LOCUS       NP_080454                238 aa            linear   ROD 28-APR-2025
DEFINITION  monocyte to macrophage differentiation factor isoform 1 [Mus
            musculus].
ACCESSION   NP_080454 XP_920155
VERSION     NP_080454.1
DBSOURCE    REFSEQ: accession NM_026178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 238)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 238)
  AUTHORS   Zhao,L., Thomson,E., Ng,E.T., Longmuss,E., Svingen,T.,
            Bagheri-Fam,S., Quinn,A., Harley,V.R., Harrison,L.C., Pelosi,E. and
            Koopman,P.
  TITLE     Functional Analysis of Mmd2 and Related PAQR Genes During Sex
            Determination in Mice
  JOURNAL   Sex Dev 16 (4), 270-282 (2022)
   PUBMED   35306493
REFERENCE   3  (residues 1 to 238)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 238)
  AUTHORS   Huang,M., Lin,Y., Wang,L., You,X., Wang,S., Zhao,J., Bai,M., Li,Z.
            and Chen,Y.
  TITLE     Adipose tissue lipolysis is regulated by PAQR11 via altering
            protein stability of phosphodiesterase 4D
  JOURNAL   Mol Metab 47, 101182 (2021)
   PUBMED   33549845
  REMARK    GeneRIF: Adipose tissue lipolysis is regulated by PAQR11 via
            altering protein stability of phosphodiesterase 4D.
REFERENCE   5  (residues 1 to 238)
  AUTHORS   Lin,Y., Huang,M., Wang,S., You,X., Zhang,L. and Chen,Y.
  TITLE     PAQR11 modulates monocyte-to-macrophage differentiation and
            pathogenesis of rheumatoid arthritis
  JOURNAL   Immunology 163 (1), 60-73 (2021)
   PUBMED   33421113
  REMARK    GeneRIF: PAQR11 modulates monocyte-to-macrophage differentiation
            and pathogenesis of rheumatoid arthritis.
REFERENCE   6  (residues 1 to 238)
  AUTHORS   Liu,Q., Zheng,J., Yin,D.D., Xiang,J., He,F., Wang,Y.C., Liang,L.,
            Qin,H.Y., Liu,L., Liang,Y.M. and Han,H.
  TITLE     Monocyte to macrophage differentiation-associated (MMD) positively
            regulates ERK and Akt activation and TNF-alpha and NO production in
            macrophages
  JOURNAL   Mol Biol Rep 39 (5), 5643-5650 (2012)
   PUBMED   22203480
  REMARK    GeneRIF: These results suggested that MMD modulates TNF-alpha and
            NO production in macrophages, and this process might involves Erk
            or Akt.
REFERENCE   7  (residues 1 to 238)
  AUTHORS   Gonez,L.J., Naselli,G., Banakh,I., Niwa,H. and Harrison,L.C.
  TITLE     Pancreatic expression and mitochondrial localization of the
            progestin-adipoQ receptor PAQR10
  JOURNAL   Mol Med 14 (11-12), 697-704 (2008)
   PUBMED   18769639
REFERENCE   8  (residues 1 to 238)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   9  (residues 1 to 238)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   10 (residues 1 to 238)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC021914.1.
            
            On Dec 7, 2005 this sequence version replaced XP_920155.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021914.1, SRR1660811.62885.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 54.89 cM"
     Protein         1..238
                     /product="monocyte to macrophage differentiation factor
                     isoform 1"
                     /note="monocyte to macrophage differentiation protein;
                     progestin and adipoQ receptor family member XI; monocyte
                     to macrophage differentiation factor; progestin and adipoQ
                     receptor family member 11"
                     /calculated_mol_wt=27546
     Region          27..227
                     /region_name="hlyIII"
                     /note="channel protein, hemolysin III family; TIGR01065"
                     /db_xref="CDD:273425"
     Site            29..49
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQY7.1)"
     Site            62..82
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQY7.1)"
     Site            102..122
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQY7.1)"
     Site            124..144
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQY7.1)"
     Site            152..172
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQY7.1)"
     Site            175..195
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQY7.1)"
     Site            199..219
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQY7.1)"
     CDS             1..238
                     /gene="Mmd"
                     /gene_synonym="1200017E07Rik; 1810073C06Rik; Paqr11"
                     /coded_by="NM_026178.2:235..951"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25240.1"
                     /db_xref="GeneID:67468"
                     /db_xref="MGI:MGI:1914718"
ORIGIN      
        1 mrfrnrfqrf mnhrapangr ykptcyehaa ncythafliv paivgsallh rlsddcweki
       61 tawiygmglc alfivstvfh ivswkkshlr tvehcfhmcd rmviyffiaa syapwlnlre
      121 lgplashmrw fiwlmaaggt iyvflyheky kvvelffylt mgfspalvvt smnntdglqe
      181 lacggliycl gvvffksdgi ipfahaiwhl fvataaavhy yaiwkylyrs ptdfirhl
//
