LOCUS       NM_029956               2991 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus methylmalonic aciduria (cobalamin deficiency) cblB
            type homolog (human) (Mmab), transcript variant 1, mRNA.
ACCESSION   NM_029956
VERSION     NM_029956.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Moreno-Garcia,M.A., Rosenblatt,D.S. and Jerome-Majewska,L.A.
  TITLE     The methylmalonic aciduria related genes, Mmaa, Mmab, and Mut, are
            broadly expressed in placental and embryonic tissues during mouse
            organogenesis
  JOURNAL   Mol Genet Metab 107 (3), 368-374 (2012)
   PUBMED   23022071
  REMARK    GeneRIF: The mouse methylmalonic aciduria- related genes, Mmaa,
            Mmab, and Mut may have specialized functions depending on the
            tissue or cell type.
REFERENCE   3  (bases 1 to 2991)
  AUTHORS   Leal,N.A., Park,S.D., Kima,P.E. and Bobik,T.A.
  TITLE     Identification of the human and bovine ATP:Cob(I)alamin
            adenosyltransferase cDNAs based on complementation of a bacterial
            mutant
  JOURNAL   J Biol Chem 278 (11), 9227-9234 (2003)
   PUBMED   12514191
REFERENCE   4  (bases 1 to 2991)
  AUTHORS   Dobson,C.M., Wai,T., Leclerc,D., Kadir,H., Narang,M.,
            Lerner-Ellis,J.P., Hudson,T.J., Rosenblatt,D.S. and Gravel,R.A.
  TITLE     Identification of the gene responsible for the cblB complementation
            group of vitamin B12-dependent methylmalonic aciduria
  JOURNAL   Hum Mol Genet 11 (26), 3361-3369 (2002)
   PUBMED   12471062
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057558.1.
            
            [WARNING] On Jan 29, 2025 this sequence was replaced by
            NM_029956.5.
            
            On Mar 26, 2018 this sequence version replaced NM_029956.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057558.1, SRR1660817.122536.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2991              BC057558.1         1-2991
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..2991
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /note="methylmalonic aciduria (cobalamin deficiency) cblB
                     type homolog (human)"
                     /db_xref="GeneID:77697"
                     /db_xref="MGI:MGI:1924947"
     exon            1..152
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..750
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /EC_number="2.5.1.17"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cob(I)yrinic acid a,c-diamide
                     adenosyltransferase, mitochondrial; methylmalonic aciduria
                     (cobalamin deficiency) type B homolog; ATP:co(I)rrinoid
                     adenosyltransferase MMAB; corrinoid adenosyltransferase
                     MMAB; ATP:cob(I)alamin adenosyltransferase; cob(II)alamin
                     adenosyltransferase; cobinamide/cobalamin
                     adenosyltransferase; cob(II)yrinic acid a,c-diamide
                     adenosyltransferase"
                     /codon_start=1
                     /product="corrinoid adenosyltransferase MMAB isoform 1
                     precursor"
                     /protein_id="NP_084232.1"
                     /db_xref="CCDS:CCDS19565.1"
                     /db_xref="GeneID:77697"
                     /db_xref="MGI:MGI:1924947"
                     /translation="MAVWLFGGRLGLRGRLSACRLLCPRFQSRGPQGGEDGDRLQPSS
                     TAAKIPKIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFAMELVTEKGH
                     MFAEELQKIQCMLQDVGSALATPRSSAREAHLKHTAFQEGPVLELERWIDKYSSQLPP
                     LKAFILPSGGKSSSALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSDYLFTVA
                     RYAAMKEGSQEKIYKKHDV"
     exon            153..214
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     exon            215..308
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     exon            309..366
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     exon            367..439
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     exon            440..537
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     exon            538..602
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     exon            603..662
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     exon            663..2987
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2947..2952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /note="hexamer: AATAAA"
     polyA_site      2974
                     /gene="Mmab"
                     /gene_synonym="9130222L19Rik; ATR"
                     /note="major polyA site"
ORIGIN      
        1 cctagccggg tcagtcttgg atgcgttacc gtgcgcatgg ctgtgtggct ctttgggggt
       61 cgcctcggcc tgcgcgggcg tctcagcgcc tgcagactgc tgtgtccccg tttccagagc
      121 cgtggccctc agggcgggga agacggggac aggctgcagc cgtcctcgac ggcagccaag
      181 atccccaaga tttacaccaa gacgggagac aaagggtttt ccagcacctt cacaggagaa
      241 aggagaccta aagatgatca agtatttgaa gccgtgggga ccacggatga gctaagctca
      301 gctattgggt ttgccatgga gttggtcaca gaaaaaggcc acatgtttgc cgaagagctt
      361 cagaaaatcc agtgcatgct acaggacgtc ggctccgccc tggccactcc acgttcctca
      421 gccagggagg ctcacttaaa gcacacggcc ttccaggaag ggcctgtcct ggagctggag
      481 cggtggattg acaagtactc cagccagctc cccccgctca aggccttcat tctgccttct
      541 ggaggcaaga gcagctctgc cctgcacttc tgccgcgctg tatgccgtcg tgccgagaga
      601 cgtgtggtgc ctcttgtcca gatgggagag acggatgcaa acgtggcgaa gttcttaaac
      661 aggctcagtg attacctctt cactgtagcc agatatgcag ccatgaagga gggcagccaa
      721 gagaaaatat acaagaaaca tgatgtgtga agcatgaatt tgcacagtgg gcgagaggtc
      781 aactccagac agtcgtgctg agagtggaag tgggggttgg ctacagactc agcatcacct
      841 tgtgctcacc cccccgccct ccagggactt tcgagactcc tggcttctcc aggttgtgtc
      901 gaacatgtca gctgacttcc aaattctggg aaggcaaggt aaactggagg ccacggaggg
      961 gatgggctcc tcggaattga gaatgaacat ggggaaggtt tgaactgtgc acttgggctt
     1021 tctgtgtgtg tgtgtctgtg tgtgtgtgtg tgtgtgagtg tgtgtgtgag agagagagag
     1081 agtgtgtgag agagagagca cactgccaac tcgggctgtt caaggacttg gaatgtacca
     1141 gaggcctctg gaaatgtact agtgatttac ctgtgccgac gggactttaa atgtcacatt
     1201 tataaaggga aggcaggcag gcttgaggag tttagtcacc tctgtgccgc ccatcactgc
     1261 cacagtgtcg gggaaagaca gctgcaggtc cacaggggtt cagctcggag tatcctctcc
     1321 atcaaggcag gaggcaggtg gccctccctg tcccgggtgg tggcagagat ttggtcttca
     1381 gcctgacact tgctctctga tgtcccttgg ctggtctgtg cttccgtgag ccacaccatg
     1441 gcctgtctgt aactctaccg gccaccactg cttcctctcc ctatgaagtg acatcgcagt
     1501 gacacctgtg tccttgggaa gagggatatt tatgagaggc tggaggccgc cctgagaacc
     1561 tcatggtatg cggtgactta ggaagggcag atctgagaca ccctagactc tgctcagcta
     1621 ttgccctctt ccctgtgcac ctgcttggca cgccttccgt gctagctgcc ctgatggtca
     1681 atcagcgagc ctttggtttc agccgtgtat cttctgggtc ctgtgaaggg gagaggccca
     1741 gcagggagga acatccctag gaggctgtcc tgtccaatgc cattgcagcc accatagtga
     1801 gacacggatt gggtacagag ttggtgccat gtgtgtgaga ccagagacag gaggcacagt
     1861 cttagggaac ttaaacacca tgctgttggt ccagacctgg cgggggaagc catgttccaa
     1921 gagctcgaag cggccctgac actccgccta cagctccaga tcttcctaaa aaagatagta
     1981 tgaactcaag agaataggaa gccacgcccc tcgcctgtgc ccaggtcgga tgttgagtgg
     2041 cactcgaaag gtcaatcccc accttcaggc tccaggcatt gcctagcttc gtgtacacca
     2101 cccacgctcc tcatacagtc atacagtgag tctcactgcg agctaacaag ctgcaaaagc
     2161 cgcctttaca ttgtacccat tcaccattga tctctctgtc tgtctctcgg tctctcacaa
     2221 ttcaaccctt gaaaccattg cgggaaggct ttctctcctt ggaacttttg tagaaagcgc
     2281 ttttattgag atacagtcca accaccataa aatgtgtctt tttaaaatgg acatttcagt
     2341 gggttttagg gtattgccca gtttttgcca ccccatacct cacacccagg aggatgcccc
     2401 ctagaacagc attcatcagc atcacagagg tgaacaaact tggtcagtga agccatgcta
     2461 ccaaagggcc caagccaagc acttacactg gacctcacct gagcctcact gggggcgtgg
     2521 agttcacatt actacaggaa gggaaacgga ggctcagcac tgacctagac tgtggcctca
     2581 cacacacaca ccgcccactg gcacttgaca gttgttttaa tcacaacctg ggccgcggca
     2641 ggcagtgcca ggcactaaca gattgctgtc gcatctctca gctcagtctt ccttagctga
     2701 tacttcacga ctcttgttaa tgtgcgtttc tcatggagta attttcagag cctgaacttg
     2761 tagcacatcc caatgataaa tgtcccccgt tccaagtccc ttgtcagctg caatgtcacc
     2821 cttacttcct ccccagcacc tcccgacagc ccatccagtt ttacgatccc tctgtcccag
     2881 tgatcacggc tgaaccttta agaatccgga cgcacttcaa gtttaattga atagaattct
     2941 ttgtataata aattccgcat gaatgctaca taaatcagtg cctggaaaaa a
//
