LOCUS       NM_026178               2780 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus monocyte to macrophage differentiation-associated
            (Mmd), transcript variant 1, mRNA.
ACCESSION   NM_026178 XM_915062
VERSION     NM_026178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2780)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2780)
  AUTHORS   Zhao,L., Thomson,E., Ng,E.T., Longmuss,E., Svingen,T.,
            Bagheri-Fam,S., Quinn,A., Harley,V.R., Harrison,L.C., Pelosi,E. and
            Koopman,P.
  TITLE     Functional Analysis of Mmd2 and Related PAQR Genes During Sex
            Determination in Mice
  JOURNAL   Sex Dev 16 (4), 270-282 (2022)
   PUBMED   35306493
REFERENCE   3  (bases 1 to 2780)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2780)
  AUTHORS   Huang,M., Lin,Y., Wang,L., You,X., Wang,S., Zhao,J., Bai,M., Li,Z.
            and Chen,Y.
  TITLE     Adipose tissue lipolysis is regulated by PAQR11 via altering
            protein stability of phosphodiesterase 4D
  JOURNAL   Mol Metab 47, 101182 (2021)
   PUBMED   33549845
  REMARK    GeneRIF: Adipose tissue lipolysis is regulated by PAQR11 via
            altering protein stability of phosphodiesterase 4D.
REFERENCE   5  (bases 1 to 2780)
  AUTHORS   Lin,Y., Huang,M., Wang,S., You,X., Zhang,L. and Chen,Y.
  TITLE     PAQR11 modulates monocyte-to-macrophage differentiation and
            pathogenesis of rheumatoid arthritis
  JOURNAL   Immunology 163 (1), 60-73 (2021)
   PUBMED   33421113
  REMARK    GeneRIF: PAQR11 modulates monocyte-to-macrophage differentiation
            and pathogenesis of rheumatoid arthritis.
REFERENCE   6  (bases 1 to 2780)
  AUTHORS   Liu,Q., Zheng,J., Yin,D.D., Xiang,J., He,F., Wang,Y.C., Liang,L.,
            Qin,H.Y., Liu,L., Liang,Y.M. and Han,H.
  TITLE     Monocyte to macrophage differentiation-associated (MMD) positively
            regulates ERK and Akt activation and TNF-alpha and NO production in
            macrophages
  JOURNAL   Mol Biol Rep 39 (5), 5643-5650 (2012)
   PUBMED   22203480
  REMARK    GeneRIF: These results suggested that MMD modulates TNF-alpha and
            NO production in macrophages, and this process might involves Erk
            or Akt.
REFERENCE   7  (bases 1 to 2780)
  AUTHORS   Gonez,L.J., Naselli,G., Banakh,I., Niwa,H. and Harrison,L.C.
  TITLE     Pancreatic expression and mitochondrial localization of the
            progestin-adipoQ receptor PAQR10
  JOURNAL   Mol Med 14 (11-12), 697-704 (2008)
   PUBMED   18769639
REFERENCE   8  (bases 1 to 2780)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   9  (bases 1 to 2780)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   10 (bases 1 to 2780)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC021914.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_915062.1, NM_026178.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021914.1, SRR1660811.62885.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 54.89 cM"
     gene            1..2780
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /note="monocyte to macrophage differentiation-associated"
                     /db_xref="GeneID:67468"
                     /db_xref="MGI:MGI:1914718"
     exon            1..260
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..951
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monocyte to macrophage differentiation protein; progestin
                     and adipoQ receptor family member XI; monocyte to
                     macrophage differentiation factor; progestin and adipoQ
                     receptor family member 11"
                     /codon_start=1
                     /product="monocyte to macrophage differentiation factor
                     isoform 1"
                     /protein_id="NP_080454.1"
                     /db_xref="CCDS:CCDS25240.1"
                     /db_xref="GeneID:67468"
                     /db_xref="MGI:MGI:1914718"
                     /translation="MRFRNRFQRFMNHRAPANGRYKPTCYEHAANCYTHAFLIVPAIV
                     GSALLHRLSDDCWEKITAWIYGMGLCALFIVSTVFHIVSWKKSHLRTVEHCFHMCDRM
                     VIYFFIAASYAPWLNLRELGPLASHMRWFIWLMAAGGTIYVFLYHEKYKVVELFFYLT
                     MGFSPALVVTSMNNTDGLQELACGGLIYCLGVVFFKSDGIIPFAHAIWHLFVATAAAV
                     HYYAIWKYLYRSPTDFIRHL"
     exon            261..342
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /inference="alignment:Splign:2.1.0"
     exon            343..503
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /inference="alignment:Splign:2.1.0"
     exon            504..578
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /inference="alignment:Splign:2.1.0"
     exon            579..680
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /inference="alignment:Splign:2.1.0"
     exon            681..750
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /inference="alignment:Splign:2.1.0"
     exon            751..2661
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2070..2075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /note="hexamer: AATAAA"
     polyA_site      2095
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
     regulatory      2639..2644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /note="hexamer: AATAAA"
     polyA_site      2661
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /note="major polyA site"
ORIGIN      
        1 cgggaggcgc cggggccgtt taagcggcct ccctcccgcc cccaggcgcc tgctctggcc
       61 cgggccctgt gctgaccgac ccccggtgtg gcccactccg gccctgccca gttgcgtggc
      121 tcccgcctgg cacgccagcg gcctcggagc agctcaagcc catgaggccg gcgcgccctg
      181 ccgccggtgc aaaagagacg gagctcccgg cccccgcggt ggagcggtgg atcaatgcgg
      241 ttcaggaatc gattccagcg tttcatgaac catcgggccc cagctaatgg ccgctacaaa
      301 ccaacgtgct acgaacatgc tgccaattgc tacacacacg cattcctcat tgttccggcc
      361 attgtgggca gtgccctcct ccatcggctg tctgatgact gctgggagaa gataacagca
      421 tggatctacg ggatgggcct ttgcgccctc ttcatagtct ccacagtgtt tcacatagta
      481 tcatggaaga agagccactt gagaacagtg gagcattgtt tccacatgtg cgatcggatg
      541 gtcatctact tcttcattgc tgcttcctac gccccatggt taaatctccg tgaacttgga
      601 cccctggcat ctcatatgcg ttggtttatc tggctcatgg cagctggagg aaccatttat
      661 gtatttctct accatgaaaa gtataaagtg gttgaacttt tcttctatct cacgatggga
      721 ttttctccag ccttggtggt gacatcaatg aataacactg acggacttca ggagctcgcc
      781 tgtgggggat tgatttactg cttgggagtt gtgttcttca agagcgatgg catcattccg
      841 ttcgcccatg ccatctggca cctgtttgtg gccacggcag ctgccgtaca ctactatgcc
      901 atttggaaat acctgtaccg aagtcccaca gactttattc ggcatttatg accagtctgt
      961 gctaggtttt caaatcagta ttatcacgat ggaggcactt gggtgggggg aggggcgggg
     1021 ggagaactga atgtcgcaca cagaagaaga gtgagcaaac ttgcactgac ttcgttttaa
     1081 ttttttttta atataattac tgtgaaagta taaaagctgt gtctcggagt tttcctcttc
     1141 acaggcaaca gatgaggtag tgaatcaatt cttcattcca ttccactatc atgaaggact
     1201 cgggagagac ttggccaact gatgtttaca aaccagaaat ttttgtattt ttcttttaca
     1261 gattttaact acgatgattt ttttctaaat taagtaggtc aggttgtcaa agtcagtgca
     1321 atagtaatac aacttccttt ttaagaaaac ccaaagttgt ttctatcacg tttcccgttc
     1381 actgtgtaaa agaatcatgg aaactgaaca ctacttttta ccatgtttca tcttgacata
     1441 acatggttat tttttaaaaa ggaggcttta gttcttttgt aaatttttaa agaaacgatt
     1501 ccattgacgc acacccccac tggctcctca tccatgcgag gtttttgcag caaacggtca
     1561 acattccacg aacaaacatt atacctcttc tggcagtttt attaagtgtg gagaacttgc
     1621 caatttttta gaaacactgc agttttttcc aaccttttct gccaatctct aaccctgaac
     1681 tcagtgctgc tttgggctga catccatgac tggtgtgggc caccaggagt aagacagtag
     1741 tgttttgata ccatccactt tttcagaaga cataacttcg ctacatgcct ttgccccagt
     1801 ttttctccag ggtctctctc cacagtcggg gaggatcctg tccggattat gatagtatta
     1861 ttgggttgcc catctgccat gagctttctg aatcatggcg aattgtattt gccactttgg
     1921 tgcccaacgg ttcaagtcat tgtggttaag ccacttaact ttattgtatg agtttgatat
     1981 tcattttaat tgtgggacta gacacataaa ctcacatttc tgccttttcc tctgcatttc
     2041 tcaatatatt atgtttttct cacgccataa ataaaacatt gattggcagg ttgaagcttg
     2101 tgtcagttgt tgatgggttt tatgctgact ctgtggagtg atatttatat attattttta
     2161 gtttcctctc aatgtcttat attaagattg atgtattagt tgctttgttg gttaatcttt
     2221 cttggtgttt aagagaaatg aagtcacctt gcctttagat cagatgctat tataacctgt
     2281 ctgtctagga acaagctgtc agactaaaga tatggtttat tcattgaaat tctggacagc
     2341 tgtacgttta aaagaaagtt tattttgtat gtgtgtctag gctctgattt ttggtaaatt
     2401 gtaaaggaac aactgaagaa ctggttgctg gggatgtctt cagtagtcag gagtacccaa
     2461 ggataacacc agccacaccg ctgtatatgc atgattctga acagttagcc gcctgttatt
     2521 ttactgtgta tatttgactt taaatatatt aactttttgt ggattcattt aaagtctgct
     2581 catatgcagc actgtcaaaa ccactaaact gtatttgaga acttgtgctg taggttagaa
     2641 taaagttgtt acttgggttg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2761 aaaaaaaaaa aaaaaaaaaa
//
