells; propose PAQR10 may act at level of the mitochondrion to
            regulate pancreatic endocrine cell development/survival
REFERENCE   9  (bases 1 to 2168)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   10 (bases 1 to 2168)
  AUTHORS   Menke,D.B. and Page,D.C.
  TITLE     Sexually dimorphic gene expression in the developing mouse gonad
  JOURNAL   Gene Expr Patterns 2 (3-4), 359-367 (2002)
   PUBMED   12617826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158310.3.
            
            On Mar 10, 2023 this sequence version replaced NM_175217.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY424299.1, BC025064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC158310.3         184739-184954       c
            217-298             AC158310.3         156362-156443       c
            299-459             AC158310.3         151367-151527       c
            460-534             AC158310.3         150978-151052       c
            535-636             AC158310.3         145647-145748       c
            637-706             AC158310.3         144046-144115       c
            707-2168            AC158310.3         139661-141122       c
FEATURES             Location/Qualifiers
     source          1..2168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 81.53 cM"
     gene            1..2168
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /note="monocyte to macrophage differentiation-associated
                     2"
                     /db_xref="GeneID:75104"
                     /db_xref="MGI:MGI:1922354"
     exon            1..216
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..910
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monocyte to macrophage differentiation factor 2; progestin
                     and adipoQ receptor family member X; progestin and adipoQ
                     receptor family member 10"
                     /codon_start=1
                     /product="monocyte to macrophage differentiation factor 2
                     isoform 1"
                     /protein_id="NP_780426.1"
                     /db_xref="CCDS:CCDS39363.1"
                     /db_xref="GeneID:75104"
                     /db_xref="MGI:MGI:1922354"
                     /translation="MFTLARLLDFQKTKYARFMNDRVPAHKRYQPTEYEHAANCATHA
                     FWIIPSILGSSNLYFLSDDDWETISAWIYGLGLCGLFVVSTIFHTVSWKKSHLRMVEH
                     CLHMIDRMVIYFFIAASYAPWLNLRELGPWASHMRWLVWIMASIGTIYVFFFHERYKL
                     VELLCYVVMGFFPALVILSMPNTDGIWELMTGGAFYCLGMVFFKSDGRIPFAHAIWHL
                     FVAFGAGTHYYAIWRYLYLPSTLQTKVSK"
     exon            217..298
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            299..459
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            460..534
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            535..636
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            637..706
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            707..2168
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2139..2144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2168
                     /gene="Mmd2"
                     /gene_synonym="4930518M15Rik"
                     /note="major polyA site"
ORIGIN      
        1 actccaggct caggggctcg gggctccgga ggcaactgat cgggtctgtt caaggccctg
       61 gagcagcccg aggatctgac acctttccaa cctgctgcgc ctcccgaagc ggctcctggt
      121 gttcccgcgt cccagccctg gtctgggcgc tgatggaacc gcggcgatgt tcactctggc
      181 caggctgctg gatttccaga aaaccaaata tgcaaggttt atgaatgacc gagtcccggc
      241 gcacaagagg taccagccca ctgagtatga acacgcagca aactgtgcca cccatgcttt
      301 ctggatcatt cccagcatcc ttggcagctc caacctctac ttcctgtccg atgacgactg
      361 ggagaccata tctgcctgga tctacggcct tggcctctgt ggcctctttg tggtatccac
      421 cattttccac acagtctcat ggaaaaagag ccacctcagg atggtagagc actgcctgca
      481 catgatcgac aggatggtga tctacttctt cattgccgcc tcctatgctc cttggctgaa
      541 ccttcgggag ctgggcccct gggcctccca catgcgctgg ctggtgtgga tcatggcctc
      601 catcggtacc atctatgtct ttttcttcca tgaacggtac aagcttgtgg agctgctttg
      661 ctatgtggtg atgggtttct tccctgccct ggtcatcctc tccatgccca acactgatgg
      721 catctgggag ctgatgacag gaggggcttt ctactgcctg ggcatggtgt tctttaagag
      781 tgatggaaga attccctttg cccatgccat ctggcacctc tttgtggcat ttggtgctgg
      841 tacccactac tatgccatct ggaggtacct ctacctgccc agcacactgc aaaccaaggt
      901 gtccaaatga gtggcccaga ctccatgggt catttggact ttgggatcaa agcaacatgg
      961 gaagtgaact gtgccaagat ctgcctgtct tttcctggat ggaattcttc atgggtctaa
     1021 ggaacctttc agtgacaaca agaccacctt ttgaatcccc aacaaggaag aaaacattta
     1081 gccctttcta tggaggagaa attaattcag tactgtgttt ctactttaga cagttttttt
     1141 ttttttttta ctataaccaa tattaacatc ttcagaaaag ggccaaacag ggaatgacca
     1201 tccagaaggt aatttttaaa gttctgaggg cctccctttc tgcttcagga gaaagtgatt
     1261 agcattatag atgatctatg gggaatatcc ctgaccatgg taggcatcac caatcaattg
     1321 cagcacgcat gtagcagtag aattcaacat agtgtcccat gcagacatta ctaattgatt
     1381 ctgtgctcat gatggaacct tttggctggc ctggtgtgtt aggagacagg atcacagaat
     1441 aactattaga agtcactgta tgtaggagca tgcttatctc tgggcaccat taccttctac
     1501 tcccttctgt ccatatttga ggaagttctt taagtgagct ctttggaggc agtgcaggga
     1561 gaccaaggca tacattccaa acaggtcctg acactctgtt ccgccatggt tggctcttgg
     1621 ttctagagga gctgagatct gggatgaaga tgctgatacc tggccatttt ttctcatctc
     1681 aaagaatctg gagaaaggat gctgtgttca ccagaggggc ttttcctcag tgtcaggaaa
     1741 cggctctcgg aggcccctca gatggcccta ggagcagggt cttcctctat cagaatgggt
     1801 ggaatatctt catccctcaa cctctgaagt gacctgtcag ctaagagcat ggctcccagg
     1861 ggcctgtcct cagccacctc tattcctggg ctagcctcat cctaagatgc cacatggaca
     1921 ctggctgagt attgagcagc tggcctggct cctgacctga actgacatct cagactctct
     1981 gcaagagtct gctggaaatc caaggtcttg ttcaacaact gccagccaga tgggtgtggg
     2041 caagggtgtg ccaagacagg gtgccttata ctttgttcta gtgcattcca aggtgtttca
     2101 gggcttcagc acctggaatc ccatatgtca aagccagtat taaatcaagt ttatgcattc
     2161 ctcagaaa
//
